Clinical trials: Premenopausal
Stress Urinary Incontinence
Effect of Vitamin D Supplementation on Severity of Stress Urinary Incontinence in Premenopausal Women With Vitamin D Insufficiency
The rationale for conducting the study is based on the fact that stress urinary incontinenc is a prevalent condition among middle age or older women and Vitamin D deficiency may have clinical effects on the pelvic floor muscles…
- Trial name
- NCT06689813
- Testing
- Vitamin D tablets, Ispaghula husk
- Where
- Pakistan
- Volunteers
- 86 people
- Sponsor
- Shalamar Institute of Health Sciences
Preeclampsia
Safety, Tolerability, and PK/PD of Telpegfilgrastim in Premenopausal Non-pregnant Females
This is an open-label, Phase Ia clinical study to evaluate the safety, tolerability, and pharmacokinetic/pharmacodynamic (PK/PD) characteristics of single dose of telpegfilgrastim injection in healthy premenopausal non-pregnant…
- Trial name
- NCT06893796
- Testing
- Telpegfilgrastim Injection
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Xiamen Amoytop Biotech Co., Ltd.
Healthy Adult Premenopausal Female Volunteers
Study of the Effect of ITCA 650 on the PK/PD of Oral Contraceptive in Healthy Female Subjects
A Phase 1, randomized, double-blind, placebo-controlled, crossover study to assess the effect of ITCA 650 on the pharmacokinetics (PK) of once daily administration of Levora® (ethinyl estradiol 0.3 mg (EE) and levonorgestrel 0.15…
- Trial name
- NCT02641990
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Intarcia Therapeutics
Breast Cancer
Study to Compare the Combination of Ribociclib Plus Goserelin Acetate With Hormonal Therapy Versus Combination Chemotherapy in Premenopausal or Perimenopausal Patients With Advanced or Metastatic Breast Cancer
To compare the combination of Ribociclib plus goserelin acetate with hormonal therapy versus combination chemotherapy in premenopausal or perimenopausal patients with advanced or metastatic breast cancer
- Trial name
- RIGHT Choice (NCT03839823)
- Testing
- Docetaxel / Capecitabine, Capecitabine / Vinorelbine, Paclitaxel / Gemcitabine
- Where
- 50 sites in Egypt, India and 11 more
- Volunteers
- 222 people
- Sponsor
- Novartis Pharmaceuticals
Estrogen Receptor Positive, HER2/Neu Negative
Akt Inhibitor MK-2206 and Anastrozole With or Without Goserelin Acetate in Treating Patients With Stage II-III Breast Cancer
This phase II trial studies how well Akt inhibitor MK-2206 (MK-2206) and anastrozole with or without goserelin acetate works in treating patients with stage II-III breast cancer.
- Conditions
- Estrogen Receptor Positive, HER2/Neu Negative, Recurrent Breast Carcinoma, Stage IIA Breast Cancer
- Trial name
- NCT01776008
- Testing
- Akt Inhibitor MK2206, Anastrozole, Goserelin Acetate
- Where
- 8 sites in United States
- Volunteers
- 16 people
- Sponsor
- National Cancer Institute (NCI)
Cardiovascular Diseases, Ischemic Heart Disease
Breast Disease and Cardiovascular Disease
Cardiovascular disease (CVD) occurs less frequently in women than in juvenile men.Frequently the estrogen deficiency associated with the menopausal state affects cardiovascular outcomes.
- Trial name
- NCT03779217
- Testing
- screening mammography, mastoplasty and breast fat excission
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- University of Campania Luigi Vanvitelli
Systemic Lupus Erythematosus
Dehydroepiandrosterone (DHEA) in Systemic Lupus Erythematosus (SLE) for Coronary Artery Disease (CAD) Prevention
The purpose of this study is to evaluate the effect of DHEA on endothelial dysfunction in patients with systemic lupus by measuring: 1. changes in brachial artery flow-mediated dilatation (FMD) and 2.
- Trial name
- NCT00189124
- Testing
- Dehydroepiandrosterone (DHEA)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Michigan
Breast Cancer
Combination Chemotherapy With or Without Colony-stimulating Factors in Treating Women With Breast Cancer
RATIONALE: 1. . To compare the effects on breast cancer of three different combinations of drugs which are commonly used to treat this disease. 2. . It is not yet known which treatment regimen is most effective for breast cancer.
- Trial name
- NCT00014222
- Testing
- epoetin alfa, filgrastim, cyclophosphamide
- Where
- 78 sites in United States, Canada
- Volunteers
- 2,104 people
- Sponsor
- NCIC Clinical Trials Group
Osteoporosis
Study of Low Bone Mass in Premenopausal or Perimenopausal Women
OBJECTIVES: I. Determine the possible causes of bone loss in premenopausal or perimenopausal women.
- Trial name
- NCT00005101
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Sedentary
Comparison of Gut Microbiota in Sedentary and Active Women
Gut microbiota comparison of active and sedentary women
- Trial name
- NCT02901912
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Europea de Madrid
Menopause, Fracture
Forteo for the Treatment of Unexplained Osteoporosis in Premenopausal Women
Idiopathic osteoporosis (IOP) is an uncommon disorder in which otherwise healthy young individuals sustain one or more low-trauma fractures.
- Conditions
- Menopause, Fracture, Osteoporosis
- Trial name
- IOPForteo (NCT00697463)
- Testing
- Teriparatide (PTH 1-34)
- Where
- 2 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Columbia University
Dense Breasts, Breast Cancer
Histology of Functional Density in Premenopausal Breast
The investigators hypothesize that knowledge of the functional behavior of areas of mammographic density will enable more specific identification of dense tissue at-risk for breast cancer, ultimately providing predictive…
- Trial name
- NCT01588834
- Testing
- breast biopsy
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthy
Pergoveris FD and Liquid China BE Study
The main purpose of this study is to assess the bioequivalence (BE) of the fixed combination of follitropin alfa and lutropin alfa in Pergoveris freeze-dried (FD) (Test 1) or in Pergoveris Liquid (Test 2) versus the…
- Trial name
- NCT04899193
- Testing
- Pergoveris FD, Pergoveris Liquid, Gonal-f
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Benign Breast Disease, Fibrocystic Disease of Breast
Effects of Tamoxifen in Premenopausal Women With Benign Breast Disease Not at High-Risk of Developing Breast Cancer
The purpose of the study is to determine the efficacy and relapse rate of low dose, short duration treatment with tamoxifen in benign breast disease amenable to hormonal therapy with respect to etiology and estrogen receptor…
- Conditions
- Benign Breast Disease, Fibrocystic Disease of Breast, Fibroadenoma, Mastalgia
- Trial name
- NCT00999921
- Testing
- Tamoxifen, Evening Primrose Oil
- Where
- India
- Volunteers
- 256 people
- Sponsor
- Medical College and Hospital Kolkata
Bone, Bone Health
Fermented Foods and Bone Health: Investigating the Gut-Bone Axis in Premenopausal Vegan Women
Plant-based diets are increasingly adopted for health and environmental reasons, but they are associated with lower bone mineral density, higher fracture risk, and elevated bone turnover markers, particularly in women.
- Trial name
- FERMBONE (NCT07645885)
- Testing
- Fermented Plant-Based Foods, Non-Fermented Plant-Based Foods
- Where
- 2 sites in Czechia, Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Isabelle Herter-Aeberli
Breast Cancer
Chemosensitivity During Phases of the Menstrual Cycle in Breast Cancer Patients
This study is a prospective, multicenter study in which a serum sample will be collected at the day of starting neo adjuvant treatment in breast cancer patients
- Trial name
- Chemosense (NCT06273800)
- Testing
- Blood sample
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- The Netherlands Cancer Institute
Breast Cancer
Raloxifene in Preventing Breast Cancer in Premenopausal Women
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of raloxifene may be an effective way to prevent breast cancer in premenopausal women.
- Trial name
- NCT00019500
- Testing
- raloxifene, evaluation of cancer risk factors
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
TMD, Temporomandibular Disorders (TMDs)
Effects of Vagus Nerve Stimulation on Temporomandibular Disorders.
The study aims to examine the effects of transcutaneous non-invasive vagus nerve stimulation (nVNS) on symptoms and brain mechanisms in premenopausal women with temporomandibular disorders (TMD).
- Trial name
- NCT07288411
- Testing
- nVNS Treatment
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Arpana Church
Bariatric Surgery, Bone Health
Bone and Muscle Health Following Sleeve Gastrectomy in Men, Premenopausal and Postmenopausal Women
Background: Bariatric surgery is gaining in popularity. While it's health benefits are undisputed, the older malabsorptive bariatric procedures (Roux-in-Y gastric bypass - RYGB and biliopancreatic diversion - BPD) are associated…
- Conditions
- Bariatric Surgery, Bone Health, Severe Obesity, Muscle Health
- Trial name
- BONUS (NCT06547515)
- Testing
- Bariatric surgery
- Where
- Canada
- Volunteers
- 156 people
- Sponsor
- CHU de Quebec-Universite Laval
Postmenopausal, Premenopausal
Oxytocin in Postmenopausal Women
The aim of the present study is to assess whether cumulative endogenous neurophysin I secretion over one month differs between premenopausal and postmenopausal women.
- Trial name
- OxyMENO (NCT07742124)
- Testing
- Repeated assessments
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Basel, Switzerland