Clinical trials: Pregnancy Early
Continuous Glucose Monitoring, Diabetes, Gestational
Early Pregnancy Lifestyle and Glucose Patterns: A Substudy of TOFFFY
The goal of this clinical trial is to examine how daily behavioral patterns in early pregnancy, including sleep, physical activity, and meal timing, influence continuous glucose dynamics and subsequent risk of gestational…
- Conditions
- Continuous Glucose Monitoring, Diabetes, Gestational, Diet During Pregnancy, Meal Time
- Trial name
- NCT07534670
- Testing
- Continuous glucose monitor (CGM), Wrist actigraphy device, AI-based dietary and meal timing logging mobile application
- Where
- Singapore
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Anemia and Pregnancy, Metabolism and Foetal Growth
Foetal Exposure and Epidemiological Transition: Role of Anaemia in Early Life for Non-communicable Diseases Later
Study Hypotheses: 1. Anaemia, which is frequent before conception as well as during early pregnancy, affects metabolism and foetal growth trajectories, influencing the risk of NCDs in the offspring. 2.
- Conditions
- Anemia and Pregnancy, Metabolism and Foetal Growth, Epigenetics
- Trial name
- FOETALforNCD (NCT02191683)
- Where
- Tanzania
- Volunteers
- 1,748 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Cardiovascular Diseases, Pregnancy Related
Early Intervention to Promote Cardiovascular Health of Mothers and Children (ENRICH) During Pregnancy
This pilot study aims to examine the feasibility and acceptability of adding a cardiovascular health module to the existing Nurse Family Partnership (NFP) home visitation program delivered by trained nurses in the Northern…
- Conditions
- Cardiovascular Diseases, Pregnancy Related, Sedentary Behavior
- Trial name
- ENRICH (NCT05822531)
- Testing
- Maternal CVH Intervention
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Penn State University
Chronic Kidney Disease, Congenital Anomalies of Kidney and Urinary Tract
A Study of a Renal Autologous Cell Therapy (REACT) in Patients With Chronic Kidney Disease (CKD) From Congenital Anomalies of the Kidney and Urinary Tract (CAKUT).
A phase 1, open-label safety, tolerability and early efficacy study of a Renal Autologous Cell Therapy (REACT) in patients with Chronic Kidney Disease from Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) (REGEN-004)
- Trial name
- NCT04115345
- Testing
- Renal Autologous Cell Therapy (REACT)
- Where
- 5 sites in United States
- Volunteers
- 6 people
- Sponsor
- Prokidney
Acute Kidney Injury (Nontraumatic), Pneumoperitoneum
A New Marker for Early Diagnosis of Pneumoperitoneum-Related Acute Kidney Injury: Insulin-Like Growth Factor-1 (IGF-1)
In our study, to show the effect of pneumoperitoneum on acute kidney injury in patients scheduled for laparoscopic surgery, NGAL and IGF-1 values will be measured before, after and 24 hours after pneumoperitoneum, and these…
- Trial name
- NCT05612802
- Testing
- IGF-1
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Baskent University
Miscarriage, Recurrent
Sildenafil Citrate in Early Unexplained Recurrent Pregnancy Loss
Recurrent unexplained spontaneous miscarriage (RSM) is defined as three consecutive pregnancy loss prior to 20 weeks from the last menstrual period. 1% to 2% of women experience RSM. Treatment of URSM is a challenging issue.
- Trial name
- NCT03766594
- Testing
- Sildenafil Citrate, Folic Acid
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Infertility, Female
The Relationship Between Serum AMH Dynamics and Early or Normal Ovarian Response to Corifollitropin Alfa
The objective of this study is to evaluate the trend of serum AMH during IVF (in vitro fertilization) cycles, in particular the possible relationship between the dynamics of AMH and the early or normal response to therapies for…
- Trial name
- ACO (NCT04482751)
- Testing
- Corifollitropin alfa
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Bronchopulmonary Dysplasia
The Role of Volatile Organic Compounds (VOCs), Airway Mucins and the Microbiome in the Early Prediction of Bronchopulmonary Dysplasia (BPD)
Bronchopulmonary dysplasia (BPD), the most common respiratory complication of extremely preterm birth, significantly impacts healthcare with high morbidity and mortality rates.
- Trial name
- INFANCY (NCT06342752)
- Testing
- Breath test, Throat swabs, Placental samples
- Where
- Belgium
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Early Fetal Growth Restriction (FGR)
Characterization of Neonatal Clinical Risk Profiles in Relation to Prenatal Obstetric Characteristics in Infants With Early-FGR Secondary to Doppler Flowmetry Alterations
This study aims to characterize neonatal clinical risk profiles in relation to prenatal obstetric characteristics in infants with early fetal growth restriction (early-FGR) secondary to Doppler flowmetry alterations.
