Clinical trials: Pregnancy, Physical Activity
Lupus Nephritis
Anti-alpha-actinin Antibodies and Lupus Nephritis Activity
Lupus nephritis (LN) develops in 30-60% of systemic lupus erythematosus (SLE) patients and remains a leading cause of morbidity, with 10-30% progressing to end-stage renal disease within 15 years.
- Trial name
- NCT07505576
- Testing
- renal biopsy, serum anti-alpha-actinin antibodies, CBC, serum creatinine and urea, estimated GFR, ESR, CRP, urine analysis, ANA, anti dsDNA, C3 & C4, serum albumin, 24-hrs urinary protein, and U. ACR
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Assiut University
Young Adult, Hypertension in Pregnancy
Cardiovascular Longitudinal ALSPAC Research Investigations Following Hypertensive Pregnancy in Young Adulthood
The purpose of this study is to understand more about why young people who were born to a hypertensive pregnancy may have increased risk of high blood pressure and are often at increased risk of heart and blood vessel disease…
- Conditions
- Young Adult, Hypertension in Pregnancy, Hypertension, Cardiovascular Diseases
- Trial name
- CLARITY (NCT05683093)
- Testing
- History of being born to hypertensive or normal pregnancy
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University of Oxford
Systemic Lupus Erythematosus, Lupus Nephritis
Serum MPO-DNA Complexes as a Biomarker of Disease Activity in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by immune system dysregulation and inflammation affecting multiple organs.
- Trial name
- NCT07805863
- Volunteers
- 90 people
- Sponsor
- Assiut University
Chronic Kidney Disease
Resistance Exercise Training in Chronic Kidney Disease
The investigators aim to evaluate the feasibility of a resistance exercise training program among individuals with CKD and its impact on endothelial and vascular function.
- Trial name
- NCT03120416
- Testing
- Resistance exercise training
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Illinois Chicago
Gestational Diabetes
Physical Activity Intervention for Gestational Diabetes
Gestational diabetes mellitus (GDM) portends an immediate, increased risk for Type 2 diabetes mellitus (T2DM). The increased risk associated with having GDM is compounded by excess weight retention.
- Trial name
- GDM (NCT03664089)
- Testing
- Ankle weights (2.5 pounds [1.1 kg]/ankle), Control
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Sarah Keim
Myotonic Dystrophy Type 1, Urinary Incontinence
Pelvic Floor Muscle Training for Women with Myotonic Dystrophy
Myotonic dystrophy type 1 (DM1) is a neuromuscular disease characterized by multisystem manifestations. DM1 can affect the urinary system through the impact of the pelvic floor muscles (PFM).
- Trial name
- NCT06316778
- Testing
- Pelvic floor muscle training
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Université de Sherbrooke
Chronic Kidney Disease, End-stage Renal Disease
Home-based Exercise in Chronic Kidney Disease
A home-based exercise program will be implemented in three different groups of participants: advanced chronic kidney disease, end-stage renal disease in substitutive treatment hemodialysis or peritoneal dialysis.
- Trial name
- HBCKD-BCN (NCT03621176)
- Testing
- Home-based exercise
- Where
- Spain
- Volunteers
- 57 people
- Sponsor
- Cardenal Herrera University
Chronic Kidney Disease, Hypertension
Aerobic Training and Arterial Stiffness in Chronic Kidney Disease (CKD) Patients
The current study is designed to examine the impact of 16 weeks of moderate intensity aerobic training on arterial stiffness and blood pressure in stage 3 chronic kidney disease (CKD) patients.
- Conditions
- Chronic Kidney Disease, Hypertension, Diabetes
- Trial name
- NCT01399489
- Testing
- Exercise training
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Springfield College
Endometriosis
Effect of a Rehabilitation Program to Improve Quality of Life in Women Diagnosed With Endometriosis (Physio-EndEA Study)
Given (1) the high volume of women on reproductive age that have a clinical diagnosis of endometriosis and (2) the poor management of symptoms that medical treatment usually achieves, new therapeutic interventions need to be…
- Trial name
- Physio-EndEA (NCT03979183)
- Testing
- Lumbopelvic, stretching, aerobic and relaxation exercises
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Universidad de Granada
End-Stage Kidney Disease
PrEscription of Intra-Dialytic Exercise to Improve quAlity of Life in Patients With Chronic Kidney Disease
The PEDAL study aims to evaluate the effectiveness of a 9-month intradialytic exercise training intervention designed to improve quality of life (QOL) and alleviate functional limitations in patients with stage 5 Chronic Kidney…
- Trial name
- PEDAL (NCT02222402)
- Testing
- INTRA-DIALYTIC EXERCISE TRAINING
- Where
- United Kingdom
- Volunteers
- 335 people
- Sponsor
- King's College Hospital NHS Trust
Pregnancy
Exercise During Pregnancy: Effects on the Maternal-Fetal Unit
Metabolic alterations during pregnancy have been associated with adverse maternal-fetal outcomes, including low birth weight and pregnancy complications.
