Clinical trials: Preimplantation Genetic Testing (PGT)
Infertility
Metabolomics Non Selection Study - Vitrolife Media
In this study, study investigators will collect embryo culture media on day 5 of vitro fertilization (IVF) culture, prior to vitrification and embryo transfer for testing via Metabolomic screening.
- Trial name
- NCT04976920
- Testing
- Overture Metabolomics Embryo Selection
- Where
- 2 sites in Argentina, Spain
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Overture Life
Non-obstructive Azoospermia, Male Infertility
Preimplantation Genetic Testing for Aneuploidy (PGT-A) in Couples With Non-obstructive Azoospermia (NOA)
Objective: To examine the rate of embryo aneuploidy in patients with non-obstructive azoospermia (NOA) who utilize in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) and compare live birth rates with the…
- Trial name
- NCT06566599
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Inception Fertility Research Institute, LLC
Infertility
Preimplantation Genetic Screening in IVF Treatment
This is the pilot phase of a randomised controlled trial. The purpose of the pilot study is to assess the ability to recruit, randomise, adherence to the study protocol and plan for a full study.
- Trial name
- PGSINIVF (NCT05009745)
- Testing
- PGT-A Strategy
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- King's College London
Infertility
Outcome of Embryos Transferred After Initial Chaotic Results on PGT-A
This is a retrospective review of treatment outcomes from fertility clinics in The Prelude Network who have used Igenomix for PGT-A and have transferred embryos with initial chaotic results, regardless if re-biopsy was performed.
- Trial name
- NCT06373237
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Inception Fertility Research Institute, LLC
Infertility, Aneuploidy
Noninvasive Chromosomal Screening for Embryo Selection Trial
To determine the diagnostic accuracy of non-invasive preimplantation genetic testing for aneuploidy (NI-PGT-A) for embryo selection.
- Trial name
- NICEST (NCT04732013)
- Testing
- No clinical intervention is planned; study is observational
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Olive Fertility Centre
Preimplantation Genetic Testing (PGT), ICSI
Noninvasive Preimplantation Genetic Testing for Aneuploidy
The study is conducted to evaluate the sensitivity and specificity of non-invasive preimplantation genetic testing for aneuploidy (NiPGT-A) using cell free DNA into spent culture medium (SCM).
- Trial name
- NCT04490889
- Testing
- NiPGT-A
- Where
- 2 sites in Vietnam
- Volunteers
- 218 people
- Sponsor
- Mỹ Đức Hospital
Secondary Infertility
Non-invasive Preimplantation Genetic Testing for Aneuploidies Using Cell-free DNA in Spent Culture Media
Analysis of embryonic cell-free DNA (cfDNA) present in the spent culture media (SCM) is a non-invasive alternative for preimplantation genetic testing for aneuploidies (PGT-A) that avoids the technical challenges and limitations…
- Trial name
- niPGT-A (NCT04711239)
- Testing
- PGT-A / niPGT-A
- Volunteers
- healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Preimplantation Genetic Testing (PGT), Frozen Embryo Transfer Cycle
Effects of Trophectoderm (TE) Biopsy on the Health and Development of Children Born After Preimplantation Genetic Testing (PGT) Cycles.
This study aims to investigate the effects of trophectoderm (TE) biopsy on the health and development of children born after preimplantation genetic testing (PGT) cycles.
- Conditions
- Preimplantation Genetic Testing (PGT), Frozen Embryo Transfer Cycle, Assisted Reproduction Technologies, Postnatal Health
- Trial name
- NCT07349966
- Testing
- Questionnaire
- Where
- Italy
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Aneuploidy, Chromosome Abnormality
Clinical Value of Mosaicism Diagnosis on the Trophectoderm Biopsies
Mosaicism within an embryo is defined as the presence of two or more cell populations with different genotypes. Blastocysts classified as mosaic by Preimplamtation Genetic Testing for Aneuploidy (PGT-A) have been reported to…
- Trial name
- NS-MOSAICISM (NCT03673592)
- Testing
- PGT-A
- Where
- 3 sites in Italy
- Volunteers
- 783 people
- Sponsor
- Igenomix
Infertility of Uterine Origin
Clinical Study of PGT-A Versus PGT-A+ERA
Patients who have shown previous implantation failures, despite transferring good quality and chromosomally normal embryos (diagnosed by PGT-A), could have a displaced Window of Implantation (WOI) and consequently, alterations in…
- Trial name
- PGT-A&ERA (NCT03530254)
- Testing
- PGT-A, ERA Test
- Where
- 15 sites in United States, Argentina and 10 more
- Volunteers
- 368 people
- Sponsor
- Igenomix
Recurrent Implantation Failure
Preimplantation Genetic Testing for Aneuploidies in Patients With Recurrent Implantation Failure
Assessing whether Preimplantation Genetic Testing for Aneuploidy (PGT-A) can increase the ongoing pregnancy rate per transferred embryo and can decrease the time to pregnancy and miscarriage rate in patients with Recurrent…
- Trial name
- NCT03900780
- Testing
- PGT-A, Control
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
IVF
Euploid Rate of Blastocyst Derived From PPOS VS Antagonist Protocol
In-vitro fertilization (IVF) involves multiple follicular development, oocyte retrieval and embryo transfer after fertilization.
- Trial name
- NCT04989348
- Testing
- Gonadotrophin releasing hormone antagonist protocol, Progestin-primed ovarian stimulation protocol
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
Infertility
Preimplantation Genetic Testing for Aneuploidy (PGT-A) in Women Aged 37-41 Years
A multinational multi-centre, randomized, controlled non-blinded trial with participation of three fertility clinics in Denmark and one in Spain to assess the efficacy and safety of preimplantation genetic testing for aneuploidy…
- Trial name
- NCT06358547
- Testing
- PGT-A
- Where
- Denmark
- Volunteers
- 590 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Preimplantation Genetic Testing, Progestin-primed Ovarian Stimulation
Comparison of the Euploid Rate of Blastocyst Between PPOS and GnRH Antagonist Protocol in Women With PCOS Undergoing PGT-A
This randomized trial aims to compare the euploid rate of blastocysts between PPOS (progestin-primed ovarian stimulation) and GnRH (gonadotrophin releasing hormone) antagonist protocols in patients with PCOS (polycystic ovary…
- Conditions
- Preimplantation Genetic Testing, Progestin-primed Ovarian Stimulation, Polycystic Ovarian Syndrome, GnRH Antagonist
- Trial name
- NCT05326087
- Testing
- GnRH antagonist, MPA
- Volunteers
- 204 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Infertility, Female, Infertility, Male
Cell Free Preimplantation Genetic Testing
This study aims to develop preimplantation genetic testing methods from embryo culture media (cell free). Genetic testing of culture media will be compared to conventional methods based on embryo biopsies.
- Trial name
- NCT04628507
- Testing
- Spent media collection
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Genomic Prediction Inc.
Pregnancy Outcome, Time-to-Pregnancy
2.Comparison of the Live Birth Rate of PGT Versus Expectant Management in Patients With RPL
Recurrent pregnancy loss (RPL) is a multifactorial disorder defined by the American Society for Reproductive Medicine (ASRM) as two or more clinical miscarriages (CMs).
- Trial name
- NCT05457335
- Testing
- undergoing PGT
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Shanghai First Maternity and Infant Hospital