Clinical trials: Pregnancy Termination
Abortion Early
MA-ASAP at Independent Abortion Clinics: A Demonstration Project
In this study, the investigators propose to conduct a parallel study to MA-ASAP (ClinicalTrials.gov Identifier: NCT05278780) at an independent clinic.
- Trial name
- NCT05781061
- Testing
- Screening for Eligibility
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Abortion, Induced
Mifepristone Plus Misoprostol Versus Misoprostol Alone for 2nd Trimester Abortion (14 - 21 Weeks Last Menstrual Period (LMP))
The primary goal of this study is to determine the clinical advantage of pre-treatment with mifepristone in second trimester misoprostol induction abortion.
- Trial name
- NCT00969982
- Testing
- mifepristone+misoprostol
- Where
- 2 sites in Moldova, Tunisia
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Abortion in First Trimester
Telemedicine for First Trimester Abortion in South Africa
The study aim to determine if medical abortion facilitated by a physician online (s.c. telemedicine), combined with a simplified physical exam, is equally effective, safe and acceptable to women in South Africa as standard…
- Trial name
- NCT04336358
- Testing
- Telemedicine
- Where
- 4 sites in South Africa
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- University of Cape Town
Termination of Pregnancy
Uptake and Acceptability of Home-use of Mifepristone for Medical Abortion
The primary aim of this study is to assess the acceptability of home-use mifepristone for termination of pregnancy among women who choose it and their providers.
- Trial name
- NCT00994734
- Testing
- Mifepristone
- Where
- 7 sites in United States, Moldova and 1 more
- Volunteers
- 615 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Abortion in First Trimester
Dextromethorphan as a Novel Non-opioid Adjunctive Agent for Pain Control in Medication Abortion
This study evaluates dextromethorphan as a non-opioid adjunctive medication for pain control during medication abortion. This is double-blinded, four-arm randomized controlled trial enrolling 156 women over a period of 9-12…
- Trial name
- DexMab (NCT03480009)
- Testing
- Dextromethorphan Hydrobromide, Avicel PH101 (Microcrystalline Cellulose NF) for Compounding, Oxycodone
- Where
- 2 sites in United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Study Investigator-Sponsor
Labor Induction
A Randomized Trial of Two Regimens of Misoprostol for Second Trimester Termination for Intrauterine Fetal Death
Misoprostol (Cytotec®) is a synthetic prostaglandin E1 analog that has been marketed in the United States since 1988 as a gastric cytoprotective agent.
- Trial name
- NCT00141895
- Testing
- Misoprostol
- Where
- Lebanon
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Medical; Abortion, Fetus
Fetal Fibronectin as a Predictor of Successful Induction of Mid-trimester Abortion
Fetal Fibronectin as a Predictor of Successful Induction of Mid-trimester abortion.
- Trial name
- NCT02694198
- Testing
- fetal fibronectin measurement
- Where
- Egypt
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Contraception
RCT: Can a Single Counseling Phone Call Improve Contraception After an Abortion?
Hypothesis: Use of an effective contraceptive six weeks after abortion will be higher in the treatment group than in the control group.
- Trial name
- PPR (NCT01199952)
- Testing
- Treatment group: receives counseling phone call intervention
- Where
- United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Contraception
Study of Immediate Start of Progestin Contraceptives in Medical Abortion
This study will compare immediate to post-abortion start of two progestin-based contraceptives (DMPA and etonorgestrel implants) among women having first trimester medical abortion who wish to use that method for post-abortion…
- Trial name
- Quickstart (NCT01902485)
- Testing
- Timing of Contraceptive Initiation in Medical Abortion
- Where
- 8 sites in United States, Mexico
- Volunteers
- 937 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Infertility
Pregnancy/Implantation Rates Using a Day 3 Score Versus Graduated Embryo Score Plus a Biochemical Marker (sHLA-G)
Objective: To compare pregnancy rates and implantation rates when embryos are selected based on a single Day 3 (D.3) score vs. a GES score plus sHLA-G expression.
- Trial name
- NCT00680238
- Testing
- Human derived FSH
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Stellenbosch
Spontaneous Abortion, Malaria
Study of DDT and Loss of Clinically-Recognized Pregnancies in South Africa
Background: In some countries, such as South Africa, the pesticide DDT is an important chemical for control of malaria-carrying mosquitoes. However, there is little evidence about the effects that it might have on human health.
- Conditions
- Spontaneous Abortion, Malaria, Pregnancy Outcome, Stillbirth
- Trial name
- NCT00878098
- Where
- South Africa
- Volunteers
- 513 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Medical Abortion
Self-Assessment of Medical Abortion Outcome Using Serial Multi-level Pregnancy Tests
This study aims to investigate the effectiveness and acceptability of the multi-level pregnancy test for self-assessment of abortion outcomes, without a routine provider contact.
- Trial name
- NCT02570204
- Testing
- Self-assessment
- Where
- 3 sites in United States
- Volunteers
- 343 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Pregnancy Related
Medication Abortion for Pregnancy of Unknown Location
The purpose of this study is to compare time to completed abortion between two protocols for patients seeking medication abortion - same-day start versus delay-for-diagnosis - in the setting of asymptomatic, low-risk, pregnancy…
- Trial name
- MAPUL (NCT04026789)
- Testing
- Same-day-start, Delay-for-diagnosis
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood League of Massachusetts
Second Trimester Labor Induction
Second Trimester Labor Induction
A superior second trimester medical abortion regimen has not been identified. Studies suggest that a regimen of mifepristone and misoprostol given 36 to 48 hours apart has the shortest median induction-to-abortion interval…
- Trial name
- NCT00592215
- Testing
- Experimental (mifepristone and misoprostol)
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Abortion
Intrafetal Digoxin as an Adjuvant for Dilation and Evacuation at 20 to 24 Weeks' Gestation
This is a research study to measure the effect of digoxin injection on Dilation and Evacuation (D\&E) procedure duration. Digoxin is the most commonly used feticidal agent among family planning subspecialists, and is commonly…
- Trial name
- NCT03136068
- Testing
- Digoxin
- Where
- 3 sites in United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Missed Miscarriage
Mifepristone and Misoprostol Versus Misoprostol Alone in the Medical Management of Missed Miscarriage
Miscarriage is the most common complication of pregnancy. As many as 15-25% of pregnancies end in miscarriage, and the number of miscarriages in England is estimated to be approximately 125,000 per year.
- Trial name
- MifeMiso (NCT03065660)
- Testing
- Mifepristone, Oral, 200 Mg
- Where
- 28 sites in United Kingdom
- Volunteers
- 711 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Threatened Miscarriage in First Trimester
Value of CA125 and Yolk Sac Morphology in Prediction of Pregnancy Outcome in Threatened Miscarriage
evaluation of serum CA125 level and yolk sac morphology in women with threatened miscarriage is very important to predict pregnancy outcome
- Trial name
- NCT03320213
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Recurrent Miscarriages
Maternal KIR and Fetal HLA-C Genes in Recurrent Miscarriages
For implantation of developing conceptus, placental cells need to invade mother's uterus to access maternal blood supply in a control manner.
- Trial name
- NCT00180804
- Where
- United Kingdom
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Fibroid, Miscarriage in First Trimester
Fibroids and the Risk of Miscarriage: a Prospective Observational Study in an Early Pregnancy Population
The aim of this observational study is to whether fibroids increase the risk of miscarriage in women in our early pregnancy population.
- Conditions
- Fibroid, Miscarriage in First Trimester, Miscarriage in Second Trimester
- Trial name
- FiRM (NCT06986616)
- Where
- United Kingdom
- Volunteers
- 436 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Post Abortion Care
Contraceptive Counseling Following an Abortion
The purpose of this study is to determine whether contraceptive counseling is effective on acceptance and use of methods in women following an abortion.
- Trial name
- APA (NCT00756314)
- Testing
- Personalized contraceptive counseling
- Where
- Brazil
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira