Clinical trials: Pregnancy Termination
Induced Abortion
Post Abortion IUD & Recurrent Abortion 2005-2006
The rate of repeat abortions will be lowest in those women who choose immediate insertion of an IUD post-abortion versus those who immediately choose oral contraceptive pills and those who indicate all other contraceptive choices…
- Trial name
- NCT01776957
- Testing
- Device: Intrauterine device (IUD)
- Volunteers
- 1,308 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Induction of Second Trimester Abortion
Use of Ulipristal Acetate in Induction of Second Trimester Missed Abortion
The aim of this work is to assess the effectiveness and safety of Ulipristal Acetate in the management of 2nd trimester missed abortion along with misoprostol in pregnant women with previous caesarean section versus the use of…
- Trial name
- NCT04989400
- Testing
- Ulipristal Acetate, Misoprostol
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Cerclage, Cervical, Cervical Insufficiency
Long-Term Patient-Reported Maternal Outcomes Following Abdominal Cerclage for the Prevention of Preterm Birth
This study aims to explore the maternal patient reported outcomes on pelvic pain sexual health anxiety and depression bladder discomfort foreign body sensation trust in the cerclage, and how these parameters affect the general…
- Trial name
- NCT06875401
- Testing
- Abdominal cerclage (open or laparoscopic)
- Where
- Denmark
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Abortion, First Trimester
Acceptability and Feasibility of a Demedicalized Medical Abortion Regimen in the Caucasus
This study examined the acceptability and feasibility of using a simplified regimen of medical abortion in Armenia and Azerbaijan.
- Trial name
- NCT02219100
- Testing
- Home administration of 200 mg mifepristone
- Where
- 5 sites in Armenia, Azerbaijan
- Volunteers
- 613 people
- Sponsor
- Gynuity Health Projects
Infertility, Miscarriage
A Trial of Sperm Injection (PICSI) on Miscarriage Rates in Assisted Conception
Physiological intracytoplasmic sperm injection (PICSI) is a technique used to select healthy, mature sperm for use in infertility treatment based on their physiological ability to bind to hyaluronan (HA), a natural compound found…
- Trial name
- PICSI (NCT05762770)
- Testing
- PICSI
- Where
- United Kingdom
- Volunteers
- 140 people
- Sponsor
- Shrewsbury and Telford Hospitals NHS Trust
Abortion, Induced
Study of 400mcg Sublingual Versus 400mcg Buccal Misoprostol Following 200mg Mifepristone for Medical Abortion up to 63 Days Last Menstrual Period (LMP)
This open-label, randomized study is being conducted to determine whether a dose of 400 mcg of buccal misoprostol (i.e., in the cheek) taken 24 hours following administration of mifepristone 200 mg is as effective and acceptable…
- Trial name
- NCT00870272
- Testing
- Misoprostol
- Where
- Moldova
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Abortion, Dilation and Evacuation
Effect of Prophylactic Tranexamic Acid on Bleeding Outcomes for Dilation and Evacuation
Prophylactic tranexamic acid has shown been shown to reduce maternal mortality from postpartum hemorrhage with no adverse effects, but has not been studied to reduce bleeding complications with dilation and evacuation (D\&E).
- Conditions
- Abortion, Dilation and Evacuation, Hemorrhage, Blood Loss
- Trial name
- NCT04651166
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
Pain
12 Versus 20 mL PCB for D&E Cervical Prep
More research is needed to investigate methods of pain control for cervical preparation for abortion procedures. Women report pain with paracervical block injection as well as with osmotic dilator placement.
- Trial name
- NCT03356145
- Testing
- 12 mL paracervical block, 20 mL paracervical block
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Stanford University
Labor Induction
A Randomized Trial of Two Regimens of Misoprostol for Second Trimester Termination for Intrauterine Fetal Death
Misoprostol (Cytotec®) is a synthetic prostaglandin E1 analog that has been marketed in the United States since 1988 as a gastric cytoprotective agent.
- Trial name
- NCT00141895
- Testing
- Misoprostol
- Where
- Lebanon
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Missed Abortion
Buccal Versus Vaginal Misoprostol in Surgical Termination of the First Trimester Missed Abortion in Erbil
The purpose of this study is to determine the effectiveness of buccal misoprostol and comparing this with vaginal route of the same drug.
- Trial name
- NCT00892229
- Testing
- Misoprostol (given buccally), Misoprostol (given vaginally)
- Where
- Iraq
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hawler Medical University
Early Abortion, Pregnancy Loss, Early
Comparison of Surgical Management of Early Pregnancy Loss by Suction Curettage Versus Hysteroscopy in Patients Undergoing In-vitro Fertilization (IVF)
Early pregnancy loss occurs in ~15% of pregnancies. The treatment options include surgical uterine evacuation by suction curettage, medical management with misoprostol, or conservative management without interventions.
- Trial name
- NCT07143578
- Testing
- Operative hysteroscopy using tissue removal device, suction curettage
- Where
- 2 sites in Israel
- Volunteers
- 50 people
- Sponsor
- Assaf-Harofeh Medical Center
Infertility, Recurrent Implantation Failure
Effect of Reproductive Tract Microbiota on Pregnancy Outcome in IVF/ICSI
A single center，observational cohort study to explore the relationship between reproductive tract microbiota and pregnancy outcome in the patients accepted IVF/ICSI.
- Conditions
- Infertility, Recurrent Implantation Failure, Recurrent Miscarriage
- Trial name
- NCT04293068
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University Third Hospital
Ultrasound-guided Manual Vacuum Aspiration, First Trimester Spontaneous Abortion
Ultrasound-guided Manual Vacuum Aspiration (USG-MVA)
This is a retrospective study to review the current experience of USG-MVA in Hong Kong and also evaluate the effectiveness of USG-MVA in cytological analysis in the management of first trimester miscarriage.
- Trial name
- NCT05413525
- Testing
- ultrasound-guided manual vacuum aspiration (USG- MVA)
- Where
- 2 sites in Hong Kong
- Volunteers
- 200 people
- Sponsor
- Chinese University of Hong Kong
Induced Abortion
The Feasibility of Simplified Telephone Follow-up After Medical Abortion
To assess the feasibility of using simplified telephone follow-up to predict pregnancy expulsion after medical abortion, and if in-person follow-up is required to determine the percentage of women that will present for that…
- Trial name
- SMART (NCT00619658)
- Testing
- telephone follow-up
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Infertility, Miscarriage, Recurrent
ANXA5 M2 Haplotyping in IVF Patients and Embryos
This study aims to characterize the association between history of pregnancy complications and M2 carrier status in IVF patients and the utility of M2 haplotype preimplantation genetic testing (PGT) in embryos produced by carrier…
- Conditions
- Infertility, Miscarriage, Recurrent, Pregnancy Complications
- Trial name
- NCT04544462
- Testing
- M2 Test
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Genomic Prediction Inc.
Arrhythmia, ECG Changes
Intra Amniotic Injection of DIGOXIN for Feticide in Second Trimester Termination of Pregnancy
In second trimester abortion above 22 weeks the investigators usually inject intra-cardiac Kcl for feticide. Digoxin intra-amniotic injection has been described in the literature in doses of 1-1.5 mg.
- Conditions
- Arrhythmia, ECG Changes, Hypotension
- Trial name
- NCT01951079
- Testing
- Intra-amniotic injection of DIGOXIN
- Where
- 2 sites in Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Missed Abortion
Letrozole Pretreatment With Misoprostol Induction of Abortion in First Trimester Missed Abortion
this study will compare the efficacy of using letrozole pre treatment before misoprostol versus using misoprostol only in the induction of first trimester missed abortion.
- Trial name
- NCT04590482
- Testing
- letrozole
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Shereen Rady Abou El-fetouh
Pregnancy Loss, Early
Patient Satisfaction With the Management of a Stopped Pregnancy in the First Trimester
The clinical practice recommendations highlight the fact that the patient's choice concerning the management of her aborted pregnancy in the first trimester should be privileged, after clear and appropriate information on the…
- Trial name
- MYFEFACY (NCT05049980)
- Testing
- Medical treatment with Mifégyne® and MisoOne®, Endo-uterine aspiration
- Where
- France
- Volunteers
- 52 people
- Sponsor
- University Hospital, Toulouse
Induced Abortion, Instrumental Induced Abortion Between 14 and 16 Weeks of Amenorrhea
Retrospective Study of Surgical Induced Abortions Between 14 and 16 Weeks of Amenorrhea At Croix Rousse University Hospital in Lyon
In France, induced abortions can be carried out by two different methods: the medicinal one, which involves taking medications to expel the pregnancy (MIFEPRISTONE and then MISOPROSTOL), and the instrumental one, which involves…
- Trial name
- TARDIVG (NCT06871618)
- Testing
- Retrospective
- Where
- France
- Volunteers
- 700 people
- Sponsor
- Hospices Civils de Lyon
Medical Abortion
Safety and Efficacy of Medical Abortion Provided by Midlevel Providers or Physicians
The physical examination before an abortion is usually performed by a physician. However, in many countries access to physicians is limited.
- Trial name
- NCT01612923
- Testing
- Midwife
- Where
- Sweden
- Volunteers
- 1,180 people
- Sponsor
- Kristina Gemzell Danielsson