Clinical trials: Premalignant
Barrett Esophagus, Esophageal Adenocarcinoma
The Microbiome, Bile Acids, and Notch in Barrett's Esophagus (BE)
The purpose of this study is to prospectively collect and analyze clinical data and biospecimens from a cohort of 100 patients without BE (20), with non-dysplastic BE (40), or with BE and high grade dysplasia (HGD) or EAC (40).
- Trial name
- NCT05524844
- Testing
- Sample Collection, Endoscopy results, Dietary questionnaire
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Columbia University
Gastro Esophageal Reflux, Barrett Esophagus
PPI Therapy Impact on GERD After Sleeve Gastrectomy
The trial would to try to establish: The best post-operative PPI prescription protocol after Sleeve Gastrectomy The impact of PPI therapy on postoperative peptic diseases (erosive gastropathies, ulcers, duodenitis, esophagitis…
- Conditions
- Gastro Esophageal Reflux, Barrett Esophagus, Bariatric Surgery Candidate
- Trial name
- NCT04400136
- Testing
- Lansoprazole oral tablets 30 mg
- Where
- Italy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Pachyonychia Congenita
International Pachyonychia Congenita Research Registry
International Pachyonychia Congenita Research Registry (IPCRR) is a patient registry for those suffering from Pachyonychia Congenita (PC).
- Trial name
- IPCRR (NCT02321423)
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Pachyonychia Congenita Project
Lichen Planus, Oral, Preneoplastic Condition
Treatment Protocols for Patients With Symptomatic Oral Lichen Planus
The primary objective of this study was to compare the therapeutic efficacy of clobetasol propionate 0.05% oral gel versus an anti-inflammatory mouthwash in an oral solution for the management of patients suffering from…
- Trial name
- NCT04673916
- Testing
- Healing evaluation
- Where
- Italy
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Messina
Vaginal Flora Imbalance, ASC-US
"Lactobacillus Crispatus M247, LSIL and Microbiota"
Patients affected by ASC-US/ low-grade HPV cervical lesions will be randomly assigned to treatment arm vs control arm. The treatment arm will include the characterization of the vaginal microbiota at enrollment (T0), 4 months of…
- Conditions
- Vaginal Flora Imbalance, ASC-US, LSIL, HPV Infection
- Trial name
- NCT05808816
- Testing
- Lactobacillus Crispatus M247
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Early Gastric Cancer
Screening for Early Gastric Cancer in Shaanxi Province
This study collect the relevant data of local residents over 20 years old in 11 regions of Shaanxi Province, The basic information of the subjects was collected by filling in the questionnaire, and serum helicobacter pylori…
- Trial name
- NCT05291728
- Where
- China
- Volunteers
- 12,500,000 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Human Papillomavirus Type 16, Cervical Intraepithelial Neoplasia Grade II
HPV DNA Vaccine Via Electroporation for HPV16 Positive Cervical Neoplasia
The primary goal of this phase I open label study is to determine the safety and tolerability of pNGVL4aCRTE6E7L2 DNA vaccine, as administered by intramuscular (IM) injection with TriGrid™ electroporation to both HIV- or HIV+…
- Conditions
- Human Papillomavirus Type 16, Cervical Intraepithelial Neoplasia Grade II, Cervical Intraepithelial Neoplasia, Grade III
- Trial name
- NCT04131413
- Testing
- pNGVL4aCRTE6E7L2
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins