Clinical trials: Pregnancy Related Complications
Polycystic Ovarian Syndrome,, Nonalcoholic Fatty Liver Disease
THE ASSOCIATION BETWEEN FATTY LIVER (NAFLD) DISEASE AND PCOS
Since both pathologies (PCOS and NAFLD) involve disturbed carbohydrate economy, which revolve around insulin resistance, it is tempting to examine the specific "liver profile" of women with PCOD.
- Trial name
- NCT01735799
- Where
- Israel
- Sponsor
- Assy Nimer
Diabetes Mellitus, Hypertension
Correlation of Albuminuria With Arterial Stiffness
The investigators aim to investigate the relationship between albuminuria and arterial stiffness in diabetic patients, hypertensive patients and healthy subjects.
- Conditions
- Diabetes Mellitus, Hypertension, Albuminuria, Vascular Stiffness
- Trial name
- NCT01041599
- Where
- Turkey (Türkiye)
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Papillomavirus Infections, Dysplasia
Matrix Metalloproteinases and Human Papillomavirus in Dysplasias and Cancers of the Cervix
This study aims to compare the expression of matrix metalloproteinases and their tissue inhibitors between 4 groups of patients defined according to the severity of the cervical lesion.
- Conditions
- Papillomavirus Infections, Dysplasia, Cervix Cancer
- Trial name
- MMP-HPV (NCT04072913)
- Testing
- Vaginal samples (biopsies + vaginal smear)
- Where
- France
- Volunteers
- 216 people
- Sponsor
- University Hospital, Bordeaux
Breast Cancer, Drug/Agent Toxicity by Tissue/Organ
Pyridoxine in Preventing Hand-Foot Syndrome in Patients Who Are Receiving Liposomal Doxorubicin for Cancer
RATIONALE: Pyridoxine (vitamin B6) may prevent or lessen hand-foot syndrome caused by chemotherapy. It is not yet known whether pyridoxine is more effective than a placebo in preventing hand-foot syndrome.
- Conditions
- Breast Cancer, Drug/Agent Toxicity by Tissue/Organ, Endometrial Cancer, Fallopian Tube Cancer
- Trial name
- NCT00245050
- Testing
- pyridoxine hydrochloride, doxorubicin HCL liposome
- Where
- 8 sites in United States
- Volunteers
- 34 people
- Sponsor
- Case Comprehensive Cancer Center
Trauma, Psychological, Sexual Violence
CFT Self-Help for Accessing Cervical Screening After Sexual Assault
The aim of this study is to evaluate the feasibility of a new self-help intervention designed to support individuals (anyone with a cervix) to access cervical cancer screening following the experience of sexual assault, by…
- Conditions
- Trauma, Psychological, Sexual Violence, Cervical Cancer
- Trial name
- NCT04104724
- Testing
- Self-help
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Royal Holloway University
CKD (Chronic Kidney Disease) Stage 5D, Hemodialysis
Effect of Kidney Replacement Therapy with Polymethylmethacrylate Membranes on Pruritus-related Quality of Life in Patients Receiving Maintenance Haemodialysis
This randomized controlled trial aims to evaluate the effect of polymethylmethacrylate dialysis membranes use on the intensity of pruritus in patients with CKD stage 5D receiving maintenance hemodialysis.
- Conditions
- CKD (Chronic Kidney Disease) Stage 5D, Hemodialysis, Pruritis
- Trial name
- NCT06671535
- Testing
- Polymethylmethacrylate membrane, polysulfone membranes
- Where
- Russia
- Volunteers
- 62 people
- Sponsor
- Saint Petersburg State University, Russia
Endometriosis
Study of the Effectiveness of Dydrogesterone in the Treatment of Endometriosis-related Pain
The study is an observational, multicenter, prospective, single arm study to evaluate the efficacy of dydrogesterone in endometriosis-related pain (EAP).
- Trial name
- Daisy (NCT06952296)
- Testing
- Dydrogesterone
- Volunteers
- 250 people
- Sponsor
- Abbott
HPV Infections, Precancerous Disease of the Cervix
Primary and Secondary Prevention of Human Papillomavirus (HPV) Disease in China
In a hospital-based multi-center study in China, HPV 16 was found to be the predominant type (72.9%) in cervical cancer, followed by HPV 18(8.0%) which indicated that if the HPV prophylactic vaccine are wisely applied in China…
- Conditions
- HPV Infections, Precancerous Disease of the Cervix, Cervical Cancer, HPV Related Diseases
- Trial name
- NCT01021904
- Testing
- Gardasil (VLP, HPV Quadrivalent prophylactic vaccine)
- Volunteers
- 6,200 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences
Pregnancy Related, Delivery; Injury, Maternal
Manual Physical Therapy During Pregnancy on Post Partum Perineal Trauma and Pain
The purpose of this study is to explore the impact of pelvic floor physical therapy during pregnancy on delivery and the impact on the woman's body and function.
- Conditions
- Pregnancy Related, Delivery; Injury, Maternal, Pelvic Floor Disorders
- Trial name
- NCT04660708
- Testing
- manual physical therapy
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Milwaukee
Spontaneous Abortion
Post-traumatic Stress Disorder in Spontaneous Abortion
The objective of this questionnaire-based study is to prospectively assess the prevalence of post-traumatic stress disorder (PTSD) symptoms in a population of women who have experienced a spontaneous miscarriage during the first…
- Trial name
- NCT07306676
- Testing
- Impact of Event Scale - Revised (IES-R) questionnaire, Posttraumatic Stress Disorder Checklist - Specific (PCL-S) questionnaire, Trauma Recovery Measure (TRM) questionnaire
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Jagiellonian University
Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose…
- Conditions
- Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension
- Trial name
- POPS or POP02 (NCT04278404)
- Testing
- The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Inflammatory Response, Chronic Renal Disease
Hemadsorption During and After Cardiopulmonary Bypass to Modulate the Inflammatory Response
Chronic kidney disease (CKD) is a risk factor for the development of cardiovascular disease, which increases the risk of death after cardiac surgery.
- Conditions
- Inflammatory Response, Chronic Renal Disease, Cardiac Surgery
- Trial name
- IMHeS (NCT04157647)
- Testing
- CytoSorb, Control
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University Magna Graecia
Sepsis, Acute Kidney Injury
Gut Microbiota and Sepsis-associated Acute Kidney Injury
Sepsis has emerged as one of the important life-threatening infectious diseases with high morbidity and mortality. Sepsis-associated kidney injury (SAKI) is one of the most common and serious complications of sepsis.
- Trial name
- GMASAKI (NCT05718804)
- Testing
- Whether renal injury occurred and differences in intestinal flora
- Where
- China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Urinary Incontinence
Self-Care to Prevent Birth-Related Urinary Incontinence in Diverse Women
The primary goal of this project is to determine the efficacy of an antenatal Bladder Health class to prevent UI in a diverse sample of African American, Caucasian, and Hispanic childbearing women.
- Trial name
- NCT00763984
- Testing
- Usual Care, Bladder Health class
- Where
- 3 sites in United States
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Post Traumatic Stress Disorder, Rape Sexual Assault
Early Psychological Intervention After Rape
Rape is a common cause of post-traumatic stress disorder (PTSD) among women, as around 30-50% will develop PTSD in the aftermath of rape.
- Conditions
- Post Traumatic Stress Disorder, Rape Sexual Assault, Sexual Dysfunctions, Psychological, Pelvic Floor Myalgia
- Trial name
- EIR (NCT05489133)
- Testing
- Modified prolonged exposure
- Where
- 4 sites in Norway
- Volunteers
- 166 people
- Sponsor
- St. Olavs Hospital
Pregnancy Related, Maternal-Fetal Relations
Maternal and Fetal Metabolic Changes
The goal of this observational prospective project is to study the metabolic alterations during normal and complicated pregnancies, obtaining an early detection of metabolic changes, offering new insights into future prevention…
- Conditions
- Pregnancy Related, Maternal-Fetal Relations, Metabolism Disorder, Glucose
- Trial name
- MoMM-FET (NCT06288126)
- Where
- Italy
- Volunteers
- 457 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Intrauterine Adhesions
hBMSC Uterine Artery Infusion for Severe IUA-Related Infertility
The goal of this clinical trial is to test a new approach: delivering human bone marrow mesenchymal stem cells (hBMSCs) via the uterine artery to treat infertility caused by severe intrauterine adhesions (IUA).
- Trial name
- NCT07176143
- Testing
- Delivering human bone marrow mesenchymal stem cells via the uterine artery
- Volunteers
- 60 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Preterm Birth
Examination of the Relationship Between Home Affordances With Development
Babies with a history of premature birth and low birth weight are at risk for developmental disorders. These infants may have motor, cognitive and behavioral problems compared to their term peers.
- Trial name
- NCT05210985
- Testing
- Affordances in the Home Environment for Motor Development-Infant Scale, Peabody Developmental Motor Scales-2, Test Of Sensory Functions In Infants (Tsfı)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Gazi University
Postpartum Depression, Anxiety
Coparenting Intervention to Prevent Postpartum Depression
The goal of this pilot randomized controlled trial was to examine the feasibility and acceptability of an ehealth antenatal coparenting intervention (eACoP) in primiparous Pakistani women.
- Trial name
- NCT06305325
- Testing
- eHealth Antenatal Coparenting Intervention
- Where
- Pakistan
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Brock University
Hypertension in Pregnancy
Chronic Hypertension and Pregnancy 2 (CHAP2) Pilot Project
The CHAP2 study is designed to provide preliminary data for a larger multicenter study to assess whether treatment of stage 1 hypertension (HTN) in pregnancy improves maternal and or neonatal outcomes.
- Trial name
- CHAP2 (NCT05989581)
- Testing
- Labetalol or Nifedipine
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
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