Clinical trials: Pregnancy Induced Hypertension
Pre-Eclampsia, Premature Birth
PREPARE, Prematurity Reduction by Pre-eclampsia Care
Investigators will test a novel system of integrated care, to promote the use of the WORLD HEALTH ORGANIZATION Guidelines for the management of pre-eclampsia and initiate the use of a structured risk assessment strategy to reduce…
- Trial name
- PREPARE (NCT03073317)
- Testing
- FullPIERS and sFlit/PLGF (Soluble fms-Like Tyrosine Kinase-1-to-Placental Growth Factor Ratio)
- Where
- 8 sites in Brazil
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Instituto Fernandes Figueira
Pre-Eclampsia
Maternal Serum Stathmin-1 Levels in Preeclampsia
This study investigates maternal serum Stathmin-1 (STMN-1) levels in pregnancies complicated by preeclampsia and severe preeclampsia, compared to healthy pregnancies.
- Trial name
- NCT06623955
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Drug-Induced Nephropathy, Hypertension
Arginine in Treating Patients With Anti-VEGF Induced Kidney Injury
This phase II trial studies how well arginine works in treating patients with kidney injury caused by anti-VEGF drugs used in standard treatment for cancer.
- Conditions
- Drug-Induced Nephropathy, Hypertension, Proteinuria
- Trial name
- NCT02882373
- Testing
- Arginine
- Where
- United States
- Sponsor
- M.D. Anderson Cancer Center
Pre-Eclampsia, Eclampsia
Prospective Study in Pregnant Women With Hypercoagulopathy
Pre-eclampsia is one of the most common causes of maternal and fetal morbidity and mortality. The aim of this study is to identify pregnant women at risk for pre-eclampsia or other cardiovascular complications at a very early…
- Trial name
- NCT00215969
- Where
- 2 sites in Denmark
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Hillerod Hospital, Denmark
Hypertensive Disorders of Pregnancy (HDP), Hypertension, Pregnancy Induced
Community Support and Mobile Apps to Help Black Women Control High Blood Pressure After Pregnancy
The goal of this randomized clinical trial is to evaluate the effectiveness of a collaborative care intervention, consisting of remote blood pressure monitoring and support from community health workers, in improving blood…
- Conditions
- Hypertensive Disorders of Pregnancy (HDP), Hypertension, Pregnancy Induced, Severe Maternal Morbidity, Postpartum Hypertension
- Trial name
- PRIME CARE (NCT07606027)
- Testing
- Collaborative care, Standard of Care (SOC)
- Volunteers
- 404 people
- Sponsor
- University of Nebraska
Brain Health, Gestational Hypertension
Brain Health in Midlife
The purpose of this study is to learn if hypertensive disorders during pregnancy affects brain health in midlife.
- Conditions
- Brain Health, Gestational Hypertension, Alzheimer Disease, Dementia
- Trial name
- ADORE BRAIN (NCT06640842)
- Testing
- A combination of various tests and biomarkers will be completed to understand the effect of hypertensive disorders of pregnancy on brain health in midlife.
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Pregnancy, Eclampsia
Microcirculatory and Tissue and Cerebral Oxygenation in Preeclampsia and Normal Pregnancy: An Observation Study
Preeclampsia is a disease of pregnancy affecting 3% to 8% of all pregnancies and is a major cause of maternal and perinatal morbidity and mortality.
- Trial name
- NCT02351583
- Testing
- CytoCam, NIRS Artinis PortaLite with OxySoft softwear
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Virginia
Preeclampsia
Hypertonic Saline Use in Preeclampsia
To compare hypertonic saline to Lactated Ringer's solution and assess whether one speeds up the process of getting rid of extra body water faster in women with preeclampsia.
- Trial name
- NCT00181077
- Testing
- 2% buffered hypertonic saline administration
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Adverse Effect
Norepinephrine Prophylaxis for Postspinal Anesthesia Hypotension in Parturients With Preeclampsia
The purpose of this study is to investigate the efficacy and safety of norepinephrine for prophylaxis against postspinal anesthesia hypotension in parturients with preeclampsia undergoing cesarean section.
- Trial name
- NCT04556357
- Testing
- Phenylephrine, Norepinephrine
- Where
- China
- Volunteers
- 138 people
- Sponsor
- General Hospital of Ningxia Medical University
Renal Cell Carcinoma, Cardiotoxicity
A Prospective Study of Acute Cardiovascular Effects of First-line Sunitinib in Metastatic Renal Cell Carcinoma Patients (SUnitinib Prospective CardiovasculaR Effect)
While sunitinib can be very helpful to treat kidney cancer, these medications can also cause side effects, including heart damage.
- Conditions
- Renal Cell Carcinoma, Cardiotoxicity, Heart Failure, Hypertension
- Trial name
- SUPER (NCT01014065)
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- AHS Cancer Control Alberta
Gestational Hypertension, Prematurity
Effects of Exercise During Pregnancy on Maternal and Child Health: a Randomized Clinical Trial
The Pamela Study is a clinical trial carried out during pregnancy to assess the potential effects of physical activity during pregnancy among previously inactive women.
- Conditions
- Gestational Hypertension, Prematurity, Maternal Post-partum Depression, Maternal Post-partum Weight Retention
- Trial name
- PAMELA (NCT02148965)
- Testing
- Physical Exercise / Physical Activity
- Where
- Brazil
- Volunteers
- 639 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Pre-Eclampsia
Prevention of Preeclampsia With Aspirin in Recipients of Donated Oocytes.
The main objective of this trial is to study the occurrence of preeclampsia in recipients of donated oocytes receiving aspirin at an early stage during pregnancy and to compare the results with those obtained in patients…
- Trial name
- PROVAS (NCT02174328)
- Testing
- Acetylsalicylic acid
- Where
- Spain
- Volunteers
- 81 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Pre-Eclampsia
Evaluation of the Safety of Relaxin in Preeclampsia
The purpose of this study is to determine whether different doses of recombinant human relaxin is safe when given to women with severe preeclampsia
- Trial name
- NCT00333307
- Testing
- recombinant human relaxin
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Corthera, Inc.(formerly BAS Medical, Inc.), a member of the Novartis group of companies
Preeclampsia, Pregnancy
MitoQ to Improve Vascular Funciton in Preeclampsia
Preeclampsia is a leading cause of maternal and neonatal morbidity and mortality. There is a lack of effective therapeutics for prevention or treatment.
- Trial name
- MAVEN (NCT07229261)
- Testing
- Mitoquinol Mesylate
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Medical College of Wisconsin
Preeclampsia
Hemodynamic Measurements in Women With Serious Preeclampsia
This trial is examining hemodynamic measurements in women with serious preeclampsia.
- Trial name
- NCT00199810
- Where
- Norway
- Volunteers
- 68 people
- Sponsor
- Oslo University Hospital
Preeclampsia, Renal Function
Soluble Factors and Renal Outcome in Preeclampsia
Preeclampsia (PE) is an important complication of pregnancy and can lead to chronic kidney disease by causing endothelial damage and podocyte loss, Soluble forms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF)…
- Trial name
- NCT04940260
- Testing
- Renal function, proteinuria
- Where
- Thailand
- Volunteers
- 42 people
- Sponsor
- Bangkok Metropolitan Administration Medical College and Vajira Hospital
Hypertension
Efficacy of Nifedipine Versus Hydralazine in Management of Severe Hypertension in Pregnancy
Introduction - Hypertension is the commonest medical complication of pregnancy. When severe, it puts the lives of both the mother and the unborn baby at risk.
- Trial name
- NCT04435210
- Testing
- Hydralazine, Nifedipine
- Where
- Nigeria
- Volunteers
- 69 people
- Sponsor
- Adebayo Joshua Adeniyi
Hypertension in Pregnancy
The Effect of Hydroxytyrosol Administration on Superoxide Dismutase, Pulsatility Index and Resistance Index of Uterine Artery Doppler and Flow-Mediated Dilatation of Brachial Artery In Mothers With Hypertension In Pregnancy
The purpose of this clinical trial is to evaluate the effect of hydroxytyrosol 10 mg/day administered for 4 weeks in pregnant individuals with hypertension.
- Trial name
- HYDROXY-2 (NCT07298759)
- Testing
- Hydroxytyrosol
- Where
- Indonesia
- Volunteers
- 52 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Placenta Vascular Malformation
Estimation of the Placental Volume by 3D Ultrasound at 12, 16 and 22 Weeks : Relation With Growth Factors and D-Dimers
Pregnancy complications called PVP are mainly responsible for perinatal mortality. In these cases, the placenta is smaller and often the centre of thrombotic lesions.
- Trial name
- VOLUPLA (NCT00767182)
- Testing
- blood sample
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Uric Acid and Hypertension in Pregnancy
Study of Association Between Maternal Uric Acid , Maternal and Fetal Outcome in Pregnant Women With Hypertension
Association of maternal uric acid with maternal condition and fetal outcome in pregnant women with hypertension.
- Trial name
- NCT01523327
- Testing
- measuring protein creatinin ratio,serum uric acid
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams Maternity Hospital