Clinical trials: Prenatal Diagnoses
Normal Pregnancy, Labor Active Dilated Cm
Comparison Between Using 10min CTG in Fetal Monitoring Instead of 30min Monitoring in Low Resources Overcrowded Hospitals.
Cardiotocography (CTG) is a cornerstone of intrapartum fetal monitoring but requires a minimum of 30 minutes for a reliable trace, creating a significant bottleneck in high-volume, low-resource settings like Egypt As it is…
- Trial name
- NCT07250620
- Volunteers
- 200 people
- Sponsor
- Assiut University
Patients With Spontaneous Rupture of the Fetal Membranes
Kinetics of Inflammation Markers in Maternal Plasma: Study of the Correlation With the Diagnosis of Chorioamnionitis in Women Hospitalized for Spontaneous Rupture of the Fetal Membranes
The principal aim of this study is to help obstetricians to diagnose chorioamniotic infection early, in cases of premature rupture of the fetal membranes before 34 WA, by proposing earlier and more specific markers of infection…
- Trial name
- NCT01903759
- Testing
- Blood samples
- Where
- France
- Volunteers
- 97 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Pregnancy Related, Mental Health Issue
MamaConecta: Digital Tool for Maternal Mental Health
The goal of this randomized controlled trial is to validate a digital health tool, Dana app, that enhances well-being and supports mental health monitoring for women during the perinatal period.
- Conditions
- Pregnancy Related, Mental Health Issue, Postpartum Depression, Postpartum Anxiety
- Trial name
- DDT (NCT06442774)
- Testing
- Mobile application, Monitoring via wearable
- Where
- 3 sites in Spain
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- A Thousand Colibris, S.L
IUGR
HMGB1 Levels at Fetal Growth Restriction
The primary aim of this study is to evaluate HMGB1 levels in cases of intrauterine growth restriction (IUGR). The secondary aim is to determine whether the cerebroplacental ratio interacts with these levels.
- Trial name
- NCT07857525
- Testing
- hmgb1
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Anorectal Malformations
Study of Antenatal and Postnatal Data of Anorectal Malformations Diagnosed at Montpellier University Hospital Over a 10-year Period (2010-2020)
Objective : Anorectal malformations (ARMs) are part of a spectrum of malformations due to an abnormal separation between the urogenital and digestive tracts during embryonic life.
- Trial name
- NCT05045560
- Where
- France
- Volunteers
- 98 people
- Sponsor
- University Hospital, Montpellier
Urinary Tract Dilatation
Urinary Tract Dilations in Prenatal and Postnatal Life
The goals of this study are to use a questionnaire survey to determine the state of awareness of the diagnosis and management of patients with urinary tract dilation across several medical professionals, to predict the severity…
- Trial name
- NCT06317623
- Testing
- Prenatal and postnatal ultrasound examination
- Where
- Slovakia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- SonoClinic
Prenatal Diagnosis and Closed-loop Management System of Congenital Talipes Equinovarus
Study on Prenatal Diagnosis and Closed-loop Management System of Congenital Talipes Equinovarus
The study intends to establish a closed-loop management from prenatal to postnatal through prospective cohort, and comprehensively utilize ultrasound and MRI technology to establish a prenatal diagnosis and evaluation system for…
- Trial name
- NCT05638490
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Aneuploidy, Trisomy 21
Prenatal Test for Fetal Aneuploidy Detection
The purpose of this study is to develop and evaluate a blood test for pregnant women for detection of fetal aneuploidy.
- Trial name
- NCT01256606
- Where
- 6 sites in United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Roche Sequencing Solutions
Neurological Development After Exposition to an Antenatal Nuchal Translucency
Follow up of Neurologic Development of Children Who Presented at the First Trimester of Pregnancy an Isolated Nuchal Anomaly With Normal Karyotype
Prospective, multicenter study following for 2 years, 250 children who presented during the first trimester of pregnancy an isolated nuchal translucency over the 95th percentile of Nicolaïdes Curves on ultrasound and comparing…
- Trial name
- EDEN (NCT02223936)
- Testing
- group exposed, Control
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Prenatal Screening, Pregnancy Related
Fetal Cell Analysis From Maternal Blood
The aim of this clinical study is the evaluation of clinical performance of a cell-based non-invasive test technology for fetal aneuploidies and segmental imbalances detection in a high-risk pregnancies population.
- Conditions
- Prenatal Screening, Pregnancy Related, Genetic Disease
- Trial name
- NCT05671744
- Testing
- Cell-based non-invasive prenatal testing
- Where
- Italy
- Volunteers
- 1,500 people
- Sponsor
- Menarini Biomarkers Singapore
Genetic Counseling, Prenatal Diagnosis
Influence of Prenatal Counseling in Invasive Testing
It is well established that screening for Down syndrome should be offered in the first trimester to each pregnant woman. The most common screening method is nowadays the first trimester combined test which consists of a Bayesian…
- Trial name
- INVASIVE (NCT04119349)
- Testing
- Extra counseling
- Where
- Spain
- Volunteers
- 75 people
- Sponsor
- Hospital Clinic of Barcelona
Congenital Heart Disease, Cyanotic Congenital Heart Disease
Prenatal Maternal Mental Health and Neurodevelopment in Congenital Heart Disease
Congenital heart disease (CHD) is the leading cause of congenital malformations, representing 1% of live births. Progress in surgical care have led to the dramatic increase in the population of children and adults living with…
- Conditions
- Congenital Heart Disease, Cyanotic Congenital Heart Disease, d-Transposition of the Great Arteries, Hypoplastic Left Heart Syndrome
- Trial name
- Neuro-Moms (NCT06711666)
- Where
- 5 sites in France
- Volunteers
- 174 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Prenatal, Genome-wide High Throughput Sequencing
ANDDI-PRENATOME - Feasibility Study for a " Fast " Pangenomic High Throughput Sequencing Analysis in Prenatal Diagnosis
Prenatal diagnosis of genetic diseases is a real medical challenge. The discovery of antenatal abnormalities on ultrasound is frequent (5 to 10% of pregnancies), and when an abnormalities is seen on ultrasound, it raises the…
- Trial name
- AnddiPrenatome (NCT03964441)
- Testing
- Invasive fetal sampling, blood sampling of mother and father, blood sampling from the mother to recover the circulating cell free fetal DNA, Parent interviews (optional organizational study)
- Where
- France
- Volunteers
- 149 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Fetal Growth Retardation
Doppler at the Diagnosis in Predicting Perinatal Outcomes in Early and Late-onset Fetal Growth Restriction
When a FGR is diagnose, the challenge in his monitoring is to assess the benefit-risk balance between continuing the pregnancy in order to limit complications related to prematurity and birth in order to minimize any risk of…
- Trial name
- NCT05696223
- Testing
- Ultrasound
- Where
- France
- Volunteers
- 220 people
- Sponsor
- Central Hospital, Nancy, France
Trisomy 21
Diagnosis Accuracy of Noninvasive Screening by PCR Digital for Down Syndrom
The main objective of this study is to estimate the intrinsic diagnostic qualities of the digital dPCR in the screening of T21 from a multicentrique sample of patients with pregnancies at high risk of T21 (risk > 1/250).
- Trial name
- DIgiT21 (NCT02872948)
- Testing
- Diagnostic
- Where
- France
- Volunteers
- 1,260 people
- Sponsor
- University Hospital, Grenoble
Intrauterine Growth Restriction, Fetal Growth Restriction (FGR)
Diagnostic Value of sFlt-1/PlGF Ratio for the Etiology of Intra Uterine Growth Restriction - ANGIOPAG
The main aim of this project is to determine the Placental Growth Factor and Vascular Endothelial Growth Factor ratio's performance (sFlt-1/PlGF) for the etiological diagnosis of vascular Intrauterine growth restriction (IUGR)…
- Trial name
- ANGIOPAG (NCT05151289)
- Testing
- Blood test at time of inclusion for sFlt-1/PlGF ratio, Follow-up blood test 2 to 4 weeks after inclusion, Placenta analysis for all included patients, even in case of normal birthweight
- Where
- France
- Volunteers
- 167 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Complicated Twin Pregnancy
The Value of Prenatal Ultrasound in Complicated Twin Pregnancy and Its Correlation With Chromosomal Anomalies
Recent years, women with infertility have become more and more and thus assisted reproductive technology has been applied in a broad range. And the quantities of twin pregnancies are larger and larger.
- Trial name
- NCT02732717
- Testing
- ultrasound (observation)
- Where
- China
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Pregnancy Related
Cell- Based Noninvasive Prenatal Testing (NIPT): Single Cell Prenatal Diagnosis (SCPD)
The purpose of the overall study is to develop improved methods for recovery of fetal cells from the mother's blood in order to develop a clinically useful form of cell-based, diagnostic, noninvasive prenatal testing (NIPT).
- Trial name
- NIPT & SCPD (NCT05076734)
- Testing
- Redraw for analysis of blood samples from healthy pregnant women
- Where
- United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Luna Genetics
Antenatal Management of the Fetal Gastrointestinal Atresia
Prenatal Diagnosis of the Fetal Esophageal or Intestinal Atresia
Aim- to investigate how prenatal diagnosis of fetal esophageal or intestinal atresia impacts obstetric and neonatal outcomes. Methods- This was a retrospective cohort study at a single center.
- Trial name
- DANATRESIA (NCT05362604)
- Testing
- scheduled delivery at a tertiary center
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Poitiers University Hospital
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- 2 sites in United States, Australia
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health