Clinical trials: Pregnancy, High-Risk
Pregnancy, High Risk
Coconut Oil vs. Commercial Ultrasound Gel In Obstetric Ultrasounds
The goal of this randomized controlled trial is to compare the use of coconut oil with commercial ultrasound gel for obstetrical ultrasounds. The main questions it aims to answer are: 1.
- Trial name
- NCT05653362
- Testing
- Coconut Oil, Commercial Ultrasound Gel
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Indiana University
Ovarian Diseases
4K Versus 3D Total Laparoscopic Bilateral Oophorectomy: Tools in Comparison
Evaluate whether the 4K laparoscopic vision system can provide an advantage in performing bilateral oophorectomy procedures for benign conditions carried out by trainee surgeons compared to 3D laparoscopy
- Trial name
- TOLSTOY (NCT06750003)
- Testing
- 3D versus 4K laparoscopic bilateral salpingo-oophorectomy
- Volunteers
- 22 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Respiratory Distress Syndrome, Preterm Infant
Nasal High Frequency Oscillation Ventilation(NHFOV) for Respiratory Distress Syndrome
In very preterm infants with severe respiratory distress syndrome(RDS), invasive ventilation(IV) , besides nasal continuous positive airway pressure (NCPAP) and early/selective pulmonary surfactant administration, is one key…
- Trial name
- NHFOV (NCT03140891)
- Testing
- NHFOV, NCPAP
- Where
- China
- Volunteers
- 206 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Birth Weight, Weight Gain Trajectory
Effects of Monitoring Blood Pressure During Pregnancy
In this study, at least 400 women with high-risk of pregnancy hypertension will use a wearable device to monitor the blood pressure during gestational age from 12 weeks to 28weeks.
- Trial name
- NCT06217913
- Testing
- wearable device to monitor the blood pressure
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Cervical Cancer, Endometrial Cancer
A Study of Patients Receiving High-Dose Rate Brachytherapy
Background: One standard way of giving radiation is to combine external beam treatments with internal brachytherapy treatments, which involve short-range radiation therapy that gives a high dose of radiation directly to a cancer…
- Conditions
- Cervical Cancer, Endometrial Cancer, Esophageal Cancer, Prostate Cancer
- Trial name
- NCT00924027
- Testing
- High Dose Radiation (HDR) Brachytherapy, MRI, CT
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- National Cancer Institute (NCI)
Urinary Bladder Neoplasms
A Study Comparing the Efficacy and Safety of Nivolumab in Combination With Bacillus Calmette-Guerin (BCG) Versus BCG Alone in Participants With High-Risk Non-Muscle Invasive Bladder Cancer (HR NMIBC)
A study comparing nivolumab and bacterial drugs given to help the body's immune system in the bladder versus bacterial drugs alone in high risk bladder cancer participants.
- Trial name
- CheckMate 7G8 (NCT04149574)
- Testing
- nivolumab, Bacillus Calmette-Guérin (BCG)
- Where
- 63 sites in United States, Argentina and 14 more
- Volunteers
- 13 people
- Sponsor
- Bristol-Myers Squibb
Pregnancy
Ultrasound Assessment of Gastric Emptying
Hypothesis: The volume of gastric contents will be the same for a high protein drink versus ice chips as measured by ultrasound at 20 minute intervals for two hours in the laboring parturient.
- Trial name
- NCT01672424
- Testing
- Ice Chips, Protein Drink
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Ovarian Cancer
Alpelisib Plus Olaparib in Platinum-resistant/Refractory, High-grade Serous Ovarian Cancer, With no Germline BRCA Mutation Detected
The objective of this study was to evaluate the efficacy and safety of alpelisib in combination with olaparib compared with single-agent cytotoxic chemotherapy in participants with platinum-resistant or platinum-refractory…
- Trial name
- NCT04729387
- Testing
- Alpelisib, Olaparib, Paclitaxel
- Where
- 93 sites in United States, Argentina and 24 more
- Volunteers
- 358 people
- Sponsor
- Novartis Pharmaceuticals
Sepsis, Acute Renal Failure
Super High-Flux - High Volume Dialysis in Sepsis-Induced Acute Renal Failure
Patients within the intensive care unit who have severe infections causing shock and kidney failure have almost a 60% risk of dying despite antibiotic therapy, surgical drainage of the site of infection and intensive care support…
- Trial name
- NCT00333593
- Testing
- Large pore dialyser, Standard dialyser
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- Austin Health
Advanced Malignancies, Metastatic Cancer
INCAGN01876 in Combination With Immune Therapies in Subjects With Advanced or Metastatic Malignancies
The purpose of this study is to determine the safety, tolerability, and efficacy of INCAGN01876 when given in combination with immune therapies.
