Clinical trials: Premalignant Lesion
Actinic Keratosis
Evaluation of Two Different Non-invasive Techniques to Monitor the Clearance of Actinic Keratosis Lesions
The purpose of this study is to evaluate the performance of two techniques to monitor the clearance of AK lesions when treated with Aldara 5% cream.
- Trial name
- NCT00294320
- Testing
- Aldara (Imiquimod), Vehicle cream
- Where
- France
- Volunteers
- 12 people
- Sponsor
- MEDA Pharma GmbH & Co. KG
High-grade Squamous Intraepithelial Lesions (HSIL), Cervical Conization
Predicting Treatment Failure in HSIL Patients with Positive Margins After Conization Via Detection of PAX1 Methylation
The goal of this multicenter, observational study is to evaluate whether methylation testing of paired box gene 1 (PAX1) can better predict and diagnose recurrence or persistent disease in patients with positive margins after…
- Trial name
- NCT06713655
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Actinic Keratosis
Photodynamic Therapy Mediated by Topical Application of 5- ALA for the Treatment of Actinic Keratoses
The purpose of this study is to compare the treatment of skin growths called actinic keratoses (AK) with 5-ALA PDT, an FDA-approved treatment, versus treatment with other conventionally used FDA-approved agents such as…
- Trial name
- NCT00814528
- Testing
- 5-ALA plus Blu-Light, 5-FU, Imiquimod or treatment with cryotherapy
- Where
- United States
- Sponsor
- University of Chicago
Gastric Precancerous Condition
Jianpi Huoxue Recipe in Treating Gastric Premalignant Lesion
This study had adopted the multi-center, randomized and controlled experiment design based on standardized mucosal biopsy and pathohistological operation, as well as therapeutic evaluation methodology.
- Trial name
- NCT03823248
- Testing
- MoLuoDan, Sanchi powder, Folic Acid Tablet
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
Cervical Dysplasia, Cervical Disease
iMproving thE DIagnostics And Treatment Of ceRvical Precancer
Cervical cancer screening is important as it enables identification of women at increased risk of the disease, but high-quality diagnostics of screen-positive women and effective treatment of those with precancer are critical in…
- Conditions
- Cervical Dysplasia, Cervical Disease, Cervical Lesion, Cervical Cancer
- Trial name
- MEDIATOR (NCT05870787)
- Testing
- Swede score colposcopy
- Where
- 7 sites in Denmark
- Volunteers
- 929 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Upper Aerodigestive Tract Neoplasms, Upper AerodigestiveTract Cancer
AI-Assisted Endoscopy for Upper Aerodigestive Tract Lesions
This is a prospective observational clinical study designed to evaluate the performance of artificial intelligence (AI) algorithms applied to upper aerodigestive tract (UADT) video-endoscopy.
- Conditions
- Upper Aerodigestive Tract Neoplasms, Upper AerodigestiveTract Cancer, Upper Aero-digestive Tract (UADT) Neoplasm, Squamous Cell Carcinoma
- Trial name
- H&NANCE (NCT07596355)
- Where
- 3 sites in Belgium, Italy and 1 more
- Volunteers
- 283 people
- Sponsor
- Istituto Italiano di Tecnologia
Oral Cancer
Expression of VEGF-C and VEGF-CR in Oral Cancers and Premalignant Lesions
The role of vascular endothelial growth factor-C (VEGF-C) and its receptors induced lymphangiogenesis and host inflammatory responses on the carcinogenesis of oral cancers and premalignant lesions
- Trial name
- NCT00173316
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Cervical Dysplasia, Cervical Lesion
See and Treat in an Outpatient Setting in Women Above 45 Years With Cervical Dysplasia
The study will investigate if implementation of "see and treat" in the outpatient clinic can optimize the diagnosis, clinical follow-up and treatment of older women with positive cervical screening test.
- Conditions
- Cervical Dysplasia, Cervical Lesion, Cervix Disease
- Trial name
- NCT04298957
- Testing
- Cone biopsy
- Where
- 3 sites in Denmark
- Volunteers
- 109 people
- Sponsor
- University of Aarhus
Oral Dysplasia, Leukoplakia Oral
Topical Imiquimod Treatment of Oral Dysplasia
The goal of this clinical trial is to determine the effectiveness of imiquimod in treating oral dysplasia in adult patients. Imiquimod 5% cream could be a safe and practical treatment for oral epithelial dysplasia (a precancerous…
- Conditions
- Oral Dysplasia, Leukoplakia Oral, Leukoplakia
- Trial name
- NCT07210775
- Testing
- Imiquimod (topical use)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Southern California
Cervical Cancer, Precancerous Condition
Gene Expression Profiling of Cervical Cancer Progression in Biopsies and Tissue Samples
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- SAGE (NCT00629577)
- Testing
- microarray analysis, flow cytometry, biopsy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- British Columbia Cancer Agency
Screening for Colon Cancer, Blood Samples
Evaluation of PreveCol's Efficiency As a Second Line Method for the Early Colorectal Cancer Detection
The objective of this low-risk interventional study is to evaluate whether the PreveCol® test has sufficient efficiency to be considered as a second-line method for the detection of both colorectal cancer and advanced adenomas…
- Conditions
- Screening for Colon Cancer, Blood Samples, Survey and Questionnaire, Colorectal Carcinoma
- Trial name
- MS-Prevecol (NCT06703632)
- Testing
- blood sampling, Survey using a questionnaire.
