Clinical trials: Pregnancy Induced Hypertension
Preeclampsia
Preeclampsia Ratio (sFlt-1/PlGF)
The aim of the PRECOG study is to determine in a prospective interventional randomized study whether the implementation of a predictive test based on the sFLT-1/PlGF ratio improves perinatal care and reduces costs, in patients…
- Trial name
- PRECOG (NCT03289611)
- Testing
- sFlt-1 / PlGF ratio
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertension in Pregnancy, Obstetrical Complications
Gestational Hypertension and Preeclampsia Blood Pressure (BP) Treatment Goals Less Than 140/90 vs. Less Than 160/110 mmHg: The GOALPOST Trial
This is a phase-III multi-center open-label randomized clinical trial of 4,120 individuals between 23 weeks, 0 days and 35 weeks, 6 days gestation with gestational hypertension or preeclampsia without severe features randomized…
- Trial name
- GOALPOST (NCT07746271)
- Testing
- Anti-hypertensive medication titrated to a BP goal of <140/90 mmHg, Usual Care: Anti-hypertensive medication for BP ≥160/110 mmHg titrated to a goal of < 160/110 mmHg
- Where
- 14 sites in United States
- Volunteers
- 4,120 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Preeclampsia
Aspirin for Prevention of Preeclampsia
Prophylaxis with low-dose aspirin has been recommended to prevent preeclampsia, the rationale being that hypertension and abnormalities of coagulation in this disease are caused in part by an imbalance between vasodilating and…
- Trial name
- NCT03726177
- Testing
- aspirin 162 mg, aspirin 81 mg
- Where
- Egypt
- Volunteers
- 600 people
- Sponsor
- Aswan University Hospital
Pregnancy, Vitamin D Deficiency
Trial of Vitamin D Supplements to Raise Calcidiol Levels of Pregnant Women in Mongolia
A double-blind randomized, placebo-controlled trial comparing the impact of 600 IU, 2000 IU, or 4000 IU of Vitamin D3 on third trimester 25(OH)D levels and change from baseline.
- Trial name
- NCT02395081
- Testing
- 600 IU Vitamin D3 in prenatal vitamin, 2000 IU Vitamin D3 in prenatal vitamin, 4000 IU Vitamin D3 in prenatal vitamin
- Where
- Mongolia
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Hypertension, Pregnancy-Induced
Kidney Injury Biomarkers in Preeclampsia
we found different pattern of podocyte glycoproteins and kidney injury biomarkers in urine specimens between preeclampsia and pregnancy complicated with chronic hypertention compared with normotensive pregnant controls.abnormally…
- Trial name
- NCT03217916
- Testing
- Elisa assay of podocyte glycoprotein in urine
- Volunteers
- 40 people
- Sponsor
- Woman's Health University Hospital, Egypt
Arterial Stiffness, Fetal Growth Retardation
Bioimpedence and Arterial Function Monitoring at Birth and in Infants
Babies may be born appropriately grown for gestational age (AGA, >10th centile) or small for gestational age (SGA, <10th centile).
- Conditions
- Arterial Stiffness, Fetal Growth Retardation, Small for Gestational Age at Delivery, Pre-Eclampsia
- Trial name
- BAMBI (NCT04720690)
- Testing
- Vicorder: pulse wave velocity, pulse wave analysis, stroke volume, cardiac output, NICaS, Echocardiography and ultrasound of arteries
- Where
- 2 sites in United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Imperial College Healthcare NHS Trust
Preeclampsia, Severe Preeclampsia
First-trimester Prediction of Preeclampsia
Preeclampsia is a complication of pregnancy related to adverse maternal and neonatal outcomes, including fetal growth restriction and perinatal death.
- Conditions
- Preeclampsia, Severe Preeclampsia, Fetal Growth Restriction, Preterm Birth
- Trial name
- PREDICTION (NCT02189148)
- Where
- 4 sites in Canada
- Volunteers
- 7,554 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Preeclampsia
Clinical Trial of a COX-2 Inhibitor for the Treatment of Women With Preeclampsia
Preeclampsia is a hypertensive disorder of pregnancy and a leading cause of fetal and maternal morbidity and mortality. Recent findings indicate preeclampsia is an inflammatory disorder associated with increased expression of…
- Trial name
- NCT00442676
- Testing
- Celecoxib
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Magnesium Sulfate, Labetalol
Evaluation of Intravenous Infusion of Labetalol Versus Magnesium Sulfate
the purpose of this study is to compare Intravenous infusion of Labetalol versus Magnesium Sulfate on Cerebral Hemodynamics of Severe Preeclampsia Patients using Transcranial Doppler
- Trial name
- NCT04539379
- Testing
- Magnesium sulfate, Labetolol
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Zagazig University
Preeclampsia
Pravastatin for Prevention of Preeclampsia
The primary purpose of this pilot study is to determine the pharmacokinetic (PK) parameters and collect preliminary safety data for pravastatin when used as a prophylactic daily treatment in pregnant women at high risk of…
- Trial name
- Statin (NCT01717586)
- Testing
- Pravastatin
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Hypertension in Pregnancy
SASH Study - Sonographic Assessment for Severe Hypertension in Pregnancy
Adjunctive use of easily-obtainable maternal sonographic vascular measurements assessing volume status, cardiac output, and systemic vascular resistance by means of inferior vena cava collapsibility/caval index (ICV CI)…
- Trial name
- SASH (NCT03783169)
- Testing
- Cardiovascular Sonographic Assessment
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- TriHealth Inc.
