Clinical trials: Pregnancy Induced Hypertension
Preeclampsia, Pregnancy
Aspirin Role for Preventing Clinical Risks Related to High Risk Pregnancy
Preeclampsia and its related consequences significantly contribute to maternal and neonatal morbidity and mortality, particularly in high-risk pregnancies.
- Trial name
- NCT07087067
- Testing
- Aspirin 75 mg
- Where
- Egypt
- Volunteers
- 87 people
- Sponsor
- Galala University
Gestational Diabetes Mellitus, Preeclampsia
Leptin and Cytokines in Diabetic Pregnancy - Physiologic or Pathogenic Role
Leptin, a circulating hormone expressed abundantly in adipose tissue, has been reported to be a satiety factor. In addition, it has been shown to increase during pregnancy in maternal blood, parallel to increase in body fat mass…
- Conditions
- Gestational Diabetes Mellitus, Preeclampsia, Placental Hypoxia
- Trial name
- NCT00334841
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Pregnancy Induced Hypertension (PIH)
Randomized Controlled Study to Compare Efficacy of Aspirin 75mg and 150mg In the Prevention of Preeclampsia In High Risk Pregnant Women
Preeclampsia in pregnancy is a dreaded complication which has both fetal and maternal adverse outcomes. Studies and WHO have advocated that this complication can be prevented by Aspirin.
- Trial name
- NCT07373756
- Testing
- Aspirin
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Dr. Sunita Pun
Preeclampsia, Preeclampsia (PE)
Evaluation of Patients With Hypertensive Disorders of Pregnancy: An Ambispective Observational Study
The overall objective of this study is to evaluate the prognostic role of ultrasound and laboratory parameters, specifically their potential ability to predict severe forms of preeclampsia and adverse maternal-fetal outcomes.
- Conditions
- Preeclampsia, Preeclampsia (PE), Hypertensive Disorder of Pregnancy
- Trial name
- PREP (NCT07299773)
- Testing
- Doppler evaluation
- Volunteers
- 120 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Preeclampsia, Intrauterine Growth Restriction
sFlt1/PlGF and Planned Delivery to Prevent Preeclampsia at Term.
Preeclampsia (PE) affects ~5% of pregnancies. Although improved obstetrical care has significantly diminished associated maternal mortality, PE remains a leading cause of maternal morbidity and mortality in the world.
- Conditions
- Preeclampsia, Intrauterine Growth Restriction, Maternal Hypertension, Neonatal Outcome
- Trial name
- PE37 (NCT04766866)
- Testing
- sFlt1/PlGF screening in maternal blood at 35 to 36.6 weeks of gestation
- Where
- 21 sites in Belgium, Colombia and 7 more
- Volunteers
- 9,132 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
HELLP Syndrome
Study of Prognostic Values of Platelet Indices and Inflammatory Markers in Patients With HELLP Syndrome.
This study aims to evaluate the prognostic values of platelet indices and inflammatory markers in patients with HELLP syndrome as:- :-Primary outcome To investigate prognostic values of platelet indices and. .
- Trial name
- NCT07377786
- Testing
- Group I: 30 patients with HELLP syndrome
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sohag University
Pre-eclampsia, Hypertension, Pregnancy-Induced
Assessment of Physical Exercise Using Stationary Bicycle for Pregnant Women With Risk for Preeclampsia Development
Introduction: Hypertensive disorders during pregnancy are an important issue in global public health. It is current the leading cause of maternal mortality in Brazil.
- Conditions
- Pre-eclampsia, Hypertension, Pregnancy-Induced, Pregnancy, High-Risk
- Trial name
- NCT01395342
- Testing
- Exercise using stationary bicycle
- Where
- Brazil
- Volunteers
- 116 people
- Sponsor
- University of Campinas, Brazil
Pre-Eclampsia
Neurobehavioural Outcomes in Late Preterm Neonates
Hypertensive disorders are the most common medical complications in pregnancy and major causes of maternal, fetal, and neonatal morbidity and mortality.
- Trial name
- PRENB (NCT02443259)
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Lady Hardinge Medical College
Preeclampsia
Knowledge and Attitude of Pregnant Women Towards Preeclampsia in Assiut Governorate
Our study will be a cross sectional study to evaluate the knowledge level and attitude of pregnant women towards preeclampsia and factors affecting it ,the study will be done at Assiut University Hospitals - Women's Health…
- Trial name
- NCT05955690
- Where
- Egypt
- Volunteers
- 261 people
- Sponsor
- Assiut University
Preeclampsia
Balance of Angiotensin II Receptors in Vessel Function After Preeclampsia
Otherwise healthy women who develop preeclampsia during pregnancy are more likely to develop and die of cardiovascular disease later in life.
- Trial name
- NCT06157580
- Testing
- Compound 21, Angiotensin II
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Anna Stanhewicz, PhD
Pre-Eclampsia, IUGR
Fetal Doppler Indices in Predicting Perinatal Outcome Among Severely Hypertensive Pregnant Patients.
60 pregnant women with singleton living fetus between 34 -38 wks gestation known to have severe hypertension in the current pregnancy were included.
- Trial name
- NCT03515759
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Preeclampsia
Angiotensin II and Chronic Inflammation in Persistent Microvascular Dysfunction Following Preeclampsia
Women who develop preeclampsia during pregnancy are more likely to develop cardiovascular disease later in life, even if they are otherwise healthy.
- Trial name
- NCT03482440
- Testing
- Salsalate Oral Tablet
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Young Adult, Hypertension in Pregnancy
Cardiovascular Longitudinal ALSPAC Research Investigations Following Hypertensive Pregnancy in Young Adulthood
The purpose of this study is to understand more about why young people who were born to a hypertensive pregnancy may have increased risk of high blood pressure and are often at increased risk of heart and blood vessel disease…
- Conditions
- Young Adult, Hypertension in Pregnancy, Hypertension, Cardiovascular Diseases
- Trial name
- CLARITY (NCT05683093)
- Testing
- History of being born to hypertensive or normal pregnancy
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University of Oxford
Pre-Eclampsia
State of Coagulation in Pre-eclampsia: Comparing Sonoclot Signature Analysis With Conventional and Specific Haemostasis Assays
Detection of the presence or absence of coagulopathy in cases with pre-eclampsia. Investigate the value of global hemostasis studies (Sonoclot signature analysis) in cases of pre-eclampsia and if there a correlation between it…
- Trial name
- NCT05625763
- Testing
- sonoclot signature analysis
- Volunteers
- 55 people
- Sponsor
- Assiut University
Pregnancy, Obesity
Advanced MRI for Uteroplacental Flow, Perfusion, Oxygenation & Inflammation
The purpose of the study is to develop advanced ultrasound (U/S) and Magnetic Resonance Imaging, known as MRI to study uteroplacental health.
- Conditions
- Pregnancy, Obesity, Preeclampsia
- Trial name
- NCT02791568
- Testing
- Ultrasound Scan, MRI Scan, Ferumoxytol
- Where
- 2 sites in United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Pulmonary Artery Doppler
Pulmonary Artery Doppler in Preeclamptic Mothers
Evaluation of Pulmonary artery Doppler parameters in fetuses of mothers with severe preeclampsia
- Trial name
- NCT06755073
- Testing
- Pulmonary artery Doppler ultrasound
- Where
- Egypt
- Volunteers
- 86 people
- Sponsor
- Assiut University
Preeclampsia
Vanadium in Late-onset Preeclampsia
Introduction: Cadmium, lead and vanadium important pollutants produced from anthropogenic activities, has been suggested to be embryotoxic and fetotoxic in a lot of studies.
- Trial name
- Vanadium PE (NCT04200222)
- Testing
- cadmium, lead and vanadium measurements and compare
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Cengiz Gokcek Women's and Children's Hospital
Sepsis, Pre-Eclampsia
Establishment of an ELISA for the Recognition of Procalcitonin Variants in Patients With Hyperprocalcitonemia.
Procalcitonin is a protein consisting of 116 amino-acids which can rapidly rise under inflammatory conditions and sepsis. More than 20 years ago it has been shown that dipeptidylpeptidase-4 (DPP-4) cleaves procalcitonin from the…
- Conditions
- Sepsis, Pre-Eclampsia, Granulomatosis With Polyangiitis, Microscopic Polyangiitis
- Trial name
- NCT05703802
- Testing
- Procalcitonin-variants ELISA-Assay
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Muenster
Elevated Blood Pressure, Pregnancy Induced Hypertension
Treatment of Elevated Blood Pressures in Early Pregnancy
This is a randomized controlled trial comparing the outcomes of treatment and non-treatment of elevated blood pressures in early pregnancy.
- Trial name
- NCT05955040
- Testing
- Nifedipine, Labetalol
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Marshall University
Pre-Eclampsia, Stage 1 Hypertension
Aspirin to Prevent Preeclampsia in Women With Elevated Blood Pressure and Stage 1 Hypertension (ASPPIRE)
To determine if low dose aspirin reduces the incidence of hypertensive disorders of pregnancy (gestational hypertension, preeclampsia, eclampsia, and HELLP syndrome) in pregnant women with stage 1 hypertension and elevated blood…
- Conditions
- Pre-Eclampsia, Stage 1 Hypertension, Elevated Blood Pressure
- Trial name
- NCT04402385
- Testing
- Aspirin 81 mg
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
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