- Trial name
- NCT03277352
- Testing
- INCAGN01876, Epacadostat, Pembrolizumab
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Incyte Biosciences International Sàrl
Polycystic Ovary Syndrome
The Phenotype and Clinical Intervention of High BCAA Type of PCOS
Polycystic ovary syndrome is one of the main diseases leading to infertility in women of childbearing age. In addition to endocrine and reproductive dysfunction, it is often accompanied by significant metabolic abnormalities…
- Trial name
- BCAAPCOS (NCT06192147)
- Testing
- protein restricted diet combined with vitamin D intervention
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Platinum Sensitive Recurrent High-grade Serous Ovarian Cancer With Mutated p53
p53 Suppressor Activation in Recurrent High Grade Serous Ovarian Cancer, a Phase Ib/II Study of Systemic Carboplatin Combination Chemotherapy With or Without APR-246
The purpose of this study is to make a preliminary assessment of the efficacy of a combined APR-246 and carboplatin/PLD chemotherapy regimen, compared with carboplatin/PLD chemotherapy regimen alone, in patients with platinum…
- Trial name
- NCT02098343
- Testing
- APR-246, Carboplatin and Pegylated Liposomal Doxorubicin Hydrochloride (PLD)
- Where
- 55 sites in United States, Belgium and 6 more
- Volunteers
- 247 people
- Sponsor
- Aprea Therapeutics
Pregnant, High Altitude
The Effect of Different Altitude Levels on Spinal Anesthesia in Cesarean Section Surgery
The aim of the researchers in this prospective study is to determine the differences, if any, in terms of anesthetic parameters among pregnant women who live at different altitudes and undergo cesarean section under neuraxial…
- Trial name
- altitude (NCT05715476)
- Testing
- cesarian surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Giresun University
Myocardial Infarction
Accelerated Rule Out of Myocardial Infarction
Every year > 50.000 people in Denmark are hospitalized with a suspected acute myocardial infarction (AMI). The majority has other explanations of their chest discomfort and most are discharged again without any initiation of…
- Trial name
- AROMI (NCT02666326)
- Testing
- Accelerated, combined biomarker rule-out strategy for MI
- Where
- 3 sites in Denmark
- Volunteers
- 4,516 people
- Sponsor
- Aarhus University Hospital Skejby
Kidney Cancer
Interleukin-2 and Pembrolizumab for Metastatic Kidney Cancer
The main purpose of this study is to evaluate the effects of the interleukin-2 given in combination with pembrolizumab. Interleukin-2 (IL-2) is also called aldesleukin, or Proleukin™.
- Trial name
- NCT02964078
- Testing
- Pembrolizumab, Interleukin-2
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Ovarian Cancer, Fallopian Tube Cancer
Factors Associated With the Use of a High Volume Cancer Center by Black Women With Ovarian Cancer: A Qualitative Study
The purpose of this study is to explore the experiences of Black women who receive care for ovarian cancer at Memorial Sloan Kettering Cancer Center, or "MSK" for short.
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer
- Trial name
- NCT02928549
- Testing
- semi-structured interviews
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cervical Cancer, Radiation Toxicity
Radiation Therapy and Cisplatin With or Without Amifostine for Patients With Stage IIIB or IVA Cervical Cancer
RATIONALE: Drugs used in chemotherapy, such as cisplatin, use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00012012
- Testing
- Amifostine trihydrate, Cisplatin, Intracavitary brachytherapy
- Where
- 17 sites in United States
- Volunteers
- 45 people
- Sponsor
- Radiation Therapy Oncology Group
Diabetes Mellitus
Early Pregnancy Serum Ferritin Levels as a Predictor for Gestational Diabetes Mellitus
This prospective study evaluates a target population of pregnant women at the time of pregnancy diagnosis to investigate the predictive value of serum ferritin (SF) levels for the later development of gestational diabetes…
- Trial name
- NCT07433465
- Testing
- Glycemic Markers
- Where
- Egypt
- Volunteers
- 556 people
- Sponsor
- Zagazig University
End Stage Renal Disease
Safety and Efficacy Study of Thymoglobulin Versus IL2 Receptor Antagonists
The purpose of this study is to evaluate the safety and efficacy of induction therapy with Thymoglobulin in comparison with IL2 receptor antagonists (daclizumab or basiliximab).
- Trial name
- NCT00859131
- Testing
- Rabbit Antithymocyte globulin, Daclizumab
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Medical University of South Carolina
End-Stage Renal Disease
Comparison of Post-dilution On-line Hemodiafiltration and Hemodialysis
This study aims to compare high-efficiency post-dilution on-line hemodiafiltration and high-flux hemodialysis regarding mortality, hospitalization rate, several clinical and laboratory parameters, and required medications.
- Trial name
- NCT00411177
- Testing
- post-dilution on-line hemodiafiltration, high flux hemodialysis
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 782 people
- Sponsor
- Ercan OK