Clinical trials: Preimplantation Genetic Testing
Increase the Number of Blastocyst to Biopsy for Preimplantation Genetic Testing
PGS on Blastocysts From Vitrified and Fresh Oocytes
Oocyte accumulation by vitrification is a valid strategy to increase the number of available embryos for biopsy and the number of viable euploid embryos to transfer after preimplantation genetic testing.
- Trial name
- PGSvitfreov (NCT02820415)
- Testing
- chromosomal status of blastocysts from fresh and vitrified/warmed oocytes
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Unità di Medicina della Riproduzione, Italy
Infertility
Metabolomics Non Selection Study - Vitrolife Media
In this study, study investigators will collect embryo culture media on day 5 of vitro fertilization (IVF) culture, prior to vitrification and embryo transfer for testing via Metabolomic screening.
- Trial name
- NCT04976920
- Testing
- Overture Metabolomics Embryo Selection
- Where
- 2 sites in Argentina, Spain
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Overture Life
Preimplantation Genetic Testing (PGT), Frozen Embryo Transfer Cycle
Effects of Trophectoderm (TE) Biopsy on the Health and Development of Children Born After Preimplantation Genetic Testing (PGT) Cycles.
This study aims to investigate the effects of trophectoderm (TE) biopsy on the health and development of children born after preimplantation genetic testing (PGT) cycles.
- Conditions
- Preimplantation Genetic Testing (PGT), Frozen Embryo Transfer Cycle, Assisted Reproduction Technologies, Postnatal Health
- Trial name
- NCT07349966
- Testing
- Questionnaire
- Where
- Italy
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Infertility, Female, Infertility, Male
Embryo Assessment Utilizing Timelapse Imaging in Conjunction With Preimplantation Genetic Testing for Aneuploidy With Next Generation Sequencing
The goal of this observational study is to discern if there is a relationship between timelapse imagery of human oocytes/embryos and PGT results.
- Conditions
- Infertility, Female, Infertility, Male, Infertility, IVF
- Trial name
- NCT06419127
- Testing
- Timelapse incubation and PGT
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Gattaca Genomics
Secondary Infertility
Non-invasive Preimplantation Genetic Testing for Aneuploidies Using Cell-free DNA in Spent Culture Media
Analysis of embryonic cell-free DNA (cfDNA) present in the spent culture media (SCM) is a non-invasive alternative for preimplantation genetic testing for aneuploidies (PGT-A) that avoids the technical challenges and limitations…
- Trial name
- niPGT-A (NCT04711239)
- Testing
- PGT-A / niPGT-A
- Volunteers
- healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Infertility, Aneuploidy
Noninvasive Chromosomal Screening for Embryo Selection Trial
To determine the diagnostic accuracy of non-invasive preimplantation genetic testing for aneuploidy (NI-PGT-A) for embryo selection.
- Trial name
- NICEST (NCT04732013)
- Testing
- No clinical intervention is planned; study is observational
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Olive Fertility Centre
Infertility, Recurrent Pregnancy Loss
Microfluidics Versus Gradient Centrifugation Effect on Euploidy Rates
This research is being done to determine if using a microfluidics chamber, a device used to process sperm, will be effective in improving the rates of embryos with normal chromosomes (structures that carry genetic information)…
- Trial name
- NCT04744025
- Testing
- Microfluidics chamber, Density Gradient Centrifugation
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Lawrence Engmann
Recurrent Implantation Failure
Preimplantation Genetic Testing for Aneuploidies in Patients With Recurrent Implantation Failure
Assessing whether Preimplantation Genetic Testing for Aneuploidy (PGT-A) can increase the ongoing pregnancy rate per transferred embryo and can decrease the time to pregnancy and miscarriage rate in patients with Recurrent…
- Trial name
- NCT03900780
- Testing
- PGT-A, Control
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Patient Education
Preimplantation Genetic Testing for Aneuploidy Counseling
Purpose: To evaluate preimplantation genetic testing counseling interventions on patients undergoing in vitro fertilization treatment.
- Trial name
- PGT-A (NCT06018454)
- Testing
- Handout on PGT-A, Handout on PGT-A and genetic counseling
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Eyup Hakan Duran
Polycystic Kidney Disease, Assisted Reproductive Technology
Descriptive Analysis of Preimplantation Genetic Test (PGT)in Couples With Polycystic Kidney Disease (PKD). In the ADPKD Subgroup Evaluation of Outcomes and Complications Comparing Couples in Which the Father is Affected With Couples in Which the Mother is Affected
The goal of this observational study is to evaluate the outcomes of assisted reproductive technology (ART) combined with preimplantation genetic testing for monogenic diseases (PGT-M) in couples affected by or carriers of…
- Conditions
- Polycystic Kidney Disease, Assisted Reproductive Technology, Preimplantation Genetic Testing (PGT)
- Trial name
- PGT-M PKD (NCT07310641)
- Testing
- Assisted reproductive technology and preimplantation diagnosis for monogenic diseases
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- Azienda Sanitaria Universitaria Integrata del Trentino
in Vitro Fertilization, Single Embryo Transfer
eSET or eDET Associated to PGT in IVF
In vitro fertilization (IVF) techniques have been improving performance recently and, nowadays, provide a live birth rate of around 25%.
- Conditions
- in Vitro Fertilization, Single Embryo Transfer, Preimplantation Genetic Diagnosis, Pregnancy
- Trial name
- SetDetPgt (NCT03758833)
- Testing
- preimplantation genetic test of embryo by new generation sequencing (NGS), Single embryo transfer, Double embryo tranfer
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- University of Sao Paulo General Hospital
Infertility
Predictive Value of Embryonic Testing
The primary objective of this study is to determine the predictive value of preimplantation genetic screening (PGS) as a marker of embryonic competence.
- Trial name
- PROV-ET (NCT03604107)
- Testing
- Preimplantation Genetic Testing-Aneuploidy
- Where
- 4 sites in United States
- Volunteers
- 237 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Infertility, Chromosome Abnormality
Embryo Selection by Noninvasive Preimplantation Genetic Test
The objective of this study is to explore whether non-invasive chromosome screening (NICS) can be used as an effective indicator for embryos selection besides morphology through a multicenter randomized controlled trial, by…
- Trial name
- ESNi-PGT (NCT04339166)
- Testing
- Non-invasive chromosome screening（NICS）
- Where
- 13 sites in China
- Volunteers
- 1,152 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Preimplantation Genetic Testing (PGT), ICSI
Noninvasive Preimplantation Genetic Testing for Aneuploidy
The study is conducted to evaluate the sensitivity and specificity of non-invasive preimplantation genetic testing for aneuploidy (NiPGT-A) using cell free DNA into spent culture medium (SCM).
- Trial name
- NCT04490889
- Testing
- NiPGT-A
- Where
- 2 sites in Vietnam
- Volunteers
- 218 people
- Sponsor
- Mỹ Đức Hospital
De Novo Mutation, Preimplantation Genetic Testing
Optimized PGT-M Strategy for Patients With No Proband
The clinical practice of PGT-M for monogenetic disease usually adopted a double-checking strategy, which detect the mutation by Sanger sequencing and meantime construct haplotypes using the DNA sample of the proband so as to…
- Conditions
- De Novo Mutation, Preimplantation Genetic Testing, Without Proband
- Trial name
- NCT06722313
- Testing
- Gametes (sperm or second polar bodies, MI eggs) or arrested embryos were reserved for identification of a proband
- Where
- China
- Volunteers
- 5 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Recurrent Early Pregnancy Loss
PGT-A in Screening of Embryos in the Treatment of Unexplained Recurrent Miscarriage
uRM patients selected PGT-A from 2012 to 2016 were included in this study. Their clinical outcomes were prospectively observed and analyzed to explore the factor influenced the outcomes.
- Trial name
- NCT04643938
- Where
- China
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Aneuploidy, Chromosome Abnormality
Multi-center Study to Validate niPGT-A
Abnormal chromosome number, or aneuploidy, is common in human embryos. It is responsible for more than half of all miscarriages, and it is the leading cause of congenital birth defects.
- Conditions
- Aneuploidy, Chromosome Abnormality, Infertility
- Trial name
- niPGT-A (NCT03520933)
- Testing
- PGT-A, niPGT-A
- Where
- 10 sites in United States, Argentina and 6 more
- Volunteers
- 2,586 people
- Sponsor
- Igenomix
Preimplantation Genetic Testing, Progestin-primed Ovarian Stimulation
Comparison of the Euploid Rate of Blastocyst Between PPOS and GnRH Antagonist Protocol in Patients Undergoing PGT-A
This randomized trial aims to compare the euploid rate of blastocysts between PPOS and GnRH antagonist protocols in patients undergoing PGT-A.
- Conditions
- Preimplantation Genetic Testing, Progestin-primed Ovarian Stimulation, Euploid Rate, GnRH Antagonist
- Trial name
- NCT04414748
- Testing
- GnRH antagonist, oral Duphaston
- Where
- China
- Volunteers
- 400 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Genetic Disease
Technological Development and Clinical Parallel Testing of PGT-G
Preimplantation genetic testing (PGT) has three different testings according to the type of genetic disease, which was classified as PGT-M, PGT-SR and PGT-A.
- Trial name
- NCT05609708
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Infertility, Male Infertility
To Investigate if the Harvester® Improves Sperm Motility and Blastocyst Utilization (the Percent of Fertilized Eggs That Develop to the Point That They Are Able to be Transferred) in IVF Cycles.
The goal of this prospective, multicenter randomized controlled clinical trial is to evaluate whether the SwimCount Harvester microfluidic sperm preparation device can achieve equivalent or superior clinical outcomes compared to…
- Conditions
- Infertility, Male Infertility, InVitro Fertilization, Aneuploidy Rate
- Trial name
- NCT07369362
- Testing
- microfludics semen processing device
- Where
- United States
- Volunteers
- 1,600 people
- Sponsor
- MotilityCount aps