Clinical trials: Pregnancy Termination
Legally Induced Abortion Without Mention of Complication
Pre-Operative Effects of Mifepristone on Dilation and Evacuation Services
This research study investigates the use of a drug, mifepristone, given before second trimester abortion. Mifepristone is a medication that is approved for medical abortion during the first trimester.
- Trial name
- POEM (NCT01862991)
- Testing
- Hygroscopic cervical dilators, Misoprostol, Intra-amniotic digoxin
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Stanford University
Cervical Preparation
Mifepristone vs Misoprostol
The Investigator team hypothesizes that in a randomized trial comparing mifepristone-alone or misoprostol-alone for cervical preparation for procedural abortions at 12 to 16 weeks in hospital-based care, the proportion of…
- Trial name
- NCT06502158
- Testing
- Mifepristone, Misoprostol
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Recurrent Spontaneous Abortion
Prospective Study of BMD and Ca-P Metabolism in RSA Patients: LMWH Use Versus Control
The goal of this prospective observational study is to learn about the effect of low molecular weight heparin (LMWH) application on bone mineral density (BMD) and on calcium-phosphorus metabolism in patients with recurrent…
- Trial name
- NCT05878574
- Testing
- Low molecular weight heparin
- Where
- China
- Volunteers
- 344 people, healthy volunteers welcome
- Sponsor
- Aimin Zhao
Pregnancy
Feasibility of Telemedicine Medical Abortion
This pilot study is designed to obtain data on the safety, acceptability, and feasibility of providing abortion by direct-to-patient telemedicine and mail.
- Trial name
- NCT04599725
- Testing
- medical abortion
- Where
- 15 sites in United States
- Volunteers
- 413 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Abortion, Second Trimester, Abortion, Medical
Foley Balloon for Cervical Preparation Before Dilation and Evacuation
To evaluate the Foley Balloon technique for cervical preparation before second trimester surgical abortion between 16 and 21 weeks estimated gestational age in combination with misoprostol to prepare the cervix before dilation…
- Trial name
- NCT06850974
- Testing
- Foley Balloon Catheter, Misoprostol, Laminaria
- Where
- Mozambique
- Volunteers
- 102 people
- Sponsor
- Stony Brook University
Abortion, Habitual
Pr-conceptional Progesterone for Unexplained Recurrent Miscarriage
In women with unexplained recurrent miscarriages, progesterone (400 mg pessaries, twice daily), started soon as possible at luteal phase and after a positive pregnancy test and continued to 28 weeks of gestation, compared to…
- Trial name
- NCT01670929
- Testing
- Progesterone
- Where
- Egypt
- Volunteers
- 700 people
- Sponsor
- Woman's Health University Hospital, Egypt
Second Trimester Abortion
Laminaria Compared to Dilapan-S for Cervical Preparation Before Dilation and Evacuation at 18-24 Weeks of Gestation
Primary objective: To study the difference in dilation and evacuation (D\&E) procedure time following overnight cervical preparation with laminaria or Dilapan-S™.
- Trial name
- NCT02033083
- Testing
- Laminaria, Dilapan-S
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood of Greater New York
Infertility, Intellectual Disability
Prospective Study to Assess Medical Performance of Optical Mapping and Long Read Sequencing in Detecting Numerical and Structural Chromosome Abnormalities
Chromosomal aberrations are major causes of developmental disorders (Intellectual disability (ID), multiple congenital anomalies (MCA), autism spectrum disorders (ASD)) as well as reproductive disorders (RD) in particular…
- Conditions
- Infertility, Intellectual Disability, Malformation, Miscarriage
- Trial name
- CHROMAPS (NCT05290051)
- Testing
- Optical Genome Mapping (Bionano®), Longread sequencing (Nanopore®)
- Where
- France
- Volunteers
- 350 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Medical Abortion
Exploring the Role of At-home Semi-Quantitative Pregnancy Tests for Medical Abortion Follow-up
This study will examine the feasibility, acceptability and usability of a semi-quantitative urine pregnancy test (dBest One Step hCG Panel Test Kit) for at-home follow-up after early medical abortion using…
- Trial name
- NCT01150279
- Where
- 11 sites in United States, Mexico and 2 more
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Spontaneous Abortion, Fetal Death
Environmental Factors and Embryonic Development Project
The Environmental Factors and Embryonic Development Project was set up to investigate environmental exposures and behavioral factors responsible for embryonic dysplasia and gestational complications in pregnant women.
