Clinical trials: Pregnancy Termination
Medical; Abortion, Fetus
Fertility and Obstetric Outcomes After Medical Management Versus Surgical Treatment for First-trimester Miscarriage First-trimester Miscarriage
Study Objective: To compare the time to new pregnancy and pregnancy outcomes in women who received Misoprostol for uterus evacuation versus those treated surgically with dilatation and curettage.
- Trial name
- NCT03570307
- Testing
- medical VS surgical evacuation of the uterus
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Endometritis
Doxycycline Prophylaxis at Vacuum Aspiration Trial
This study is a randomized, double-blinded, controlled trial comparing two regimens of doxycycline for the prevention of infection after surgical abortion.
- Trial name
- Tu Du Doxy (NCT00547170)
- Testing
- Doxycycline pre-operatively, Doxycycline post-operatively
- Where
- Vietnam
- Volunteers
- 1,000 people
- Sponsor
- University of Pittsburgh
Contraception
A Trial of Group Versus Individual Family Planning Counseling in Ghana
This study uses a randomized, noninferiority design to determine whether group family planning counseling is as effective as individual family planning counseling among gynecological patients with unmet need at two teaching…
- Trial name
- GCFP (NCT00814411)
- Testing
- group family planning counseling, Individual family planning counseling
- Where
- 3 sites in United States, Ghana
- Volunteers
- 648 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Medical; Abortion, Fetus, Second Trimester Abortion
Uterocervical Angle in the Pregnancy Termination of Multiparous Women
To evaluate the uterocervical angle (UCA) in the prediction of second trimester termination success of multiparous women.
- Trial name
- NCT03400358
- Testing
- uterocervical angle
- Where
- Turkey (Türkiye)
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Early Pregnancy Failure, Miscarriage
MiMi: A Randomized Trial of Mifepristone and Misoprostol for Treatment of Early Pregnancy Failure
The purpose of this study is to compare two combinations of drugs (mifepristone and misoprostol versus placebo and misoprostol) used for medical treatment for early pregnancy failure.
- Conditions
- Early Pregnancy Failure, Miscarriage, Fetal Demise, Anembryonic Pregnancy
- Trial name
- MiMi (NCT00468299)
- Testing
- Mifepristone and misoprostol
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Boston University
Early Pregnancy Failure
Early Pregnancy Failure: Factors Affecting Successful Medical Termination Treatment
The main purpose of our study was to which determine factors, those measured by ultrasound and also demographic and clinical factors (age, number of previous pregnancies, abortions and deliveries) predict outcome of medical…
- Trial name
- NCT00782860
- Where
- Israel
- Sponsor
- Western Galilee Hospital-Nahariya
Abortion, Dilation and Evacuation
Effect of Prophylactic Tranexamic Acid on Bleeding Outcomes for Dilation and Evacuation
Prophylactic tranexamic acid has shown been shown to reduce maternal mortality from postpartum hemorrhage with no adverse effects, but has not been studied to reduce bleeding complications with dilation and evacuation (D\&E).
- Conditions
- Abortion, Dilation and Evacuation, Hemorrhage, Blood Loss
- Trial name
- NCT04651166
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
Infertility, Female
Immediate Ambulation Versus Short-time Bed Rest in Sub-fertile Women Undergoing Embryo Transfer
Bed rest after embryo transfer (ET) has been clinically advised without robust scientific evidence. In investigators' unit, post ET instructions are given immediately after ET to sub-fertile women while lying in bed.
- Trial name
- NCT05148624
- Testing
- embryo transfer
- Where
- United Arab Emirates
- Volunteers
- 156 people
- Sponsor
- Dubai Fertility Center
Abortion, Stillbirth
Perioperative Dexmedetomidine to Reduce Post-procedure Grief Following Second-trimester Dilation and Evacuation
People seeking second-trimester dilation and evacuation (D\&E) procedures are often facing profoundly challenging circumstances, including desired pregnancies complicated by fetal anomalies or demise, serious maternal health…
- Conditions
- Abortion, Stillbirth, PTSD (Childbirth-Related), Grief (Traumatic Grief and Existential Grief)
- Trial name
- NCT07537894
- Testing
- Dexmedetomidine (IV) 0.5 mcg/kg
- Where
- United States
- Sponsor
- Stanford University
Abortion Threatened
Biochemical Versus Ultrasound Findings as Predictors of Fetal Loss in Cases of First Trimester Threatened Miscarriage
Threatened miscarriage occurs in about one-fifth of pregnancies with an estimated miscarriage rate of 3-16% after successful demonstration of fetal cardiac activity.
