Clinical trials: Pregnancy Induced Hypertension
Pregnancy, Eclampsia
A Cluster-Randomized Trial of Ultrasound Use to Improve Pregnancy Outcomes in Low Income Country Settings
In many low-income countries, the use of ultrasound by medical officers and non-physician health care staff (e.g., midwives) for antenatal identification of high risk pregnancies is a new intervention requiring authoritative…
- Conditions
- Pregnancy, Eclampsia, Placenta Previa, Stillbirth
- Trial name
- NCT01990625
- Testing
- Antenatal Ultrasound Scan
- Where
- 5 sites in Guatemala, Kenya and 3 more
- Volunteers
- 45,038 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Pregnancy, Eclampsia
Microcirculatory and Tissue and Cerebral Oxygenation in Preeclampsia and Normal Pregnancy: An Observation Study
Preeclampsia is a disease of pregnancy affecting 3% to 8% of all pregnancies and is a major cause of maternal and perinatal morbidity and mortality.
- Trial name
- NCT02351583
- Testing
- CytoCam, NIRS Artinis PortaLite with OxySoft softwear
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Virginia
Pre-eclampsia, Hypertension, Pregnancy-Induced
Assessment of Physical Exercise Using Stationary Bicycle for Pregnant Women With Risk for Preeclampsia Development
Introduction: Hypertensive disorders during pregnancy are an important issue in global public health. It is current the leading cause of maternal mortality in Brazil.
- Conditions
- Pre-eclampsia, Hypertension, Pregnancy-Induced, Pregnancy, High-Risk
- Trial name
- NCT01395342
- Testing
- Exercise using stationary bicycle
- Where
- Brazil
- Volunteers
- 116 people
- Sponsor
- University of Campinas, Brazil
Puerperal Sepsis, Postpartum Hemorrhage
Assessing Childbirth-related Complications at the Community Level in Kenya
Kenya is one of the countries in sub-Saharan Africa that still experience high maternal mortality. For instance, in 2008/09 maternal mortality ratio was estimated to be 488/100,000 live births.
- Conditions
- Puerperal Sepsis, Postpartum Hemorrhage, Preeclampsia and Eclampsia, Retained Placenta, Without Hemorrhage
- Trial name
- NCT01665456
- Where
- Kenya
- Volunteers
- 585 people, healthy volunteers welcome
- Sponsor
- Wilson Liambila
Pregnancy, Primiparity
MorbiMortality Amelioration in Preeclamptic Primiparas Study. MoMA Pre Prim Study
The purpose of this study is to determine whether close monitoring of patients with a high sFlt1 plasma level between 25 and 28 weeks of gestation (i.e.
- Conditions
- Pregnancy, Primiparity, Hypertension, Preeclampsia
- Trial name
- MOMA (NCT00763672)
- Testing
- Transmission of sFlt-1 results to the investigator, No transmission of the sFlt-1 results to the investigator
- Where
- France
- Volunteers
- 1,040 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertensive Disorders of Pregnancy, Pre-eclampsia
Ophthalmic Artery Doppler in the Puerperium After Hypertensive Disorders of Pregnancy (OPHELIA-PP)
Hypertensive disorders of pregnancy frequently fail to resolve at delivery. A substantial proportion of women remain hypertensive at the six-week postnatal review, postpartum eclampsia occurs days to weeks after birth, and a…
- Conditions
- Hypertensive Disorders of Pregnancy, Pre-eclampsia, Postpartum Hypertension, Puerperal Disorders
- Trial name
- OPHELIA-PP (NCT07841795)
- Where
- Italy
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Chronic Kidney Diseases, Pregnancy
Kynurenine Concentrations During Pregnancy in Women With or Without Chronic Kidney Disease - A Prospective Multicenter Study
Chronic kidney disease (CKD) affects more than 10% of the population worldwide and represents the second most important risk factor for preeclampsia, a life-threatening complication of pregnancy responsible for approximately…
- Conditions
- Chronic Kidney Diseases, Pregnancy, Preeclampsia
- Trial name
- KIDNEY-MOM (NCT07411937)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 204 people
- Sponsor
- CHU de Reims
Pre-Eclampsia, Preeclampsia
Internal Jugular Vein Collapsibility Index for Volume Status Assessment in Preeclampsia in Correlation With Normotensive Parturients
This study aims to assess and analyze volume status in preeclamptic patients and compare these parameters with those of normotensive pregnant ones based on the change in internal jugular vein ultrasound-based indices.
- Trial name
- NCT07786246
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tanta University
Pre-Eclampsia
Cardiovascular Changes in Infants of Preeclampsia Mother
Preeclampsia (hypertension during pregnancy) is a common problem affecting 2-8% of pregnancies worldwide and is typically diagnosed by increased blood pressure and proteinuria.
- Trial name
- NCT04699825
- Testing
- Cardiovascular and immunological changes
- Volunteers
- 20 people
- Sponsor
- Assiut University
Pre Eclampsia
Transcranial Doppler in Preeclampsia and Its Complications.
Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality. It is defined by new-onset hypertension after 20 weeks of gestation, often associated with proteinuria and/or systemic complications such as…
- Trial name
- DTC-PE (NCT07646561)
- Testing
- Transcranial doppler ultrasound
- Where
- Tunisia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Obstructive Sleep Apnea of Adult, Preeclampsia
Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy
A randomized controlled trial of 1,500 women to assess whether treatment of obstructive sleep apnea with continuous positive airway pressure (CPAP) in pregnancy will result in a reduction in the rate of hypertensive disorders of…
- Conditions
- Obstructive Sleep Apnea of Adult, Preeclampsia, Obstetrical Complications
- Trial name
- SLEEP (NCT03487185)
- Testing
- Continuous Positive Airway Pressure, Sleep Advice Control
- Where
- 14 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- The George Washington University Biostatistics Center
Preeclampsia
NOPE37: Angiogenic Factors for Managing Term Preeclampsia
This study tests the hypothesis that, in women with preeclampsia without severe features, delivery management based on sFlt-1/PlGF would reduce the rate of induction of labor without worsening the rate of progression to…
- Trial name
- NOPE37 (NCT07193680)
- Testing
- Intervention arm: expectant management if sFlt-1/PlGF<38, Standard care: elective delivery at 37 weeks of gestation
- Where
- 23 sites in Spain
- Volunteers
- 750 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Preeclampsia (PE)
Non-Invasive Preeclampsia Screening and Biobank
Women pregnant between 11-14 weeks gestation will be enrolled with blood samples collected to evaluate for preeclampsia.
- Trial name
- NCT06643741
- Where
- 21 sites in United States
- Volunteers
- 6,550 people, healthy volunteers welcome
- Sponsor
- Sequenom, Inc.
Hypertensive Disorder of Pregnancy, Pre-Eclampsia, Severe
Low-Sodium Diet for Postpartum Blood Pressure Control
The goal of this randomized controlled trial is to learn if a low-sodium diet improves postpartum blood pressure control in adults who were diagnosed with a late-onset hypertensive disorder of pregnancy.
- Conditions
- Hypertensive Disorder of Pregnancy, Pre-Eclampsia, Severe, Pre-Eclampsia; Mild, Postpartum
- Trial name
- NCT07752056
- Testing
- Low Sodium Diet
- Volunteers
- 110 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Drug-Induced Nephropathy, Hypertension
Arginine in Treating Patients With Anti-VEGF Induced Kidney Injury
This phase II trial studies how well arginine works in treating patients with kidney injury caused by anti-VEGF drugs used in standard treatment for cancer.
- Conditions
- Drug-Induced Nephropathy, Hypertension, Proteinuria
- Trial name
- NCT02882373
- Testing
- Arginine
- Where
- United States
- Sponsor
- M.D. Anderson Cancer Center
Pregnancy, Preeclampsia
The Impact of Pregnancy and Pregnancy-associated Hypertension on Human Uterine Myometrial Artery Reactivity
The investigators seek to describe the composition, architecture, and electrical conduction properties of the human uterine myometrial artery and their impact on vascular reactivity upon exposure to hypertensive stress.
- Conditions
- Pregnancy, Preeclampsia, Hypertension in Pregnancy
- Trial name
- NCT03888170
- Testing
- No intervention
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Arizona
Maternal Sepsis During Labor, Hemorrhage, Postpartum
Scaling Up an Integrated Approach to Improve Delivery Care in North Guatemala With Stepped Wedge Design
"¡Que Vivan las Madres!: Venga a tener su parto al CAP" (QVLM) is a guatemalan quasi-experimental study that has been performed from January 2014 to January 2017 by the Epidemiological Research Center in Sexual and Reproductive…
- Conditions
- Maternal Sepsis During Labor, Hemorrhage, Postpartum, Eclampsia; Complicating Pregnancy, Pre-Eclampsia
- Trial name
- QVLM (NCT03151070)
- Testing
- QVLM Intervention package
- Volunteers
- 32,000 people
- Sponsor
- Hospital San Juan de Dios Guatemala
Preeclampsia (PE)
Comparing the Efficacy of 75mg Versus 150mg Aspirin for the Prevention of Preeclampsia in High-Risk Pregnant Women
This study aims to evaluate the effectiveness of 75 mg aspirin versus 150 mg aspirin in preventing preeclampsia among individuals with high risk for the condition.
- Trial name
- NCT07041385
- Testing
- Aspirin 75 mg, Aspirin 150 mg
- Where
- Pakistan
- Volunteers
- 340 people
- Sponsor
- Shalamar Hospital
Pre-Eclampsia, Hypertension in Pregnancy
Effectiveness of Higher Aspirin Dosing for Prevention of Preeclampsia in High Risk Obese Gravida
To compare the incidence of preeclampsia in obese pregnant women (BMI greater than 30) with a singleton gestation at less than 20 weeks and either a history of preeclampsia in a prior pregnancy or stage I hypertension or…
- Conditions
- Pre-Eclampsia, Hypertension in Pregnancy, Obesity
- Trial name
- ASPREO (NCT03961360)
- Testing
- Aspirin 81 mg, Aspirin 162 mg
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- The University of Texas Health Science Center, Houston
Pre-Eclampsia, Hypertension, Pregnancy-Induced
Self-management of Postnatal Anti-hypertensive Treatment: a Trial Development Pilot Study
New-onset raised blood pressure (BP) affects about one in ten pregnancies. For some women, raised BP is an indication of pre-eclampsia: newly arising high blood pressure in pregnancy combined with protein leaking into the urine.
- Trial name
- SNAP-HT (NCT02333240)
- Testing
- Self-management of postnatal anti-hypertensive treatment
- Where
- 5 sites in United Kingdom
- Volunteers
- 101 people
- Sponsor
- University of Oxford
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