Clinical trials: Prehypertension
Prehypertension
When the Kidney Reacts to Nutritional Changes
Hypertension is one of the leading causes of morbidity and mortality in the industrialized world, attributed mostly to modifiable lifestyle factors.
- Trial name
- NCT04142138
- Testing
- DASH
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Rockefeller University
Pre-hypertension, Cardiovascular Diseases
Watermelon Dose Response Blood Pressure Study
1. Primary outcome: To evaluate the dose response effects of watermelon flesh in regulating Blood Pressure (BP) in individuals with pre-hypertension. 2.
- Trial name
- WMBP (NCT05892328)
- Testing
- Watermelon Flesh Dose 1, Watermelon Flesh Dose 2, Control
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Prehypertension
Potassium Supplementation to Reduce Blood Pressure
The aim of this study is to conduct a definitive trial to assess the efficacy of consuming 1L/day of water rich in potassium to reduce blood pressure in mild to moderately hypertensive adults.
- Trial name
- NCT05412654
- Testing
- High potassium water, Control low potassium water
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Oxford Brookes University
Prehypertension, Hypertension
Nebivolol and the Endothelin (ET)-1 System
The investigators hypothesize that nebivolol will reduce ET-1-mediated vasoconstrictor tone in adult humans with elevated blood pressure to a greater extent than either metoprolol or placebo.
- Trial name
- NETS (NCT01395329)
- Testing
- Nebivolol, Metoprolol, Forearm Blood Flow (FBF) response to BQ-123 (100 mol/min)
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Pre-hypertension
Study: Effects of Strawberries on Blood Pressure
The specific aim of the study is to determine whether a freeze dried powder provided by the California Strawberries Commission, can reduce blood pressure in patients with pre-hypertension.
- Trial name
- CSCBP (NCT01190319)
- Testing
- Strawberry Beverage
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, Davis
Hypertension, Prehypertension
Healthy Aging Practice-centered Instruction Cardiovascular Health Investigation (HAPI-CHI)
Over 30% of American adults have hypertension (HTN) (high blood pressure), and the rate increases considerably with age; 64% of men and 78% of women over 65 have HTN.
- Trial name
- HAPI-CHI (NCT02761603)
- Testing
- Healthy Aging Practice-centered Instruction (HAPI), Tai Chi (CHI)
- Volunteers
- 250 people
- Sponsor
- University of California, San Diego
Prehypertension, Hypertension
Hypertension and Osteopathic Treatment
The goal of this study is to demonstrate the use of osteopathic manipulative therapy (OMT) in the effective management of hypertension.
- Conditions
- Prehypertension, Hypertension, Osteopathic Manipulation, Sympathetic Nervous System
- Trial name
- HOT (NCT02605551)
- Testing
- Osteopathic Manipulative Therapy, Lifestyle Modification
- Volunteers
- healthy volunteers welcome
- Sponsor
- Larkin Community Hospital
Prehypertension, Masked Hypertension
Arterial Function After Two Different Physical Exercise Intensities in Prehypertension
Individuals with prehypertension, diagnosed according to the 7th Brazilian Guidelines on Hypertension with the presence of systolic blood pressure (SBP) between 121 and 139 and / or diastolic (DBP) between 81 and 89 mmHg, are…
- Trial name
- PREHTEXVAS (NCT04200716)
- Testing
- Moderate intensity continuous training - session, High intensity interval training - session
- Where
- Brazil
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Prehypertension, Hypertension
Nebivolol and Endothelial Regulation of Fibrinolysis (NERF)
The investigators hypothesize that nebivolol will improve endothelial t-PA release in adult humans with elevated blood pressure to a greater extent than either metoprolol or placebo.
- Trial name
- NCT01595516
- Testing
- Nebivolol, Metoprolol, Bradykinin
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Prehypertension
Investigate the Effectiveness of KEFPEP® on Regulating High Blood Pressure
To assess the ability of KEFPEP® to reduce blood pressure
- Trial name
- NCT06393621
- Testing
- KEFPEP®
- Where
- Taiwan
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- National Chung Hsing University
Pre-hypertension
A Study to Investigate the Effect of a Nitric Oxide Supplementation on Pre- and Mildly Hypertensive Adults
This study will investigate the effect of a nitric oxide supplementation product, Neo40 Daily®, on blood pressure in pre-hypertensive and mildly hypertensive adults.
- Trial name
- 15NBHN (NCT02679248)
- Testing
- Neo40 Daily®
- Where
- 2 sites in Canada
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- KGK Science Inc.
Prehypertension
Prehypertension and Dietary Supplements - The PYRAMIDS Study
The primary objective of this study is to compare the efficacy and tolerability of a life-style modifications protocol versus a protocol including life-style modifications along with a novel combination of dietary supplement in…
- Trial name
- PYRAMIDS (NCT01682291)
- Testing
- Life-style modifications, Dietary supplements
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- University of Roma La Sapienza
Pre-hypertension
Different Dosages of Bioactive Wheat Peptides and Blood Pressure Level and CVD Risk Biomarkers in Healthy Subjects
In this study we will assess the effects of bioactive peptide rich wheat products on blood pressure and estimated cardiovascular disease risk.
- Trial name
- NCT02197910
- Testing
- Comparisons of two kind of pasta with low or high content of wheat bioactive peptides (sequence Low->High), Comparisons of two kind of pasta with low or high content of wheat bioactive peptides (sequence High->Low)
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Bologna
Hypertension
Diet and Other Non Pharmacological Interventions to Reduce Cardiovascular Risk in Hypertensive Patients
The purpose of this study is to evaluate the effectiveness of diet change and other non-pharmacological treatments which includes physical activity and integrative therapies oriented to reduce the blood pressure in hypertensive…
- Trial name
- NCT04746118
- Testing
- DIET CHANGE, PHYSICAL ACTIVITY, INTEGRATIVE PRACTICES
- Where
- Brazil
- Volunteers
- 240 people
- Sponsor
- Hospital Universitário Clementino Fraga Filho
Pre-hypertension
Personalized Blood Pressure Care Using IoMTs and Artificial Intelligence
In this RCT, up to 100 adults classified as pre-hypertensive will be randomized to either an artificial intelligence (AI) based lifestyle intervention group or an active control group with a 1 to 1 ratio.
- Trial name
- NCT04543656
- Testing
- AI-Based Lifestyle Recommendations, No Lifestyle Recommendations
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Prehypertension, Hypertension Stage 1
Efficacy Testing of Djulis-Buckwheat Drink on Cardiovascular Protection
The purpose of the trial is to evaluate the effect of Djulis-Buckwheat drink on cardiovascular protection after ingesting for 8 weeks.
- Trial name
- NCT02825901
- Testing
- Djulis-Buckwheat, Buckwheat
- Sponsor
- Taipei Medical University Hospital
Pre-hypertension, Hypertension
The Effects of Polyphenol-rich Berry Juice on Blood Pressure in Hypertensive Subjects
The purpose of this study is to investigate the effects of berry juices containing different levels of polyphenols on blood pressure and other cardiovascular risk factors.
- Trial name
- NCT01568983
- Testing
- Mana-juice, Optijuice
- Where
- Norway
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Hypertension Uncomplicated, Pre Hypertension
A Biomarker to Detect Salt Sensitivity
The investigators are proposing that individuals with elevated levels of NT-proBNP are resistant to natriuretic peptides and are unable to handle sodium loads and maintain optimal blood pressure values.The investigators will test…
- Trial name
- NCT03147170
- Testing
- High and low salt diets
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Pre-Hypertension
Study of Hispanics to Assess Risk Prevention in Prehypertension
The purpose of this study is to assess the efficacy of lifestyle modification in reducing blood pressure values in Hispanics at risk for hypertension.
- Trial name
- SHARPP (NCT01025323)
- Testing
- Lifestyle modification
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Florida Heart Research Institute
METABOLIC SYNDROME, HYPERTENSION
A 16 Week Study to Evaluate the Effect on Insulin Sensitivity of Valsartan (320 mg) and Hydrochlorothiazide (25 mg) Combined and Alone, in Patients With Metabolic Syndrome
The metabolic syndrome is a classification for patients with a constellation of risk factors which may include abdominal obesity, hypertension, elevated blood lipids and sugar.
- Conditions
- METABOLIC SYNDROME, HYPERTENSION, PRE-HYPERTENSION
- Trial name
- NCT00170937
- Testing
- valsartan plus hydrochlorothiazide
- Where
- United States
- Volunteers
- 507 people, healthy volunteers welcome
- Sponsor
- Novartis