Clinical trials: Pregnancy in Diabetic
Gestational Diabetes
Effect of Omega-3 Fatty Acids on Insulin Sensitivity in Chinese Gestational Diabetic Patients
This study is to examine the change of fasting insulin, glucose, insulin sensitivity and related traits in response to the 14 wk treatment of omega-3 fatty acids, including fish oil (n=25) and flaxseed oil(n=25), in Chinese…
- Trial name
- NCT01912170
- Testing
- Fish oil, Flaxseed oil
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Zhejiang University
Gestational Diabetes, Pelvic Girdle Pain
Pelvic Girdle Pain in Pregnant Women
Pelvic girdle pain and gestational diabetes mellitus are experienced in similar trimesters of pregnancy. The aim of this study is to examine the effect of gestational diabetes mellitus on the occurrence of pelvic girdle pain and…
- Conditions
- Gestational Diabetes, Pelvic Girdle Pain, Pregnant Woman
- Trial name
- NCT04769375
- Testing
- Evaluation of pain, Application of pelvic girdle pain tests, Application of pelvic girdle questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Gestational Diabetes Mellitus in Pregnancy, Diet- Controlled
Maternal Glucose, Cortisol, and Neonatal Outcomes With and Without GDM
This study will compare maternal blood glucose and cortisol responses and neonatal outcomes between women with gestational diabetes mellitus and women without gestational diabetes mellitus who receive epidural analgesia during…
- Trial name
- NCT07870629
- Where
- 3 sites in Vietnam
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Hanoi Medical University
Diabetes Mellitus, Type 2, Diabetic Nephropathy
Enhancing Adherence in Type 2 Diabetes: The ENHANCE Study
This randomized study will test a behavioral intervention, based on social cognitive theory (SCT), to improve regimen adherence in three different groups of people with type 2 diabetes; (1) those with well controlled blood…
- Trial name
- ENHANCE (NCT00222846)
- Testing
- Attention control, Intervention
- Where
- United States
- Volunteers
- 288 people
- Sponsor
- University of Pittsburgh
Chronic Kidney Diseases
CLBS201 in Patients with Chronic Kidney Disease (CKD) and Type 2 Diabetes Mellitus (T2DM)
CLBS201 will evaluate the safety, tolerability, and therapeutic effect in subjects with CKD and T2DM.
- Trial name
- NCT04990427
- Testing
- CLBS201
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Lisata Therapeutics, Inc.
Diabetic Nephropathy
Sex-specific Association With Kidney Disease
Oxidative stress is involved in the pathophysiology of diabetic nephropathy. The superoxide-generating nicotinamide adenine dinucleotide phosphate-oxidase 2 (NOX2, encoded by the CYBB gene) and the antioxidant enzyme glutathione…
- Trial name
- NCT01810822
- Where
- Brazil
- Volunteers
- 1,396 people
- Sponsor
- University of Sao Paulo General Hospital
Heart Failure, Chronic Kidney Disease
Efficacy, Safety and Tolerability of AZD9977 and Dapagliflozin in Participants With Heart Failure and Chronic Kidney Disease
The purpose of the study is to evaluate the efficacy and safety of AZD9977 in combination with dapagliflozin compared with dapagliflozin alone and to assess the dose-response relationship, dapagliflozin alone and 3 doses of…
- Trial name
- MIRACLE (NCT04595370)
- Testing
- AZD9977, Dapagliflozin
- Where
- 156 sites in United States, Belgium and 20 more
- Volunteers
- 153 people
- Sponsor
- AstraZeneca
Diabetic Kidney Disease
Role of Finerenone in African American Veterans With Diabetic Kidney Disease
Primary Objectives: To study podocyte specific injury markers (podocyte specific proteins, PSP) nephrin, podocalyxin and Wilms'Tumor (WT-1) protein in exosomes urine from African American Veterans with albuminuric stage 2 and 3…
- Trial name
- NCT07155694
- Testing
- Finerenone 10 MG, Empagliflozin 10 MG
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Washington D.C. Veterans Affairs Medical Center
Fetal Cardiac Anomaly, Gestational Diabetes
Fetal Cardiac Remodeling in Gestational Diabetic Pregnancies at the Moment of Diagnosis
The aim of the present study will be to evaluate whether fetal cardiac remodeling is already present at the moment of the diagnosis of gestational diabetes (GD) in comparison with fetuses of healthy pregnant women.
- Trial name
- NCT05260931
- Testing
- Fetal echocardiography
- Where
- Mexico
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Diabetic Nephropathy
To Determine the Efficacy and Safety of DW1029M on Microalbuminuria in Patients With Diabetic Nephropathy
Phase 2 clinical study to evaluate of the efficacy and safety of DW1029M on microalbuminuria in Patients With Diabetic Nephropathy
- Trial name
- NCT01935167
- Testing
- DW1029M 600mg, DW1029M 1200mg
- Where
- South Korea
- Volunteers
- 158 people
- Sponsor
- Dong Wha Pharmaceutical Co. Ltd.
Chronic Kidney Diseases, Diabetes Mellitus, Type 2
Curcumin on NFE2L2 Gene Expression, Antioxidant Capacity and Renal Function According to rs35652124 in Diabetic Nephropathy
The increase in the prevalence of diabetes mellitus (DM) is one of the greatest public health challenges worldwide. Epidemiological studies have shown that DM is the leading cause of chronic kidney disease (CKD) in patients…
- Conditions
- Chronic Kidney Diseases, Diabetes Mellitus, Type 2, Polymorphism
- Trial name
- CURCUNRF2 (NCT03262363)
- Testing
- Curcumin/NFE2L2 A>G
- Where
- Mexico
- Volunteers
- 176 people
- Sponsor
- Unidad de Investigacion Medica en Enfermedades Renales
Obesity, Maternal, Gestational Diabetes Mellitus in Pregnancy
Cologne Placenta Cohort (CPC)
Aim of the study was to determine if signaling pathways in placentas of mothers affected by overweight/obesity or by gestational diabetes are altered compared to placentas of a control group (normal weight, no gestational…
- Trial name
- NCT05424965
- Testing
- no intervention
- Where
- Germany
- Volunteers
- 247 people
- Sponsor
- Sarah Appel
Diabetic Kidney Disease, Diabetes Mellitus Type 2
Empaglifozin in Early Diabetic Kidney Disease
Background: Diabetes is common among American Indian people and diabetic kidney disease is a common complication. Kidney disease caused by diabetes can lead to the need for kidney replacement, by dialysis or kidney transplant…
- Trial name
- NCT03173963
- Testing
- Empagliflozin
- Where
- United States
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetic Kidney Disease
Gut Microbiota and Serum Metabolites as Predictors of Glycemic Variability and Outcomes in Diabetic Kidney Disease
Diabetic kidney disease (DKD) is one of the main complications of diabetes and a leading cause of end-stage kidney disease. Blood glucose variability is closely associated with disease progression in individuals with DKD.
- Trial name
- NCT07352436
- Volunteers
- 270 people
- Sponsor
- Eighth Affiliated Hospital, Sun Yat-sen University
Diabetes Mellitus, Diabetes Mellitus, Type 1
An International Non-interventional Cohort Study to Evaluate the Safety of Treatment With Insulin Detemir in Pregnant Women With Diabetes Mellitus. Diabetes Pregnancy Registry
This study is conducted in Europe and Asia. The purpose of the study (Diabetes Pregnancy Registry) is to evaluate the safety of treatment with insulin detemir in pregnant women with diabetes mellitus.
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT01892319
- Testing
- insulin detemir, other injectable antidiabetic treatment regimens
- Where
- 93 sites in Croatia, Finland and 14 more
- Volunteers
- 2,446 people
- Sponsor
- Novo Nordisk A/S
Gestational Diabetes Mellitus in Pregnancy, Macrosomia, Fetal
Late Gestational Diabetes Mellitus Diagnosis in Obese Women
In the current work, we aim to perform a prospective study that will investigate the relationship between maternal obesity (BMI >30 kg/m2) and morbid obesity (BMI >35 kg/m2) with a late GDM diagnosis (>32 weeks), with an emphasis…
- Conditions
- Gestational Diabetes Mellitus in Pregnancy, Macrosomia, Fetal, Dystocia, Shoulder, Neonatal Jaundice
- Trial name
- NCT05510518
- Testing
- oral glucose tolerance test (OGTT)
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Western Galilee Hospital-Nahariya
Diabetic Nephropathies
Gemigliptin and Biomarkers of Kidney Injury and Vascular Calcification
Dipeptidyl peptidase-4 (DPP-4) inhibitors improve glycemic control and contain pleiotropic actions on kidney injury, albuminuria and vascular inflammation especially in animal models.
- Trial name
- NCT04705506
- Testing
- Gemigliptin
- Where
- 3 sites in Thailand
- Volunteers
- 201 people
- Sponsor
- Bangkok Metropolitan Administration Medical College and Vajira Hospital
Chronic Kidney Disease, Hypertension
Patiromer in the Treatment of Hyperkalemia in Patients With Hypertension and Diabetic Nephropathy (AMETHYST-DN)
This study determined the optimal starting dose of patiromer in treating hyperkalemia in participants with hypertension and diabetic nephropathy who were already receiving ACEI and/or ARB drugs, with or without spironolactone.
- Conditions
- Chronic Kidney Disease, Hypertension, Hyperkalemia
- Trial name
- AMETHYST-DN (NCT01371747)
- Testing
- patiromer, losartan, spironolactone
- Where
- 43 sites in Croatia, Georgia and 3 more
- Volunteers
- 324 people
- Sponsor
- Relypsa, Inc.
Type 2 Diabetes, Cardiovascular Complication
Effects and Safety of Diabetic GUideline Algorithm Implementation Performed by Primary Care Physicians in the Community
The Effects and Safety of Diabetic GUideline Algorithm Implementation in the Community (GUARD-Community) study is a 2-arm, cluster-randomized control trial to evaluate the effect and safety of guideline algorithm intervention…
- Conditions
- Type 2 Diabetes, Cardiovascular Complication, Diabetic Kidney Disease
- Trial name
- GUARD (NCT05349955)
- Testing
- Intensive guideline algorithm implementation, Conventional guideline algorithm implementation
- Where
- 13 sites in China
- Volunteers
- 5,600 people
- Sponsor
- Shanghai Zhongshan Hospital
Fetal Macrosomia
Estimation of Fetal Weight by MR Imaging to PREdict Neonatal MACROsomia (PREMACRO Study)
Macrosomia and growth restriction are important causes of perinatal morbidity, at or near to term. However, clear identification of 'at risk' foetuses is difficult and clinical estimates of fetal weight are poor.
- Trial name
- NCT02713568
- Testing
- Ultrasound examination, Magnetic resonance examination
- Where
- Belgium
- Volunteers
- 2,413 people, healthy volunteers welcome
- Sponsor
- Brugmann University Hospital