- Trial name
- NEO-FGR (NCT07466693)
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Endometrial Adenocarcinoma, Endometrial Mixed Cell Adenocarcinoma
Testing the Combination of Olaparib and Durvalumab, Cediranib and Durvalumab, Olaparib and Capivasertib, and Cediranib Alone in Recurrent or Refractory Endometrial Cancer Following the Earlier Phase of the Study That Tested Olaparib and Cediranib in Comparison to Cediranib Alone, and Olaparib Alone
This phase II trial studies the effects of the combination of olaparib and durvalumab, cediranib and durvalumab, olaparib and capivasertib, and cediranib alone in treating patients with endometrial cancer that has come back…
- Conditions
- Endometrial Adenocarcinoma, Endometrial Mixed Cell Adenocarcinoma, Endometrial Serous Adenocarcinoma, Endometrial Undifferentiated Carcinoma
- Trial name
- NCT03660826
- Testing
- Biospecimen Collection, Bone Marrow Aspirate, Bone Marrow Biopsy
- Where
- 761 sites in United States, Canada
- Volunteers
- 288 people
- Sponsor
- National Cancer Institute (NCI)
Infertility
SprmPik AI Sperm Selection Study SiD, an Assistant for Sperm Selection During Intracytoplasmic Sperm Injection in Medically Assisted Reproduction: Effect on Fertilization, Blastocyst Formation, Early Pregnancy Loss, and Consistent Practice. A Prospective Pilot Study.
SprmPik AI Assisted Sperm Selection Study SiD, an assistant for sperm selection during intracytoplasmic sperm injection in medically assisted reproduction: effect on fertilization, blastocyst formation, early pregnancy loss, and…
- Trial name
- SprmPik (NCT06518928)
- Testing
- Artificial Intelligence assisted sperm selection
- Where
- 2 sites in United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Ovation Fertility
Preterm Birth
Assessment of DHA On Reducing Early Preterm Birth
The purpose of this study is to determine if giving a larger amount of DHA than currently included in some prenatal supplements can reduce early preterm birth (birth before 34 weeks of pregnancy).
- Trial name
- ADORE (NCT02626299)
- Testing
- Docosahexaenoic acid - 800mg/day, Docosahexaenoic acid - 200mg/day
- Where
- 3 sites in United States
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Childhood Obesity, Adiposity
Lifestyle in Pregnancy and Offspring
Children born to obese women are at risk of increased adiposity and later adverse metabolic outcomes. We have conducted a follow-up study on an existing clinical trial, called the LiP study (Lifestyle in Pregnancy), registration…
- Conditions
- Childhood Obesity, Adiposity, Body Composition, Metabolic Risk Factors
- Trial name
- LiPO (NCT01918319)
- Testing
- Lifestyle intervention
- Where
- Denmark
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Systolic Hypertension, Pregnancy Related
Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by ICG in Early Pregnancy
The purpose of the research is to characterize the effect of labetalol, atenolol, and nifedipine on maternal hemodynamics early in pregnancy.
- Conditions
- Systolic Hypertension, Pregnancy Related, Diastolic Hypertension, Cardiac Output, Low
- Trial name
- NCT04755764
- Testing
- Labetalol, Atenolol, Nifedipine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Marshall University
Cervical Cancer
Efficacy of Chemotherapy Alone in Patients With Poor-differentiated Early-stage Cervical Cancer
This study is aimed to enroll patients with early-stage cervical cancer (FIGO 2018 IB1-IB2) who undergo radical hysterectomy and the postoperative pathology doesn't meet Sedlis criteria or the "four-factor" model but with poorly…
- Trial name
- NCT05863377
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Acute Kidney Injury
Cystatin and Early AKI Detection Contrast Induced Acute Kidney Injury
To determine the clinical utility of serum cystatin C in early detection of acute kidney injury (AKI).
- Trial name
- NCT07197957
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- BayCare Health System
Pregnancy
Effectiveness of Two Regimens of Misoprostol Alone for Early Pregnancy Termination and Use of SQPT for At-Home Follow-Up
This randomized trial will compare the rates of ongoing pregnancy, safety/side effects and acceptability of two medical abortion regimens that are commonly used in Latin America.
- Trial name
- NCT02299401
- Testing
- Misoprostol, Semi-quantitative pregnancy test
- Where
- 2 sites in Bolivia, Ecuador
- Volunteers
- 401 people
- Sponsor
- Gynuity Health Projects
Covid19, Stage 1 Acute Kidney Injury
Phase 2a MIB-626 vs. Placebo COVID-19
The proposed phase 2a trial will determine whether MIB-626 treatment in adults with COVID-19 infection and stage 1 acute kidney injury is more efficacious than placebo in preventing worsening of kidney function, as assessed by…
- Trial name
- NCT05038488
- Testing
- MIB-626, Home Treatment
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Metro International Biotech, LLC
PGT-A, PCOS
PIMS vs PGT-A in Infertile PCOS Patients
This experiment has become a serious issue for two reasons: DNA methylation plays an important role during embryogenesis, global abnormal methylome reprogramming often occurs in human embryos, and DNA methylome pattern is…
- Conditions
- PGT-A, PCOS, PIMS
- Trial name
- NCT06887881
- Testing
- PIMS screening, PGT-A screening
- Where
- China
- Volunteers
- 766 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Gestational Diabetes
Randomization of Early Diabetes Screening Among Obese Pregnant Women.
This will be a randomization of two groups of obese pregnant women into early screening for diabetes mellitus at the time of their first or subsequent prenatal visits before 20 weeks of gestation versus standard time of screening…
- Trial name
- REDSOAP (NCT03116009)
- Testing
- Screening for diabetes with 1-hour GCT and HbA1
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- University of Illinois at Chicago