Clinical trials: Prehospital Emergency
Trauma Injury, Haemorrhagic Shock
Prediction of Massive Transfusion in Trauma Patients
Since the 2000s, many prognostic scores were developed to predict traumatic haemorrhage. Most of these studies were retrospectives based on registers.
- Conditions
- Trauma Injury, Haemorrhagic Shock, Bleeding, Emergencies
- Trial name
- MTP (NCT04561050)
- Testing
- Comparison of score performances (Overall performance, discrimination and calibration)
- Where
- Switzerland
- Volunteers
- 13,222 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Acute Ischemic Stroke
Prehospital Response and Emergency Stroke Transport Optimisation
This study aims to develop and evaluate an innovative prehospital emergency transport system for patients with acute ischemic stroke to reduce delays in reperfusion treatment.
- Trial name
- PRESTO (NCT07892053)
- Testing
- Innovative pre-hospital emergency transport system for acute ischemic stroke
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Xuanwu Hospital, Beijing
Epilepsy, Coma
Feasibility of Mini-EEG in the Prehospital Setting
The EEG is widely used in the diagnosis of central nervous system pathology, including epileptic seizures and epilepsy. Presently, EEG is available only during office hours in most hospitals, pending on the availability of a…
- Trial name
- NCT02329028
- Testing
- Prehospital mini-EEG
- Where
- Finland
- Volunteers
- 23 people
- Sponsor
- Helsinki University Central Hospital
Prehospital Airway Management in Patients With Cardiac Arrest
A RCT on Supraglottic Airway Versus Endotracheal Intubation in OHCA
In this 3-year successive research plan, investigators will conduct a prehospital randomized controlled trial to address the following question: In adult patients with non-traumatic cause of out-of-hospital cardiac arrest…
- Trial name
- SAVE (NCT02967952)
- Testing
- supraglottic airway (SGA) V.S. endotracheal intubation (ETI)
- Volunteers
- 852 people
- Sponsor
- National Taiwan University Hospital
Telemedicine Usage, Teleconsultation Usage
Implementation Strategy and Systemic Effects of Routine Telemedical Care in Prehospital Emergency Medicine
In two research projects a comprehensive prehospital telemedicine system was developed and general feasibility as well as impact on guideline adherence were evaluated.
- Conditions
- Telemedicine Usage, Teleconsultation Usage, Emergency Medical Service Missions
- Trial name
- NCT04127565
- Volunteers
- 51,649 people
- Sponsor
- RWTH Aachen University
Prehospital Emergency, Neck Injury
IPSTRAUC : Impact on Care Pathways of a New Management of Cervical Trauma in Conscious Patients Stable in Pre-hospital Care
The aim of the study is to evaluate the application of Canadian C-Spine rules adapted to pre-hospital settings in France in order to improve the appropriateness of cervical spine immobilisation, reduce unnecessary imaging…
- Conditions
- Prehospital Emergency, Neck Injury, Neck Trauma, Emergency Medical Services
- Trial name
- IPSTRAUC (NCT06983873)
- Testing
- adapted Canadian C-Spine rules
- Where
- 14 sites in France
- Volunteers
- 840 people
- Sponsor
- Rennes University Hospital
Intubation Complication, Intubation; Difficult or Failed
Prehospital Intubation of COVID-19 Patient With Personal Protective Equipment
The safety and efficacy of a laryngoscopy as a primary intubation tool in urgent endotracheal intubation of cardiac arrest patients with suspected/confirmed COVID-19 has not been well-described in the literature.
- Conditions
- Intubation Complication, Intubation; Difficult or Failed, Cardiac Arrest, Influenza
- Trial name
- NCT04365608
- Testing
- Direct laryngoscopy, Vie Scope laryngoscopy
- Where
- 2 sites in Poland
- Volunteers
- 90 people
- Sponsor
- Lazarski University
Prehospital Emergency Medical Services, Point-of-care Ultrasound
Ultrasound Applications for Emergency Medical Technicians in Taiwan
The goal of this prospective observational study is to develop and assess the core ultrasound applications for emergency medical technicians (EMTs) in Taiwan.
- Trial name
- NCT06950333
- Testing
- POCUS education curriculum
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Myocardial Infarction
Accelerated Rule Out of Myocardial Infarction
Every year > 50.000 people in Denmark are hospitalized with a suspected acute myocardial infarction (AMI). The majority has other explanations of their chest discomfort and most are discharged again without any initiation of…
- Trial name
- AROMI (NCT02666326)
- Testing
- Accelerated, combined biomarker rule-out strategy for MI
- Where
- 3 sites in Denmark
- Volunteers
- 4,516 people
- Sponsor
- Aarhus University Hospital Skejby
Out-of-hospital Cardiac Arrest
Prehospital Resuscitation Intra Nasal Cooling Effectiveness Survival Study
Promising result of intra-arrest cooling on neurological intact survival in cardiac arrest patients has recently been published in the PRINCE-study in Circulation 2010.
- Trial name
- PRINCESS (NCT01400373)
- Testing
- Prehospital intra-nasal cooling with RhinoChill
- Where
- 2 sites in Belgium, Sweden
- Volunteers
- 700 people
- Sponsor
- Karolinska Institutet
Heart Arrest, Out-Of-Hospital, Wounds and Injuries
Pediatric Prehospital Airway Resuscitation Trial
This study is a Phase 3, multi-center, Bayesian Adaptive Sequential Platform Trial testing the effectiveness of different prehospital airway management strategies in the care of critically ill children.
- Conditions
- Heart Arrest, Out-Of-Hospital, Wounds and Injuries, Respiratory Insufficiency in Children, Child, Only
- Trial name
- Pedi-PART (NCT06364280)
- Testing
- BVM, SGA, ETI
- Where
- 10 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Ohio State University
Intracranial Hypertension, Acute Brain Injury
Non-Invasive Triage for Intracranial Hypertension in Prehospital Care
This study tests whether two non-invasive tools can help paramedics detect dangerously high pressure inside the skull in patients with a sudden brain injury, such as stroke or head trauma, before they reach the hospital.
- Conditions
- Intracranial Hypertension, Acute Brain Injury, Stroke, Traumatic Brain Injury
- Trial name
- B4C-APH (NCT07747636)
- Testing
- Brain4care non-invasive intracranial pressure monitor, Optic nerve sheath diameter ultrasound
- Volunteers
- 180 people
- Sponsor
- Juliana Caldas
Acute Respiratory Failure Requiring Intubation
Bougie Versus Endotracheal Tube Alone on First-attempt Intubation Success in Prehospital Emergency Intubation (BETA Trial)
Emergency intubation is routinely performed in the prehospital setting. Airway management in the prehospital setting has substantial challenges, such as hostile environment or lack of technical support in case of first attempt…
- Trial name
- BETA (NCT06307392)
- Testing
- First intubation attempt with endotracheal tube plus bougie, First intubation attempt with endotracheal tube alone
- Where
- 10 sites in France
- Volunteers
- 710 people
- Sponsor
- Nantes University Hospital
Dyspnea, Heart Failure
Dyspnea and Biomarkers in a Prehospital Setting
In patients presenting with acute dyspnea in a pre-hospital setting, the early and correct diagnosis may present a significant clinical challenge.
- Conditions
- Dyspnea, Heart Failure, Asthma, COPD
- Trial name
- NCT00878475
- Where
- Slovenia
- Volunteers
- 546 people
- Sponsor
- Community Healthcare Center dr. Adolf Drolc Maribor (HCM)
Chest Pain, Acute Coronary Syndrome
Digital Decision Support in the Management of Patients With Chest Pain
The goal of this observational study is to develop a decision support system in patients presenting with chest pain in the prehospital setting.
- Conditions
- Chest Pain, Acute Coronary Syndrome, Chest--Diseases
- Trial name
- BRIAN2 (NCT05767619)
- Testing
- Troponin hs-cTnI, Plasma glucose
- Where
- 3 sites in Sweden
- Volunteers
- 2,000 people
- Sponsor
- Vastra Gotaland Region
Out-Of-Hospital Cardiac Arrest After Initial Successful Resuscitation, Out of Hospital Cardiac Arrest
RESTORE-ZG: Return of Effective Spontaneous Circulation Resuscitation Evaluation Canton of Zug
This study looked at cardiac arrest that happens outside a hospital. Cardiac arrest means the heart suddenly stops pumping blood. When this happens, a person collapses and needs help right away.
- Conditions
- Out-Of-Hospital Cardiac Arrest After Initial Successful Resuscitation, Out of Hospital Cardiac Arrest, Out of Hospital Setting, Defibrillation
- Trial name
- RESTORE-ZG (NCT07750119)
- Testing
- Prehospital resuscitation care
- Where
- Switzerland
- Volunteers
- 240 people
- Sponsor
- Felix Brinkmann
Anesthesia, Hypoxia
Assessment of Preoxygenation Strategies in the Prehospital Environment
Comparison of the preoxygenation efficacy of tidal volume breathing using three different preoxygenation techniques which are available to providers in the prehospital environment.
- Trial name
- NCT02694705
- Testing
- Continuous Positive Airway Pressure (CPAP), Bag-Valve-Mask (BVM), Non-rebreather Mask (NRM)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Respiratory Failure
King Video Laryngoscope Versus Direct Laryngoscopy for Prehospital Intubation: A Randomized Controlled Trial
The goal of this study is to compare the first pass success rate of intubation between video assisted intubation and traditional direct visualization intubation in the field by Emergency Medical Service (EMS) professionals
- Trial name
- NCT02208349
- Testing
- King Video Laryngoscope, traditional direct laryngoscopy (DL)
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Saint Vincent Hospital, Pennsylvania
ACS, NSTEMI - Non-ST Segment Elevation MI
Prehospital Triage of Patients With Suspected Non-ST-segment Elevation Acute Coronary Syndrome: the TRIAGE-ACS Study
With the Emergency Medical Services (EMS), no prehospital risk stratification and triage is performed for patients suspected of having an Non-ST-segment elevation Acute Coronary Syndrome (NSTE-ACS).
- Conditions
- ACS, NSTEMI - Non-ST Segment Elevation MI, Unstable Angina
- Trial name
- NCT05243485
- Testing
- PreHEART
- Where
- Netherlands
- Volunteers
- 1,071 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Traumatic Brain Injury
Prehospital Traumatic Brain Injury
The aim of the study is to measure the effect of Finnish physician-staffed EMS unit treatment methods on traumatic brain injury (TBI) patient prognosis.
- Trial name
- NCT01454648
- Where
- Finland
- Volunteers
- 458 people
- Sponsor
- Tampere University Hospital