Clinical trials: Premature Menopause
Premature Ovarian Failure
Ovarian Injection of PRP (Platelet -Rich Plasma) Vs Normal Saline in Premature Ovarian Insufficiency
60 cases with premature ovarian insufficiency will be randomized to either receive PRP or saline injection in their ovaries. Then follow up by hormonal \& ultrasound \& clinically to monitor any changes
- Trial name
- NCT04922398
- Testing
- platelet rich plasma, Normal saline
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ahmed Saad
Primary Ovarian Insufficiency, Premature Ovarian Failure
A Therapeutic Trial of Human Amniotic Epithelial Cells Transplantation for Primary Ovarian Failure
This project will clarify the safety and effectiveness of human amniotic epithelial cells transplantation for the treatment of primary ovarian failure (POF) patients and provide a new therapeutic method for patients with…
- Conditions
- Primary Ovarian Insufficiency, Premature Ovarian Failure, Infertility
- Trial name
- POF (NCT02912104)
- Testing
- human amniotic epithelial cells (hAECs) transplantation
- Where
- China
- Volunteers
- 36 people
- Sponsor
- International Peace Maternity and Child Health Hospital
Anti-Müllerian Hormone, Polycystic Ovarian Syndrome
Clinical Application of Serum Anti-Müllerian Hormone (AMH) Measurements
This study aims to assess the association of Anti-Müllerian hormone (AMH) with polycystic ovarian syndrome, premature ovarian insufficiency and fertility. The main objectives include the following: 1.
- Conditions
- Anti-Müllerian Hormone, Polycystic Ovarian Syndrome, Premature Ovarian Insufficiency, Fertility Issues
- Trial name
- NCT05858307
- Where
- Hong Kong
- Volunteers
- 300 people
- Sponsor
- Chinese University of Hong Kong
Premature Ovarian Failure (POF), Incipient Ovarian Failure
Pheno- & Genotyping POF (WHO III)
This study focuses on the phenotyping and genotyping of women with hypergonadotropic ovarian dysfunction (WHO III status).
- Conditions
- Premature Ovarian Failure (POF), Incipient Ovarian Failure, Poor Response After Ovarian Hyperstimulation, Early Menopause
- Trial name
- NCT01411644
- Where
- Netherlands
- Volunteers
- 650 people
- Sponsor
- UMC Utrecht
Premature Ovarian Failure
Levels of Selected Microelements in Premature Ovarian Insufficiency
Aim: To evaluate plasma/urine/hair Lead (Pb), Cadmium (Cd), Gadolinium (Gd), Arsenic (As), Mercury (Hg), Cobalt (Co), Vanadium (V), Titanium (Ti), Sulfur (S), Chromium (Cr), Silver (Ag), Molybdenum (Mo), Boron (B), Lithium (Li)…
- Trial name
- POI&MICROs (NCT04767451)
- Testing
- ultrasound assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cengiz Gokcek Women's and Children's Hospital
Autoimmune Disease, Infertility
Steroid Therapy in Autoimmune Premature Ovarian Failure
No therapy for infertile patients with premature ovarian failure has been proven effective. Some anecdotal reports have suggested that high dose, long term prednisone (steroid) therapy may be useful in treating autoimmune ovarian…
- Conditions
- Autoimmune Disease, Infertility, Premature Ovarian Failure
- Trial name
- NCT00001306
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Infertility, Premature Ovarian Failure
Single Follicular Dexarelix for LH Suppression During Ovarian Stimulation in Oocyte Donors.
A randomized prospective study in the evaluation of the long acting GnRH antagonist Degarelix against the classical multidose regime with Ganirelix for LH suppression during the follicular phase of an ovarian stimulation cycle in…
- Trial name
- NCT03861715
- Testing
- live birth rate
- Where
- Greece
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Assisting Nature
Autoimmune Prematur Ovarian Insuffience
Immunomodulatory Therapy to Restore Ovarian Function and Improve Fertility in Women With Autoimmune Premature Ovarian Insufficiency
Several autoimmune diseases such as Addison's disease are associated with failing ovarian function, known as premature ovarian insufficiency (POI), which can lead to early menopause and reduced fertility.The underlying cause of…
- Trial name
- REFINE (NCT07509840)
- Testing
- Rituximab (Arm A), Rituximab (Arm B)
- Where
- 2 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Angelica Lindén Hirschberg
Menopause
Bioidentical 'Natural' Hormone Evaluation in Early Menopause
Prospective double blind pilot study comparing bioidentical 'natural' hormones to low-dose PremPro. Forty participants will be enrolled.
- Trial name
- NCT00302731
- Testing
- Estradiol , estriol , progesterone, estradiol, progesterone, estriol, progesterone
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Jeanne Drisko, MD, CNS, FACN
Stem Cell Transplant Complications, Premature Ovarian Failure
Very Small Embryonic-like Stem Cells for Ovary
The aim of this study is the safety and efficacy of autologous very small embryonic-like stem cells(VSELs) to premature ovarian failure.
- Trial name
- NCT03985462
- Testing
- very small embryonic-like stem cell
- Where
- China
- Sponsor
- Fuda Cancer Hospital, Guangzhou
Primary Ovarian Insufficiency, Premature Ovarian Failure
The Impact of Granulocyte Colony Stimulating Factor on Premature Ovarian Insufficiency
The goal of this pilot study is to improve ovarian reserve markers in patients with premature ovarian insufficiency. The main question it aims to answer is: Will treatment with G-CSF allow improvement in markers of ovarian…
- Trial name
- NCT06117982
- Testing
- Neupogen
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Trio Fertility
Premature Ovarian Insufficiency, Diminished Ovarian Reserve
Precise Stratification of Genetic Risk of Ovarian Function Impairment
Aging is a common problem in human society at present. The fertility decline, perimenopausal symptoms and senile diseases caused by ovarian aging seriously affect women's own health, offspring's health, family and social…
- Conditions
- Premature Ovarian Insufficiency, Diminished Ovarian Reserve, Early Menopause
- Trial name
- NCT05665010
- Testing
- Genetic susceptibility
- Where
- 18 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Tongji Hospital
Primary Ovarian Insufficiency, Low Ovarian Reserve
Rejuvenation of Premature Ovarian Failure With Stem Cells
The ROSE-1 study is designed to determine the efficacy of bone marrow derived stem cell therapy on ovarian function recovery in subjects with idiopathic and other types of premature or primary ovarian failure (POF or POI) and low…
- Conditions
- Primary Ovarian Insufficiency, Low Ovarian Reserve, Premature Ovarian Failure
- Trial name
- ROSE-1 (NCT02696889)
- Testing
- ROSE-1 Protocol
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Illinois at Chicago
Premature Ovarian Failure
Evaluation of Physiologic and Standard Sex Steroid Replacement Regimens in Women With Premature Ovarian Failure
The aim of the study is to determine whether physiological sex steroid replacement improves parameters of skeletal, cardiovascular and reproductive health of women treated with current sex steroid replacement regimens.
- Trial name
- NCT00732693
- Testing
- Ethinylestradiol / Norethisterone, Estradiol / Progesterone
- Where
- 2 sites in United Kingdom
- Volunteers
- 42 people
- Sponsor
- University of Edinburgh
Premature Ovarian Failure (POF)
The Influence of Gut Microbiota on Ovarian Function: A Single-center, Randomized,Double Blind, Parallel-controlled, Exploratory Clinical Trial
In order to study the community profile of the intestinal microbiome in women with ovarian dysfunction, as well as the relationship between the changes in the intestinal microbiota and sex hormones, this study recruited 30 women…
- Trial name
- NCT07308327
- Testing
- Akk Gut Bacteria Supplement
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Songling Zhang
Premature Ovarian Insufficiency, Bone Diseases, Metabolic
The Bone Metabolism Characteristics of Premature Ovarian Insufficiency
Explore the bone metabolism characteristics of premature ovarian insufficiency.
- Conditions
- Premature Ovarian Insufficiency, Bone Diseases, Metabolic, Bone Mineral Density
- Trial name
- POI (NCT06339489)
- Testing
- Testing the serum levels of bone metabolic markers
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shi Yun
Hematopoietic Stem Cell Transplantation, Premature Ovarian Failure
A Multicenter Open-label Clinical Study on the Prevention of Premature Ovarian Failure After HSCT
HSCT is an effective method to cure hematologic malignancies. However, the reproductive system is prone to be damaged during radiotherapy and chemotherapy before transplantation, leading to ovarian failure, followed by…
- Trial name
- NCT05667428
- Testing
- leuprorelin, normal saline
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Primary Ovarian Insufficiency
Establishing of an Early Warming System of Premature Ovarian Insufficiency
Premature ovarian insufficiency (POI) is a clinical syndrome defined by loss of ovarian activity before the age of 40 years. The POI guideline development group of ESHRE recommends the following diagnostic criteria: oligo/…
- Trial name
- NCT03518944
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Primary Ovarian Insufficiency, Premature Menopause
Causes and Consequences of Primary Ovarian Insufficiency
100 women with primary ovarian insufficiency will be included for extensive diagnostic workup to improve diagnostic precision by extended autoantibody screening and genetic and toxicological testing.
- Trial name
- Clinical POI (NCT04082169)
- Where
- Norway
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Premature Ovarian Failure
Effects of an Estrogen Replacement Therapy Skin Patch on Ovulation in Women With Premature Ovarian Failure
This study will determine whether giving estrogen replacement therapy through an estradiol patch can improve ovulation rates in women with spontaneous premature ovarian failure.
- Trial name
- NCT00370019
- Testing
- Estradiol/Medroxyprogesterone acetate
- Where
- United States
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)