Clinical trials: Pregnancy Anemia
Heart Failure, Anemia
Effects of SGLT2 Inhibitors on Erythropoiesis in Heart Failure
This retrospective cohort study investigates the effects of SGLT2 inhibitor therapy on erythropoiesis and its association with cardiac and renal outcomes in patients with chronic heart failure.
- Conditions
- Heart Failure, Anemia, Renal Insufficiency
- Trial name
- SGLT2-RISE (NCT07478575)
- Where
- Slovenia
- Volunteers
- 85 people
- Sponsor
- University Medical Centre Ljubljana
Intrauterine Growth Restriction, Preeclampsia
Low Dose Aspirin for Preventing Intrauterine Growth Restriction and Preeclampsia in Sickle Cell Pregnancy (PIPSICKLE)
Pregnancy in sickle cell disease (SCD) is fraught with many complications including preeclampsia (PE) and intrauterine growth restriction (IUGR).
- Conditions
- Intrauterine Growth Restriction, Preeclampsia, Sickle Cell Disease, Pregnancy Complications
- Trial name
- PIPSICKLE (NCT05253781)
- Testing
- Low-dose aspirin
- Where
- 16 sites in Nigeria
- Volunteers
- 476 people, healthy volunteers welcome
- Sponsor
- University of Lagos, Nigeria
Kidney Failure, Chronic, Anemia
Cholecalciferol Supplementation for Anemia and Mineral and Bone Disorder in Hemodialysis Patients
The purpose of this study is to determine whether cholecalciferol supplementation decrease the blood concentrations of hepcidin-25 in hemodialysis patients.
- Conditions
- Kidney Failure, Chronic, Anemia, Vitamin D Deficiency, Bone Diseases, Metabolic
- Trial name
- CHAMBER (NCT02214563)
- Testing
- Cholecalciferol, Olive oil
- Where
- 7 sites in Japan
- Volunteers
- 90 people
- Sponsor
- Takayuki Hamano
Anemia, Renal Insufficiency, Chronic
Maintenance Treatment of Anemia in Pre-dialysis Subjects With Chronic Kidney Disease on Darbepoetin Treatment Versus BAY85-3934
Anaemia is a condition in which blood has a lower than normal number of red blood cells. It can also occur if red blood cells do not contain enough haemoglobin, an oxygen carrying part of blood.
- Trial name
- DIALOGUE 2 (NCT02021409)
- Testing
- BAY85-3934, Darbepoetin alfa
- Where
- 51 sites in Australia, Bulgaria and 12 more
- Volunteers
- 126 people
- Sponsor
- Bayer
Chronic Kidney Disease (Stages 3b-5), Anemia Associated With Chronic Kidney Disease
Effect of Daprodustat and Epoetin Alpha on Anemia in Patients Not Undergoing Dialysis
Anemia in CKD patients is mainly attributed to impaired kidney being unable to adequately respond to hypoxia and/or anaemia by inducing erythropoietin (EPO) production iron disorders, blood loss, shortened erythrocyte survival…
- Trial name
- NCT07755683
- Testing
- Epoetin Alfa (drug), Daprodustat
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Services Hospital, Lahore
Sickle Cell Disease, Pregnancy Related
LEARNER- Low dosE AspiRiN prEterm tRial (Angola)
This study is being conducted to evaluate the safety and effect of starting daily use of low dose (100 mg) aspirin in pregnant women with sickle cell disease, who are being followed in two county hospitals in Angola, in the first…
- Conditions
- Sickle Cell Disease, Pregnancy Related, Pregnancy Complications, Pre-Eclampsia
- Trial name
- LEARNER (NCT06417411)
- Testing
- Aspirin 100mg
- Where
- Angola
- Volunteers
- 450 people
- Sponsor
- Instituto Nacional de Investigacao em Saude, Angola
Hemolytic-Uremic Syndrome, Atypical
Personalized Spacing of Eculizumab Infusions Based on Therapeutic Pharmacological Monitoring (EspacECU)
Eculizumab is an anti-C5 monoclonal antibody approved for rare diseases including atypical haemolytic-uraemic syndrome. The maintenance phase dosing regimen is identical for all adult patients but several studies have shown a…
- Trial name
- EspacECU (NCT04859608)
- Testing
- Spacing of Eculizumab infusions
- Where
- 18 sites in France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Tours
Anemia, Non-Dialysis-Dependent Chronic Kidney Disease
Study to Evaluate Vadadustat for the Correction of Anemia in Participants With Non-dialysis-dependent Chronic Kidney Disease
A multicenter, randomized, open-label, active-controlled Phase 3 study for the correction of anemia and maintenance of hemoglobin (Hb) in participants with Non-Dialysis-Dependent Chronic Kidney Disease (NDD-CKD)
- Trial name
- NCT02648347
- Testing
- Vadadustat, Darbepoetin alfa
- Where
- 439 sites in United States, Argentina and 18 more
- Volunteers
- 1,751 people
- Sponsor
- Akebia Therapeutics
Anemia, Dialysis-Dependent Chronic Kidney Disease
Efficacy and Safety Study to Evaluate Vadadustat for the Maintenance Treatment of Anemia in Participants With Dialysis-dependent Chronic Kidney Disease (DD-CKD)
A multicenter, randomized, open-label, active-controlled Phase 3 study for the maintenance treatment of anemia in participants with dialysis-dependent chronic kidney disease (DD-CKD)
- Trial name
- NCT02892149
- Testing
- Vadadustat, Darbepoetin alfa
- Where
- 278 sites in United States, Argentina and 16 more
- Volunteers
- 3,554 people
- Sponsor
- Akebia Therapeutics
Anemia, Chronic Kidney Disease
Peginesatide for Anemia in Chronic Hemodialysis Patients
The purpose of this study is to evaluate the safety, pharmacodynamics (PD), and pharmacokinetics (PK) of multiple intravenous doses of peginesatide in participants with chronic kidney disease (CKD) who are on hemodialysis.
- Conditions
- Anemia, Chronic Kidney Disease, Chronic Renal Failure
- Trial name
- NCT00228449
- Testing
- peginesatide
- Where
- 14 sites in United States
- Volunteers
- 165 people
- Sponsor
- Affymax
End Stage Renal Disease
Less Frequency Hemodialysis and COVID-19
Facing the unusual situation imposed by the coronavirus disease, the aim of this study is to evaluate the risk and effects of less frequent hemodialysis on prevalent patients
- Trial name
- NCT04374058
- Testing
- less-frequency hemodialysis
- Where
- Argentina
- Volunteers
- 50 people
- Sponsor
- Dialisis Madariaga
Anemia, Iron-Deficiency, Kidney Failure, Chronic
Effect of Ferrlecit® Versus Oral Iron on Iron Deficient Chronic Kidney Disease (CKD) Patients
This study compares the effect of Ferrlecit® (a form of intravenous iron) to ferrous sulfate (a form of oral iron) in treating anemia and iron deficiency in chronic kidney disease patients who are not receiving erythropoietic…
- Trial name
- NCT00224055
- Testing
- Sodium Ferric Gluconate Complex in Sucrose Injection, Ferrous sulfate tablets
- Where
- 24 sites in United States, Puerto Rico
- Volunteers
- 89 people
- Sponsor
- Watson Pharmaceuticals
Post Partum Hemorrhage, Anemia
Single Dose Intravenous Iron Isomaltoside in Combination With Oral Iron vs Oral Iron Monotherapy in Patients With Anemia After Postpartum Haemorrhage
The investigator's study is going to compare effectiveness of single dose intravenous iron in combination with oral iron versus oral iron monotherapy in correcting haemoglobin deficit, replenishing iron stores and improving…
- Trial name
- IVIronPPH (NCT04505514)
- Testing
- Iron Isomaltoside 1000, Iberet-Folic-500
- Where
- Malaysia
- Volunteers
- 60 people
- Sponsor
- University of Malaya
Hemoglobinuria
Paroxysmal Nocturnal Hemoglobinuria (PNH), Level of CD59 on Red and White Blood Cells in Bone Marrow Failure Syndromes
Examine red and white blood cells of PNH patients with bone marrow failure syndromes.
- Trial name
- EXPLORE (NCT01192425)
- Volunteers
- 5,580 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Kidney Disease, Chronic
An Observational Study of Mircera (Methoxy Polyethylene Glycol-epoetin Beta) in Patients With Chronic Kidney Disease Not On Dialysis
This observational, prospective, multicenter study will describe the mean dose of Mircera (methoxy polyethylene glycol-epoetin beta) and the hemoglobin levels in patients with chronic kidney disease.
- Trial name
- NCT01318512
- Where
- Czechia
- Volunteers
- 340 people
- Sponsor
- Hoffmann-La Roche
Peritoneal Dialysis (PD), Anemia
Study of Intraperitoneal Triferic in Patients on Chronic Peritoneal Dialysis
The main purpose is to determine the pharmacokinetic (PK) profile, maximum concentration (Cmax) and Area Under the Concentration Time Curve (AUC0-t) of Triferic iron administered intraperitoneally in patients with chronic kidney…
- Conditions
- Peritoneal Dialysis (PD), Anemia, Chronic Kidney Disease
- Trial name
- NCT02909153
- Testing
- Triferic
- Volunteers
- 30 people
- Sponsor
- Rockwell Medical Technologies, Inc.
Anemia of Prematurity
The Effect of Blood Transfusion on Blood Flow to the Intestines of Premature Infants
The purpose of the study is to see if a blood transfusion changes how fast blood flows to the intestines of a premature baby. Blood flow is measured by an ultrasound test.
- Trial name
- NCT00167388
- Testing
- feed during blood transfusion
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Pittsburgh
Chronic Kidney Diseases, Sickle Cell Disease
Sickle Cell Uric Acid (SCUA) - Cohort Repository
The purpose of this research is to study the causes of Sickle Cell kidney disease, as well as to collect and store samples and information about people with Sickle Cell Disease.
- Trial name
- NCT04190888
- Testing
- No intervention
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Virginia Commonwealth University
Breast Cancer, Ovarian Cancer
Risk Education and Assessment for Cancer Heredity
Individuals living in geographically underserved areas encounter considerable barriers to access of quality cancer genetic services.
- Conditions
- Breast Cancer, Ovarian Cancer, Genetic Predisposition
- Trial name
- REACH (NCT01346761)
- Testing
- Telephone Genetic Counseling, In-Person Genetic Counseling
- Where
- United States
- Volunteers
- 1,012 people, healthy volunteers welcome
- Sponsor
- University of Utah
Chronic Kidney Disease, Hemodialysis
Low Sirtuin-1 Levels Are Linked to Erythropoietin Resistance in Hemodialysis Patients.
This study investigates the relationship between Sirtuin-1 (SIRT1) levels and erythropoietin resistance in hemodialysis patients.
- Conditions
- Chronic Kidney Disease, Hemodialysis, Anemia in End Stage Renal Disease, Erythropoietin
- Trial name
- NCT06877286
- Testing
- Sirtuin-1 Level Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 391 people
- Sponsor
- Cuma Bulent Gul