Clinical trials: Pregnancy Related Complications
Fetal Alcohol Spectrum Disorders, Fetal Alcohol Syndrome
Postnatal Choline Supplementation in Children With Prenatal Alcohol Exposure
The purpose of this study is to determine if choline bitartrate can be administered daily to children with prenatal alcohol exposure, ages 2.5 to 5, as a potential treatment for brain development and cognitive functioning.
- Conditions
- Fetal Alcohol Spectrum Disorders, Fetal Alcohol Syndrome, Partial Fetal Alcohol Syndrome, Alcohol Related Neurodevelopmental Disorder
- Trial name
- NCT01149538
- Testing
- Choline bitartrate
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Minnesota
Hyperoxaluria
Validation Testing for Plasma Oxalate Levels in the Biochemical Laboratory at the Galilee Medical Center, in Collaboration With the Biochemistry Laboratory at CHARITE Hospital in Berlin, and Testing the Relationship Between Oxalate Levels and Vitamin C Levels in Plasma
Background: Elevated plasma oxalate levels in various conditions, including: primary hyperoxaluria due to increased production in the liver, renal failure due to decreased renal excretion, intestinal diseases with fatty diarrhea…
- Trial name
- NCT06578754
- Testing
- This is an non-interventional study
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
FASD
Hyperbaric Oxygen Therapy Compared to Cognitive Training in FASD
Fetal Alcohol Spectrum Disorder (FASD) describes a wide range of adverse physical, behavioral and cognitive effects resulting from prenatal alcohol exposure (PAE) during embryonic and fetal development.
- Trial name
- NCT04664790
- Testing
- Hyperbaric Oxygen, Cognitive training
- Where
- Israel
- Sponsor
- Assaf-Harofeh Medical Center
Papillomavirus Infections, Cervical Intraepithelial Neoplasia
E7 TCR T Cells for Human Papillomavirus-Associated Cancers
Background: Human papillomavirus (HPV) can cause cervical, throat, anal, and genital cancers. Cancers caused by HPV have an HPV protein called E7 inside of their cells.
- Conditions
- Papillomavirus Infections, Cervical Intraepithelial Neoplasia, Carcinoma In Situ, Vulvar Neoplasms
- Trial name
- NCT02858310
- Testing
- E7 TCR cells, Aldesleukin, Fludarabine
- Where
- 2 sites in United States
- Volunteers
- 224 people
- Sponsor
- National Cancer Institute (NCI)
Human Papillomavirus-Related Malignant Neoplasm
Study of Molecular-targeted Therapy Using Zinc Finger Nuclease in Cervical Precancerous Lesions
This research study is being carried out to study a new way to possibly treat human cervical intraepithelial neoplasia (CIN) without invasion.
- Trial name
- NCT02800369
- Testing
- ZFN-603 and ZFN-758
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Huazhong University of Science and Technology
Sarcoma, Endocrine Tumors
Comprehensive Omics Analysis of Pediatric and Adult Solid Tumors and Establishment of a Repository for Related Biological Studies
Background: Laboratory investigators who are studying common childhood cancers are interested in developing a tissue repository to collect and store blood, serum, tissue, urine, or tumors of children who have cancer or adults who…
- Conditions
- Sarcoma, Endocrine Tumors, Neuroblastoma, Retinoblastoma
- Trial name
- NCT01109394
- Where
- 5 sites in United States
- Volunteers
- 6,035 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Endometriosis, Anakinra
Pilot Study of the IL-1 Antagonist Anakinra for the Treatment of Endometriosis Related Symptoms
All current FDA approved medications to treat endometriosis pain including danazol, GnRH agonists (Lupron, Zoladex and Synarel), GnRH antagonist (elagolix) and depo-provera prevent or contradict pregnancy.
- Conditions
- Endometriosis, Anakinra, Markers of Inflammation
- Trial name
- NCT03991520
- Testing
- Anakinra 100Mg/0.67Ml Inj Syringe
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Diego
Pregnancy Related, Postpartum Complication
Comparison of Maternal Role Preparation and Awareness-Centred Occupational Therapy Trainings in Pregnant Women
The aim of this study was to compare maternal role preparation and mindfulness-centred occupational therapy trainings in pregnant women: a randomised controlled trial with postpartum follow-up.
- Trial name
- NCT06422780
- Testing
- Maternal Role Preparation Training, Awareness Centred Occupational Therapy Group
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Çankırı Karatekin University
Urogenital Neoplasms
Association Between the SPHERTEST in Vitro Test and Response to Checkpoint Inhibitor Treatments in Patients With Advanced or Metastatic Urothelial Carcinoma
First-line systemic treatments for bladder cancer are based on a combination of cytotoxic and immunotherapy, sequentially or concomitantly.
- Trial name
- PROMES-URO (NCT06738797)
- Testing
- SPHERTEST test
- Where
- 5 sites in France
- Volunteers
- 32 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Maternal Care Patterns, Pregnancy Related
Cash Benefits and Reproductive/Perinatal Health
During the first two years of the COVID-19 pandemic, the City of Chelsea, Massachusetts held a lottery to allocate cash benefits to its residents for ten months.
