Clinical trials: Premedication
Anesthesia Refusal
A Comparative Evaluation of Nebulized Dexmedetomidine and Nebulized Ketamine as a Premedication in Pediatric Surgeries
preoperative anxiety and parental deprivation can be a traumatic time for young children undergoing surgery and remain challenges to anesthesiologists.
- Trial name
- NCT05719506
- Testing
- normal saline without drug, Dexmedetomidine, Ketamine
- Where
- 2 sites in Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tanta University
Dexmedetomidine, Adenotonsillectomy
Intranasal Dexmedetomidine in Children Undergoing Adenotonsillectomy Suffering From Mild Upper Respiratory Tract Infection
The purpose of this study is to detect the efficacy of intranasal dexmedetomidine as a premedication to general anesthesia in pediatric patients with respiratory comorbidities undergoing adenotonsillectomy.
- Conditions
- Dexmedetomidine, Adenotonsillectomy, Respiratory Tract Infections
- Trial name
- NCT05639777
- Testing
- Dexmedetomidine group, control group
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Tanta University
Emergence Delirium, Anesthesia, Child
Melatonin vs Midazolam in Children Undergoing Tonsillectomy
Used as a premedication to decrease anxiety (Caumo et al., 2007). Midazolam, though has several drawbacks (McCann and Kain, 2001). Hence, an alternative premedication to midazolam will definitely have a widespread appeal.
- Conditions
- Emergence Delirium, Anesthesia, Child, Anxiety, Midazolam Premedication
- Trial name
- NCT07336095
- Testing
- Melatonin group, Midazolam group, Control group
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Coronary Arterial Disease (CAD), Ischemic Heart Disease (IHD)
Heart Rate Control Before Cardiac Computed Tomography in Adults for the Evaluation of Coronary Artery Disease
The goal of this clinical trial is to describe which type and dose of commonly used heart rate reducing drugs (metoprolol, atenolol, or ivabradine) has the swiftest heart rate reduction from baseline in patients aged 30 to 80…
- Trial name
- HEART-BEAT (NCT07268170)
- Testing
- atenolol, Metoprolol tartrate, Ivabradine
- Where
- Denmark
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Gødstrup Hospital
Pain, Discomfort
TAmoxifen Versus LIdocaine Cream. A Randomized Clinical Trial for Reducing Pain and Discomfort During Mammography
This is a double-blind placebo-controlled randomized clinical trial to test the use of tamoxifen or lidocaine for diminishing the pain and discomfort while performing mammography, intending to include 450 patients distributed…
- Trial name
- TALI (NCT02801786)
- Testing
- Lidocaine, Tamoxifen
- Where
- Brazil
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Goias
Premedication
Oral Dexmedetomidine vs Midazoam For Premedication
The aim of this study was to compare the effect of 2 µg/kg of oral dexmedetomidine (DEX) and 0.5 mg/kg dormicum as premedication among children undergoing dental procedures.
- Trial name
- NCT03357718
- Testing
- Precedex, Midazolam
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Pre Operative Sedation, Mask Acceptance
Effect of Dexmedetomidine Versus Midazolam Versus a Combination of the Two as a Premedication for Children Undergoing Bilateral Myringotomy Tube Insertion
Following an obtained written consent, a child presenting for ear tube surgery will be randomized into one of three groups for receiving a premedication.
- Conditions
- Pre Operative Sedation, Mask Acceptance, Post Operative Delerium
- Trial name
- NCT02134327
- Testing
- Combination of Dexmedetomidine with Midazolam
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Anti-spasmodics, Gastric Peristalsis
Effect of Oral Phloroglucin (Flospan®) as Premedication of Non-sedative Diagnostic Esophagogastroduodenoscopy
Gastric peristalsis, which occurs during the endoscopic procedure, limits the visual inspection of the inspection field, causing interference in the inspection.
- Conditions
- Anti-spasmodics, Gastric Peristalsis, Non-sedative Endoscopy
- Trial name
- NCT03342118
- Testing
- Phloroglucin(Flospan®), Normal saline
- Where
- South Korea
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Keimyung University Dongsan Medical Center
Bowel Preparation Scale, the Amount of Air Bubble
Premedication Simethione Improves Visibility During Bowel Cleansing for Colonoscopy
To evaluate the efficacy, visibility of low volume polyethyleneglycol-simeticone (2-LPEG-S) for colonoscopy.
- Conditions
- Bowel Preparation Scale, the Amount of Air Bubble, Adenoma Detection Rate
- Trial name
- NCT02540239
- Testing
- 2L PEG, 2L PEG+simethicone
- Where
- China
- Volunteers
- 590 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Sedative; Anxiety Disorder
Intranasal Remimazolam for Premedication in Pediatric Patient
Anesthetic inhalation induction could be one of the most stressful experiences for children during the perioperative period, with almost 50% of them showing anxiety.
- Trial name
- NCT04720963
- Testing
- Remimazolam, Distilled water for injection, Dexmedetomidine
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Chronic Periodontitis, Bacteremia
Amoxicillin to Prevent Bacteria and Inflammatory Biomarkers After Intensive Periodontal Therapy
There are not published studies evaluating the incidence, nature, magnitude and/or duration of bacteremia after periodontal treatment.
- Trial name
- AMX-Perio (NCT03354338)
- Testing
- Amoxicillin
- Where
- Colombia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universidad El Bosque, Bogotá
Stomach Diseases
Repetitive Position Change Improves Gastric Cleanliness for MCE
By comparing dimethicone administration with/without subsequent repetitive position change before magnetically controlled capsule endoscopy (MCE) examination, the investigators aim to determine the efficacy of repetitive position…
- Trial name
- NCT03514966
- Testing
- Position change group
- Where
- China
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Child Preschool
Premedication by Clonidine Intranasal in Pediatric Surgery
There are few studies using intra nasal way to dispense premedication in pediatrics. This study will evaluate anxiolysis effect of Intranasal premedication with Clonidine vs Placebo.
- Trial name
- CLONIPREM (NCT03725930)
- Testing
- Clonidine
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Tubal Obstruction
Antispasmodic Drug for Diagnosis Proximal Tubal Occlusion on Hysterosalpingography
This study finds premedication Hyoscine-N-butylbromide before hysterosalpingography have a potential effect for diagnosis of proximal tubal obstruction in infertile women.
- Trial name
- NCT02618785
- Testing
- hysterosalpingography
- Where
- Thailand
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Gastric Mucosal Lesion
Simethicone and N-acetylcysteine in Upper Endoscopy - Prospective Double-blinded Randomized Controlled Trial
The upper endoscopy is one of the most common methods for the diagnosis and treatment of upper gastrointestinal (GI) tract diseases and provides a unique opportunity to identify early neoplastic lesions.
- Trial name
- NCT02357303
- Testing
- Simethicone, Acetylcysteine
- Where
- Portugal
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Portuguese Oncology Institute, Coimbra
Anxiety, Separation
A Comparison of Two Doses of Intranasal Dexmedetomidine for Premedication in Children
The purpose of the study is to determine if 4mcg/kg of intranasal dexmedetomidine is better than 2mcg/kg in successfully sedating a child prior to induction of anesthesia.
- Trial name
- NCT02459509
- Testing
- Dexmedetomidine
- Where
- Hong Kong
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Symptomatic Irreversible Pulpitis
Effect of Diclofenac Potassium Versus Prednisolone on Post-endodontic Pain and Pulpal IL-8 Expression
To assess the effect of using diclofenac potassium versus prednisolone as a pre-medication compared to placebo on: Intensity of post-endodontic pain in patients with symptomatic irreversible pulpitis. Pulpal IL-8 expression.
- Trial name
- NCT04608981
- Testing
- Prednisolone 30 mg, Diclofenac Potassium 50mg Tab
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
Acute Pulpitis
The Effect of Premedication With Curcumin on Post-endodontic Pain
Will premedication with Curcumin in single endodontic treatment in patients having acute pulpitis in mandibular molars affect post- operative pain? This the present study hopes to bring an evidence based decision on the…
- Trial name
- NCT04012424
- Testing
- curcumin group:Curcumin is an ancient coloring spice . Interestingly, it has various pharmacological activities including analgesic, anti-inf, 400mg starch
- Where
- Egypt
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Cairo University
Anterior Cruciate Ligament (ACL) Reconstruction
Gabapentin Premedication for ACL Reconstruction: RCT
This double blind randomized control trial will enroll 100 participants ages 12-18 years, undergoing ACL repair. Participants receive gabapentin or placebo preoperatively.
- Trial name
- NCT03417479
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Children's Healthcare of Atlanta
Premedication
Premedication on Post-endodontic Pain
The goal of this clinical trial is to compare the efficacy of preoperative administration of alpha-chemo-trypsin, ibuprofen, and acetaminophen in managing post-endodontic pain in patients with symptomatic irreversible pulpitis.
- Trial name
- NCT06671743
- Testing
- Root canal treatment
- Where
- United Arab Emirates
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Gulf Medical University