- Trial name
- NCT03797508
- Testing
- ultrasound
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Ain Shams University
Chronic Endometritis, in Vitro Fertilization
Chronic Endometritis and IVF
Background: Embryo quality is known to be a very important determinant to predict the implantation and pregnancy rate in IVF patients, however, the role of uterine integrity or endometrial receptivity cannot be overlooked.
- Trial name
- CEIVF (NCT02646930)
- Testing
- Endometrial biopsy
- Where
- 2 sites in United States
- Volunteers
- 57 people
- Sponsor
- Duke University
Pregnancy Trimester, First, Abortion, Threatened
Thromboelastometry Prediction Utility for Risk of Abortion
This study will use thromboelastometry in ED patients with vaginal bleeding, as well as healthy pregnant controls, to determine if abnormal results are associated with the presence of vaginal bleeding as well as later…
- Trial name
- TEMPURA (NCT03548701)
- Testing
- Thromboelastometry testing
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Missed Abortion
Comparison of Efficacy and Safety of Oral Versus Vaginal Misoprostol in Missed Abortion in First Trimester of Pregnancy
Incomplete abortion has an eminent clinical diagnosis and is characterized by transvaginal bleeding associated with an open uterine cervix upon physical examination when the products of conception have not been wholly discharged.
- Trial name
- NCT07526064
- Testing
- Oral misoprostol, Misoprostol (given vaginally)
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Hamna Khaliq
Abortion, Missed
Testing the Efficiency of Karman Curette in the Treatment of Misoprostol Failure in Women With Missed Abortion
the purpose of this study is to examine the success rates of Karman curettage in completing the abortion after failed recurred treatment with Misoprostol for women with missed abortion.
- Trial name
- NCT02917785
- Testing
- Karman curettage
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Antepartum Bleeding, Preterm Birth
Progesterone and Second Trimester Bleeding
Working hypothesis and aims: To investigate whether progesterone treatment affects the incidence of preterm labor compared to placebo, among women with 2nd trimester bleeding.
- Trial name
- NCT01269450
- Testing
- micronized progesterone 200 mg (Utrogestan)
- Where
- 3 sites in Israel
- Volunteers
- 128 people
- Sponsor
- HaEmek Medical Center, Israel
Intrauterine Adhesion
Clinical Study on a Novel Anti-adhesion Barrier Film
The aim of this clinical study was to verify the effectiveness and safety of the anti-adhesion diaphragm in preventing intrauterine adhesions.
- Trial name
- NCT05888545
- Testing
- anti-adhesion diaphragm
- Where
- 8 sites in China
- Volunteers
- 1,176 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Pregnancy of Unknown Location
Hysteroscopy for the Diagnosis and Treatment of Pregnancy of Unknown Location
Infertility patients have a higher baseline risk of ectopic pregnancy compared to the general population. If an early pregnancy is not visible by ultrasound, patients with a pregnancy of unknown location (PUL) will undergo…
- Trial name
- NCT07469605
- Testing
- Hysteroscopy for diagnosis and treatment of pregnancy of unknown location
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania
Infertility, Intellectual Disability
Prospective Study to Assess Medical Performance of Optical Mapping and Long Read Sequencing in Detecting Numerical and Structural Chromosome Abnormalities
Chromosomal aberrations are major causes of developmental disorders (Intellectual disability (ID), multiple congenital anomalies (MCA), autism spectrum disorders (ASD)) as well as reproductive disorders (RD) in particular…
- Conditions
- Infertility, Intellectual Disability, Malformation, Miscarriage
- Trial name
- CHROMAPS (NCT05290051)
- Testing
- Optical Genome Mapping (Bionano®), Longread sequencing (Nanopore®)
- Where
- France
- Volunteers
- 350 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Abortion Early
Transabdominal and Transvaginal Sonography in Medical Abortion
The investigator will perform a multicenter, randomized controlled trial in practices that routinely use transvaginal sonography (TVS) to compare how often clinicians order additional testing prior to medical abortion after the…
- Trial name
- TASvTVS (NCT03047551)
- Testing
- Transabdominal sonography, Transvaginal sonography
- Where
- 2 sites in United States
- Volunteers
- 634 people, healthy volunteers welcome
- Sponsor
- Columbia University
Placenta Retained, Uterine Diseases
Effectiveness of Hyaluronic Acid Gel in the Prevention of Intrauterine Adhesions After Second Trimester Abortion
This prospective, randomized, controlled study evaluates the efficacy of self-crosslinked hyaluronic acid gel to prevent the development of de-novo intrauterine adhesions following curettage for retained product after second…
- Trial name
- NCT02868437
- Testing
- intrauterine self-cross-linked hyaluronic acid gel
- Volunteers
- 60 people
- Sponsor
- Istanbul University