Clinical trials: Pregnancy Related Complications
Endometrial High Grade Endometrioid Adenocarcinoma, Fallopian Tube Clear Cell Adenocarcinoma
A Study Combining the Peposertib (M3814) Pill With Standard Chemotherapy in Patients With Ovarian Cancer With an Expansion in High Grade Serous Ovarian Cancer and Low Grade Serous Ovarian Cancer
This phase I trial studies the side effects and best dose of peposertib when given together with pegylated liposomal doxorubicin hydrochloride in treating patients with high or low grade ovarian cancer that has come back after a…
- Conditions
- Endometrial High Grade Endometrioid Adenocarcinoma, Fallopian Tube Clear Cell Adenocarcinoma, Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube High Grade Serous Adenocarcinoma
- Trial name
- NCT04092270
- Testing
- Biospecimen Collection, Computed Tomography, Echocardiography Test
- Where
- 11 sites in United States
- Volunteers
- 55 people
- Sponsor
- National Cancer Institute (NCI)
Renal Impairments, Chronic Kidney Disease
Evaluation of Clinical Pharmacy Services and Drug Use in Renal Impairment.
Clinical pharmacy services aim to optimise medication use, enhance patient outcomes, and reduce the risk of drug-related harm through patient-centred pharmaceutical care.
- Conditions
- Renal Impairments, Chronic Kidney Disease, Acute Kidney Disease, Medication Errors
- Trial name
- RECAP-Rx (NCT07241494)
- Testing
- Clinical Pharmacist-Led Pharmaceutical Care Service and Renal Dose Adjustment, Education for renal adjusments
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Istanbul University - Cerrahpasa
Oncology
Promoting Response to IMmunotherapy by Exercise in Patients With Advanced Renal Cell Carcinoma
The primary aim of this study is to evaluate the feasibility of a supervised high intensity interval training (HIIT) program during first-line dual immune checkpoint inhibitor (ICI) therapy (nivolumab plus ipilimumab) in patients…
- Trial name
- PRIMER (NCT07680556)
- Testing
- HIIT
- Where
- 2 sites in Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Preterm Birth, Parent-Child Relations
Skin-to-skin Contact in Neonatal Intensive Care Unit (NICU), Caregiving Touch and Neural Correlates of Slow Stroking Touch in Preterm Infants
Preterm (PT) infants spend their first weeks of life in Neonatal Intensive Care Unit (NICU) where receive little affective physical contact, which plays a crucial role in brain development.
- Trial name
- NCT04293939
- Testing
- Functional Magnetic Risonance Imaging (fMRI) acquisition
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Infant Apnea, Neonatal Abstinence Syndrome
Interventions to Help Infants Recover in the Hospital
This pilot project will evaluate independently two non-pharmacological interventions, 1) Neurosensory, Environmental Adaptive Technology (NEATCAP) and 2) Stochastic Vibrotactile Stimulation (SVS), as adjuvant non-pharmacological…
- Conditions
- Infant Apnea, Neonatal Abstinence Syndrome, Sleep
- Trial name
- NCT03881553
- Testing
- NEATCAP, SVS mattress
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Elisabeth Salisbury, PhD
Pregnancy Related, Delivery Complication
Pre-labor Ultrasound as a Visual Biofeedback Device for Maternal Pushing Education
The study will observe the effect of antenatal biofeedback with transperineal and abdominal ultrasound applied by a pelvic floor physical therapist.
- Trial name
- NCT05258786
- Testing
- Pre-labor ultrasound as a visual biofeedback device for maternal pushing education and pelvic floor training
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ariel University
Amyotrophic Lateral Sclerosis (ALS), Angina, Stable
Quest to Analyze One Thousand Humans Meditating
This study will be focused on assessing the molecular, physiological, and emotional correlates of an intensive meditation experience in the context of a retreat setting in a large 2000 plus-person cohort comprised of healthy and…
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, Asthma
- Trial name
- QUANTUM (NCT06583395)
- Testing
- Advanced multi-component meditation practice
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Tobias Moeller-Bertram
Acute Kidney Injury
External Validation of IRRIV Test Relationship With Renal Functional Reserve
The assessment of renal functional reserve (RFR) has been proposed for the risk stratification of patients undergoing potentially nephrotoxic procedures.
- Trial name
- IRRIV-RFR (NCT03756402)
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Ospedale San Bortolo di Vicenza
HIV Infections, Cervix, Dysplasia
Safety and Effectiveness of Giving Isotretinoin to HIV-Infected Women to Treat Cervical Tumors
The purpose of this study is to see if it is safe and effective to give isotretinoin to HIV-infected women with cervical tumors to prevent these tumors from becoming cancerous.
- Trial name
- NCT00001073
- Testing
- Isotretinoin
- Where
- 40 sites in United States, Puerto Rico and 1 more
- Volunteers
- 150 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Puerperal Sepsis, Postpartum Hemorrhage
Assessing Childbirth-related Complications at the Community Level in Kenya
Kenya is one of the countries in sub-Saharan Africa that still experience high maternal mortality. For instance, in 2008/09 maternal mortality ratio was estimated to be 488/100,000 live births.
