Clinical trials: Premature Ovarian Failure
Premature Ovarian Failure
Endocan Levels in Women With Premature Ovarian Insufficiency
Objective: To evaluate serum endocan levels in women with premature ovarian insufficiency (POI) and to compare the results with those of healthy subjects.
- Trial name
- Endocan&POI (NCT03924648)
- Testing
- Endocan levels
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people
- Sponsor
- Cengiz Gokcek Women's and Children's Hospital
Turner Syndrome, Hypogonadism
Estrogen Dosing in Turner Syndrome: Pharmacology and Metabolism
Estrogen is necessary for feminization during puberty and to decrease bone resorption, the latter critical for the achievement of peak bone mass and normal bone health in the female.
- Conditions
- Turner Syndrome, Hypogonadism, Premature Ovarian Failure
- Trial name
- NCT00837616
- Testing
- 17 B estradiol orally, 17 B estradiol
- Where
- 3 sites in United States, Chile
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Female Infertility Due to Diminished Ovarian Reserve
Human Growth Hormone Pre-treatment for 6 Weeks Prior to Ovulation Induction for IVF
Synthetic human growth hormone (HGH) has been available for more than a decade for specific indication in children and adults. Past Randomized Control Trials (RCT)s of HGH (under off-label use) for improving ovarian function have…
- Trial name
- NCT02179255
- Testing
- Human Growth Hormone, Follicle Stimulating Hormone
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Center for Human Reproduction
Women's Health: Neoplasm of Breast, Menopause, Premature
Nurse-led Mind-body Intervention on Sexual Health for Breast Cancer Survivors
The goal of this clinical trial is to test the efficacy of a nurse-led psychoeducational sexual health intervention for young women breast cancer survivors. The main questions it aims to answer are: 1.
- Conditions
- Women's Health: Neoplasm of Breast, Menopause, Premature, Body Image, Sexual Dysfunction
- Trial name
- NCT06307470
- Testing
- EMBRACE (Empowerment through Mind and Body Reclamation After Cancer Experience)
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Arkansas
Cognitive Impairment, RRSO
IMProving Executive Function Study
This is a double-blind, placebo-controlled, crossover study testing whether Vyvanse (lisdexamfetamine; LDX) improves executive functioning (EF) in 100 postmenopausal women who report onset of EF difficulties after oophorectomy.
- Trial name
- IMPRES (NCT03187353)
- Testing
- Lisdexamfetamine
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Osteoporosis
Effects of Phytoestrogen-rich Diets on Bone Turnover in Postmenopausal Women
Osteoporosis is a major health problem. It was hypothesized that isoflavone-containing products may be a potential alternative to HRT for preventing bone loss during the menopausal transition.
- Trial name
- NCT00301353
- Testing
- Isoflavones-enriched foods
- Where
- 3 sites in France, Italy and 1 more
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- TNO
Premature Ovarian Failure
Human Amniotic Epithelial Cells Treatment for Ovarian Insufficiency
This project will investigate the safety and effectiveness of human amniotic epithelial cells in primary ovarian insufficiency patients and provide a new cell therapy against infertility.
- Trial name
- NCT03207412
- Testing
- hAECs, Minimally invasive implantation
- Volunteers
- 20 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Premature Ovarian Failure
Platelet Rich Plasma Injection Into Ovary of Patients With Premature Ovarian Insufficiency
All encountered cases with POI will be assessed and examined then investigated. Eligible cases will be included in the study
- Trial name
- NCT04149028
- Testing
- PRP injection inside the ovary by laparoscoy. The injection volume is 2 ml
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Tanta University
Ovarian Insufficiency
Deep Reading as a Contemplative Practice for Women With Primary Ovarian Insufficiency
Background: Women with Primary Ovarian Insufficiency (POI) have ovaries that stopped working normally before they turned 40. This usually causes infertility, which challenges many women with the condition to ask themselves, Why…
- Trial name
- NCT02181595
- Testing
- Group reading and discussion
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Breast Cancer
Goserelin Acetate Study for Ovarian Function in Patients With Primary Breast Cancer
Primary Objective: To determine the effectiveness of goserelin acetate (Zoladex) in preserving ovarian function in premenopausal women undergoing neoadjuvant and/or adjuvant chemotherapy for primary invasive breast cancer by…
- Trial name
- NCT00429403
- Testing
- Goserelin
- Where
- 2 sites in United States, Japan
- Volunteers
- 1 people
- Sponsor
- M.D. Anderson Cancer Center
Galactosemia, Premature Ovarian Failure
Inactive FSH in Galactosemia
The aim of the study is to investigate whether inactive FSH plays a role in the development of Premature Ovarian Failure in women with Classic Galactosemia
- Trial name
- NCT00619333
- Testing
- follitropin and lutropin
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Maastricht University Medical Center
Premature Ovarian Failure
Autologous Adipose Derived Mesenchymal Stromal Cells Transplantation in Women With Premature Ovarian Failure (POF)
The goal of this study is to determine safety and tolerability and of intra-ovarian injection of adipose derived stromal cell in women with premature ovarian failure and to study the preliminary efficacy ADSCs intra ovarian…
- Trial name
- NCT02603744
- Testing
- Intraovarian injection of Adipose derived Stromal cells (ADSCs)
- Where
- Iran
- Volunteers
- 9 people
- Sponsor
- Royan Institute
Premature Ovarian Insufficiency
Efficacy and Safety of Huanjingjian Decoction in Women With Premature Ovarian Insufficiency
Study Summary This clinical trial aims to evaluate the efficacy and safety of the traditional Chinese herbal formula Huanjingjian decoction in women with premature ovarian insufficiency (POI).
