Clinical trials: Premature Ovarian Failure
Early Menopause
Singapore Population Research on Integrated exposoMe & Early Menopause
Brief Summary The goal of this observational study is to learn how environmental factors, lifestyle choices, and social conditions affect the timing of menopause in Asian women aged 40-50 years living in Singapore.
- Trial name
- SG-PRIME (NCT07100639)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Primary Ovarian Insufficiency, Unexplained Infertility
Study of Oral Dehydroepiandrosterone(DHEA) to Treat Previously Unexplained Infertility
The experimental focus of this project is on the interaction of DHEA treatment on pregnancy in women with otherwise unexplained infertility and evidence of premature ovarian aging (POA).
- Trial name
- DHEAFert (NCT00650754)
- Testing
- Dehydroepiandrosterone
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Familial Premature Ovarian Failure
Genetic Analysis of Familial Cases of Premature Ovarian Failure
The Premature ovarian failure (POF) is a rare syndrome observed in women under 40 who induced estrogen deficiency and often leads to infertility final. The etiologies of POF remain unknown in more than 85% of cases.
- Trial name
- FAMIOP (NCT01177891)
- Where
- 2 sites in France
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Premature Ovarian Insufficiency
Effect and Mechanism of Jiajian Guishen Optimized Formula on Premature Ovarian Insufficiency: Insights Into m6A Modification and Oxidative Stress
The goal of this clinical study is to evaluate the effectiveness of JiaJian GuiShen Optimized Formula (JJGS) and explore its mechanisms involving m6A modification and oxidative stress in women with premature ovarian insufficiency…
- Trial name
- JJGS ; POI (NCT07843030)
- Testing
- JJGS
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Shi Yun
Turner Syndrome, Ovarian Failure, Premature
Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure
Premature ovarian failure (POF) is known to be associated with an increased risk of ocular surface disease (dry eye), likely due to the reduction of both estrogens and androgens seen in this condition.
- Conditions
- Turner Syndrome, Ovarian Failure, Premature, Sex Chromosome Aberrations, Menopause
- Trial name
- NCT00471731
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Oxidative Stress, Ovarian Insufficiency, Primary
Ovarian Reserve and Matrix Metalloproteinases
Primary Ovarian Insufficiency (POI) is dysfunction of ovaries before 40 years of age. It has been reported that genetic factors, endocrine disorders, previous pelvic surgeries, chemotherapy and radiotherapy, and autoimmune…
- Conditions
- Oxidative Stress, Ovarian Insufficiency, Primary, Ovarian Failure, Premature
- Trial name
- NCT05443282
- Testing
- Prolidase Level, Follicle Stimulating Hormone Level, Estradiol Level
- Where
- Turkey (Türkiye)
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Menopausal Syndrome
Early Menopause Hormone Treatment and Cognition
The objective of this study is to evaluate the neurobiological effects of hormone therapy (HT) in healthy early postmenopausal women.
- Trial name
- R21 (NCT01046643)
- Testing
- Estradiol (E2), Progesterone (P10) x90, Progesterone (P10) x10
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Premature Ovarian Failure
X-Chromosome Inactivation Status and Premature Ovarian Failure
Women who are affected with premature ovarian failure will exhibit skewed X-chromosome inactivation patterns compared to women with normal menstrual function (as defined by being pregnant), indicating a possible X-chromosome…
- Trial name
- NCT00295087
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Infertility, Premature Ovarian Failure
Modified Natural Cycle Offers a Chance of Pregnancy in Patients With Poor Response and High Basal FSH
The purpose of this study is to evaluate the effectiveness of a modified natural cycle in patients with previous poor response to infertility drugs and high basal FSH, prior to proceeding to oocyte donation or abandoning…
- Trial name
- NCT00417157
- Testing
- recombinant FSH (Puregon, Organon, The Netherlands), GnRH antag: Ganirelix (Orgalutran, Organon, The Netherlands), hCG (Pregnyl, Organon, The Netherlands)
- Where
- Greece
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Eugonia
Menstrual Disorder, Premature Ovarian Failure
The Effect of HPV Vaccine on Menstrual Cycle in Women of Reproductive Age
Cervical cancer is one of the most common cancer in women, making it the fourth largest cause of female cancer mortality worldwide.
