Clinical trials: Pregnancy in Diabetic
Chronic Kidney Disease, Diabetic Nephropathy
Evaluate the Efficacy and Safety of Once Daily Administration of Atrasentan Tablets (Low and High) Compared to Placebo in Reducing Residual Albuminuria in Type 2 Diabetic Patients With Nephropathy Who Are Treated With the Maximum Tolerated Labeled Dose of a Renin Angiotensin System (RAS) Inhibitor
Prospective, Randomized, Double-Blind, Placebo-Controlled Multicenter Study. The objective of the study is to evaluate the efficacy and safety of once daily administration of atrasentan tablets (low dose and high dose) compared…
- Trial name
- RADAR (NCT01356849)
- Testing
- Atrasentan
- Where
- 72 sites in United States, Canada and 2 more
- Volunteers
- 149 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Diabetic Kidney Disease
P2a Open Label Study to Evaluate 2-HPβCD in Subjects With Diabetic Kidney Disease
This is an open label, two to three center study to evaluate the clinical efficacy and safety of 1 dose level of 2-hydroxypropyl-β-cyclodextrin (2-HPβCD) given intravenously in adult patients with type 2 diabetes with diabetic…
- Trial name
- NCT06489340
- Testing
- 2HPβCD
- Where
- United States
- Sponsor
- ZyVersa Therapeutics, Inc.
Type 2 Diabetes Mellitus, Obesity
Effect of Gastric Bypass Surgery on Diabetes Status and Microvascular Complications in Obese Type 2 Diabetic Patients
This study evaluates the long-term benefits of Roux-en-Y gastric bypass (RYGB) on type 2 diabetes mellitus, focussing on the prevalence and predictors of T2DM improvement and remission after RYGB, and subsequently relapse of type…
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Diabetic Retinopathy, Diabetic Nephropathy
- Trial name
- NCT02625649
- Where
- Denmark
- Volunteers
- 148 people
- Sponsor
- University of Aarhus
Diabetic Nephropathy, Endothelial Dysfunction
Flavonoids in the Treatment of Endothelial Dysfunction in Children With Diabetes
Diabetes is the most common metabolic disease of childhood. Vascular disease is a leading complication of diabetes, and attempts to maintain close glycemic control do not prevent the sequelae that claim the lives and quality of…
- Trial name
- flavonoid (NCT01307917)
- Testing
- flavonoids
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Gestational Diabetes Mellitus in Pregnancy
D-chiro Inositol in Prevention of Gestational Diabetes Mellitus in China
Inositol is a type of food additives, which plays an important role in insulin signal pathway and is related to insulin sensitivity.
- Trial name
- NCT04801485
- Testing
- D-chiro inositol
- Where
- China
- Volunteers
- 291 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Gestational Diabetes
Continuous Glucose Monitoring for Screening for Diabetes in Pregnancy
The purpose of this study is to evaluate whether Continuous glucose monitoring (CGM) for diagnosis of gestational diabetes mellitus (GDM) improves maternal and neonatal outcomes related to GDM and to evaluate whether CGM for GDM…
- Trial name
- NCT05430204
- Testing
- Group 1: one-hour GCT, Group 2: CGM placement
- Where
- United States
- Volunteers
- 1,628 people
- Sponsor
- The University of Texas Health Science Center, Houston
Glomerulonephritis, Membranous, Diabetic Nephropathies
The Influencing Factors and Mechanism of High Incidence of Thrombotic Events in Patients With MN and DKD
Influence factors and preliminary mechanism of high incidence of thrombotic events in patients with idiopathic membranous nephropathy and diabetes kidney disease
- Conditions
- Glomerulonephritis, Membranous, Diabetic Nephropathies, Thrombelastography, Thromboembolism
- Trial name
- NCT05656963
- Testing
- Grouping based on previous laboratory results, no intervention.
- Where
- China
- Volunteers
- 741 people
- Sponsor
- Yipeng Liu
Gestational Diabetes Mellitus in Pregnancy
First Trimester Prediction of Gestational Diabetes Mellitus by Continuous Glucose Monitoring.
Gestational diabetes mellitus (GDM) is the most common complication of pregnancy, with an incidence rate of 10-15% [1]. Common risk factors for GDM are increased maternal age and weight and as a consequence of women delaying…
- Trial name
- GLUCO-GCM (NCT06874907)
- Testing
- Glucose monitoring
- Where
- Spain
- Volunteers
- 1,000 people
- Sponsor
- Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
Diabetic Pregnancy, Pregnancy Related
Comparison of Factor XII Levels in Gestational Diabetic and Healthy Pregnancies
To compare Factor XII levels in gestational diabetic and healthy pregnancies.
