Clinical trials: Pregnancy Anemia
Anemia, Malnutrition
Efficacy of Lipid-Based Nutrient Supplements (LNS) for Pregnant and Lactating Women and Their Infants
In Ghana, low micronutrient intakes among pregnant women are a major problem. The standard nutritional intervention during pregnancy is iron-folic acid tablets, but adherence is low.
- Conditions
- Anemia, Malnutrition, Stunting
- Trial name
- NCT00970866
- Testing
- Iron and Folic Acid (IFA), Multiple Micronutrient (MMN) group, Lipid-based Nutrient Supplements (LNS) group
- Where
- 4 sites in Ghana
- Volunteers
- 3,499 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Kidney Disease
Single Dose Safety Study for Compound to Treat Anemia in Patients With Renal Impairment
The purpose of this study is to characterize the safety and tolerability of single doses of compound 1278863A in subjects with renal impairment.
- Trial name
- NCT00935831
- Testing
- GSK1278863A
- Where
- New Zealand
- Volunteers
- 12 people
- Sponsor
- GlaxoSmithKline
Hypophosphatemia, Chronic Kidney Diseases
Investigation of Hypophosphataemia Following Intravenous Iron
Anaemia (low haemoglobin levels) can develop in a number of conditions, including chronic kidney disease (CKD) and intestinal conditions (e.g. inflammatory bowel disease, intestinal failure).
- Conditions
- Hypophosphatemia, Chronic Kidney Diseases, Intestinal Disease, Anemia
- Trial name
- NCT04502784
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Belfast Health and Social Care Trust
Kidney Disease
Treatment for Subjects With Chronic Kidney Disease (CKD) Not Receiving Dialysis
The proposed study is designed to test a novel dosing paradigm that would facilitate the treatment of anemia in CKD patients not on dialysis.
- Trial name
- NCT00111098
- Testing
- Darbepoetin Alfa
- Volunteers
- 150 people
- Sponsor
- Amgen
Anemia, Chronic Renal Insufficiency
Randomized, Controlled, Double-blind Multicenter Safety Study to Evaluate the Safety and Immunogenicity of Subcutaneous EPO HEXAL vs. ERYPO® in the Treatment of Anemia Associated With Chronic Renal Insufficiency in Predialysis Patients
This is a randomized, controlled, double-blind, multicenter multinational safety study involving about 300 predialysis patients aged 18 years or above suffering from anemia. Symptomatic anemia will be corrected by s.c.
- Trial name
- NCT00701714
- Testing
- HX575 recombinant human erythropoietin alfa, ERYPO
- Where
- 123 sites in Austria, Bulgaria and 8 more
- Volunteers
- 337 people
- Sponsor
- Sandoz
Hypertensive Emergency-associated Hemolytic Uremic Syndrome
Eculizumab in Hypertensive Emergency-associated Hemolytic Uremic Syndrome
Hemolytic and uremic syndrome (HUS) is a clinic-biological syndrome related to thrombotic microangiopathy affecting predominantly the kidney.
- Trial name
- HYPERSHU (NCT05726916)
- Testing
- Soliris®, Renin angiotensin system blockers
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hemolytic Uremic Syndrome, Hemorrhagic Colitis
Study of Repetitive Intestinal Lavage in Patients With EHEC Associated Hemorrhagic Colitis
The investigators examined the outcome of patients with severe Enterohaemorrhagic E. Coli (EHEC) O104:H4 infection suffering from bloody diarrhoea that were at risk to develop hemolytic uremic syndrome and underwent repetitive…
- Conditions
- Hemolytic Uremic Syndrome, Hemorrhagic Colitis, Intestinal Infectious Disease, Intestinal Infection Due to E. Coli
- Trial name
- EHEC-PEG (NCT01561248)
- Testing
- polyethylene glycol solution for daily bowel lavage.
- Where
- Germany
- Volunteers
- 33 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Anemia Renal
Erythropoietin Role in Acute Kidney Injury
The use of erythropoietin to treat anemia in acute kidney injury (AKI) is controversial. No previous clinical trial has assessed the possible reduction of transfusions when erythropoietin is started very early in a setting of…
- Trial name
- EAKI (NCT03401710)
- Testing
- Erythropoietin
- Where
- Lebanon
- Volunteers
- 134 people
- Sponsor
- Saint-Joseph University
Anemia of Pregnancy, Gestational Diabetes
SMART Health Pregnancy 2 - Intervention to Reduce Anaemia and Cardiometabolic Risk During Pregnancy and in the First Year Following Birth
The goal of this clinical trial is to determine if a complex intervention called SMARThealth Pregnancy can improve the detection and management of high-risk conditions during pregnancy and in the first year after birth in women…
- Conditions
- Anemia of Pregnancy, Gestational Diabetes, Gestational Hypertension, Pre-Eclampsia
- Trial name
- NCT05752955
- Testing
- SMARThealth Pregnancy
- Where
- India
- Volunteers
- 3,446 people
- Sponsor
- The George Institute
Iron Deficiency Anemia of Pregnancy
Daily vs Intermittent Iron Therapy in Pregnancy
This is a randomized non inferiority trial to evaluate the response to iron therapy in the standard daily vs. intermittent (three-four times a week on nonconsecutive days) groups by using hematological markers (hemoglobin…
- Trial name
- NCT03706638
- Testing
- Ferrous Sulfate
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- UConn Health
End Stage Renal Disease, Hypertension
Electronic Decision Support for Deprescribing in Patients on Hemodialysis
Dialysis patients are prescribed an average of 10-12 medications per day, from up to 4-5 different clinicians and have the heaviest pill burden of all chronic conditions given their degree of comorbidity.
- Conditions
- End Stage Renal Disease, Hypertension, Diabete Type 2, Renal Failure Chronic
- Trial name
- MedSafer-HD (NCT05585268)
- Testing
- Medication reconciliation supplemented with MedSafer and deprescribing brochures
- Where
- Canada
- Volunteers
- 195 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Fanconi Anemia Complementation Group A
A Clinical Trial to Evaluate the Safety of RP-L102 in Pediatric Subjects With Fanconi Anemia Subtype A
The objective of this study is to assess the therapeutic safety and preliminary efficacy of a hematopoietic cell-based gene therapy consisting of autologous CD34+ enriched cells transduced with a lentiviral vector carrying the…
- Trial name
- NCT03814408
- Testing
- RP-L102
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Rocket Pharmaceuticals Inc.
Epithelial Ovarian Cancer, Anemia
Evaluation and Treatment of Iron Deficiency in Ovarian Cancer Patients
This study tests the hypothesis that IV iron sucrose infusions given to iron deficient ovarian cancer patients prior to debulking surgery can improve pre-operative iron stores and decrease transfusion of packed red blood cells in…
- Conditions
- Epithelial Ovarian Cancer, Anemia, Iron Deficiency Anemia
- Trial name
- NCT03933813
- Testing
- Iron Sucrose
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Wisconsin, Madison
Anemia
Correction of Hemoglobin and Outcomes in Renal Insufficiency (CHOIR)
The purpose of this study is to compare the outcomes of patients with chronic kidney disease (CKD) randomly assigned to 2 treatment groups, which differ only in their targeted hemoglobin levels.
- Trial name
- NCT00211120
- Testing
- Epoetin Alfa
- Volunteers
- 1,432 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Kidney Failure, Chronic
Darbepoetin Treatment of Anemia in Children With Chronic Renal Failure
This is a study to determine the safety and effectiveness of Darbepoetin (Aranesp) given every 14 to 28 days to treat low red blood cells in children with chronic kidney failure.
- Trial name
- NCT00213291
- Testing
- darbepoetin alfa
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- The Hospital for Sick Children
Chronic Renal Failure
Docohexanoic Acid in Hemodialysis Patients
Docohexanoic acid (DHA), a dietary n-3 polyunsaturated fatty-acid omega-3 (n-3, PUFA), showed potential beneficial effects in reducing all-cause mortality in hemodialysis (HD) patients.
- Trial name
- NCT04536636
- Testing
- Docohexanoic acid, Control-No drug
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Ultomiris-exposed Pregnant/ Postpartum, Pregnancy
Study of Ultomiris® (Ravulizumab) Safety in Pregnancy
The primary objective of this study is to describe the frequency and characteristics of pregnancy outcomes and maternal complications among participants exposed to Ultomiris and to describe the frequency and characteristics of…
- Conditions
- Ultomiris-exposed Pregnant/ Postpartum, Pregnancy, Paroxysmal Nocturnal Hemoglobinuria (PNH), Atypical Hemolytic Uremic Syndrome (aHUS)
- Trial name
- NCT06312644
- Testing
- Ultomiris
- Where
- 7 sites in United States, Australia and 5 more
- Volunteers
- 75 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
s100b, Hypoxia-Ischemia, Brain
Cord Blood S100B Protein Levels in Neonates Following Intrauterine Transfusions for HDFN-Associated Fetal Anemia
levated levels of S100B protein are a well-established marker of central nervous system (CNS) damage. Fetal anemia resulting from hemolytic disease of the fetus and newborn (HDFN) often necessitates intrauterine transfusions…
- Conditions
- s100b, Hypoxia-Ischemia, Brain, Hemolytic Disease of the Fetus and Newborn, Fetal Anemia
- Trial name
- NCT06984445
- Testing
- Cord blood S100B protein level prior to IUT, Umbilical cord blood gas analysis prior to IUT, Fetal blood count evaluation prior to IUT
- Where
- Poland
- Volunteers
- 180 people
- Sponsor
- Institute of Mother and Child, Warsaw, Poland
Chronic Kidney Disease, Blood Pressure
Mechanisms of EPO-induced Hypertension
The investigators hypothesize that compared to untreated controls, erythropoietin (EPO) therapy in anemic patients with chronic kidney disease will raise diastolic blood pressure (BP).
- Conditions
- Chronic Kidney Disease, Blood Pressure, Anemia
- Trial name
- EPIC (NCT03810911)
- Testing
- Darbepoetin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- VA Office of Research and Development
Anemia of Pregnancy
Prevalence and Determinants of Anemia During the Third Trimester of Pregnancy
This cross-sectional study was conducted on 383 pregnant women who attended the antenatal care clinic during their third trimester at Beni-Suef University Hospital. A proper history was taken from each participant.
- Trial name
- NCT05479799
- Where
- Egypt
- Volunteers
- 383 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University