Clinical trials: Premenopausal
Breast Cancer, Weight Loss
Low Fat Versus Protein Sparing Diet for Weight Loss & Impact on Biomarkers Associated With Breast Cancer Risk
The primary specific aim of this study was to determine if overweight and obese premenopausal women can lose weight and if long term weight loss impacts biomarkers associated with breast cancer risk.
- Trial name
- LEAF (NCT01559194)
- Testing
- Low Fat Diet plus exercise, Low Carbohydrate diet + Exercise
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Overweight
Effects of a Health-At-Every-Size Approach on Weight Management in Premenopausal Overweight Women
The purpose of this study is to measure the effects of a Health-At-Every-Size (HAES) approach on global health status of premenopausal overweight women preoccupied about their weight and who have been unsuccessful in previous…
- Trial name
- CHOIX (NCT01240499)
- Testing
- Health-At-Every-Size (HAES)
- Where
- Canada
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Laval University
Healthy
Study of Relugolix Alone and Relugolix Combined With Hormonal Add-Back Therapy in Healthy Premenopausal Female Participants
This was a randomized, open-label, repeat dose study of once daily relugolix alone or relugolix combined with hormonal add-back therapy (combination estradiol/norethindrone acetate) (E2/NETA) to assess safety, including markers…
- Trial name
- NCT04978688
- Testing
- Relugolix, E2/NETA
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Myovant Sciences GmbH
Insulin Sensitivity/Resistance, Breast Cancer
Insulin Sensitivity After Breast Cancer
Epidemiological studies have revealed that 60-80% of women with breast cancer (BC) develop metabolic disorders that are similar to those observed in conditions like type 2 diabetes.
- Conditions
- Insulin Sensitivity/Resistance, Breast Cancer, Survivorship, Metabolic Disturbance
- Trial name
- NCT05010356
- Testing
- Insulin
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Female Sexual Dysfunction
PK Study of Testosterone Nasal Gel (TBS-2) in Healthy Premenopausal Women
The purpose of this study was to assess the bioavailability of total testosterone through pharmacokinetic profiles obtained following (a) single administration of three doses of TBS-2 b) multiple administration TBS-2.
- Trial name
- NCT01364623
- Testing
- Low dose testosterone nasal gel, single dose, Medium dose testosterone nasal gel, single dose, High dose testosterone nasal gel, single dose
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Acerus Pharmaceuticals Corporation
Breast Cancer
Serum Biomarkers to Characterize the Effects of Therapy on Ovarian Reserve in Premenopausal Women With Early-stage Breast Cancer or BRCA Mutations
The purpose of this study is to learn more about the effects of your BRCA mutation on the ovaries. The BRCA gene can make it hard to conceive a child in the future. It may also bring on early menopause.
- Trial name
- NCT00823654
- Testing
- Blood draw and questionnaires
- Where
- 8 sites in United States
- Volunteers
- 609 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Nausea
Study to Evaluate Rate of Nausea in Healthy Premenopausal Female Subjects Treated With Single Dose of Bremelanotide Alone or With Zofran
This is a Phase 1, randomized study to evaluate the rate of nausea in healthy premenopausal study participants following a single dose of BMT with or without a single 8 mg po dose of Zofran given 30 minutes before BMT dosing.
- Trial name
- NCT03973047
- Testing
- Bremelanotide, Zofran
- Where
- United States
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- AMAG Pharmaceuticals, Inc.
Polycystic Ovary Syndrome
Prevalence of Polycystic Ovary Syndrome (PCOS) in Obese Premenopausal Women
Between 40% and 85% of women with Polycystic Ovary Syndrome (PCOS) are overweight or obese and obesity is closely linked to the development of PCOS.
- Trial name
- NCT01319162
- Testing
- Weight reduction regimen
- Where
- Sweden
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Hot Flashes
Understanding Experimentally Induced Hot Flushes
The purpose of the study is to examine the impact of hot flushes on sleep, mood, and well-being. The investigators will cause hot flushes by giving study participants the hormone medication, leuprolide (Lupron), which is a…
- Trial name
- NCT00455689
- Testing
- Leuprolide acetate
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Aquacycling
Aquatic Exercise and Metabolism in Women
Exercise training on an immersible ergocycle is becoming more popular as it appears to be more suitable for men and women even with poor physical activity level.
- Trial name
- NCT02895217
- Testing
- ergocycle
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Premenopausal Breast Cancer, Hormone Receptor-positive Breast Cancer
Higher Dose Preoperative taMOxifen in Premenopausal bREast Cancer Patients
MORE-T trial is designed to investigate the effect of Tamoxifen 40mg (vs. Tamoxifen 20mg) for 2wks in presurgical setting. The greater reduction in Ki-67 might be observed in Tamoxifen 40mg arm compared to the Tamoxifen 20mg arm.
- Trial name
- MORE-T (NCT04997941)
- Testing
- Tamoxifen Oral Product, Assessment of Ki-67, Surgery
- Where
- South Korea
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Obesity
Relationships Between GLP-2 and Markers of Bone Turnover Following Feeding
This study has been designed to study differences bone turnover in relation to glucagon-like peptide-2 (GLP-2) following feeding in lean and obese premenopausal women.
- Trial name
- GLP-2 (NCT01531907)
- Testing
- Study visit procedures
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Healthy
This Study Tests in Healthy Korean Women Which Effects BI 409306 and a Birth-control Pill Have on Each Other
The primary objective of this trial is to investigate the effect of multiple doses of ethinylestradiol / levonorgestrel (Microgynon®) on single dose pharmacokinetics of BI 409306 and the effect of single dose of BI 409306 on…
- Trial name
- NCT03193307
- Testing
- Microgynon® 30, BI 409306
- Where
- South Korea
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Skin Aging, Weight Loss
Effect of Revival Soy on Weight Loss and Skin, Hair, and Nails in Premenopausal Women
The purpose of this study is to determine if dietary consumption of Revival Soy can improve the appearance of the skin, hair, and finger nails and support weight loss in overweight, premenopausal women.
- Trial name
- NCT00352157
- Testing
- Revival Soy Dietary Supplement
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Physicians Pharmaceuticals, Inc.
Breast Cancer
Study of Vitamin D for Premenopausal Women at High Risk for Breast Cancer
This proposal is for a pilot study of 20 premenopausal women at high risk for breast cancer development who will receive high dose vitamin D3, cholecalciferol 20,000 IU (2 capsules) weekly, or 30,000 IU (3 capsules) weekly, for 1…
- Trial name
- NCT00976339
- Testing
- Cholecalciferol
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Katherine D. Crew
Healthy
A Study in Healthy Women to Test Whether BI 425809 Influences the Amount of a Contraceptive in the Blood
The main objective of this trial is to investigate the possible effect of multiple oral doses of BI 425809 on the steady state pharmacokinetics of ethinylestradiol (EE) and levonogestrel (LNG) (administered as the combined oral…
- Trial name
- NCT05613777
- Testing
- Microgynon®, Iclepertin
- Where
- Germany
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Premenstrual Syndrome
Altered Calcium and Vitamin D in PMDD or Severe PMS
Osteoporosis has become one of the most widely recognized disorders of our times affecting an estimated 25 million women in this country.
- Trial name
- NCT00005119
- Testing
- Measures of calcium and bone turnover
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Breast Cancer
Celecoxib in Preventing Breast Cancer in At-Risk Premenopausal Women
RATIONALE: Chemoprevention therapy uses certain drugs to try to prevent the development or recurrence of cancer. Celecoxib may be effective in preventing breast cancer in at-risk women.
- Trial name
- NCT00056082
- Testing
- celecoxib
- Where
- 3 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Osteoporosis
The Effectiveness of Individualised Bone Density Feedback and Osteoporosis Education in Premenopausal Women
The purpose of this study is to determine whether giving women feedback concerning their bone mineral density, combined with either an information leaflet or group education concerning osteoporosis changes women's behavior and/or…
- Trial name
- NCT00273260
- Testing
- individualised bone density feedback and education
- Where
- Australia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Menzies Institute for Medical Research
Breast Cancer
Tailored Screening for Breast Cancer in Premenopausal Women
The Tailored Breast Screening Trial (TBST) is a population-based, non-inferiority randomised trial aimed at evaluating the impact of tailored screening strategies addressed to premenopausal women, by using breast density as…
- Trial name
- TBST (NCT02619123)
- Testing
- Tailored screening according to breast density, Annual invitation to mammography
- Where
- 5 sites in Italy
- Volunteers
- 33,200 people, healthy volunteers welcome
- Sponsor
- Cancer Prevention and Research Institute, Italy