Clinical trials: Pregnancy, High Risk
Cervical Cancer, Prevention
Primary HPV-based Cervical Cancer Screening Algorithms in Botswana
Primary high-risk human papillomavirus (HPV) testing has become first line screening for cervical cancer in high-income countries.
- Trial name
- NCT04242823
- Testing
- 8-type HPV genotype restriction
- Where
- Botswana
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Pregnancy
Combined Hormonal Contraceptive Use in High Risk Women: A Longitudinal Study
This study is an examination of "high risk" young women, 15-24 years of age, who initiate first time use of vaginal ring, oral contraceptives, contraceptive path, or Depo-provera.
- Trial name
- NCT00361400
- Where
- 5 sites in United States
- Volunteers
- 1,387 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC)
18F-T2 PET/CT Imaging for CAIX Positive Solid Tumors
The goal of this clinical trial is to evaluate the diagnostic value of CAIX protein specific probe 18F-T2 in PET/CT imaging in participants with solid tumors.
- Conditions
- Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC), Colorectal Cancer, Cervical Cancer
- Trial name
- NCT07557225
- Testing
- 18F-T2 PET/CT
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Diabetic Kidney Disease, Diabetes Mellitus, Type 2
Possible Ameliorating Effect of N- Acetylcysteine (NAC) on Type-II Diabetes Induced Nephropathy
The study is focused on the possible improving effect of N-acetylcysteine on nephropathy of type-2 diabetic patients. Study design: Prospective clinical based study.
- Conditions
- Diabetic Kidney Disease, Diabetes Mellitus, Type 2, Diabetic Nephropathies
- Trial name
- (NAC) (NCT04531163)
- Testing
- N Acetylcysteine
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Pregnancy, High Risk Pregnancies
DVA Risk Pregnancy
Maternal obesity, overweight and hypertensive disorders are among the most important risk factors for complications during pregnancy.
- Trial name
- NCT02340442
- Testing
- Obstetrical care parameters, DVA measurements, Fundus photographs
- Where
- 2 sites in Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
High Risk Pregnancy
Music Therapy and High-risk Pregnancy
The objective of this clinical trial is to assess the impact of a music therapy intervention on reactive psychological components related to the risk of preterm birth in hospitalized pregnant women.
- Trial name
- NCT06279559
- Testing
- Music-therapy
- Where
- Italy
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Istituto Giannina Gaslini
Anxiety, Fetal Conditions
The Effect of Stress Ball Intervention During Non-Stress Test on Anxiety and Fetal Well-Being in High-Risk Pregnancy
This research will be conducted to determine the effect of stress ball intervention during NST on anxiety and fetal well-being in high-risk pregnant women.
- Conditions
- Anxiety, Fetal Conditions, Pregnancy Related
- Trial name
- NCT06302010
- Testing
- Stress Ball Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Hümeyra TÜLEK DENİZ
Polycystic Ovary Syndrome
Functional Study of the Hypothalamus in Magnetic Resonance Imaging (MRI) in Polycystic Ovary Syndrome (PCOS)
The aim to evaluate whether activation of the hypothalamic-pituitary-gonadal axis in PCOS is associated with transient microstructural and metabolic changes in the female hypothalamus using MRI approaches to assess water…
- Trial name
- MRI-PCOS (NCT03043924)
- Testing
- Cyproterone Acetate + estradiol, Levonorgestrel, Ethinyl Estradiol 0.1-0.02Mg Oral Tablet
- Where
- France
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Postpartum Hemorrhage
Video Debriefing at the Delivery Ward
Postpartum hemorrhage continues to be the leading cause of maternal morbidity and mortality worldwide. Successful management of postpartum hemorrhage requires not only administration of the right medicine, but also a rapid and…
- Trial name
- NCT04646486
- Testing
- Video debriefing
- Where
- 2 sites in Denmark
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Telomere Length, Mechanisms of Telomter Homeostasis
The Telomere System in Cord Blood and in the Placenta in High Risk Pregnancies
The telomere system stabilizes the chromosomes. Telomeres are shortened during senescence, in cases of genetic instability and secondary to stress.
- Conditions
- Telomere Length, Mechanisms of Telomter Homeostasis, High Risk Pregnancies
- Trial name
- NCT01384136
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Nephropathy
A Prospective, Randomized TrialComparing Oral N-Acetylcysteine and Intravenous Sodium Bicarbonate
The purpose of this study is to compare the efficacy of oral N-acetylcysteine and intravenous sodium bicarbonate for the prevention of Contrast-Induced Nephropathy (CIN) after cardiac catheterization.