- Trial name
- PREGFIT (NCT07264231)
- Testing
- Intervention
- Where
- Spain
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Universidad Pública de Navarra
Pelvic Floor Disorders, Obstetric Trauma
Repair by Rehabilitation of Pelvic Floor Lesions After Vaginal Delivery Identified by Transperineal Ultrasound 3/4 D
SUMMARY: (Objective, design, scope of the study, subjects of study, instrumentation, results, conclusions) Objectives: To evaluate if the physiotherapy treatment in pelvic floor dysfunctions, identified by transperineal…
- Conditions
- Pelvic Floor Disorders, Obstetric Trauma, Physical Disorder, Physical Activity
- Trial name
- NCT03686956
- Testing
- Physiotherapy treatment
- Where
- Spain
- Volunteers
- 92 people
- Sponsor
- Hospital Universitario de Valme
Stress Urinary Incontinence, Postpartum
Differences in the Effectiveness of Electromagnetic Stimulation Therapy and Kegel Exercises Based on Compliance, Subjective - Objective Symptoms and Pelvic Floor Muscle Strength in Postpartum Stress Urinary Incontinence
Electromagnetic stimulation is a new modality and alternative in women with urinary incontinence (UI). However, there was not much evidence that compares the use of electromagnetic stimulation to Kegel Exercises in post-partum…
- Trial name
- NCT05021302
- Testing
- NOVAMAG NT-60, Kegel Exercises
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Indonesia
Cervical Cancer, Fallopian Tube Cancer
Gefitinib in Treating Patients With Cervical Cancer
RATIONALE: Biological therapies such as gefitinib may interfere with the growth of the tumor cells and slow the growth of cervical cancer.
- Conditions
- Cervical Cancer, Fallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cavity Cancer
- Trial name
- NCT00049556
- Testing
- gefitinib, immunohistochemistry staining method, surface-enhanced laser desorption/ionization-time of flight mass spectrometry
- Where
- 2 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Urinary Incontinence
Variation of Physical Activity, Measured by the Number of Steps Per Day, After Artificial Urinary Sphincter Implantation
The management of urinary incontinence seems to improve daily activities and the practice of physical activity, according to the literature.
- Trial name
- AP-SU (NCT04008108)
- Testing
- Activity sensor
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Endometriosis
Effect of Physical Activity and Pain Education on Endometriosis-associated Pain
Endometriosis is a benign gynecological condition where the uterine endometrium is located outside the uterus. The condition affects up to 10% of women of fertile age and up to 70% of women with endometriosis have symptoms with…
- Trial name
- NCT05091268
- Testing
- Exercise
- Where
- Norway
- Volunteers
- 83 people
- Sponsor
- University Hospital, Akershus
Epithelial Ovarian Cancer, Fallopian Tube Cancer
Study of Safety & Biological Activity of IP IMNN-001 (also Known As GEN-1) with Neoadjuvant Chemo in Ovarian Cancer
This dose escalation study will determine a maximum tolerated dose and/or optimal biological dose of GEN-1 for carboplatin/paclitaxel combination in newly diagnosed ovarian cancer.
- Conditions
- Epithelial Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer
- Trial name
- NCT02480374
- Testing
- IMNN-001
- Where
- 4 sites in United States
- Volunteers
- 18 people
- Sponsor
- Imunon
Renal Cell Carcinoma
Study to Evaluate Safety, Pharmacokinetics and Therapeutic Activity of RO6874281 as a Combination Therapy in Participants With Unresectable Advanced and/or Metastatic Renal Cell Carcinoma (RCC)
This is an open-label, multi-center, randomized, Phase 1b, adaptive, clinical study to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary therapeutic activity of RO6874281 in combination with…
- Trial name
- NCT03063762
- Testing
- Atezolizumab, Bevacizumab, RO6874281
- Where
- 23 sites in United States, Canada and 7 more
- Volunteers
- 69 people
- Sponsor
- Hoffmann-La Roche
Stress Urinary Incontinence, Urge Urinary Incontinence
Age-stratified Outcome of Pelvic Floor Muscle Exercise for Urinary Incontinence
In this retrospective study the outcome of pelvic floor muscle training in 150 women will be tested regarding patients reported satisfaction and achievement of the incontinence improvement.
- Trial name
- NCT01445834
- Volunteers
- 150 people
- Sponsor
- University of Zurich
Multiple Sclerosis, Urinary Incontinence
Aerobic Exercise for Urinary Incontinence in Multiple Sclerosis
Limited studies has investigated the effect of aerobic exercise program on urinary inconitenance in people with multiple sclerosis.
- Trial name
- UI-MS (NCT06843915)
- Testing
- Moderate intensity aerobic exercise, Home Exercise Program
- Where
- Jordan
- Volunteers
- 40 people
- Sponsor
- University of Sharjah
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