Clinical trials: Premature Menopause
Infertility
Use of a Calcium Channel Blocker to Prevent Premature Luteinizing Hormone Surges in Infertility Patients
Nimodipine (Nimotop® Bayer Pharmaceuticals Corporation), unlike other calcium channel blockers is fat soluble and therefore is able to cross the blood-brain barrier1.
- Trial name
- nimodipine (NCT01551368)
- Testing
- Nimodipine
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Mount Sinai Hospital, Canada
Premature Ovarian Insufficiency
Clinical Study of Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Premature Ovarian Insufficiency
This study was a single-center, randomized, controlled prospective study. Those who had premature ovarian failure and who had fertility requirements were enrolled in the study.
- Trial name
- NCT05308342
- Testing
- transplantation of human UC-MSCs into ovaries of POI patients, hormone replacement treatment
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Li-jun Ding
Infertility, Female, Premature Ovarian Failure
Second Step Protocol in Poor Ovarian Responder (POR)
Reduced ovarian reserve and the consequent poor ovarian response are very recurent in infertile patients, indeed a percentage of 10%-24% of couples addressed to infertility program may be classified as Poor Ovarian Responder…
- Conditions
- Infertility, Female, Premature Ovarian Failure, Fertility Disorders
- Trial name
- POR (NCT03480412)
- Testing
- Follicular Phase, Luteal Phase
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Università degli Studi 'G. d'Annunzio' Chieti e Pescara
Premature Ovarian Insufficiency
Hormone Replacement Therapy in Adolescents With Premature Ovarian Insufficiency
Background: Premature ovarian insufficiency (POI) is a condition in which women under the age of 40 years have absent or irregular menstrual cycles. POI can cause infertility, signs of menopause, osteoporosis, and other symptoms.
- Trial name
- NCT06851754
- Testing
- Progesterone, Estrogen Patch
- Where
- United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Menopause, Testosterone Deficiency
Estradiol and Testosterone Subdermal Implants for Menopause Treatment (ESTIME)
Estrogen and androgen deficiencies negatively impact the quality of life of women at different stages of life, especially after menopause. New modalities and new therapeutic alternatives have been researched.
- Conditions
- Menopause, Testosterone Deficiency, Estrogen Deficiency
- Trial name
- ESTIME (NCT06343870)
- Testing
- testosterone pellet (100 mg)
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- University of Sao Paulo General Hospital
Fertility Disorders, Turner Syndrome
The Danish TURNER Cryopreservation Study
The goal of this clinical trial is to investigate if cryopreservation of ovarian tissue in girls with Turner syndrome can improve their fertility and lead to increased number of liveborn babies of Turner syndrome mothers.
- Conditions
- Fertility Disorders, Turner Syndrome, Premature Ovarian Failure
- Trial name
- DANTE (NCT05740579)
- Testing
- laparoscopic cryopreservation of one ovary
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Premature Ovarian Insufficiency
Phase Ⅰ/Ⅱa Trial Evaluating Intravenous hUC-MSCs Injection for Safety, Tolerability and Efficacy in Patients With POI
A Phase I/IIa clinical study evaluating the safety, tolerability and efficacy of intravenously administered human umbilical cord mesenchymal stem cell (hUC-MSCs) injection in patients with premature ovarian insufficiency (POI).
- Trial name
- NCT07775391
- Testing
- hUC-MSCs Injection (Phase I), hUC-MSCs Injection (Phase IIa)
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Shenzhen Wingor Biotechnology Co., Ltd.
Triple Negative Breast Cancer (TNBC)
Evaluating Ovarian Toxicity Outcomes Following Immunotherapy in Patients With Triple-Negative Breast Cancer (TNBC)
This study aims to collect information about the effects of chemotherapy combined with immunotherapy (immune checkpoint inhibitors) for early-stage triple-negative breast cancer (TNBC) on ovarian function and fertility.
- Trial name
- FERTILE (NCT07527819)
- Where
- 9 sites in Australia
- Volunteers
- 75 people
- Sponsor
- Peter MacCallum Cancer Centre, Australia
Premature Ovarian Insufficiency, Diminished Ovarian Reserve
A Proof of Concept Study to Evaluate Exosomes From Human Mesenchymal Stem Cells in Women With Premature Ovarian Insufficiency (POI)
The VL-POI-01 study is designed to evaluate the safety and efficacy of human placental mesenchymal stem cell derived exosome treatment in patients with premature ovarian insufficiency (POI) and diminished ovarian reserve.
- Trial name
- VL-POI-01 (NCT06072794)
- Testing
- VL-PX10
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Vitti Labs, LLC
Hot Flushes, Menopause, Premature
The Role of Vitamin D in Menopause: Relationship to Menopausal Symptoms in Body Composition
Specific Aim 1: To compare effects of Vitamin D supplementation to usual care on symptoms in women transitioning to early postmenopause and determine the associated effect size in order to conduct a power analysis for a future…
- Conditions
- Hot Flushes, Menopause, Premature, Obesity, Vitamin D Deficiency
- Trial name
- FLASH (NCT01141972)
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Premature Ovarian Failure
Ovarian Injection of PRP (Platelet -Rich Plasma) Vs Normal Saline in Premature Ovarian Insufficiency
60 cases with premature ovarian insufficiency will be randomized to either receive PRP or saline injection in their ovaries. Then follow up by hormonal \& ultrasound \& clinically to monitor any changes
- Trial name
- NCT04922398
- Testing
- platelet rich plasma, Normal saline
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ahmed Saad
Activation of Primordial Follicles
In Vitro Follicle Activation in Patient With Premature Ovarian Failure Under 36 Years Old
This is a clinical trial that the investigators aim to validate In-vitro Activation (IVA) treatment protocol, which was previously defined by Kazuhiro Kawamura (MD) and Aaron Hsueh (PhD), in Turkish patient with Premature Ovarian…
- Trial name
- NCT04131244
- Testing
- In vitro activation of primordial follicles by PTEN inhibitor and AKT stimulator
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- Hacettepe University