Clinical trials: Premature Newborn
Infant, Newborn, Infant, Premature
Determining an Optimal Weaning Method of Nasal Continuous Positive Airway Pressure in Preterm Neonates
The purpose of this study is to determine an optimal strategy to wean nasal continuous positive airway pressure (NCPAP) in preterm babies.
- Trial name
- NCT02064712
- Testing
- Low CPAP Wean, High CPAP Wean
- Where
- United States
- Volunteers
- 226 people
- Sponsor
- University of Texas Southwestern Medical Center
Premature Birth
Facilitating Safe Transition to Home for Preterm Infants - a National Database Study
Preterm infants (i.e. born before 37 completed weeks of pregnancy) often require additional care and are admitted to neonatal units.
- Trial name
- NCT06284044
- Where
- United Kingdom
- Volunteers
- 250,000 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Infant, Premature, Diseases
Multisensory Early Oral Administration of Human Milk (M-MILK) for Very Preterm Infants
The goal of this clinical trial is to learn if the multisensory early oral administration of human milk (M-MILK) intervention helps infants who are born younger than 32 weeks gestational age (very preterm infants).
- Trial name
- M-MILK RCT (NCT07216664)
- Testing
- Multisensory early oral administration of human milk
- Where
- 2 sites in United States
- Volunteers
- 125 people
- Sponsor
- Loyola University
Kangaroo Care, Fathers
The Effect of Kangaroo Care on Parents' Perceived Parenting Self-Efficacy, Infant Attachment and Newborn Vital Signs
This study was planned to determine the effect of kangaroo care applied by parents of premature newborns in the neonatal intensive care unit on the newborn's vital signs, perceived parenting self-efficacy level and attachment to…
- Conditions
- Kangaroo Care, Fathers, Mother-Infant Interaction, Premature Infant
- Trial name
- NCT06320587
- Testing
- Kangaroo care practice by both mother and father, Kangaroo care practice only mother
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Retinopathy of Prematurity
Safety and Efficacy of Propranolol 0.2% Eye Drops in Treating Retinopathy of Premature: A Pilot Study (DROP-ROP-0.2%)
The aim of the present study is to evaluate the safety and efficacy of propranolol 0.2% eye drops in treating preterm newborns with a precocious stage of retinopathy of prematurity (ROP).
- Trial name
- NCT02504944
- Testing
- Propranolol 0.2% eye drops
- Where
- 7 sites in Italy
- Volunteers
- 98 people
- Sponsor
- Meyer Children's Hospital IRCCS
Gastro Esophageal Reflux
Effect of Right Lateral Position on Ventilated Preterm Neonates
Objective: to evaluate the effect of right lateral positioning in comparison with supine positioning on tracheal aspirate pepsin levels as a marker of aspiration of gastric contents in ventilated preterm neonates.
- Trial name
- NCT03258528
- Testing
- positioning
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Hypothermia, Newborn, Preterm Birth Complication
Umbilical or Peripheral Catheter Insertion for Preterm Infants on Admission to the NICU
Preterm infants are at risk of hypothermia following delivery and in the first few hours of life. Hypothermia in extremely low birth weight infants' is an independent risk factor for death.
- Conditions
- Hypothermia, Newborn, Preterm Birth Complication, Neonatal Hypothermia
- Trial name
- UP (NCT04761484)
- Testing
- Vascular access on admission
- Where
- Ireland
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Neonatal Respiratory Distress, Lung Ultrasound Score
Predictive Value of Lung Ultrasound Combined With Serum ANGPL4 Levels for NICU Admission Needs in Late Preterm and Term Neonates With Respiratory Distress In The Transion Period
The aim of this study is to evaluate the validity of point-of-care lung ultrasound (POC-LUS) and serum ANGPL4 levels for predicting NICU admission needs in late preterm and full-term neonates with respiratory distress shortly…
- Trial name
- NCT07809971
- Testing
- Point of care lung ultrasound (POC-LUS), Serum ANGPTL4
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Extreme Prematurity, Neurodevelopmental Abnormality
Osteopathic Manipulative Medicine to Reduce Developmental Delays
This randomized clinical trial seeks to determine if osteopathic manipulative medicine (OMM) increases the likelihood of improved neurodevelopmental outcomes as estimated by the Test of Infant Motor Performance (TIMP).
- Trial name
- NCT04652063
- Testing
- Osteopathic Manipulative Medicine
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Bronchopulmonary Dysplasia
Assessment of Lung Aeration at Birth
To determine if respiratory support at birth guided by RFM decreases BPD.
