Clinical trials: Premature Aging
HIV Infection, Vaginal Atrophy
Accelerated Genital Tract Aging in HIV: Estradiol Clinical Trial
During menopause, there is a decrease in a hormone estrogen, which leads to aging of the vagina. Vaginal aging includes changes in the type and amount of healthy bacteria in the vagina, inflammation and a breakdown of natural…
- Conditions
- HIV Infection, Vaginal Atrophy, Menopause, Menopause Related Conditions
- Trial name
- NCT04079218
- Testing
- Estradiol Vaginal Insert
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kerry Murphy
Schizophrenia, Treatment Resistant Depression
Dasatinib Plus Quercetin for Accelerated Aging in Mental Disorders
This pilot open-label study examines the effects of a combination of dasatinib plus quercetin - two drugs that have known senolytics properties - on physiological aging in older individuals with depression or schizophrenia.
- Conditions
- Schizophrenia, Treatment Resistant Depression, Aging, Premature
- Trial name
- NCT05838560
- Testing
- Dasatinib, quercetin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Washington University School of Medicine
Adverse Childhood Experiences, Endothelial Dysfunction
ACEs, SIRT1, and Premature Vascular Aging in Humans
Adverse childhood experiences (ACEs) are directly related to cardiovascular morbidity and mortality, and impaired vascular endothelial function (VEF) is an independent predictor of future cardiovascular disease (CVD) risk [1, 2].
- Trial name
- NCT07073352
- Testing
- Nicotinamide Riboside
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Obesity and Obesity-related Medical Conditions
Impact of Bariatric and Metabolic Surgery on the Reduction of Premature Aging.
We invite the participants to take a part in a research study conducted at the 2nd Department of General Surgery of the Jagiellonian University Medical College.
- Trial name
- NCT06618846
- Testing
- laparoscopic sleeve gastric bypass
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- University Hospital in Krakow
Type 2 Diabetes Mellitus
Premature Aging and Type 2 Diabetes Mellitus: an Increased Risk of Cardiomyopathy?
The potential clinical implications of this study are to optimise the selection of a population at risk for developing a diabetic cardiomyopathy among diabetic patients in order to develop early therapeutic strategies to prevent…
- Trial name
- R2D2 (NCT01536808)
- Testing
- Cardiac RMI, Analysis telomere, Stress test
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Hospices Civils de Lyon
Prematurity, Vascular Aging
Exclusive Human-milk in Preterm NEOnates and Early VASCular Aging Risk Factors (NEOVASC)
Early vascular aging has its origins in fetal and neonatal life. The NEOVASC clinical trial aims to determine the effects of an exclusive human milk diet in extremely preterm infants on long-term cardiovascular health.
- Trial name
- NEOVASC (NCT04413994)
- Testing
- Humavant
- Where
- Austria
- Volunteers
- 200 people
- Sponsor
- Prolacta Bioscience
Premature Ovarian Insufficiency, Diminished Ovarian Reserve
The Correlation Between Ovarian Function and Serum Biomarkers
The goal of this observational study is to find differences in serum biomarkers between ovarian function and normal individuals.
- Conditions
- Premature Ovarian Insufficiency, Diminished Ovarian Reserve, Biomarker, Copper
- Trial name
- NCT06096766
- Testing
- blood test
- Where
- China
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Shi Yun
Aging, Premature, HIV Infections
Epidemiological Study of the Markers of Aging in the Cohort of Patient HIV in Brest
RATIONALE: HIV pathology has been associated with accelerated aging of the infected organism, with no known knowledge of virus, immunosuppression, immune response stimulation, antiretroviral toxicity, and "classic" risks.
- Trial name
- VIHVA (NCT06554210)
- Where
- France
- Volunteers
- 213 people
- Sponsor
- University Hospital, Brest
Perimenopausal Disorder, Menopause
Inovium Ovarian Rejuvenation Trials
The Inovium Ovarian Rejuvenation Treatment is a PRP-based autologous treatment used in combination with a stimulated IVF sequence and Pre-Implantation Genetic Screening to treat infertility in women experiencing menopause…
- Conditions
- Perimenopausal Disorder, Menopause, Menopause, Premature, Menopause Related Conditions
- Trial name
- NCT03178695
- Testing
- Autologous PRP injection into human ovarian tissue
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ascendance Biomedical
Healthy, Premature Ovarian Failure
Feasibility Study for Development of an Early Test for Ovarian Failure
This purpose of this study is to gain information about normal ovarian function that will be useful in developing a test for early detection of ovarian failure.
