Clinical trials: Preimplantation Genetic Diagnosis
Infertility, Male Infertility
To Investigate if the Harvester® Improves Sperm Motility and Blastocyst Utilization (the Percent of Fertilized Eggs That Develop to the Point That They Are Able to be Transferred) in IVF Cycles.
The goal of this prospective, multicenter randomized controlled clinical trial is to evaluate whether the SwimCount Harvester microfluidic sperm preparation device can achieve equivalent or superior clinical outcomes compared to…
- Conditions
- Infertility, Male Infertility, InVitro Fertilization, Aneuploidy Rate
- Trial name
- NCT07369362
- Testing
- microfludics semen processing device
- Where
- United States
- Volunteers
- 1,600 people
- Sponsor
- MotilityCount aps
Infertility, Recurrent Pregnancy Loss
Preimplantation Genetic Diagnosis Using Blastocyst Biopsy and Array CGH
The investigators propose to perform a clinical randomized trial to evaluate the effect of single embryo (blastocyst) transfer (SET) with array CGH for the evaluation of the complete chromosome complement of the blastocyst in…
- Trial name
- NCT01546350
- Testing
- PGD
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Reprogenetics
Infertility, Recurrent Pregnancy Loss
Microfluidics Versus Gradient Centrifugation Effect on Euploidy Rates
This research is being done to determine if using a microfluidics chamber, a device used to process sperm, will be effective in improving the rates of embryos with normal chromosomes (structures that carry genetic information)…
- Trial name
- NCT04744025
- Testing
- Microfluidics chamber, Density Gradient Centrifugation
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Lawrence Engmann
Infertility of Uterine Origin
Clinical Study of PGT-A Versus PGT-A+ERA
Patients who have shown previous implantation failures, despite transferring good quality and chromosomally normal embryos (diagnosed by PGT-A), could have a displaced Window of Implantation (WOI) and consequently, alterations in…
- Trial name
- PGT-A&ERA (NCT03530254)
- Testing
- PGT-A, ERA Test
- Where
- 15 sites in United States, Argentina and 10 more
- Volunteers
- 368 people
- Sponsor
- Igenomix
Infertility
Outcome of Embryos Transferred After Initial Chaotic Results on PGT-A
This is a retrospective review of treatment outcomes from fertility clinics in The Prelude Network who have used Igenomix for PGT-A and have transferred embryos with initial chaotic results, regardless if re-biopsy was performed.
- Trial name
- NCT06373237
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Inception Fertility Research Institute, LLC
Infertility, Fertility
Mono-menotropins Versus rFSH Protocol on Embryo Quality
This study is for couples pursuing in vitro fertilization (IVF) with preimplantation genetic screening (PGS) of embryos to achieve pregnancy.
- Trial name
- NCT02418533
- Testing
- menotropin, Recominant Follicle Stimulating Hormone (rFSH)
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Main Line Fertility Center
Increase the Number of Blastocyst to Biopsy for Preimplantation Genetic Testing
PGS on Blastocysts From Vitrified and Fresh Oocytes
Oocyte accumulation by vitrification is a valid strategy to increase the number of available embryos for biopsy and the number of viable euploid embryos to transfer after preimplantation genetic testing.
- Trial name
- PGSvitfreov (NCT02820415)
- Testing
- chromosomal status of blastocysts from fresh and vitrified/warmed oocytes
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Unità di Medicina della Riproduzione, Italy
Infertility
Correlating Time-Lapse Parameters Detected by the Eeva™ System With Comprehensive Chromosome Screening Results
The purpose of this research study protocol is to collect imaging data on embryos followed to blastocyst stage (Day 5-6) and correlate Eeva System parameters with comprehensive chromosome screening (CCS) results, implantation and…
- Trial name
- CCS (NCT01635049)
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- Progyny, Inc.
Preimplantation Genetic Diagnosis (PGD)
Establishment of Comprehensive Genetic Analysis From a Single Cell
Preimplantation genetic diagnosis (PGD) is the integration of both assisted reproductive technologies and molecular genetic technologies and was shown to improve implantation rate and reduce spontaneous abortions after…
- Trial name
- NCT00173732
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Polycystic Kidney, Type 1 Autosomal Dominant Disease
Using Preimplantation Genetic Diagnosis in Autosomal Dominant Polycystic Kidney Disease Patients: a Multicenter Clinical Trial
Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic hereditary kidney disease in humans. ADPKD may affect all the generations of the ADPKD family and the probability of ADPKD is 50% in the second…
- Trial name
- ESPERANCE (NCT02948179)
- Testing
- Preimplantation Genetic Diagnosis
- Where
- 31 sites in China
- Volunteers
- 459 people
- Sponsor
- Changlin Mei
Miscarriage, Frozen Embryo Transfer
Natural Cycle Versus Hormone Replacement Therapy Cycle for a Frozen-thawed Embryo Transfer in PGT Patients
The aim of the current study is to compare miscarriage rates (before 8 weeks) between a true natural cycle (awaiting spontaneous LH surge) and a hormone replacement therapy cycle prior to blastocyst transfer in preimplantation…
- Conditions
- Miscarriage, Frozen Embryo Transfer, Natural Cycle, Hormone Replacement Therapy Cycle
- Trial name
- NCT03976544
- Testing
- Estradiol Valerate, Micronized progesterone
- Where
- Belgium
- Volunteers
- 362 people
- Sponsor
- CRG UZ Brussel
Infertility
An Randomized Double Blind Controlled Trial of niPGT-A in Women With RPL
Objectives: To compare the efficacy in embryo selection based on morphology alone compared to morphology and non-invasive preimplantation genetic testing for aneuploidy (niPGT-A) in women with recurrent pregnancy loss (RPL)…
- Trial name
- niPGTA (NCT05685147)
- Testing
- Non-invasive Preimplantation genetic testing for aneuploidy status
- Where
- Hong Kong
- Volunteers
- 152 people
- Sponsor
- Queen Mary Hospital, Hong Kong
Infertility, Male
The Aim of This Study is to Determine the Incidence of Alterations in Fluorescent In Situ Hybridisation (FISH) of Spermatozoa and to Evaluate the Efficacy of the Use of Annexin Columns (MACS®) in Patients With Altered FISH Undergoing In Vitro Fertilisation Techniques
250 petitions for FISH of spermatozoa were requested, determining the total and particular incidence in each of the indications collected. The effect of annexin columns was evaluated in 10 couples with altered FISH.
- Trial name
- NCT06524102
- Testing
- Magnetic Activated Cell Sorting
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Instituto de Investigación Sanitaria y Biomédica de Alicante
Effect of PGD on Implantation Rates in IVF Cycles
Study of the Efficacy of 24 Chromosome Preimplantation Genetic Diagnosis (PGD)
The purpose of this study is to determine if 24 chromosome preimplantation genetic diagnosis (PGD) increases implantation and delivery rates in couples attempting to conceive through in vitro fertilization (IVF).
- Trial name
- NCT01219283
- Where
- 3 sites in United States
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Reproductive Medicine Associates of New Jersey
Embryo Aneuploidies
Embryo Aneuploidies and Ovarian Stimulation
There is a considerable concern about the effects of controlled ovarian hyperstimulation (COH) for In Vitro Fertilization- Embryo Transfer (IVF-ET) on embryo quality and on the incidence of chromosomal abnormalities in oocytes…
- Trial name
- NCT00707525
- Testing
- Preimplantation Genetic Diagnosis
- Where
- Spain
- Volunteers
- healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Infertility
Preimplantation Genetic Screening in IVF Treatment
This is the pilot phase of a randomised controlled trial. The purpose of the pilot study is to assess the ability to recruit, randomise, adherence to the study protocol and plan for a full study.
- Trial name
- PGSINIVF (NCT05009745)
- Testing
- PGT-A Strategy
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- King's College London
Infertility, Genetic Disease
Follow-up With Preimplantation Genetic Testing Patients
The main purpose of this study is to perform longitudinal evaluations of clinical outcomes and personal perspectives following utilization of preimplantation genetic testing (PGT).
- Conditions
- Infertility, Genetic Disease, IVF
- Trial name
- NCT04477863
- Testing
- Follow-up Interview
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Genomic Prediction Inc.
Clinical Pregnancy, Live Birth
Efficacy Study of Segmentation of PGD Treatment
A single centre observational study into the segmentation of preimplantation genetic diagnosis (PGD) treatment by comparing cumulative pregnancy rates following cryopreservation of all genetically transferable embryos after PGD…
- Trial name
- NCT02133950
- Testing
- elective cryopreservation of available embryos after PGD, PGD and elective fresh embryo transfer plus cryopreservation of supernumerary available embryos after PGD
- Where
- Belgium
- Volunteers
- 252 people
- Sponsor
- Universitair Ziekenhuis Brussel
Infertility, Aneuploidy
Single Embryo TrAnsfeR of Euploid Embryo
The purpose of the current study is to evaluate the effect of preimplantation genetic screening (PGS) by next generation sequencing (NGS) compared to standard morphological assessment of embryos on pregnancy rates through a…
- Trial name
- STAR (NCT02268786)
- Testing
- Preimplantation Genetic Screening by NGS
- Where
- 38 sites in United States, Australia and 2 more
- Volunteers
- 661 people
- Sponsor
- Illumina, Inc.
Infertility, Preimplantation Genetic Screening
The Transition From Blastomere to Trophectoderm Biopsy: Comparing Two PGS Strategies
Shortly after the implementation of Comprehensive Chromosome Screening (CCS) techniques for Preimplantation Genetic Screening (PGS) came the transition in biopsy timing.
- Trial name
- NCT03062969
- Testing
- Cleavage stage biopsy group, Trophectoderm biopsy group
- Volunteers
- 383 people
- Sponsor
- Fundacion Dexeus