Clinical trials: Prematurity Complications
Preterm Labor
Maternal Serum Osteopontin Levels in Pregnant Women Diagnosed With PPROM
Preterm prelabor rupture of membranes (PPROM) is defined as the rupture of the fetal membranes prior to the onset of labor and before 37 weeks of gestation; it occurs in approximately 2-3% of all pregnancies and accounts for a…
- Trial name
- OPN (NCT07626385)
- Testing
- SERUM OSTEOPONTİN
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Batman Training and Research Hospital
Preterm Labor, Premature Birth
Comparison Between Natural Progesterone and Vaginal Pessary for the Prevention of Spontaneous Preterm Birth
The aim of this study is to compare the effectiveness between the cervical pessary and the natural progesterone in reduction of preterm birth rates in pregnant women with a uterine cervical length of 25 mm or less evaluated by…
- Trial name
- PAP-C (NCT02511574)
- Testing
- natural progesterone, cervical pessary
- Where
- Brazil
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Preterm Labor, Preterm Birth
Prematurity Risk Assessment Combined With Clinical Interventions for Improving Neonatal outcoMEs
This prospective, randomized, controlled study evaluates the safety and efficacy of a preterm birth (PTB) prevention strategy versus standard of care pregnancy management to reduce the incidence of adverse pregnancy outcomes.
- Trial name
- PRIME (NCT04301518)
- Testing
- Multimodal intervention strategy
- Where
- 18 sites in United States
- Volunteers
- 6,500 people, healthy volunteers welcome
- Sponsor
- Sera Prognostics, Inc.
Premature Baby, Pulmonary Hypertension of Newborn
Measuring Heart Health in Both Term, Preterm and Unwell Newborn Babies With an Advanced Ultrasound Method: Speckle Tracking Echocardiography
This study aims to improve how neonatologists check the heart function of newborn babies, especially those who are sick. While standard heart ultrasound scans are useful, a more advanced and sensitive technique called 2D speckle…
- Conditions
- Premature Baby, Pulmonary Hypertension of Newborn, Hypoxic Ischaemic Encephalopathy (HIE), Congenital Diaphragmatic Hernia
- Trial name
- NCT07364682
- Where
- United Kingdom
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Birmingham Women's NHS Foundation Trust
Premature Birth of Newborn
The Effect of Perinatal Stress on the Development of Preterm Infants
In this project, the investigators will study a cohort of preterm infants, together with their parents, during NICU hospitalization and follow their developmental trajectory until the age of two.
- Trial name
- RESILIENCE (NCT02623400)
- Where
- Belgium
- Volunteers
- 174 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Premature Ovarian Insufficiency, Reproductive Health
Microbiome and Premature Ovarian Insufficiency
This study investigates the differences in gut and vaginal microbiota between women with premature ovarian insufficiency (POI) and healthy volunteers.
- Trial name
- NCT07275671
- Where
- 2 sites in China
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Westlake University
Dysphagia
The Effects of Cold Liquids on the Swallowing Mechanism in Preterm Infants
The purpose of this study is to see if cold liquids improve the swallowing mechanisms in premature infants with swallowing difficulties (dysphagia).
- Trial name
- NCT01863264
- Testing
- Cold Thin Liquid Barium
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- NYU Langone Health
Pre-Term
Optos Versus Indirect Ophthalmoscopy for ROP Screening Examination (Optos vs BIO Study)
ROP is a preventable cause of blindness in premature infants. It is routinely screened for by using an indirect ophthalmoscope, a scleral depressor, and a condensing lens.
- Trial name
- NCT04292015
- Testing
- Optos ultra-widefield retinal imaging (Optos California)
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Preterm Birth
Study of Cervix and Inflammation in Preterm Birth Prediction
Preterm birth rate is 7.2% in Quebec, it's risen worldwide in the past decade and it's the leading cause of perinatal mortality and morbidity. Preterm birth is a major public health problem.
- Trial name
- COLIBRI (NCT01007513)
- Testing
- Transvaginal ultrasound, Vaginal secretion sampling
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Premature Rupture of Fetal Membranes
Oxytocin vs. Prostaglandin for Induction of Labor in Primiparas With Prelabor Rupture of Membrane and Low Bishop
The purpose of the study is to compare between oxytocin to prostaglandin (PGE2), regarding time from induction of labor (IOL) to delivery among primiparas at term with prelabor rupture of membrane (PROM) and an unfavorable cervix.
- Trial name
- NCT02801227
- Testing
- Oxytocin, Prostaglandin E2
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Premature Ovarian Failure
Autologous Mesenchymal Stem Cells Transplantation In Women With Premature Ovarian Failure
Stem cells (SC) are the foundation cells for every organ, tissue and cell in the body. They are undifferentiated "blank" cells that do not yet have a specific function.
- Trial name
- NCT02062931
- Testing
- Stem Cell Preparation and Injection
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sayed Bakry
Neonatal Intensive Care Unit, Parents
The Effect of Family Integrated Care on Preparing Parents With Premature Infants Hospitalized in the Neonatal Intensive Care Unit for Discharge
Physiological and structural features of premature infants differ from mature newborns. Families worry about touching their very sensitive and fragile babies, which are quite different from their expectations, and they seriously…
- Trial name
- NCT04478162
- Testing
- Supporting parents who have premature babies to be ready for discharge with the training given within the scope of FICare model.
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Preterm Premature Rupture of the Membranes
Antibiotics Study in Preterm Premature Rupture of the Membranes
The purpose of this study is to compare the efficacy on maternal infection, chorioamnionitis and neonatal morbidity and mortality, and to review the evidence and provide recommendations on the use of antibiotics in PPROM.
- Trial name
- PPROM (NCT01401179)
- Testing
- cefazolin, erythromycin, clarithromycin
- Where
- South Korea
- Volunteers
- 101 people
- Sponsor
- Samsung Medical Center
Preterm Birth
Effect of Probiotics on the Preterm Delivery Rate in Pregnant Women at High Risk for Preterm Birth
Preterm birth (PB) continues to be the main cause of perinatal morbidity and mortality, with emotional and economic consequences.
- Trial name
- PROPEV (NCT03689166)
- Testing
- Probiotic
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Maternal-Infantil Vall d´Hebron Hospital
Premature Birth
Fish Oil Supplementation to Pregnant Women in China
This randomized controlled trial with fish oil supplementation to pregnant women conducted in areas of China, which are generally low in fish intake and low income, aims at answering the following primary questions: Is a dose of…
- Trial name
- FOPCHIN (NCT02770456)
- Testing
- High dose fish oil, Low dose fish oil, Olive oil
- Volunteers
- 5,531 people, healthy volunteers welcome
- Sponsor
- Centre for Fetal Programming, Denmark
Moral Distress
The Interplay Between Moral Distress, Moral Resilience, and Mental Health Outcomes Among Neonatal Care Providers
Due to highly specialized medical care neonatal care providers are faced with numerous responsibilities which makes neonatal care a particularly challenging and stressful work environment.
- Trial name
- MoD (NCT06836323)
- Where
- Switzerland
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Preterm Birth, Caffeine
Caffeine for Infants Born at 28 to 34 Weeks Receiving Respiratory Support
The goal of this pilot clinical trial is to test if it is possible to conduct a larger study on the use of caffeine in preterm infants who need help with their breathing.
- Conditions
- Preterm Birth, Caffeine, Neonatal Outcomes
- Trial name
- CARES-Pilot (NCT07456670)
- Testing
- Caffeine
- Where
- Canada
- Volunteers
- 62 people
- Sponsor
- Queen's University
Premature Baby 25 to 32 Weeks
Cerebral Abnormalities Detected by MRI, Realized at the Age of Term and the Emergence of Executive Functions
The survival of premature babies increased during the last decades. However, the neurocognitive long term development of these children is worrying, as demonstrated by EPIPAGE 1 study.
- Trial name
- EPIRMEX (NCT02083822)
- Testing
- term MRI, executive EF functions testing
- Where
- 15 sites in France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Tours
Healthy, Osteoporosis
Hormone Replacement in Young Women With Premature Ovarian Failure
The human ovary produces male sex hormones (androgen) and female sex hormones (estrogen). Currently, androgen is not included in hormone replacement therapy for women with premature ovarian failure.
- Conditions
- Healthy, Osteoporosis, Premature Ovarian Failure
- Trial name
- NCT00001951
- Testing
- TMTDS
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Bronchopulmonary Disease
Preterm Lung Patient Registry
The goal of the Preterm Lung Patient Registry is to collect data on individuals with neonatal lung disease to better understand the illness and ultimately improve their care and survival.
- Trial name
- NCT00951366
- Testing
- Patient Registry
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- Boston Children's Hospital