- Trial name
- NCT01739114
- Testing
- "IPPV group", SI group
- Where
- Canada
- Volunteers
- 186 people
- Sponsor
- University of Alberta
Premature Birth, Feeding; Difficult, Newborn
Effects of a Valved Feeding System in Late-preterm Newborns: the Safe Oral Feeding Trial
Comparing with a randomized controlled trial two different feeding systems in two groups of late-preterm newborns for evaluating which is more efficient in promoting the coordination in the process of sucking-swallowing-breathing…
- Conditions
- Premature Birth, Feeding; Difficult, Newborn, Feeding, Bottle
- Trial name
- SOFT (NCT04400175)
- Testing
- Valved ergonomic teat, Standard silicon teat
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Turin, Italy
Premature Newborn, Necrotizing Enterocolitis
Defining Normal Citrulline Levels as a Diagnostic Tool for Screening of Gastrointestinal Disease in Premature Infants
Since the first description of citrulline as a potential marker for intestinal function in 1998, its use has been investigated in a variety of disease processes including Short Bowel Syndrome, Celiac disease, chemotherapy and…
- Trial name
- NCT01062828
- Testing
- Citrulline samples
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Miami
Retinopathy of Prematurity
Antiangiogenic Therapy With Bevacizumab in Retinopathy of Prematurity. Structural Outcome
Purpose:Retinopathy of prematurity (ROP) continues tobe a major cause of blindness in children. Although ablation of the retina with laser or cryotherapy reduces the incidence of blindness by suppressing the neovascular phase of…
- Trial name
- NCT00346814
- Testing
- intravitreal injection
- Where
- Mexico
- Sponsor
- Asociación para Evitar la Ceguera en México
Turner Syndrome, Hypogonadism
Estrogen Dosing in Turner Syndrome: Pharmacology and Metabolism
Estrogen is necessary for feminization during puberty and to decrease bone resorption, the latter critical for the achievement of peak bone mass and normal bone health in the female.
- Conditions
- Turner Syndrome, Hypogonadism, Premature Ovarian Failure
- Trial name
- NCT00837616
- Testing
- 17 B estradiol orally, 17 B estradiol
- Where
- 3 sites in United States, Chile
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Bronchopulmonary Dysplasia, Prematurity
Impact of Extended CPAP on Bronchopulmonary Dysplasia
The purpose of this pilot study is to compare if keeping infants on CPAP (continuous positive airway pressure) support for an extended period of time until they are 32 weeks corrected gestational age or 1250 grams (approximately…
- Trial name
- NCT05547139
- Testing
- Protocolized weaning of respiratory support
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
PreTerm Neonate, Positive End Expiratory Pressure (PEEP)
PEEP FOR LUNG RECRUITMENT IN PRETERM INFANTS-EIT STUDY
Babies born early (under 32 weeks) are at risk of developing lung problems after birth. A major reason for this is that the lungs are not fully developed.
- Conditions
- PreTerm Neonate, Positive End Expiratory Pressure (PEEP), Lung Recruitment, Electrical Impedance Tomography (EIT)
- Trial name
- [PEOPLE] (NCT06705257)
- Testing
- Studying the effects of varying levels of PEEP using Electrical impedance tomography
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- South Tees Hospitals NHS Foundation Trust
Bronchopulmonary Dysplasia, Encephalomalacia
Randomized Trial of Hydrocortisone in Very Preterm High-Risk Infants
The purpose of this study is to determine whether treatment of very preterm infants at high-risk for lung and brain injury with low dose hydrocortisone results in improved pulmonary and neurologic outcomes.
- Conditions
- Bronchopulmonary Dysplasia, Encephalomalacia, Premature Birth
- Trial name
- NCT00167544
- Testing
- Hydrocortisone
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Nationwide Children's Hospital
Transient Tachypnoea of the Newborn
Study Protocol Evaluating Transient Tachypnoea of the Newborn in Term and Near Term Neonates
Transient tachypnoea of the newborn (TTN) is a common cause of hospitalisation in the neonatal period, complicating 1 to 1,5 per cent life birth.
- Trial name
- NCT00213941
- Testing
- Echocardiography
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Infant,Premature, Feeding; Difficult, Newborn
Nifty Feeding Cup Versus Generic Medicine Cup Preterm Infants Who Have Difficulty Breastfeeding
The investigators will establish an evidence base for the Nifty Feeding Cup by evaluating its effectiveness and caregiver satisfaction.
- Trial name
- NCT03280381
- Testing
- Nifty feeding cup, Generic medicine cup
- Where
- Ghana
- Volunteers
- 200 people
- Sponsor
- PATH
Premature Infants, Intracranial Hemorrhages
Effect of Erythropoietin in Premature Infants on White Matter Lesions and Neurodevelopmental Outcome
Preterm and very preterm infants are at risk of developing encephalopathy of prematurity and long-term neurodevelopmental delay.
- Conditions
- Premature Infants, Intracranial Hemorrhages, Periventricular Leukomalacia, Cerebral Palsy
- Trial name
- NCT03110341
- Testing
- Erythropoietin, Normal saline
- Where
- China
- Volunteers
- 400 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University