- Trial name
- EAST-HOPE (NCT07020429)
- Testing
- Huanjingjian decoction, Hormone replacement therapy
- Where
- China
- Volunteers
- 276 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Premature Ovarian Insufficiency, Infertility, Female
Ovarian PRP (Platelet Rich Plasma) Injection for Follicular Activation
The primary objective is to investigate the efficacy, defined as an increase in oocyte numbers upon ovarian stimulation, and safety of a single intra-ovarian PRP injection vs.
- Conditions
- Premature Ovarian Insufficiency, Infertility, Female, Sterility, Female, PRP
- Trial name
- OPIF (NCT05279560)
- Testing
- autologous PRP (platelet rich plasma), Saline solution (NaCL) Injection
- Where
- Germany
- Volunteers
- 114 people
- Sponsor
- University of Luebeck
Galactosemias, Primary Ovarian Insufficiency
Pregnancy Chances in Classic Galactosemia
With this study, in which the incidence of pregnancy in classic galactosemia patients is studied, we aim to provide new insights to improve counselling.
- Trial name
- NCT02091128
- Where
- Netherlands
- Volunteers
- 85 people
- Sponsor
- Maastricht University Medical Center
Premature Ovarian Failure
Levels of Selected Macroelements in Premature Ovarian Insufficiency
Aim: To evaluate plasma zinc (Zn), copper (Cu), calcium (Ca), iron (Fe), manganese (Mn), selenium (Se), strontium (Sr), aluminum (Al), antimonium (Sb), phosphorus (P), magnesium (Mg), sodium (Na), potassium (K), barium (Ba) and…
- Trial name
- POİ&MACROs (NCT04800705)
- Testing
- ultrasound assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Cengiz Gokcek Women's and Children's Hospital
Premature Ovarian Insufficiency
A Clinical Study of Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Premature Ovarian Insufficiency
Clinical Study of Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Premature Ovarian Insufficiency
- Trial name
- CURE-POI (NCT07510139)
- Testing
- YT023, Control Arm (Conventional Therapy)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- International Peace Maternity and Child Health Hospital
Premature Ovarian Failure
Levels of Selected Microelements in Premature Ovarian Insufficiency
Aim: To evaluate plasma/urine/hair Lead (Pb), Cadmium (Cd), Gadolinium (Gd), Arsenic (As), Mercury (Hg), Cobalt (Co), Vanadium (V), Titanium (Ti), Sulfur (S), Chromium (Cr), Silver (Ag), Molybdenum (Mo), Boron (B), Lithium (Li)…
- Trial name
- POI&MICROs (NCT04767451)
- Testing
- ultrasound assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cengiz Gokcek Women's and Children's Hospital
Primary Ovarian Insufficiency
Clinical Observation on Kuntai Capsule in Treating Early-onset Ovarian Hypofunction
To evaluate the efficacy and safety of Kuntai capsule alone or combined with hormone therapy in improving ovarian function in POI patients (including subclinical stage).
- Trial name
- NCT05021094
- Testing
- Kuntai Capsule, Femoston
- Where
- 6 sites in China
- Volunteers
- 120 people
- Sponsor
- Affiliated Hospital of Nantong University
Turner Syndrome, Ovarian Failure, Premature
Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure
Premature ovarian failure (POF) is known to be associated with an increased risk of ocular surface disease (dry eye), likely due to the reduction of both estrogens and androgens seen in this condition.
- Conditions
- Turner Syndrome, Ovarian Failure, Premature, Sex Chromosome Aberrations, Menopause
- Trial name
- NCT00471731
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)