- Conditions
- Maternal Care Patterns, Pregnancy Related, Miscarriage
- Trial name
- NCT05782660
- Testing
- Cash Benefit, No Cash Benefit
- Where
- United States
- Volunteers
- 3,615 people
- Sponsor
- Harvard Medical School (HMS and HSDM)
Pre-Eclampsia, Severe, HELLP Syndrome
Promising Bimarker Prediction of Outcome of HELLP Syndrome.
HELLP syndrome is a life-threatening obstetric complication usually considered to be a variant or complication of pre-eclampsia.
- Conditions
- Pre-Eclampsia, Severe, HELLP Syndrome, Microangiopathy
- Trial name
- NCT03246542
- Testing
- shistocytes percentage
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- AYMAN ABDELKADER MOHAMED ABDELKADER
Recurrent Cervical Cancer, Recurrent Vaginal Cancer
Triapine, Cisplatin, and Radiation Therapy in Treating Patients With Cervical Cancer or Vaginal Cancer
This phase II trial is studying how triapine and cisplatin given together with radiation therapy works in treating patients with cervical cancer or vaginal cancer.
- Conditions
- Recurrent Cervical Cancer, Recurrent Vaginal Cancer, Stage IB Cervical Cancer, Stage II Vaginal Cancer
- Trial name
- NCT00941070
- Testing
- triapine, cisplatin, external beam radiation therapy
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- National Cancer Institute (NCI)
Chronic Kidney Disease
Association Between Urine Concentration Ability and the Progression of Chronic Kidney Disease
The study hypothesis is that urine concentrating ability can predict the rate of kidney function decline. Patients with kidney disease at the investigatorsclinic will be asked to give first morning urine sample and osmolarity…
- Trial name
- NCT01423045
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Benaya Rozen-Zvi
Human Papilloma Virus-Related Cervical Carcinoma
An Intervention Promoting HPV Vaccination in Safety-net Clinics
This randomized controlled trial is designed to evaluate whether a behavioral intervention that includes three components: 1) reminder letters and education materials delivered before the clinic visit, 2) telephone recalls after…
- Trial name
- NCT01729429
- Testing
- HPV brochure, recall, reminders, General Adolescent Vaccine Brochure
- Where
- 2 sites in United States
- Volunteers
- 831 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Endometriosis, Endometriosis-related Pain
Impact on Quality of Life of "Endo-App" (ELEA)
monocentric randomized controlled trial enrolment of endometriosis patients from certified endometriosis centers. Randomization to control group (no Endo App use) vs intervention group (Endo App use) 12 weeks use / no use of Endo…
- Conditions
- Endometriosis, Endometriosis-related Pain, Quality of Life
- Trial name
- ELEA (NCT04883073)
- Testing
- Use of Endo App
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- University Hospital Muenster
Depression, Postpartum
Perinatal Emotion and Relationships Longitudinal Study
This study, funded by the John Templeton Foundation, will examine birth and the early postpartum period (BEPP) as a transformative life experience that may shift women's experience of emotion in such ways as to a) support…
- Trial name
- PEARLS (NCT03027037)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Menstrual Cycle, Menstrual Distress (Dysmenorrhea)
Menstrual Cycle Symptoms and Female Health
The complexity inherent to the hormonal fluctuations associated with the female menstrual cycle (MC) has contributed, from a methodological perspective in research, to the neglect of women's physiological characteristics and to…
- Conditions
- Menstrual Cycle, Menstrual Distress (Dysmenorrhea), Premenstrual Syndrome, Abnormal Uterine Bleeding (AUB)
- Trial name
- CICLOS (NCT07699224)
- Testing
- Prevalence
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Universidad Rey Juan Carlos
Fetal Alcohol Spectrum Disorders
Families Moving Forward (FMF) Connect Pro for Mental Health Providers
The goal of this clinical trial is to test a new provider-assisted version of the caregiver Families Moving Forward (FMF) Connect app ("FMF Connect Pro") with mental health providers in the United States.
- Trial name
- NCT05960461
- Testing
- FMF (Families Moving Forward) Connect Pro, ECHO (Extension of Community Healthcare Outcomes) implementation., Self-Directed Learning implementation.
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Cervical Cancer
Evaluate Efficacy of the Association Nimotuzumab(HR3) /Cisplatin-Vinorelbine on Patients With Cervical Carcinom
The objective of the present study is to estimate the overall survival of patients with cervical cancer after the administration of monoclonal antibody (mAb) Nimotuzumab (hR3) in combination with chemotherapy of first intention.
- Trial name
- CIMAHOPE (NCT03413579)
- Testing
- Nimotuzumab ( h-R3)
- Where
- 5 sites in Algeria
- Volunteers
- 37 people
- Sponsor
- El Kendi Pharmaceuticals Manufacturing Company
Dyslipidemia
Trial to Evaluate the Efficacy of Fluvastatin on Certain Markers
To analyze efficacy of fluvastatin on patients with chronic renal disease by analyzing certain inflammatory markers. In addition, tolerability and safety will also be evaluated in a Spanish population.
- Trial name
- NCT00171262
- Testing
- Fluvastatin
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Novartis
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