Anesthesia, Spinal Aneshtesia
Renal Functions in Preeclamptic Pregnant Women Using Neutrophil Gelatinase-associated Lipocalin (NGAL) and Standard Renal Function Tests
Acute kidney injury (AKI) is a significant postoperative complication. Risk factors for AKI include impaired renal perfusion, decreased functional renal reserve, as well as advanced age, peripheral arterial disease, diabetes…
- Conditions
- Anesthesia, Spinal Aneshtesia, Acute Kidney Failure, Spinal Anesthesia Induced Hypotension
- Trial name
- NCT07015359
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Nihan Aydin Guzey
Obstructive Sleep Apnea
Targeted CPAP Therapy for Obstructive Sleep Apnea in Pregnancy
Prospective, randomized controlled trial. Pregnant women in early pregnancy will be randomized to either the Sleep Study + CPAP (Continuous Positive Airway Pressure Therapy) group or to a Standard Prenatal Care group.
- Trial name
- NCT02755831
- Testing
- CPAP, Pre-natal care
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Preeclampsia
Detection of Epileptiform Activity in Severe Preeclampsia
The primary aim of this pilot study is to prospectively quantify epileptiform activity in a cohort of preeclamptic patients before and after intravenous magnesium administration.
- Trial name
- NCT03494517
- Testing
- Magnesium Sulfate
- Where
- Switzerland
- Volunteers
- 35 people
- Sponsor
- Pascal Vuilleumier
Gestational Hypertension, Preeclampsia
Vagal Stimulation Therapy and Preeclampsia
Preeclampsia is one of the most common and serious complications of pregnancy, affecting both the mother and baby. It is a condition characterized by high blood pressure and can lead to severe complications, including…
- Trial name
- NCT06953115
- Testing
- Vagal stimulation physiotherapy with trigger point release, Positional Release Therapy
- Where
- 4 sites in Mexico
- Volunteers
- 210 people
- Sponsor
- Fundación Internacional René Mey
Preeclampsia
Use of Allied-health Professionals to Improve Treatment of Disease
The goal of this clinical trial is to learn if allied-health professionals can recruit and follow research participants, sustain engagement, and improve and diagnose treatment of diseases by facilitating transitions of care.
- Trial name
- NCT06337799
- Testing
- Research Pharmacist
- Volunteers
- 200 people
- Sponsor
- University of Iowa
Preeclampsia, Preeclampsia (PE)
Evaluation of Patients With Hypertensive Disorders of Pregnancy: An Ambispective Observational Study
The overall objective of this study is to evaluate the prognostic role of ultrasound and laboratory parameters, specifically their potential ability to predict severe forms of preeclampsia and adverse maternal-fetal outcomes.
- Conditions
- Preeclampsia, Preeclampsia (PE), Hypertensive Disorder of Pregnancy
- Trial name
- PREP (NCT07299773)
- Testing
- Doppler evaluation
- Volunteers
- 120 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Gestational Hypertension, Preeclampsia
Pregnancy-Related Hypertension: Adherence to a New Type of Monitoring
A large segment of our patient population is diagnosed with hypertensive disorders of pregnancy, including gestational hypertension and pre-eclampsia.
- Conditions
- Gestational Hypertension, Preeclampsia, Chronic Hypertension With Pre-Eclampsia Complicating Childbirth, HELLP Syndrome
- Trial name
- PHANTOM (NCT04823949)
- Testing
- Home blood pressure monitoring
- Where
- 2 sites in United States
- Volunteers
- 202 people
- Sponsor
- Prisma Health-Upstate
Severe Preeclampsia
Protocols for Magnesium Sulfate Maintenance Dose in Overweight and Obese Women Diagnosed With Preeclampsia
There is still no evidence of the appropriate dose to be used. Serum magnesium sulfate concentration is not measured regularly, thus we may be using sub-therapeutic level or reaching a toxic level.Overweight and obese women have…
- Trial name
- NCT06486025
- Testing
- maintenance magnesium sulphate1g/h, maintenance magnesium sulphate2g/h
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Preeclampsia
China Obstetrics Alliance Cohort Study
Preeclampsia (PE) is one of a common type of hypertensive disorder complicating pregnancy (HDCP). It is a class of clinical syndromes which shows relevant symptoms, hypertension and proteinuria after 20 weeks pregnant as main…
- Trial name
- COACS (NCT03038555)
- Where
- 5 sites in China
- Volunteers
- 900 people
- Sponsor
- The Third Affiliated Hospital of Guangzhou Medical University
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