- Conditions
- Puerperal Sepsis, Postpartum Hemorrhage, Preeclampsia and Eclampsia, Retained Placenta, Without Hemorrhage
- Trial name
- NCT01665456
- Where
- Kenya
- Volunteers
- 585 people, healthy volunteers welcome
- Sponsor
- Wilson Liambila
Acute Kidney Injury, Renal Tubulopathy
Prevention of Cisplatin-induced Nephrotoxicity
The research design is a prospective, randomized, controlled clinical trial in children to study effect of aminophylline in preserving renal function in oncologic patient received cisplatin either combined with other CMT or used…
- Trial name
- NCT06196853
- Testing
- Aminophylline
- Where
- Thailand
- Volunteers
- 24 people
- Sponsor
- Mahidol University
Endometriosis Related Pain, Overactive Bladder
Study on the Safety of BAY1817080 How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug Given to Participants With Moderate Renal Impairment and End Stage Renal Disease Requiring Dialysis Compared With Matched Participants With Normal Renal Function
BAY1817080 is currently under clinical development to treat pain related to unexplained chronic cough or chronic cough not affected by a treatment (refractory and/or unexplained chronic cough, RUCC), or a condition where the…
- Conditions
- Endometriosis Related Pain, Overactive Bladder, Diabetic Neuropathic Pain, Refractory or Unexplained Chronic Cough
- Trial name
- NCT04471337
- Testing
- BAY1817080
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bayer
Myeloproliferative Disorders, Kidney Cancer
Early Administration of ATG Followed by Cyclophosphamide, Busulfan and Fludarabine Before a Donor Stem Cell Transplant in Patients With Hematological Cancer
RATIONALE: Giving low doses of chemotherapy before a donor stem cell transplant helps stop the growth of cancer cells. It may also stop the patient's immune system from rejecting the donor's stem cells.
- Conditions
- Myeloproliferative Disorders, Kidney Cancer, Leukemia, Lymphoma
- Trial name
- NCT00787761
- Testing
- anti-thymocyte globulin, busulfan, cyclophosphamide
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Northside Hospital, Inc.
Pregnancy Related, Delivery Complication
Hand Forceps vs. Conventional One-hand Technique for Fetal Head Extraction During Cesarean Section
The aim of the study is to assess the efficacy and safety of an innovative two-hand (hand forceps) fetal head extraction technique during the transverse cesarean sections (LTCS) by comparing with the conventional one-hand…
- Conditions
- Pregnancy Related, Delivery Complication, Cesarean Delivery Affecting Fetus
- Trial name
- Hand forceps (NCT04159857)
- Testing
- Fetal head extraction technique during the cesarean section
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- The Reading Hospital and Medical Center
Fetal Alcohol Spectrum Disorders, Fetal Alcohol Syndrome
Scaling Up: A Multi-Site Trial of e-SBI for Alcohol Use in Pregnancy
The purpose of this research study is to find out if pregnant women screening positive for alcohol risk like the brief alcohol intervention application that the investigators have developed (called the MommyCheckup, which is a…
- Conditions
- Fetal Alcohol Spectrum Disorders, Fetal Alcohol Syndrome, Fetal Alcohol Effect
- Trial name
- e-Health (NCT04332172)
- Testing
- General information, Baseline brief intervention, Remote online booster sessions
- Where
- United States
- Volunteers
- 384 people
- Sponsor
- Michigan State University
Weight Gain, Pregnancy, Microbial Colonization
Microbiome and Malnutrition in Pregnancy (MMiP)
Nutritional status during pregnancy plays an important role in maternal health and birth outcomes. While few factors impacting nutritional status during pregnancy have been identified, studies of undernutrition in children have…
- Conditions
- Weight Gain, Pregnancy, Microbial Colonization, Pregnancy Related, Pregnancy Loss
- Trial name
- MMiP (NCT05108675)
- Where
- Pakistan
- Volunteers
- 400 people
- Sponsor
- Aga Khan University
End Stage Chronic Renal Failure, Myofacial Pain
The Herbal Acupoint Patch for Dialysis Patient With Fistula-related Pain
To evaluate the effect of a traditional Chinese medicine (TCM) intervention on pain relief, mood and quality of life (QOL) in hemodialytic patients at a dialysis center in Southern Taiwan.
- Trial name
- Fistula Pain (NCT07380581)
- Testing
- Artemisias-ginger patch (AGP)
- Where
- Taiwan
- Volunteers
- 21 people
- Sponsor
- Chang Gung Memorial Hospital
Chronic Kidney Disease Stage 3B, Chronic Kidney Disease stage4
Physiopathology of Neuromuscular Function Related to Fatigue in Chronic Renal Disease
Chronic Kidney Disease (CKD) induces many metabolic troubles especially for the advanced CKD (stage 3b-5) patients and their prevalence and importance grow with the deterioration of the glomerular filtration rate (GFR).
- Conditions
- Chronic Kidney Disease Stage 3B, Chronic Kidney Disease stage4, Chronic Kidney Disease Stage 5, Fatigue
- Trial name
- PIONEER (NCT04330807)
- Testing
- Handgrip fatigability test, Questionnaires
- Where
- France
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier le Mans
Fetal Alcohol Spectrum Disorders
Study of the Families Moving Forward Website Behavioral Intervention for Teachers of Students With Fetal Alcohol Spectrum Disorder
The purpose of this study is to find out if the FMF Connect Teacher Companion website is acceptable and usable by teachers. The FMF Connect Teacher Companion website is a website for teachers adapted from the Families Moving…
- Trial name
- NCT05986565
- Testing
- Families Moving Forward (FMF) Teacher adapted training
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Rochester
AKI
Deep Learning Model and Risk Factors for Tacrolimus-related Acute Kidney Injury
In this study, the investigators aim to develop a risk prediction model for acute kidney injury (AKI) in hospitalized patients using the calcineurin inhibitor tacrolimus.
- Trial name
- NCT06596798
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Qianfoshan Hospital
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