Clinical trials: Pregnancy in Diabetics
Type 2 Diabetes Mellitus, Gestational Diabetes
Healthy Moms, Healthy Babies
Poor glucose control during pregnancy is a significant concern for Canadian women with diabetes. This problem is magnified in First Nations women, who have among the highest rates of gestational diabetes (GDM) in the world (up to…
- Trial name
- HMHB (NCT01578460)
- Testing
- Continuous Glucose Monitoring, Glucose Meter
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Stewart Harris
Diabetes Mellitus Arising in Pregnancy, Insulin-Requiring, Diabetes Mellitus in Pregnancy
Comparative Effects of Metformin and Insulin on Stereological Studies and Immunohistochemistry of Placenta
Diabetes mellitus is a group of metabolic disorder characterized by high blood glucose level mainly due to defect in insulin secretion or resistance.
- Trial name
- NCT04907708
- Testing
- Metformin, Insulin
- Where
- Pakistan
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- University of Karachi
Diabetes Mellitus
Metformin as Adjuvant to Insulin Therapy in Insulin-resistant Diabetes Mellitus With Pregnancy
Adding metformin to insulin therapy in pregnant women with diabetes mellitus who show insulin resistance may be equivalently effective to further raising the insulin dose
- Trial name
- NCT01915550
- Testing
- Metformin, Humulin Insulin Mixtard
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Diabetic Nephropathy
Effect of Pyridorin in Patients With Diabetic Nephropathy
The primary objective of the study is to evaluate the safety and tolerability of Pyridorin (pyridoxamine dihydrochloride) 50 mg given orally twice daily in patients with diabetic kidney disease.
- Trial name
- NCT00320060
- Testing
- Pyridorin (pyridoxamine dihydrochloride)
- Volunteers
- 128 people
- Sponsor
- BioStratum
Diabetes Mellitus, Type 1, Nephropathy
Copeptin in Adolescent Participants With Type 1 Diabetes and Early Renal Hemodynamic Function
Over 1.25 million Americans have type 1 diabetes (T1D), increasing risk for early death from cardiorenal disease. The strongest risk factor for cardiovascular disease (CVD) and mortality in T1D is diabetic kidney disease (DKD).
- Conditions
- Diabetes Mellitus, Type 1, Nephropathy, Diabetic Nephropathies, Juvenile Diabetes
- Trial name
- CASPER (NCT03618420)
- Testing
- Aminohippurate Sodium Inj 20%, Iohexol Inj 300 mg/mL
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Gestational Diabetes Mellitus in Pregnancy
Digitalized Management Exploration for Gestational Diabetes Mellitus in China
Gestational diabetes mellitus (GDM) can lead to adverse perinatal and long-term outcomes, and it is so important to manage this disease in pregnancy.
- Trial name
- NCT05003154
- Testing
- Digitalized management
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Glomerulonephritis, Proteinuria
Empagliflozin in Patients With Glomerulonephritis
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are newly developed antihyperglycemic medications. In addition to their glucose lowering properties, they have been shown to have favourable effects on the cardiovascular and…
- Trial name
- NCT05283057
- Testing
- Empagliflozin 25 MG
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Kasr El Aini Hospital
Diabetic Nephropathy
Open Label Tolerability and Safety Study of KRX-101 in Australia, New Zealand, and Hong Kong
The purpose of this study is to assess the tolerability and safety of KRX-101 in treating persistent microalbuminuria in type 2 diabetic patients who are also being treated with stable, maximum tolerated doses of either ACE…
- Trial name
- NCT00462202
- Testing
- sulodexide
- Where
- Australia
- Volunteers
- 200 people
- Sponsor
- Keryx Biopharmaceuticals
Gestational Diabetes Mellitus in Pregnancy, Type 2 Diabetes Mellitus
Fresh Carts for Mom's to Improve Food Security and Glucose Management
This study will look at the benefit of decreasing food insecurity and improving glucose control among women who either report gestational diabetes (GDM) at 20-28-weeks or have type 2 diabetes (T2DM) with a confirmed pregnancy.
- Trial name
- NCT05979519
- Testing
- Fresh Funds for Mom's, Standard Medical care, Medically Tailored Frozen Meals
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Alison Gustafson
Mild Nephropathy, Moderate Nephropathy
Single Dose, Single Administration Study of Technosphere Inhalation Powder in Diabetic Subjects With Mild or Moderate Kidney Disease Compared to Diabetic Subjects With Normal Kidney Function
24 diabetics with mild \& moderate renal disease and 12 diabetics without renal disease. One screening, one dosing \& one follow-up visit with Technosphere® Inhalation Powder given at Visit 2 via MedTone® Inhaler and PK testing…
- Conditions
- Mild Nephropathy, Moderate Nephropathy, Diabetes Mellitus
- Trial name
- NCT00626249
- Testing
- Technosphere Inhalation Powder
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- Mannkind Corporation
Gestatiaonl Diabetes Mellitus, Thyroid Disease Pregnancy
Gongji Pregnancy Endorine Cohort Study
To explore the relationship between genetic factors, lifestyle, and drug interventions and the occurrence, development, adverse pregnancy outcomes, and postpartum maternal-infant outcomes of gestational endocrine diseases.
- Conditions
- Gestatiaonl Diabetes Mellitus, Thyroid Disease Pregnancy, Hyperglycemia in Pregnant Diabetic Patients
- Trial name
- GREAT (NCT07125885)
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Shanghai General Hospital, China
Diabetes Mellitus, Type 2, Diabetes Complications
Arterial Stiffness and Complication Risk in Type 2 Diabetes
Background The prevalence and incidence of type 2 diabetes is increasing globally. A common complication of diabetes is the disease of the blood vessels, vascular diseases, which can cause disorders like myocardial infarction…
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Complications, Diabetic Angiopathies, Diabetic Nephropathies
- Trial name
- NCT02001532
- Where
- Denmark
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Diabetic Nephropathies, Lupus Nephritis
Retrospective Analysis of Renal Prognosis in Patients With Chronic Kidney Disease
During 1993 and 2006, a total of 987 patients older than 20 years underwent native kidney biopsy at the Renal Division of this hospital.
- Conditions
- Diabetic Nephropathies, Lupus Nephritis, Rapidly Progressive Glomerulonephritis, Chronic Kidney Diseases
- Trial name
- NCT03201406
- Where
- 2 sites in Taiwan
- Volunteers
- 837 people
- Sponsor
- National Taiwan University Hospital
Pregnancy Complications, Obesity
Metformin in Obese Non-diabetic Pregnant Women
Obesity is on the rise in all developed countries. Of particular concern is that more young people including children are being recognised as being overweight or obese.
- Trial name
- MOP (NCT01273584)
- Testing
- Metformin
- Where
- 3 sites in United Kingdom
- Volunteers
- 450 people
- Sponsor
- Epsom and St Helier University Hospitals NHS Trust
Diabetic Nephropathy
Matrix Metalloproteinases in Atherosclerosis of Chronic Kidney Disease
The purpose of this study is to determine whether matrix metalloproteinases are associated with atherosclerosis in the different stages of chronic kidney disease.
- Trial name
- MMACKD (NCT01458158)
- Where
- Greece
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Obesity; Endocrine, Pregnancy in Diabetic
Female Obesity Cohort and Intervention Study Group (MOCART Study Group)
This prospective observational trial includes women with high risk pregnancies complicated with hyperglycemia in pregnancy and excessive body weight.
- Conditions
- Obesity; Endocrine, Pregnancy in Diabetic, Child Obesity, Hypertension in Pregnancy
- Trial name
- MOCART (NCT04924738)
- Testing
- Monitoring and lifestyle
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Poznan University of Medical Sciences
Diabetic Nephropathy, Nephrotic Syndrome
Adrenocorticotropic Hormone (ACTH) Treatment of Nephrotic Range Proteinuria in Diabetic Nephropathy (NRDN)
This is a prospective open labeled trial examining the efficacy of ACTHar Gel (porcine ACTH) on the level of proteinuria in patients with diabetic nephropathy and nephrotic range proteinuria.
- Trial name
- ACTH-NRDN (NCT01028287)
- Testing
- ACTH
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Southeast Renal Research Institute
Type1diabetes, Type1 Diabetes Mellitus
Evaluation of Coffee Therapy for Improvement of Renal Oxygenation
Over 1.25 million Americans have Type 1 Diabetes (T1D), increasing risk for early death from cardiovascular disease (CVD). Despite advances in glycemic and blood pressure control, a child diagnosed with T1D is expected to live up…
- Conditions
- Type1diabetes, Type1 Diabetes Mellitus, Diabetic Kidney Disease, Juvenile Diabetes
- Trial name
- COFFEE (NCT03878277)
- Testing
- Starbucks® Cold brew - 325ml bottle
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Colorado, Denver
Diabetic Nephropathy
The Genetics of Kidneys in Diabetes (GoKinD) Study
Kidney disease in diabetes (diabetic nephropathy) tends to run in families. It is likely, therefore, that there are genes that predict or are associated with either getting or not getting diabetic nephropathy.
- Trial name
- NCT00024921
- Where
- United States
- Volunteers
- 2,100 people
- Sponsor
- National Center for Research Resources (NCRR)
Diabetic Pregnancy, Pregnancy Related
Comparison of Factor XII Levels in Gestational Diabetic and Healthy Pregnancies
To compare Factor XII levels in gestational diabetic and healthy pregnancies.
- Conditions
- Diabetic Pregnancy, Pregnancy Related, Complement System; Disorder
- Trial name
- NCT03583216
- Testing
- Diabetic pregnancy, Non-diabetic pregnancy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Acibadem University