- Conditions
- Spontaneous Abortion, Fetal Death, Stillbirth, Birth Defects
- Trial name
- EFED (NCT04182503)
- Testing
- No intervention
- Where
- 19 sites in China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Jinling Hospital, China
Medical; Abortion, Fetus
Simplified Medical Abortion Screening: A Pilot Demonstration Project
This study aims to collection additional data on the safety and acceptability of medical abortion without pretreatment pelvic ultrasound or exam in woman who meet certain criteria.
- Trial name
- NCT02381223
- Where
- 5 sites in United States, Mexico and 1 more
- Volunteers
- 409 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Pregnancy Termination
Determinants of Success, Characterizing the Facilitators of Integrated Abortion Provision
This national, qualitative study of physicians who provide abortion care aims to better understand the facilitators of abortion provision among generalist clinicians in OB-GYN and Family Medicine.
- Trial name
- FAB (NCT03181061)
- Testing
- Semi-structured interviews
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of New Mexico
Second Trimester Abortions
Comparing Misoprostol Alone to Dilapan With Misoprostol and Comparing Buccal to Vaginal Misoprostol
This randomized controlled trial will use a 2 by 2 factorial design to assess methods of cervical preparation prior to Dilation and Evacuations (D\&Es) at 14 0/7 to 19 6/7 weeks gestational age.
- Trial name
- NCT02363556
- Testing
- Misoprostol administered vaginally, Misoprostol administered buccally, Misoprostol administered vaginally with Dilapan
- Where
- 2 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Medstar Health Research Institute
Pain
Comparison Between Two Analgesic Methods for Pain Relief Following Surgical Abortion
To compare between the efficacy of Paracetamol IV vs. Lornoxicam IV in pain relief following surgical abortion. The medication will be given at the time of the procedure. Following the abortion, pain level will be evaluated.
- Trial name
- NCT02025166
- Testing
- Paracetamol, lornoxicam
- Where
- Israel
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Social Stigma, Pregnancy
A Pre and Post Test Intervention Design to Prevent Abortion and Contraceptive-use Stigma Among School Youths in Kenya
In many low-income countries, unsafe abortion is recognized as a leading cause of maternal morbidity and mortality. Social stigma surrounding abortion and contraceptive use plays a critical role in the social, medical, and legal…
- Conditions
- Social Stigma, Pregnancy, Contraception
- Trial name
- SAC (NCT03065842)
- Testing
- Abortion- and contraceptive-use stigma reduction program, Usual Standards
- Where
- Kenya
- Volunteers
- 1,207 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Recurrent Abortion
Folic Acid vs 5-methyltetrahydrofolate (5MTHF) in Recurrent Abortion
Recent data indicates that 5 methyltetrahydrofolate (5MTHF) can reduce serum homocystein level more efficiently than folic acid.
- Trial name
- NCT01976676
- Testing
- 5-methyltetrahydrofolate, folic Acid
- Volunteers
- 220 people
- Sponsor
- National Nutrition and Food Technology Institute
Abortion
Intrafetal Digoxin as an Adjuvant for Dilation and Evacuation at 20 to 24 Weeks' Gestation
This is a research study to measure the effect of digoxin injection on Dilation and Evacuation (D\&E) procedure duration. Digoxin is the most commonly used feticidal agent among family planning subspecialists, and is commonly…
- Trial name
- NCT03136068
- Testing
- Digoxin
- Where
- 3 sites in United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Abortion; Attempted
Misoprostol in Missed Abortion
In this study we compare between the effectiveness of combined Foley's catheter with Misoprostol and intracervical Foley's catheter alone for termination of second trimester abortion.
- Trial name
- NCT06818903
- Testing
- Misopristol, Foley catheter
- Volunteers
- 122 people
- Sponsor
- Assiut University
Early Pregnancy Failure
Comparing Two Medical Treatments for Early Pregnancy Failure.
This study aims to compare whether a combination of two drugs (Mifepristone and misoprostol) are superior compared to using only one of these drugs (Misoprostol) as medical treatment for a miscarriage.
- Trial name
- Triple M (NCT03212352)
- Testing
- Mifepristone, Misoprostol
- Where
- 13 sites in Netherlands
- Volunteers
- 342 people
- Sponsor
- Radboud University Medical Center
Miscarriage
Virtual Reality in MVA for Miscarriage
We are investigating the use of a virtual reality programme to reduce pain and anxiety experienced during manual vacuum aspiration.
- Trial name
- NCT04466956
- Testing
- Virtual reality
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Barts & The London NHS Trust