Clinical trials: Pregnancy in Diabetic
Diabetic Foot Disease, Chronic Kidney Disease Due to Type 2 Diabetes Mellitus
Predictors of Diabetic Foot Outcome in Chronic Kidney Disease Patients
Individuals with diabetic neuropathy and Chronic kidney disease (CKD) are 15 times more likely to have a non-traumatic lower extremity amputation compared to those with DM alone .
- Trial name
- NCT06684886
- Testing
- Ankle Brachial Index
- Volunteers
- 60 people
- Sponsor
- Assiut University
Inflammation, Chronic Kidney Disease
Role of Prohepcidin in Uremic Patients
The investigators aimed to study the effect of prohepcidin levels on hematologic parameters and inflammatory markers in non-diabetic uremic patients.
- Trial name
- NCT01735773
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Haseki Training and Research Hospital
Diabetic Nephropathy
Effect of Pyridorin in Patients With Diabetic Nephropathy
The primary objective of the study is to evaluate the safety, tolerability and efficacy of Pyridorin (pyridoxamine dihydrochloride) up to 250 mg given orally twice daily in patients with diabetic kidney disease.
- Trial name
- NCT00320021
- Testing
- Pyridorin (pyridoxamine dihydrochloride)
- Volunteers
- 80 people
- Sponsor
- BioStratum
Type 2 Diabetes
Nutraceutical Citrulline in Pregnancy
The purpose of this study is to determine if oral of L-citrulline (3 grams/day) for 3 weeks provided in mid-pregnancy to pregnant women with type 2 diabetes will increase the plasma L-arginine/ADMA ratio, lower maternal blood…
- Trial name
- NCT02772887
- Testing
- L-Citrulline
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pittsburgh
Gestational Diabetes Mellitus in Pregnancy, Gestational Hypertension
No-worry Baby Project
The Huizhou mother-infant cohort was set up to investigate the effect of dietary factors and environmental exposures during pregnancy on health consequences of mothers and offsprings in Huizhou, China.
- Conditions
- Gestational Diabetes Mellitus in Pregnancy, Gestational Hypertension, Thyroid Disease Pregnancy, Obesity
- Trial name
- NCT03922087
- Testing
- No intervention
- Where
- China
- Volunteers
- 5,216 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Diabetes in Pregnancy
Effects of Moderate Carbohydrate Consumption on Metabolic and Obstetric Outcomes in Pregnant Women With Insulin-treated Diabetes- A Randomized Controlled Trial
Diabetes during pregnancy increases maternal and fetal complications, necessitating optimal glycemic control. The standard care diet (SCD, ≥175g/day carbohydrate) lacks robust evidence, particularly for pregnancies requiring…
- Trial name
- NCT06355154
- Testing
- Nutritional intervention
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Hadassah Medical Organization
Gestational Diabetes
Effect of Omega-3 Fatty Acids on Insulin Sensitivity in Chinese Gestational Diabetic Patients
This study is to examine the change of fasting insulin, glucose, insulin sensitivity and related traits in response to the 14 wk treatment of omega-3 fatty acids, including fish oil (n=25) and flaxseed oil(n=25), in Chinese…
- Trial name
- NCT01912170
- Testing
- Fish oil, Flaxseed oil
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Zhejiang University
Diabetic Nephropathies
Metabolic Effects of the SGLT-2 Inhibitor Empagliflozin in Patients With Diabetic Nephropathy (MEDiaN)
The MEDiaN study aims to examine the state of fuel metabolism in participants with diabetic nephropathy (DN) before and after the use of the sodium-glucose transport protein 2 inhibitor (SGLT-2i) empagliflozin.
- Trial name
- (MEDiaN) (NCT03933956)
- Testing
- Empagliflozin 10 MG
- Where
- Singapore
- Volunteers
- 2 people
- Sponsor
- Singapore General Hospital
Diabetic Kidney Disease (DKD), Heart Failure
Finerenone for Cardiorenal Protection in Diabetic CKD: Impact on Renal Function Decline and Heart Failure
To assess the effect of Finerinone on slowing renal function decline and improving cardiovascular outcomes, particularly heart failure risk, in patients with diabetic CKD.