- Trial name
- PROTECt (NCT00579995)
- Testing
- Oral N-Acetylcysteine, Sodium Bicarbonate
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Women's Health: Cervical Neoplasm
Mobile Outreach Screening of High-Risk Human Papillomavirus Infection in Women with Limited Access to Health Services in Seine-Saint-Denis (greater Paris Area, France)
The study is a prospective cervical cancer screening intervention in the nonclinical setting of a mobile testing unit in a vehicle, using point-of-care HPV PCR tests with self-collected vaginal swabs.
- Trial name
- PAPMOBILE (NCT06656611)
- Testing
- HPV self sampling
- Where
- France
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Institut de Médecine et d'Epidémiologie Appliquée - Fondation Internationale Léon M'Ba
Gestational Diabetes Mellitus
Lifestyle Intervention and Prevention of Gestational Diabetes Mellitus
The number of women with gestational diabetes mellitus (GDM) had been increasing. Maternal GDM has a great impact on both the health of the mothers and the offspring.
- Trial name
- NCT02368600
- Testing
- Lifestyle modification program
- Where
- China
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Low Birth Weight Baby, Small for Gestational Age (SGA)
Biological Impacts of Rising Temperatures on Maternal, Fetal, and Newborn Health: A Cohort Study (BIRTH Cohort)
The goal of this study is to learn how being exposed to high environmental temperatures during pregnancy affects the health of pregnant women and their babies.
- Conditions
- Low Birth Weight Baby, Small for Gestational Age (SGA), Preterm Birth, Pregnancy Complications
- Trial name
- BIRTH (NCT06957769)
- Testing
- heat stress
- Where
- 3 sites in Pakistan
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Pregnancy, High Risk, Child Development
Nurse Family Partnership for Women With Previous Live Births
The goal of this clinical trial is to test the Nurse Family Partnership (NFP) in mothers with previous live births (multiparous or multip individuals).
- Conditions
- Pregnancy, High Risk, Child Development, Post Partum Depression
- Trial name
- NCT05887115
- Testing
- Nurse Family Partnership
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Infections, Urinary Tract, Nephrolithiasis
Preoperative Prophylactic Antibiotic Duration in Moderate to High Risk Ureteroscopy
The goal of this non-inferiority randomized controlled trial: is to test the hypothesis that the that there is no additional benefit from a longer course (7 days) versus a shorter course (2 days) of pre-operative antibiotics in…
- Trial name
- NCT06149455
- Testing
- Duration of antibiotics
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pregnancy, High Risk
Coconut Oil vs. Commercial Ultrasound Gel In Obstetric Ultrasounds
The goal of this randomized controlled trial is to compare the use of coconut oil with commercial ultrasound gel for obstetrical ultrasounds. The main questions it aims to answer are: 1.
- Trial name
- NCT05653362
- Testing
- Coconut Oil, Commercial Ultrasound Gel
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Indiana University
Fasting, Chronic Disease
A Retrospective and Prospective Cohort Study of the 21-day Fasting-like Diet in Patients With Metabolic and Autoimmune Diseases
Effectiveness of fasting or fasting-mimicking diet has been proved an effective approach to treat metabolic and autoimmune diseases in mice.
- Conditions
- Fasting, Chronic Disease, Autoimmune Diseases, Metabolic Disease
- Trial name
- NCT03193177
- Testing
- the 21-day fasting-like diet
- Where
- China
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Tsinghua University
Cancer, Breast Cancer
Liquid Biopsy Evaluation and Repository Development at Princess Margaret
The objective of this protocol is to develop an institution-wide liquid biopsy protocol that will establish a common process for collecting blood and corresponding archived tumor specimens for future research studies at the…
- Conditions
- Cancer, Breast Cancer, Lung Cancer, Colon Cancer
- Trial name
- LIBERATE (NCT03702309)
- Where
- Canada
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
HIV Seropositivity, Pregnancy, High-Risk
Safer Conception Intervention for HIV-1 Serodiscordant Couples
The greatest burden of the HIV-1 epidemic lies in sub-Saharan Africa, where a substantial proportion of infections occur in long-term heterosexual HIV-1 serodiscordant partnerships.
- Trial name
- SCIP (NCT03030768)
- Testing
- PrEP, Counseling on timed condomless sex, ART and PrEP adherence
- Where
- 2 sites in United States, Kenya
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Washington