Clinical trials: Pregnancy Induced Hypertension
Preeclampsia, Hypertension
Effects of Nitrate-rich Beetroot Juice in Pregnant Women With High Blood Pressure
BACKGROUND: Preeclampsia (PE) is a serious syndrome that affects 3-7% of all pregnant women. PE is characterized by hypertension and kidney problems after the 20th week of pregnancy and is associated with an increased risk of…
- Conditions
- Preeclampsia, Hypertension, Endothelial Dysfunction, Nitric Oxide
- Trial name
- NITBEETPE (NCT05241327)
- Testing
- Beetroot Juice
- Where
- Sweden
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Preeclampsia Severe, Preeclampsia Postpartum
Effects of Vitamin C Administration on Extravascular Lung Water in Patients With Severe Features of Preeclampsia
The objective of the study is to determine whether administration of vitamin C (1.5g/6 hours) in the first three days post-partum reduces the amount of extravascular lung water assessed by lung ultrasound in patients with severe…
- Trial name
- NCT03451266
- Testing
- Vitamin C
- Where
- Slovenia
- Volunteers
- 34 people
- Sponsor
- University Medical Centre Ljubljana
Puerperal Sepsis, Postpartum Hemorrhage
Assessing Childbirth-related Complications at the Community Level in Kenya
Kenya is one of the countries in sub-Saharan Africa that still experience high maternal mortality. For instance, in 2008/09 maternal mortality ratio was estimated to be 488/100,000 live births.
- Conditions
- Puerperal Sepsis, Postpartum Hemorrhage, Preeclampsia and Eclampsia, Retained Placenta, Without Hemorrhage
- Trial name
- NCT01665456
- Where
- Kenya
- Volunteers
- 585 people, healthy volunteers welcome
- Sponsor
- Wilson Liambila
Pre-Eclampsia
Continuous Non-invasive Hemodynamic Monitoring in Early-onset Severe Preeclampsia: a Comparison of Echocardiography, Bioreactance, and Finger Cuff Measurements
The purpose of this study is to compare the feasibility and accuracy of two methods of non-invasive hemodynamic assessments - bioreactance as assessed by non-invasive cardiac output monitoring (NICOM; Cheetah Medical) and pulse…
- Trial name
- NCT05299229
- Testing
- Echocardiogrpahy and non-invasive monitoring
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Yale University
Hypertension With Pregnancy
Evaluation of Psychological Status in Pregnant Women Complaining of Hypertension With Pregnancy
This study is a case controlled study comparing mental health status and some psychological impacts between two groups of patients first group is pregnant women without any other medical disorder during pregnancy,the second group…
- Trial name
- NCT03503383
- Testing
- Patient Health Questionnaire-9, Generalized Anxiety Disorder Scale (GAD-7)
- Where
- 2 sites in Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Preeclampsia
Low Dose Aspirin for the Prevention of Preeclampsia
Preeclampsia is one of the three leading causes of maternal morbidity and mortality all over the world. The use of low dose aspirin has been mentioned in several studies with promising results.
- Trial name
- NCT01890005
- Testing
- Aspirin
- Where
- Panama
- Volunteers
- 476 people
- Sponsor
- Saint Thomas Hospital, Panama
Gestational Hypertension, Preeclampsia
Pregnancy-Related Hypertension: Adherence to a New Type of Monitoring
A large segment of our patient population is diagnosed with hypertensive disorders of pregnancy, including gestational hypertension and pre-eclampsia.
- Conditions
- Gestational Hypertension, Preeclampsia, Chronic Hypertension With Pre-Eclampsia Complicating Childbirth, HELLP Syndrome
- Trial name
- PHANTOM (NCT04823949)
- Testing
- Home blood pressure monitoring
- Where
- 2 sites in United States
- Volunteers
- 202 people
- Sponsor
- Prisma Health-Upstate
Preeclampsia
Mechanistic Underpinnings of Preeclampsia
Preeclampsia is a dreadful disease with significant morbidity and mortality. Despite decades of research, we still need a proper diagnostic test or therapeutic option to treat this disorder.
- Trial name
- MUP (NCT06567899)
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Postpartum Hypertension (PPHT)
PEACE Trial: Postpartum Evaluation of Antihypertensive Cessation and Efficacy
This randomized controlled trial compares two common medications, labetalol and extended-release nifedipine, to determine which is more effective at managing postpartum high blood pressure.
- Trial name
- PEACE (NCT06915792)
- Testing
- Labetalol, Nifedipine
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of California, Los Angeles
Chronic Hypertension in Pregnancy
Remote Patient Monitoring for Chronic Hypertension During Pregnancy (REACH)
We hypothesize that frequent remote monitoring of blood pressure and real-time antihypertensive medication titration will optimize pregnancy outcomes in a clinically meaningful and cost-effective manner compared to the current…
- Trial name
- REACH (NCT07115199)
- Testing
- Remote Patient Monitoring
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Rutgers, The State University of New Jersey
Hypertension, Cardiovascular Diseases
Hypertension Explored in Long-term Postpartum Follow-up in Later Life
The purpose of this study is to understand more about why women who have had hypertensive pregnancies may be at increased risk of high blood pressure and why these women are often at increased risk of heart and blood vessel…
- Conditions
- Hypertension, Cardiovascular Diseases, Cerebrovascular Disorders, Vascular Diseases
- Trial name
- HELPFUL (NCT06187012)
- Testing
- Hypertensive pregnancy
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University of Oxford
Preeclampsia
Different Schemes of Magnesium Sulfate for Preeclampsia
Eclampsia is an obstetric emergency capable of prophylaxis. To prevent and control seizures, there is no doubt that the magnesium sulfate (MgSO4) is the ideal drug. However, there are still questions regarding its use and dose.
- Trial name
- MGSO4 (NCT02396030)
- Testing
- Magnesium sulfate 50% - 1g/h, Magnesium sulfate 50% - 2g/h
- Where
- Brazil
- Volunteers
- 62 people
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Preeclampsia
Combined Antioxidant and Preeclampsia Prediction Studies (CAPPS)
Preeclampsia is one of the most common complications of pregnancy and is characterized by high blood pressure and protein in the urine. This can cause problems in the second half of pregnancy for both the mother and fetus.
- Trial name
- CAPPS (NCT00135707)
- Testing
- Dietary Supplement/Vitamins
- Where
- 16 sites in United States
- Volunteers
- 10,154 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Preeclampsia
Cardiovascular Risk After Preeclampsia
Investigation of cardiovascular risk 5-15 years after early or late-onset preeclampsia by adenosine stress Magnetic Resonance Imaging and non-invasive methods like retinal vessel analysis, skin measurement of advanced glycation…
- Trial name
- NCT05277233
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Pregnancy Induced Hypertension
Fractionated Vs Single Dose Injection for Spinal C-Section in Patients With Pregnancy-Induced Hypertension
The aim of this study was to compare haemodynamic changes, total dose of ephedrin requirement, and level of sensory blockade between fractionated dose and single dose spinal anesthesia injection in obstetric patients with…
- Trial name
- NCT03693638
- Testing
- Bupivacaine-fentanyl
- Where
- Indonesia
- Volunteers
- 42 people
- Sponsor
- Universitas Indonesia
Pre-Eclampsia; Complicating Pregnancy, Gestational Hypertension
Remote Postpartum Blood Pressure Monitoring and Cardiovascular Education
The goal of this clinical trial is to learn if patient education and regular text reminders are a feasible intervention to engage patients and reduce post partum hypertension.
- Trial name
- NCT06920563
- Testing
- Video, Text Reminder, Blood pressure threshold
- Where
- United States
- Volunteers
- 296 people
- Sponsor
- Ochsner Health System
Preeclampsia
Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia (Metildopape)
Introduction: Hypertensive emergency in pregnant women with pre-eclampsia should be treated for preventing stroke and placental abruption.
- Trial name
- METILDOPAPE (NCT01361425)
- Testing
- methildopa
- Where
- 2 sites in Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
Restless Leg Syndrome, Severe Preeclampsia
Restless Leg Syndrome and Severe Preeclampsia
Restless Leg Syndrome is a common but not well recognized central nervous system disorder. It is more prevalent during pregnancy and, if present before pregnancy, can develop an exacerbation of symptoms.
- Trial name
- NCT01538147
- Where
- Panama
- Volunteers
- 310 people
- Sponsor
- Saint Thomas Hospital, Panama
Hypertension in Pregnancy
Understanding Blood Pressure Changes After Birth
Research Question How does maternal blood pressure respond in the postpartum period for women who had a hypertensive disorder in pregnancy? Aim To evaluate the recovery of maternal blood pressure after a pregnancy affected by new…
- Trial name
- NCT05137808
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- St George's, University of London
Preeclampsia
China Obstetrics Alliance Cohort Study
Preeclampsia (PE) is one of a common type of hypertensive disorder complicating pregnancy (HDCP). It is a class of clinical syndromes which shows relevant symptoms, hypertension and proteinuria after 20 weeks pregnant as main…
- Trial name
- COACS (NCT03038555)
- Where
- 5 sites in China
- Volunteers
- 900 people
- Sponsor
- The Third Affiliated Hospital of Guangzhou Medical University
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