- Trial name
- NCT05838157
- Testing
- prophylactic HPV vaccine(bivalent HPV、quadrivalent HPV、9-valent HPV)
- Where
- 2 sites in China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Primary Ovarian Insufficiency, Genetic Predisposition to Disease
Genetic Etiology in Premature Ovarian Insufficiency
Premature Ovarian Insufficiency (POI), first described by Albright in 1942, is defined as an increase in Follicle Stimulating Hormone (FSH), an insufficiency of the ovarian function leading to an early menopause (<40 years of…
- Trial name
- POI (NCT01973075)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- BEGUM AYDOGAN
Healthy, Osteoporosis
Hormone Replacement in Young Women With Premature Ovarian Failure
The human ovary produces male sex hormones (androgen) and female sex hormones (estrogen). Currently, androgen is not included in hormone replacement therapy for women with premature ovarian failure.
- Conditions
- Healthy, Osteoporosis, Premature Ovarian Failure
- Trial name
- NCT00001951
- Testing
- TMTDS
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Osteoporosis
Effects of Phytoestrogen-rich Diets on Bone Turnover in Postmenopausal Women
Osteoporosis is a major health problem. It was hypothesized that isoflavone-containing products may be a potential alternative to HRT for preventing bone loss during the menopausal transition.
- Trial name
- NCT00301353
- Testing
- Isoflavones-enriched foods
- Where
- 3 sites in France, Italy and 1 more
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- TNO
Dysfunction; Endocrine, Effects of Chemotherapy
Blood Spot Self-administered Test and Assay
The current study will compare hormone levels of AMH, FSH and inhibin B in blood specimens collected by venipuncture and fingerstick in a sample of pre-menopausal women ages 18-45 years with normal menstrual cycles.
- Conditions
- Dysfunction; Endocrine, Effects of Chemotherapy, Premature Ovarian Failure
- Trial name
- NCT03840824
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Primary Ovarian Insufficiency
Ovarian Laparoscopic In Vivo Activation of Ovary for Premature Ovarian Insufficiency
The OLIVA device will enable to perform shallow slashes on the ovarian cortex in patients undergoing oophorectomy. Prior to the resection of the ovary from the pedicle we will perform 5 parallel slashes 3 cm long.
- Trial name
- OLIVA (NCT03034616)
- Testing
- OLIVA device
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Premature Ovarian Failure
Premature Ovarian Failure (Genetic and Physiopathologic Analysis)
Premature Ovarian Failure (POF), syndrome observed in young woman, present consequences on hormonal and leads at definitive infertility.
- Trial name
- GéNIOP (NCT00780897)
- Where
- France
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Early Menopause, Menopause
Influence of Early Menopause on Sympathetic Activation and Cardiovascular Function in Older Women
Women who enter menopause early are at a greater risk for developing cardiovascular disease later in life as compared to women with normal onset of menopause.
- Trial name
- NCT03692572
- Testing
- Nitrate supplementation
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Perimenopausal Disorder, Menopause
Inovium Ovarian Rejuvenation Trials
The Inovium Ovarian Rejuvenation Treatment is a PRP-based autologous treatment used in combination with a stimulated IVF sequence and Pre-Implantation Genetic Screening to treat infertility in women experiencing menopause…
- Conditions
- Perimenopausal Disorder, Menopause, Menopause, Premature, Menopause Related Conditions
- Trial name
- NCT03178695
- Testing
- Autologous PRP injection into human ovarian tissue
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ascendance Biomedical
Hypertension, Menopause, Premature
Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women
This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) women.
- Conditions
- Hypertension, Menopause, Premature, Menopause, Blood Pressure
- Trial name
- NCT04439370
- Testing
- Microneurography to measure muscle sympathetic nerve activity (MSNA), Baroreflex sensitivity testing, Sympathoexcitatory Maneuvers
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Infertility, IVF
Will Autologous Platelet Rich Plasma Able To Restore Ovarian Function?
A-PRP (Autologous Platelet Rich Plasma) is becoming widely used in a variety of medical procedures seeking tissue remodeling and/or healing as an intervention.
- Conditions
- Infertility, IVF, Premature Ovarian Failure, Anti-Mullerian Hormone Deficiency
- Trial name
- NCT04381299
- Testing
- autologous platelet rich plasma, saline solution
- Where
- United Arab Emirates
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC