Clinical trials: Premedication
Anesthesia Refusal
A Comparative Evaluation of Nebulized Dexmedetomidine and Nebulized Ketamine as a Premedication in Pediatric Surgeries
preoperative anxiety and parental deprivation can be a traumatic time for young children undergoing surgery and remain challenges to anesthesiologists.
- Trial name
- NCT05719506
- Testing
- normal saline without drug, Dexmedetomidine, Ketamine
- Where
- 2 sites in Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tanta University
Recovery From Bariatric Surgery
The Effect of Premedication With Melatonin on Postoperative Recovery From Bariatric Surgery
Melatonin has sedative, hypnotic and analgesic properties that make it a good premedication agent before anesthesia and surgery.
- Trial name
- NCT02424071
- Testing
- Melatonin
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Premedication
Oral Dexmedetomidine vs Midazoam For Premedication
The aim of this study was to compare the effect of 2 µg/kg of oral dexmedetomidine (DEX) and 0.5 mg/kg dormicum as premedication among children undergoing dental procedures.
- Trial name
- NCT03357718
- Testing
- Precedex, Midazolam
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Pediatric Sedation, Clonidine Sedation
Premedication in Children: a Clinical Trial Comparing Oral Ketamine and Oral Clonidine With Respect to Sedation Level and Opioid Consumption in Pediatrics Undergoing Elective Lower Abdominal Day-case Surgery.
Aim of the work Is to compare between oral ketamine and oral clonidine regarding the level of sedation pre and postoperatively in addition the need of opioids administration intraoperative in children undergoing elective lower…
- Conditions
- Pediatric Sedation, Clonidine Sedation, Ketamine Sedation
- Trial name
- NCT07461376
- Testing
- Oral Clonidine (OC)
- Where
- Egypt
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Cairo University
Postoperative Sleep Disturbance
Dexmedetomidine Premedication for Post-anaesthesia Sleep Disturbance
The goal of this clinical trial is to learn about the effect of preoperative nasal spry with dexmedetomidine on postoperative sleep disturbance in young to middle-aged women undergoing hysteroscopy.
- Trial name
- NCT06281561
- Testing
- Normal Saline, Dexmedetomidine
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Xiamen University
Coronary Arterial Disease (CAD), Ischemic Heart Disease (IHD)
Heart Rate Control Before Cardiac Computed Tomography in Adults for the Evaluation of Coronary Artery Disease
The goal of this clinical trial is to describe which type and dose of commonly used heart rate reducing drugs (metoprolol, atenolol, or ivabradine) has the swiftest heart rate reduction from baseline in patients aged 30 to 80…
- Trial name
- HEART-BEAT (NCT07268170)
- Testing
- atenolol, Metoprolol tartrate, Ivabradine
- Where
- Denmark
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Gødstrup Hospital
Blood Loss During Vaginal Hysterectomy
Comparison of the Effects of Cervical Vasopressin Versus no Premedication on Blood Loss During Vaginal Hysterectomy: A Randomized, Placebo Controlled Trial
Vasoconstrictive agents are increasingly being used in order to decrease blood loss during vaginal hysterectomy. The first reported study of the use of a vasoconstrictive agent for this purpose was on the use of epinephrine…
- Trial name
- NCT00799292
- Testing
- Vasopressin
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Ascher-Walsh, Charles, M.D.
Acute Pulpitis
The Effect of Premedication With Curcumin on Post-endodontic Pain
Will premedication with Curcumin in single endodontic treatment in patients having acute pulpitis in mandibular molars affect post- operative pain? This the present study hopes to bring an evidence based decision on the…
- Trial name
- NCT04012424
- Testing
- curcumin group:Curcumin is an ancient coloring spice . Interestingly, it has various pharmacological activities including analgesic, anti-inf, 400mg starch
- Where
- Egypt
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Cairo University
Anti-spasmodics, Gastric Peristalsis
Effect of Oral Phloroglucin (Flospan®) as Premedication of Non-sedative Diagnostic Esophagogastroduodenoscopy
Gastric peristalsis, which occurs during the endoscopic procedure, limits the visual inspection of the inspection field, causing interference in the inspection.
- Conditions
- Anti-spasmodics, Gastric Peristalsis, Non-sedative Endoscopy
- Trial name
- NCT03342118
- Testing
- Phloroglucin(Flospan®), Normal saline
- Where
- South Korea
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Keimyung University Dongsan Medical Center
Child Preschool
Premedication by Clonidine Intranasal in Pediatric Surgery
There are few studies using intra nasal way to dispense premedication in pediatrics. This study will evaluate anxiolysis effect of Intranasal premedication with Clonidine vs Placebo.
- Trial name
- CLONIPREM (NCT03725930)
- Testing
- Clonidine
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Anesthesia
The Premedication Properties of Oral Melatonin in Pediatrics Undergoing Therapeutic Cardiac Catheterization
The evaluation of oral melatonin efficacy as premedicant agent in pediatrics undergoing elective cardiac interventions is the primary outcomes of our trail.
- Trial name
- NCT06031961
- Testing
- melatonin
- Where
- Iraq
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Pre Operative Sedation, Mask Acceptance
Effect of Dexmedetomidine Versus Midazolam Versus a Combination of the Two as a Premedication for Children Undergoing Bilateral Myringotomy Tube Insertion
Following an obtained written consent, a child presenting for ear tube surgery will be randomized into one of three groups for receiving a premedication.
- Conditions
- Pre Operative Sedation, Mask Acceptance, Post Operative Delerium
- Trial name
- NCT02134327
- Testing
- Combination of Dexmedetomidine with Midazolam
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Stomach Diseases
Repetitive Position Change Improves Gastric Cleanliness for MCE
By comparing dimethicone administration with/without subsequent repetitive position change before magnetically controlled capsule endoscopy (MCE) examination, the investigators aim to determine the efficacy of repetitive position…
- Trial name
- NCT03514966
- Testing
- Position change group
- Where
- China
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Chronic Periodontitis, Bacteremia
Amoxicillin to Prevent Bacteria and Inflammatory Biomarkers After Intensive Periodontal Therapy
There are not published studies evaluating the incidence, nature, magnitude and/or duration of bacteremia after periodontal treatment.
- Trial name
- AMX-Perio (NCT03354338)
- Testing
- Amoxicillin
- Where
- Colombia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universidad El Bosque, Bogotá
Anterior Cruciate Ligament (ACL) Reconstruction
Gabapentin Premedication for ACL Reconstruction: RCT
This double blind randomized control trial will enroll 100 participants ages 12-18 years, undergoing ACL repair. Participants receive gabapentin or placebo preoperatively.
- Trial name
- NCT03417479
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Children's Healthcare of Atlanta
Emergence Delirium, Anesthesia, Child
Melatonin vs Midazolam in Children Undergoing Tonsillectomy
Used as a premedication to decrease anxiety (Caumo et al., 2007). Midazolam, though has several drawbacks (McCann and Kain, 2001). Hence, an alternative premedication to midazolam will definitely have a widespread appeal.
- Conditions
- Emergence Delirium, Anesthesia, Child, Anxiety, Midazolam Premedication
- Trial name
- NCT07336095
- Testing
- Melatonin group, Midazolam group, Control group
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Monitored Anaesthesia Care, Loco-regional Chronic Subdural Hematoma Evacuation
Oral Melatonin as Premedication During MAC for Patients Undergoing Loco-regional Chronic Subdural Hematoma Evacuation
investigators assume that administration of preoperative melatonin will reduce the required dose of propofol in participants undergoing loco-regional chronic subdural hematoma evacuation, it may as well provide better…
- Trial name
- NCT03732963
- Testing
- Melatonin (Group M)
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Tonsillitis, Tonsillectomy
Gabapentin Premedication to Reduce Postoperative Pain for Pediatric Tonsillectomy
The purpose of this pilot study: 1) to examine the use of gabapentin in reducing pain in the first 48 hours postoperatively including the total amount of narcotics mg/kg given 2) to record the time to first analgesic…
- Trial name
- NCT03625011
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Children's Healthcare of Atlanta
Hysterosalpingography-Related Pain
Pain Control During Hysterosalpingography: A Three-Arm Randomized Trial
Hysterosalpingography (HSG) is commonly performed during infertility evaluation and may cause pain during cervical manipulation, uterine distension, and contrast-medium injection.
- Trial name
- HSG-PAIN (NCT07792668)
- Testing
- Indomethacin 100Mg Suppository, Lidocaine %2 ampoule
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Balikesir University
Postoperative Nausea and Vomiting
Gabapentin to Reduce Postoperative Nausea and Vomiting
The intrathecal administration of morphine is gaining popularity. It is easy to do and can reduce the pain after surgery up to 24 hours.
- Trial name
- NCT02944981
- Testing
- Gabapentin
- Where
- Thailand
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University