Clinical trials: Pregnancy Hemorrhage
Hematuria, Benign Prostatic Hyperplasia
RADA16 for Aquablation Day Case
This is a pilot proof of concept single-arm study using PuraStat following Aquablation procedure to assess reduction of hematuria to allow for same day discharge.
- Conditions
- Hematuria, Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms
- Trial name
- RAD (NCT06948331)
- Testing
- PuraStat
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- NYU Langone Health
Post-partum Hemorrhage
REBOA in Life-threatening Postpartum Hemorrhage (PPH) in Uganda
Background Maternal mortality rates in many low-income countries (LMICs) remain high. The most prominent cause is bleeding after birth, called postpartum haemorrhage (PPH).
- Trial name
- REBOA-PPH (NCT05598502)
- Testing
- REBOA, Resuscitative Endovascular Occlusion of the Aorta, National guidelines
- Where
- Uganda
- Volunteers
- 95 people
- Sponsor
- Centre For International Health
Post-Partum Hemorrhage
Fibrinogen in Haemorrhage of Delivery
The purpose of the study is to assess the benefits of a therapeutic strategy that associates an early administration of human fibrinogen concentrate in the management of PPH on the reduction of bleeding after the initiation of…
- Trial name
- FIDEL (NCT02155725)
- Testing
- Human Fibrinogen concentrate
- Where
- 31 sites in France, Martinique
- Volunteers
- 448 people
- Sponsor
- Laboratoire français de Fractionnement et de Biotechnologies
Cesarean Section Complications, Uterine Bleeding
Surgical Incision Closure Method to Prevent Niche Formation After Cesarean Section- Randomized Controlled Trial
In the last decade we have been exposed to the complication of a caesarean section called a "niche". A niche is an anaerobic defect in the location of the cesarean section, which represents the discontinuity of the endometrium…
- Trial name
- NCT04766073
- Testing
- Niche prevention suture
- Where
- Israel
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Menstruation Disturbances, Metrorrhagia
Transdermal Ethinyl Estradiol and Norelgestromin for Irregular Bleeding in Contraceptive Implant Users
The goal of this clinical trial is to evaluate the effectiveness of transdermal contraceptive patches in treating irregular vaginal bleeding in women over 18 years old who are using contraceptive implants and experiencing…
- Conditions
- Menstruation Disturbances, Metrorrhagia, Uterine Hemorrhage, Contraception Behavior
- Trial name
- NCT07083635
- Testing
- Transdermal Ethinyl Estradiol/Norelgestromin Patch
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Chulalongkorn University
Post Partum Haemorrhage
Carbetocin Versus Oxytocin in the Prevention of Post Partum Haemorrhage (PPH) in Women Undergoing Caesarean Sections for Placenta Previa: A Randomised Controlled Trial
The study aims at comparing the roles of carbetocin and oxytocin in the prevention of atonic PPH in women undergoing CS for placenta previa.
- Trial name
- NCT02303418
- Testing
- Carbetocin, Oxytocin
- Where
- 2 sites in Egypt
- Volunteers
- 500 people
- Sponsor
- Cairo University
Post Partum Hemorrhage
Oral Tranexamic Acid Plus Sublingual Misoprostol in Atonic Postpartum Hemorrhage
The aim of the study is to evaluate the effect of oral tranexamic acid plus, sublingual misoprostol in the management of atonic postpartum hemorrhage (PPH) after vaginal delivery
- Trial name
- NCT03870256
- Testing
- misoprostol, Carbetocin, TA
- Where
- Egypt
- Volunteers
- 135 people
- Sponsor
- Aswan University Hospital
Postpartum Hemorrhage
Carbetocin Versus Misoprostol in Cases With Placenta Previa After C.S.
We will compare efficacy and safety of Carbetocin with Misoprostol in prevention of postpartum hemorrhage in Placenta previa women after C.S.
- Trial name
- PPH (NCT02277041)
- Testing
- Carbetocin, Misoprostol
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Beni-Suef University
Postpartum Hemorrhage, Uterine Atony
Second-Line Uterotonics in Postpartum Hemorrhage: A Randomized Clinical Trial
The aim of this study is to evaluate in a randomized fashion the comparative efficacy of two second-line medications, methylergonovine and carboprost for treating atonic postpartum hemorrhage (PPH).
- Trial name
- NCT03584854
- Testing
- 15-methyl prostaglandin F2α, Methylergonovine Maleate
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Hematuria, Nephrolithiasis
Diagnostic Relevance of Laser Confocal Microscopy for the Screening of Upper Urinary Tract Tumors
Upper Urinary Tract Tumors have an incidence of 1 to 2 cases for 100 000 persons per year. The standard treatment for these tumors is the ablation of the kidney, ureter and a part of the bladder surrounding the ureteral orifice.
- Conditions
- Hematuria, Nephrolithiasis, Cancer of Urinary Tract, Ureteropelvic Junction Obstruction
- Trial name
- UROVISIO (NCT02276924)
- Testing
- Laser confocal microscopy
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Lille Catholic University
Early Pregnancy Bleeding, Abdominal Pain
Pelvic Examination in Pregnancy
This study is designed to determine whether the pelvic examination (including bimanual and speculum examination) is necessary in patients with first trimester vaginal bleeding/ lower abdominal pain when an intra-uterine pregnancy…
- Trial name
- PEP (NCT01570413)
- Testing
- No Pelvic Exam, Pelvic Examination
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Boston Medical Center
Postpartum Hemorrhage, Obesity
Oxytocin at Elective Cesarean Deliveries: A Dose-finding Study in Women With BMI ≥ 40kg/m2
Postpartum hemorrhage (PPH) due to uterine atony is a major cause of maternal morbidity and mortality. Uterotonic drugs are used to improve the muscle tone of the uterus after birth, and these are effective at reducing the…
- Trial name
- NCT03957083
- Testing
- Oxytocin
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Turner Syndrome, Primary Ovarian Insufficiency (Poi)
Bleeding Patterns in Sequential and Continuous Progesterone Supplementation in Adolescents With Turner Syndrome
This is a single-site open label non-randomized study comparing effects of sequential versus continuous use of progesterone supplementation amongst Turner Syndrome (TS) patients with primary ovarian insufficiency (POI) prescribed…
- Trial name
- BOOST (NCT06834594)
- Testing
- Micronized progesterone 200 MG, Micronized Progesterone 100 MG
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Mercy Hospital Kansas City
Von Willebrand Diseases
Minimize Menorrhagia in Women With Von Willebrand Disease
This is an outpatient, 24-week Phase III prospective, randomized, crossover trial comparing recombinant von Willebrand factor (rVWF) and tranexamic acid (TA, Lysteda®) to minimize menorrhagia in women with von Willebrand disease…
- Trial name
- VWDMin (NCT02606045)
- Testing
- recombinant von Willebrand factor, tranexamic acid
- Where
- 19 sites in United States
- Volunteers
- 39 people
- Sponsor
- Margaret Ragni
Postpartum Hemorrhage (PPH), Postpartum Hemorrhage Third Stage of Labour Retained Placenta
Intra-Umbilical Vein Oxytocin Injection as an Adjunct to Active Management of the Third Stage of Labour
This randomized controlled clinical trial evaluates the effect of umbilical vein injection of oxytocin given in addition to routine active management of the third stage of labour.
- Trial name
- NCT07436286
- Testing
- Oxytocin
- Where
- Nigeria
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Dangana Zakari Adeka
Mouth Diseases, Bleeding Gum
The Impact of Ginger Mouthwash on the Pregnant Women With Stress and Gingivitis
The study aims to determine ginger mouthwash's impact on gingival health, IL-6, cortisol, LF, and 8-OHdG levels in pregnant women with stress and gingivitis compared to CHX and distilled water. Objectives: 1.
- Conditions
- Mouth Diseases, Bleeding Gum, Stress
- Trial name
- NCT06792812
- Testing
- ginger mouthwash, chlorohexidine mouthwash
- Where
- Iraq
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Al-Mustansiriyah University
Post-operative Complications, Surgical Site Infection
The Use of the Prevena™ Incision Management System on Post-Surgical Cesarean Section Incisions
The purpose of this study is to compare the post-surgical standard-of-care dressing to the Prevena™ Incision Management System in women undergoing Cesarean section surgery.
- Conditions
- Post-operative Complications, Surgical Site Infection, Surgical Wound Infection
- Trial name
- NCT01450631
- Testing
- Prevena™ Incision Management System (PIMS), Standard-of-care Dressing
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- KCI USA, Inc
Immediate Postpartum Hemorrhage
Intrauterine Tamponade With a Belfort-Dildy Balloon in the Treatment of Immediate Postpartum Hemorrhage
The purpose of this study is to evaluate the impact of early intrauterine tamponade with a Belfort-Dildy balloon catheter in immediate postpartum hemorrhage(IPPH) after vaginal delivery and refractory to first-line uterotonic…
- Trial name
- TUB (NCT02226731)
- Testing
- Early Belfort-Dildy Balloon, Late Belfort-Dildy balloon
- Where
- France
- Volunteers
- 405 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Post Partum Hemorrhage, Fibrinogenolysis; Hemorrhage
Patient Blood Management for Massive Obstetric Hemorrhage
Obstetric Hemorrhage continues to be the first cause of maternal morbidity and mortality around the world especially in middle to low income countriesThe blood components are high value resources; however, its use has been shown…
- Conditions
- Post Partum Hemorrhage, Fibrinogenolysis; Hemorrhage, Fibrinogen; Deficiency, Acquired, Massive Hemorrhage
- Trial name
- NCT03784794
- Testing
- Thromboelastometry, Standard Coagulation Test, Fibrinogen Concentrate Human
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Angel Augusto Perez Calatayud
Uterine Fibroids
Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids (ASTEROID 4)
The primary objective of this study was to show superiority of vilaprisan in the treatment of heavy menstrual bleeding (HMB) in subjects with uterine fibroids compared to placebo The secondary objectives of this study were to…
- Trial name
- NCT03400956
- Testing
- Vilaprisan (BAY1002670)
- Where
- 87 sites in United States, Czechia and 3 more
- Volunteers
- 103 people
- Sponsor
- Bayer
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