- Trial name
- NCT07326631
- Testing
- Finerenone
- Volunteers
- 120 people
- Sponsor
- College of Physicians and Surgeons Pakistan
Diabetes Mellitus, Type 1, Pregnancy in Diabetes
Metformin for Preeclampsia Prevention in Pregnant Women With Type 1 Diabetes Mellitus
Although major advancements have been made in improving glycemic management in type 1 diabetes mellitus (DM), women entering pregnancy with type 1 DM continue to be at dramatically increased risk for adverse maternal and neonatal…
- Trial name
- NCT03570632
- Testing
- Metformin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Maisa N. Feghali, MD
Diabetic Nephropathies
Effect of Sodium Glucose co Transporter 2 Inhibitor ( SGLT2) on Proteinuria in Diabetic Patients
Diabetes Mellitus is the leading cause of end stage renal disease. As proven by many studies , controlling proteinuria can delay the progression to end stage renal disease.This work will study the effect of sodium glucose co…
- Trial name
- NCT03573102
- Testing
- SGLT2 inhibitor, ACE inhibitor
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Nahla H Tohami
Urologic Disease
Long-Term Lead Chelation Therapy and Progressive Renal Insufficiency
Previous study showed repeated lead chelation therapy significant reduced progressive renal insufficiency in patients with chronic renal diseases and high-normal body lead burden in a placebo-controlled, randomized, 2-year…
- Trial name
- NCT00227409
- Testing
- calcium disodium EDTA (edetate calcium disodium)
- Where
- China
- Sponsor
- Chang Gung Memorial Hospital
Gestational Diabetes, Gestational Hypertension
sFlt-1:PlGF Ratio in Gestational Diabetes: PREDICTION (PREeclampsia in DIabetiC gestaTION) Study
The ratio of soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) is elevated in pregnant women before the clinical onset of preeclampsia and can be used to predict the preeclampsia.
- Conditions
- Gestational Diabetes, Gestational Hypertension, Pre-Eclampsia
- Trial name
- PREDICTION (NCT04877119)
- Where
- Italy
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Gestational Diabetes Mellitus in Pregnancy
Lifestyle Intervention for Prevention of Gestational Diabetes Mellitus in the UAE Population
Gestational diabetes mellitus (GDM) is a high blood glucose (hyperglycemia) first occurring or first recognized during pregnancy, it is affecting 16.4% of women globally and 36.6 % in this region.
- Trial name
- NCT04273412
- Testing
- moderate-intensity lifestyle intervention
- Where
- United Arab Emirates
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Rashid Centre for Diabetes and Research
Chronic Kidney Disease, Diabetic Nephropathy
Reducing Residual Albuminuria in Subjects With Diabetes and Nephropathy With Atrasentan
Prospective, randomized, double-blind, placebo controlled, 12-week, multicenter study. The objective of the study is to evaluate the efficacy and safety of once daily administration of atrasentan tablets compared to placebo in…
- Trial name
- NCT01424319
- Testing
- Atrasentan low dose group, Atrasentan high dose group
- Where
- 18 sites in Japan
- Volunteers
- 58 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Proteinuria, Kidney Dysfunction
Azilsartan in Patients With Diabetic Kidney Disease and Hypertension
Hypertension is the most common complication in patients with diabetes nephropathy. Strengthening blood pressure and blood sugar control is the basic treatment for patients with diabetes nephropathy.
- Conditions
- Proteinuria, Kidney Dysfunction, Blood Pressure, Diabetic Kidney Disease
- Trial name
- NCT05753696
- Testing
- Azilsartan, Losartan
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Gestational Diabetes, Diabetes, Gestational
Metabolic Analysis for Treatment Choice in Gestational Diabetes Mellitus
Gestational diabetes (GDM) is a significant clinical and public health burden, affecting over 400,000 pregnant women in the United States each year.
- Conditions
- Gestational Diabetes, Diabetes, Gestational, Pregnancy in Diabetes
- Trial name
- MATCh-GDM (NCT03029702)
- Testing
- Insulin, Glyburide, Metformin
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Maisa N. Feghali, MD
Pregnancy in Diabetics
Diabetes Mellitus With Pregnancy in Benisuef Localities
The aim of this work is to demonstrate the variation of Diabetes mellitus either preexisting or gestational Diabetes mellitus among pregnant ladies in our localities, detect maternal \& fetal complications and to predict the risk…
- Trial name
- NCT03169205
- Testing
- observation registry
- Where
- 2 sites in Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Diabetic Kidney Disease, Diabetes Mellitus, Type 2
EMPRA (EMPagliflozin and RAs in Kidney Disease)
This study will be a prospective, clinical pilot study in CKD patients to show whether Empagliflozin in addition to ACEi treatment significantly increases Ang 1-7 levels compared to ACEi treatment alone.
- Conditions
- Diabetic Kidney Disease, Diabetes Mellitus, Type 2, Chronic Kidney Disease stage3, Chronic Kidney Disease stage4
- Trial name
- EMPRA (NCT03078101)
- Testing
- Empagliflozin 10 MG [Jardiance]
- Where
- Austria
- Volunteers
- 51 people
- Sponsor
- Medical University of Vienna
Diabetic Nephropathy
Open Label Tolerability and Safety Study of KRX-101 in Australia, New Zealand, and Hong Kong
The purpose of this study is to assess the tolerability and safety of KRX-101 in treating persistent microalbuminuria in type 2 diabetic patients who are also being treated with stable, maximum tolerated doses of either ACE…
- Trial name
- NCT00462202
- Testing
- sulodexide
- Where
- Australia
- Volunteers
- 200 people
- Sponsor
- Keryx Biopharmaceuticals