- Where
- 2 sites in Portugal, Spain
- Volunteers
- 4,538 people, healthy volunteers welcome
- Sponsor
- ADVANCED MARKER DISCOVERY S.L.
Oral Cancer, Oral Lichen Planus
Diagnostic Accuracy of Salivary DNA Integrity Index in Oral Malignant and Premalignant Lesions
This study aims to identify the accuracy of DNA integrity index in differentiating between oral premalignant lesions and oral cancer.
- Conditions
- Oral Cancer, Oral Lichen Planus, Oral Leukoplakia
- Trial name
- NCT03682562
- Testing
- DNA Integrity Index
- Where
- Egypt
- Volunteers
- 93 people
- Sponsor
- Cairo University
Anal Cancer, Precancerous Condition
Cidofovir in Treating HIV-Infected Patients With High-Grade Squamous Intraepithelial Lesions of the Skin Near the Anus
RATIONALE: High-grade squamous intraepithelial lesions of the skin near the anus are caused by the human papillomavirus (HPV). Antiviral drugs,, such as cidofovir, act against viruses and may stop these lesions from becoming…
- Trial name
- NCT00550589
- Testing
- cidofovir, DNA methylation analysis, gene expression analysis
- Where
- 8 sites in United States
- Volunteers
- 33 people
- Sponsor
- AIDS Malignancy Consortium
Skin Lesions, Melanocytic Nevi
Evaluating an Artificial Intelligence Tool to Help Primary Care Doctors Diagnose Skin Conditions.
This study aims to determine if an artificial intelligence (AI) medical device can help primary care doctors more accurately identify and manage various skin conditions.
- Conditions
- Skin Lesions, Melanocytic Nevi, Melanoma (Skin Cancer), Basal Cell Carcinoma of Skin
- Trial name
- LegitHealth PH (NCT07428941)
- Testing
- AI-based medical device for aided diagnosis in dermatological conditions
- Where
- Spain
- Volunteers
- 9 people
- Sponsor
- AI Labs Group S.L
Actinic Keratoses
Phase I/IIa Trial to Evaluate AVX001 Gel in Doses of 1% or 3% Compared With Vehicle Over Four Weeks of Field-directed Treatment Period in Adult Subjects With AK
Actinic keratosis (AK), also known as solar keratosis, is a common skin condition characterised by abnormal growth of skin cells caused by long-term sun exposure.
- Trial name
- COAKS (NCT05164393)
- Testing
- AVX001
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Coegin Pharma AB
Esophageal Cancer, Dysplasia
VEGF-targeted Fluorescence Near-Infrared (NIR) Endoscopy in (Pre)Malignant Esophageal Lesions
To improve detection of esophageal (pre)malignant lesions during surveillance endoscopy of patients at risk of developing malignancies, for example in Barrett's Esophagus (BE), there is a need for better endoscopic visualization…
- Trial name
- VICE (NCT02129933)
- Testing
- Bevacizumab-IRDye800CW, Near infrared fluorescence endoscopy platform
- Where
- Netherlands
- Volunteers
- 14 people
- Sponsor
- University Medical Center Groningen
Pancreatic Cancer, Pancreatic Neuroendocrine Tumor
Safety and Efficacy of an Ablation Catheter for the Treatment of Pancreatic Premalignant Cyctic Lesions.
This study aims to evaluate the safety and efficacy of new ablation catheter developed by MEDICAL TAEWOONG for the treatment of pancreatic premalignant and early malignant cystic lesion.
- Conditions
- Pancreatic Cancer, Pancreatic Neuroendocrine Tumor, Pancreatic Cyst, Pancreatic Cancer Stage
- Trial name
- yes (NCT03417843)
- Testing
- EUSRA RF electrode
- Volunteers
- 20 people
- Sponsor
- HaEmek Medical Center, Israel
Head and Neck Cancer
Celecoxib in Preventing Cancer in Patients With Oral Leukoplakia and/or Head and Neck Dysplasia
Patient at increased risk for developing a new head and neck squamous cell carcinoma are invited to take part in this study. The investigators of this trial will attempt to study the effectiveness of Celecoxib in preventing…
- Trial name
- NCT00052611
- Testing
- Celecoxib
- Where
- 3 sites in United States
- Volunteers
- 23 people
- Sponsor
- Dana-Farber Cancer Institute
Cervical Cancer, Precancerous Condition
Study of Pap Smears From Patients Enrolled on Clinical Trial GOG-171
RATIONALE: Studying Pap smears in the laboratory from women with atypical glandular cells of unspecified significance may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00898144
- Testing
- Papanicolaou test, laboratory biomarker analysis
- Volunteers
- 55 people
- Sponsor
- Gynecologic Oncology Group
Anal Cancer, Precancerous Condition
Infrared Coagulation in Preventing Anal Cancer in Patients With HIV Who Have Anal Neoplasia
RATIONALE: Infrared coagulation may be effective in preventing the development of anal cancer in patients who have anal neoplasia.
- Trial name
- NCT00066430
- Testing
- infrared photocoagulation therapy, Infrared Coagulator
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- AIDS Malignancy Consortium