- Trial name
- NCT00006156
- Testing
- Control, Drug: FSH
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
HIV-1-infection, Aging, Premature
Mental Ability Challenge Study in Adults With and Without HIV
It is estimated that by 2016, nearly 50% of HIV-positive individuals in the US will be aged 50 or older, and up to 60% of those will experience some degree of cognitive impairment as they age.
- Conditions
- HIV-1-infection, Aging, Premature, Cognitive Impairment, Memory Impairment
- Trial name
- NCT03244488
- Testing
- Scopolamine Injectable Product, Mecamylamine Pill
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Age Problem
Pathology of Helicases and Premature Aging: Study by Derivation of hiPS
Topic of this work is the involvement of replicative helicases in human premature ageing syndrome. Replicative helicases are ubiquitous and essential during numerous reactions of the DNA metabolism.
- Trial name
- HeliPS (NCT03898817)
- Testing
- taking of cutaneous cells
- Where
- France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Montpellier
Aging, Premature Aging
Dissector Assisted Malar Elevation for Rhytidoplasty
BACKGROUND: Endoscopy was first used in plastic surgery for the treatment of frontal rhytides. This minimally invasive approach allows the treatment of frontal wrinkles using a practical procedure that does not directly interfere…
- Trial name
- DAME (NCT00925158)
- Testing
- Dissector Assisted Malar Elevation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of São Paulo
Telomere Length, Exercise
Physical Exercise in Patients With First Psychotic Episode
Justification: Patients with first-episode psychosis are at increased risk of premature ageing and early mortality, associated with telomere shortening and increased inflammatory markers.
- Conditions
- Telomere Length, Exercise, First Episode Psychosis (FEP)
- Trial name
- NCT07207538
- Testing
- Other: Strength physical exercise programme, Other: Normal life
- Volunteers
- 40 people
- Sponsor
- University of Salamanca
Premature Coronary Heart Disease
the Real-world Data of Risk Factor and Its Prognosis in PREmature Coronary ARtery DIseAse Study
The goal of this observational study is to explore the relationship between biological aging and long-term prognosis of patients with metabolic cardiovascular disease in premature coronary artery disease.
- Trial name
- PRE-CARDIA (NCT06695182)
- Testing
- physical activity
- Volunteers
- 3,000 people
- Sponsor
- Sun Yat-sen University
Menopausal Complaints, Vaginal Atrophy
Vaginal Estradiol vs Moisturizer to Improve Postmenopausal Vaginal Aging Symptoms and the Microbiome in Women Living With HIV
This is a research study about the effects of vaginal estradiol compared to moisturizer on vaginal symptoms of menopause and the microbiome in women with HIV.
- Conditions
- Menopausal Complaints, Vaginal Atrophy, Genitourinary Symptoms, HIV (Human Immunodeficiency Virus)
- Trial name
- NCT07526948
- Testing
- Vaginal estradiol tablets, Vaginal moisturizer
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Aging, Premature
Safety and Performance of DKL Crosslinked Sodium Hyaluronate 23 Dermal Filler for Improvement of NLF Appearance
This is a pivotal, prospective active-controlled, randomized, double blinded (blinded evaluator and subject), intra-individual split-face comparison, non-inferiority study of DKL crosslinked sodium hyaluronate 23 versus Juvederm…
- Trial name
- NCT05021913
- Testing
- DKL crosslinked sodium hyaluronate 23, Juvéderm Volift™ with lidocaine (Allergan, Inc)
- Where
- Sweden
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dr. Korman Laboratories Ltd.
Metabolic Syndrome, Premature Aging
The Safety and Efficacy Study of RiaGev in Healthy Adults
This current randomized, double-blind, comparator-controlled, cross over study investigates the efficacy and safety of RiaGev™ via evaluation of NAD+, ATP, glucose, insulin, glutathione, and cortisol levels in healthy adults of…
- Trial name
- NCT04483011
- Testing
- RiaGev
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Bioenergy Life Science, Inc.
COPD
Novel Predictors of Premature Aging in COPD Patients
•Examine whether COPD is associated with accelerated aging using a biological marker of aging and dermatological score
- Trial name
- NCT06019286
- Testing
- SCINEXA score
- Volunteers
- 100 people
- Sponsor
- Assiut University
Aging, Premature, Congenital Heart Disease
White Matter Hyperintensities Burden in Adult Patients With Cyanotic Congenital Heart Disease: a Pilot Study
The study aims at investigating the role of cyanotic congenital heart disease (cCHD) on brain aging. The investigators assume that due to congenital and acquired cardiovascular abnormalities, cCHD patients could show radiologic…
- Conditions
- Aging, Premature, Congenital Heart Disease, White Matter Hyperintensities
- Trial name
- NCT03487302
- Testing
- Brain MRI, Neuropsychological test battery
- Where
- Italy
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato