Clinical trials: Premature Ovarian Failure
Premature Ovarian Insufficiency
4-step ASCOT in POI Women to Promote Follicular Rescue
To promote follicular development in POI women, G-CSF mobilized activated platelet rich plasma will be directly injected into the ovarian medulla.
- Trial name
- NCT04475744
- Testing
- G-CSF treatment for Bone marrow derived stem cell Mobilization, Platelet Rich Plasma ovarian injection
- Where
- 2 sites in Spain
- Volunteers
- 42 people
- Sponsor
- Fundación IVI
Early Menopause, Cancer
Improving Outcomes in Early Menopause After Cancer
The goal of this study is to create and test a new program led by nurse navigators to help women who experience early menopause after cancer.
- Conditions
- Early Menopause, Cancer, Premature Menopause, Surgical Menopause
- Trial name
- NCT06982677
- Testing
- Nurse Navigator Intervention, Education Control
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Duke University
Amenorrhea, Hypoaldosteronism
Ovarian Follicle Function in Patients With Primary Ovarian Failure
No proven therapy to restore ovarian function and fertility is available to patients with karyotypically normal spontaneous premature ovarian failure.
- Conditions
- Amenorrhea, Hypoaldosteronism, Hypogonadism, Infertility
- Trial name
- NCT00001275
- Where
- United States
- Volunteers
- 1,134 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Premature Ovarian Failure
Ovarian Injection of PRP (Platelet -Rich Plasma) Vs Normal Saline in Premature Ovarian Insufficiency
60 cases with premature ovarian insufficiency will be randomized to either receive PRP or saline injection in their ovaries. Then follow up by hormonal \& ultrasound \& clinically to monitor any changes
- Trial name
- NCT04922398
- Testing
- platelet rich plasma, Normal saline
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ahmed Saad
Acute Leukemia
Gynecological Impact of Allogeneic Hematopoietic Stem Cell Transplantation in Adults
Gynecological impact and infertility are major issues for women after allogeneic hematopoietic stem cell transplantation. The aim of the present study is to investigate the prevalence of gynecological complications after…
- Trial name
- GYNEGRAFT (NCT07048730)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 51 people
- Sponsor
- University Hospital, Bordeaux
Breast Cancer
Evaluation of Individual Sensitivity to the Gonadotoxicity of Chemotherapy in Young Patients With Breast Cancer
Over the past decade, advances in diagnosis and treatments have dramatically increased the rates of cure for young patients with cancer.
- Trial name
- ESIGON (NCT03731845)
- Testing
- Blood sample for genetic test, Blood sample for hormonal measurement, Ovarian ultrasound scan
- Where
- France
- Volunteers
- 73 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Premature Ovarian Failure
Dehydroepiandrosterone (DHEA) Treatment and Premature Ovarian Failure (POF)
The experimental focus of this project is on the interaction of DHEA treatment on pregnancy in women with open tubes, fertile male partners and evidence of premature ovarian failure.
- Trial name
- DHEAFert2 (NCT00948857)
- Testing
- Dehydroepiandrosterone
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- David H. Barad
Premature Ovarian Failure (POF)
Evaluation of Child Desire in Young Women With Premature Ovarian Failure
Premature ovarian failure (POF) is a rare condition, affecting 1 in 10,000 women before age 20 and 1 in 1,000 women before age 30. The two main causes of POF are congenital and acquired.
- Trial name
- DESIOP (NCT04881695)
- Testing
- Questionary patients, Questionary controls
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Menopause, Testosterone Deficiency
Estradiol and Testosterone Subdermal Implants for Menopause Treatment (ESTIME)
Estrogen and androgen deficiencies negatively impact the quality of life of women at different stages of life, especially after menopause. New modalities and new therapeutic alternatives have been researched.
- Conditions
- Menopause, Testosterone Deficiency, Estrogen Deficiency
- Trial name
- ESTIME (NCT06343870)
- Testing
- testosterone pellet (100 mg)
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- University of Sao Paulo General Hospital
Menopause, Menopausal Hormone Therapy
A Retrospective and Prospective Clinical Registry for Data Collection of Perimenopausal, Menopausal and Premature Ovarian Insufficiency Women
This study is designed as on observational, retrospective, and prospective clinical registry aimed at collecting comprehensive real-world data on women in perimenopause, menopause, and with premature ovarian insufficiency (POI)…
- Conditions
- Menopause, Menopausal Hormone Therapy, Menopause Surgical, Menopause Related Conditions
- Trial name
- NCT07606326
- Volunteers
- 5,000 people
- Sponsor
- IRCCS San Raffaele
Premature Ovarian Insufficiency
Ventricular Repolarization in Patients With Premature Ovarian Insufficiency (QTIOP)
Ventricular repolarization, measured by corrected QT interval (QTc), is influenced by sex hormones. A QTc above 460msec predisposes to the risk of "torsades-de-pointes"(TdP).
- Trial name
- QTIOP (NCT04167033)
- Testing
- Hormone replacement therapy:effect on ventricular repolarization, ECG
- Where
- 3 sites in France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ovarian Failure, Premature Ovarian Failure
Ovarian Fragmentation Study (Crespo Medical Team)
This is a study designed to validate Kawamura´s theory and investigation of activation of primordial follicles through ovarian cortex fragmentation.
- Conditions
- Ovarian Failure, Premature Ovarian Failure, IVF
- Trial name
- NCT04306185
- Testing
- OVARIAN FRAGMENTATION
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Equipo Juana Crespo
Early Menopause, Menopause
Influence of Early Menopause on Sympathetic Activation and Cardiovascular Function in Older Women
Women who enter menopause early are at a greater risk for developing cardiovascular disease later in life as compared to women with normal onset of menopause.
- Trial name
- NCT03692572
- Testing
- Nitrate supplementation
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Infertility, Polycystic Ovary Syndrome
A New Algorithm to Predict Ovarian Age
To collect data of clinical, biochemical and 3D-ultrasonographic parameters of a population of fertile women aged 18-55 in order to design a new algorithm able to predict ovarian age and to evaluate the reliability of a…
- Conditions
- Infertility, Polycystic Ovary Syndrome, Premature Ovarian Failure (POF), Ovarian Cysts
- Trial name
- OvAge (NCT02086318)
- Testing
- OvAge assessment
- Where
- Italy
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- University Magna Graecia
Premature Ovarian Failure
Autologous ADMSC Transplantation in Patients With POI
The primary ovarian insufficiency (premature ovarian failure, premature ovarian insufficiency, premature menopause) is a hypergonadotropic hypogonadism, that failure of the ovarian function in woman younger than 40 years.
- Trial name
- ADMSC (NCT06132542)
- Testing
- stem cell therapy
- Where
- Mongolia
- Volunteers
- 10 people
- Sponsor
- Mongolian National University of Medical Sciences
Primary Ovarian Insufficiency, Female Infertility Due to Diminished Ovarian Reserve
Effect of Testosterone Treatment on Embryo Quality
The purpose of this study is to determine the effect of treatment with trans-dermal testosterone cream compared to placebo on measures of ovarian reserve, oocyte and embryo quality, and pregnancy rates among women with evidence…
- Trial name
- NCT01662466
- Testing
- Testosterone cream (0.5mg per gram), DHEA
- Where
- 2 sites in United States
- Volunteers
- 180 people
- Sponsor
- Center for Human Reproduction
Turner Syndrome, Primary Ovarian Insufficiency (Poi)
Bleeding Patterns in Sequential and Continuous Progesterone Supplementation in Adolescents With Turner Syndrome
This is a single-site open label non-randomized study comparing effects of sequential versus continuous use of progesterone supplementation amongst Turner Syndrome (TS) patients with primary ovarian insufficiency (POI) prescribed…
- Trial name
- BOOST (NCT06834594)
- Testing
- Micronized progesterone 200 MG, Micronized Progesterone 100 MG
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Mercy Hospital Kansas City
Premature Ovarian Insufficiency
Women's Experience of Premature Ovarian Insufficiency (POI) Diagnosis: Update on Actual Practices and Patient's Follow up
Premature ovarian insufficiency (POI) affects 2,8 to 3,5% of women before the age of 40. Previous foreign studies revealed that only half of POI disclosures occurred during a medical consultation and that the diagnosis was often…
- Trial name
- EMPOIHER (NCT06228547)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 101 people
- Sponsor
- University Hospital, Bordeaux
Primary Ovarian Insufficiency, Premature Menopause
Effects of Estrogen on Heart Health in Women With Primary Ovarian Insufficiency
The goal of this observational study is to study the effects of treating women with Primary Ovarian Insufficiency (POI) with estrogen replacement therapy to bolster the evidence backing cardiometabolic preventive care in women…
- Conditions
- Primary Ovarian Insufficiency, Premature Menopause, Metabolic Complications, Endothelial Function (FMD)
- Trial name
- ENCODE (NCT06866119)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Primary Ovarian Insufficiency
Development a Predictive Nomogram for Primary Ovarian Insufficiency
The purpose of this research is to develop a predictive nomogram for primary ovarian insufficiency.
- Trial name
- NCT02795000
- Where
- China
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Guangzhou University of Traditional Chinese Medicine