- Conditions
- Diabetic Pregnancy, Pregnancy Related, Complement System; Disorder
- Trial name
- NCT03583216
- Testing
- Diabetic pregnancy, Non-diabetic pregnancy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Diabetic Nephropathies, Hypertension
Efficacy and Safety of Telmisartan Compared With Losartan
A study to evaluate the efficacy and safety of telmisartan compared with losartan in patients with diabetic nephropathy and hypertension
- Trial name
- NCT06431477
- Testing
- telmisartan, Losartan
- Where
- South Korea
- Volunteers
- 98 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Type 2 Diabetes
MiTy Kids (Metformin in Women With Type 2 Diabetes in Pregnancy Kids Trial)
The prevalence of diabetes in pregnancy is rising in all maternal age groups. There is increasing evidence that in-utero exposure to maternal diabetes is associated with an increased risk of obesity and type 2 diabetes in…
- Trial name
- NCT01832181
- Where
- Canada
- Volunteers
- 287 people
- Sponsor
- Mount Sinai Hospital, Canada
Type 2 Diabetes Mellitus
A Study to Assess Efficacy and Safety of ASP1941 in Diabetic Patients With Renal Impairment
This study is to assess the effect of renal function on the efficacy and safety of ASP1941 in type 2 diabetic patients with mild to moderate renal impairment.
- Trial name
- NCT01316094
- Testing
- ASP1941
- Where
- 8 sites in Japan
- Volunteers
- 165 people
- Sponsor
- Astellas Pharma Inc
Sepsis, Acute Kidney Injury
Identifying Risk Factors for Developing AKI in Sepsis
A study to evaluate the prevalence of Acute Kidney Injury (AKI) in patients with Diabetic Ketoacidosis (DKA) and sepsis using data collected prospectively to a patient registry.
- Conditions
- Sepsis, Acute Kidney Injury, Diabetic Ketoacidosis
- Trial name
- NCT04825639
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Cardiff and Vale University Health Board
Type 1 Diabetes Mellitus, Pregnancy in Diabetics
Longitudinal Observation of Insulin Requirements and Sensor Use in Pregnancy
The overall goal of this study is to enroll pregnant women with type 1 diabetes and follow their glycemic outcomes prospectively throughout pregnancy and into the post-partum period.
- Trial name
- LOIS-P (NCT03761615)
- Testing
- Dexcom G6 CGM
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Sansum Diabetes Research Institute
Diabetes Mellitus Arising in Pregnancy, Insulin-Requiring, Diabetes Mellitus in Pregnancy
Comparative Effects of Metformin and Insulin on Stereological Studies and Immunohistochemistry of Placenta
Diabetes mellitus is a group of metabolic disorder characterized by high blood glucose level mainly due to defect in insulin secretion or resistance.
- Trial name
- NCT04907708
- Testing
- Metformin, Insulin
- Where
- Pakistan
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- University of Karachi
Diabetic Nephropathy Type 2, Type 2 Diabetes Mellitus
Beta-2-Trace Protein in Diabetic Nephropathy
This cross-sectional study aims to evaluate serum beta-2-trace protein levels in patients with diabetic nephropathy compared with healthy controls.
- Trial name
- NCT07919795
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Diabetes Mellitus, Kidney Transplantation
Influence of Pioglitazone for Renal Transplant Function in Diabetics
The purpose of this study is to test whether pioglitazone is able to prevent the progression of diabetic nephropathy in kidney transplant recipients with diabetes mellitus.
- Conditions
- Diabetes Mellitus, Kidney Transplantation, Proteinuria
- Trial name
- NCT00507494
- Testing
- pioglitazone
- Where
- Germany
- Sponsor
- Technische Universität Dresden
Nephropathy, Diabetic
DEL-1 and Thromboxane A2 in Diabetic Nephropathy Patients
Diabetic nephropathy is one of the most common microvascular complications of diabetes mellitus and a leading cause of chronic kidney disease.
- Trial name
- DEL1-DN (NCT07749664)
- Testing
- No intervention
- Volunteers
- 80 people
- Sponsor
- Aswan University
Diabetic Kidney Disease
Prevalence and Management Practice of Diabetic Kidney Disease at BADAS Affiliated Healthcare Centres in Bangladesh
Background: Diabetes is a growing public health concern in Bangladesh, with millions affected. Diabetic Kidney Disease (DKD) is a severe complication of diabetes, affecting approximately 21.3% of the diabetic population.
- Trial name
- BADAS (NCT06422598)
- Where
- 8 sites in Bangladesh
- Volunteers
- 320 people
- Sponsor
- Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders
Hypertensive Nephropathy, Auto Immune Disorders
ACE Reno, Pico Cell Matrix and Its Effect on eGFR in Chronic Kidney Diseases
This study investigates the safety and efficacy of ACE Reno, an oral transmucosal solution containing standardized bioactive peptides and amino acids, in patients with nephropathy of various etiologies and stages.
- Conditions
- Hypertensive Nephropathy, Auto Immune Disorders, Chronic Kidney Disease, Chronc Kidney Disease Stage 5
- Trial name
- ACE Reno (NCT07187713)
- Testing
- ACE Reno
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Ace Cells Lab Limited