Clinical trials: Prenatal Diagnosis
Proteinuria, Preeclampsia
Validation of a PrCr Dipstick Diagnostic Test in Ghana
This evaluation will aim to generate a body of evidence that will determine performance characteristics of the current PrCr dipstick test and the feasibility of its use in target ANC settings.
- Trial name
- NCT03510286
- Testing
- Test-it™ PrCr Urinalysis Strips
- Where
- Ghana
- Volunteers
- 1,483 people, healthy volunteers welcome
- Sponsor
- PATH
Postpartum Depression, Posttraumatic Stress Disorder
Intervention for IPV-exposed Pregnant Women
The overarching goal of the proposed project is to evaluate a randomized clinical trial of the Pregnant Moms' Empowerment Program aimed at detecting its effects on maternal mental health, re-victimization, parenting sensitivity…
- Conditions
- Postpartum Depression, Posttraumatic Stress Disorder, Infant Behavior, Violence
- Trial name
- NCT04068662
- Testing
- Pregnant Moms' Empowerment Program, Nondirective Support Group
- Where
- 2 sites in United States
- Volunteers
- 424 people
- Sponsor
- University of Notre Dame
Premature Rupture of Membrane
Preterm Premature Rupture of Fetal Membranes: Cervical Ultrasound and Biological Markers to Diagnose Prematurity (RECHOBIOL)
Our main hypothesis is to consider that the detection of biomarkers on admission combined with the length of the cervix would improve the prediction of the latency period in case of preterm premature rupture of membranes (pPROM).
- Trial name
- RECHOBIOL (NCT04237142)
- Testing
- Vaginal secretions collection, Blood sample
- Where
- France
- Volunteers
- 170 people
- Sponsor
- University Hospital, Clermont-Ferrand
Preterm Labour
Fetal Adrenal Gland Volume Estimation Compared to Cervical Length Assessment in Prediction of Preterm Birth
If the investigators could prove that three -dimensional ultrasound measurement of fetal adrenal gland volume can accurately predict the likelihood of preterm birth in patients having symptoms and signs of PTL , they would be…
- Trial name
- NCT02351336
- Testing
- Ultrasound imaging
- Where
- Egypt
- Volunteers
- 78 people
- Sponsor
- Wessam Magdy Abouelghar
Dental Caries
The Relation Between Pregnancy,Birth Outcome, Feeding , Oral Hygiene Habits and Early Childhood Caries Development.
200 children between ages 36 to 48 months will be invited for a regular dental examination Parameters to be investigated 1. Pregnancy history 2. Birth outcome 3. Child's general health 4. Feeding habits 5. Oral hygiene habits 6.
- Trial name
- NCT00334087
- Testing
- feeding habits
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Insulin Resistance, Low Birth Weight
Effects of 3 Months of Selective Serotonin Reuptake Inhibitor (SSRI)-Treatment on Metabolism and Hypothalamic-pituitary-adrenal (HPA)-Axis in Young Men Born With Low Birth Weight
Chronic stress has been proposed to be involved the development of western life-style diseases such as cardiovascular disease and type 2 diabetes (T2DM).
- Conditions
- Insulin Resistance, Low Birth Weight, Type 2 Diabetes, Cardiovascular Disease
- Trial name
- LBW-SSRI (NCT00971815)
- Testing
- Escitalopram
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Oligohydramnios, Amniotic Fluid; Disorder
Effect of Intermittent Pneumatic Compression Device of Lower Limbs in Oligohydramnios
the study will examine the effect of application of intermittent pneumatic pressure device on lower limbs on the amniotic fluid amount and fetal doppler indices in women with oligohydramnios
- Trial name
- NCT05474326
- Testing
- intermittent pneumatic pressure device (Kendall SCD™ 700 Smart Compression™ System)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Rhesus D Genotype
Evaluation of a Noninvasive Fetal RHD Genotyping Test
This study will collect whole blood samples from pregnant subjects who are RhD negative by serology to develop an assay for RHD determination of the fetus.
- Trial name
- IRIS (NCT01054716)
- Where
- 5 sites in United States
- Volunteers
- 500 people
- Sponsor
- Sequenom, Inc.
Post-partum Depression
Preventing Postpartum Depression in Prenatal Care
This is randomized control trial of a brief intervention called Bellevue ROSE (Reach Out Stay Strong Essentials). Bellevue ROSE is a manualized and highly structured interpersonal intervention that provides women with…
- Trial name
- NCT02741206
- Testing
- Bellevue ROSE Intervention, Psycho-education session and usual, Standard of care Control, One Psycho-education session and usual, standard of care Control
- Where
- United States
- Sponsor
- NYU Langone Health
Abortion Threatened
Biochemical Versus Ultrasound Findings as Predictors of Fetal Loss in Cases of First Trimester Threatened Miscarriage
Threatened miscarriage occurs in about one-fifth of pregnancies with an estimated miscarriage rate of 3-16% after successful demonstration of fetal cardiac activity.
- Trial name
- NCT03797508
- Testing
- ultrasound
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Ain Shams University
Gonad Regulating Hormone Adverse Reaction, Analgesic Adverse Reaction
Neurobehavioral Development in Toddlers and Preschoolers in Relation to Prenatal Exposure of Mild Analgesics (NeuroToP - a COPANA Follow up)
Fundamental aspects of both neurological and reproductive function are established in fetal life, and there is a present increased awareness of the potential effects of fetal exposures on neurodevelopmental and reproductive…
- Conditions
- Gonad Regulating Hormone Adverse Reaction, Analgesic Adverse Reaction, Developmental Disability, Adhd
- Trial name
- NeuroToP (NCT07316387)
- Where
- Denmark
- Volunteers
- 685 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Periodontal Diseases, Premature Birth
Prevention of Pre-Term Birth by Treatment of Periodontal Disease
The aim of the study is to investigate, in an Australian population of pregnant women, whether the treatment of periodontal disease during pregnancy prevents pre-term birth and other complications of pregnancy.
- Conditions
- Periodontal Diseases, Premature Birth, Pre-Eclampsia
- Trial name
- NCT00133926
- Testing
- Treatment of periodontal disease
- Where
- Australia
- Volunteers
- 1,094 people
- Sponsor
- King Edward Memorial Hospital
Pregnancy Related, Maternal-Fetal Relations
Maternal and Fetal Metabolic Changes
The goal of this observational prospective project is to study the metabolic alterations during normal and complicated pregnancies, obtaining an early detection of metabolic changes, offering new insights into future prevention…
- Conditions
- Pregnancy Related, Maternal-Fetal Relations, Metabolism Disorder, Glucose
- Trial name
- MoMM-FET (NCT06288126)
- Where
- Italy
- Volunteers
- 457 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Cerebral Palsy
Magnesium Sulphate for Preterm Birth (MASP Study)
The purpose of the study is to assess whether magnesium sulphate for women at risk of preterm birth can protect their children against cerebral palsy.
- Trial name
- MASP (NCT01492608)
- Testing
- Magnesium sulphate
- Where
- 14 sites in Denmark
- Volunteers
- 560 people
- Sponsor
- Hvidovre University Hospital
Heart Diseases
Development of an Screening System in Children With Congenital Heart Disease Based on Cloud Computing and Big Data
This study intends to establish an automatic system for screening on children with congenital heart disease, the system include the auscultation of cardiac murmur and the test of oxygen saturation, the data was analyzed based on…
- Trial name
- NCT03929133
- Testing
- automatic screening machine on congenital heart disease
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Pregnancy, Anxiety
Mandala Coloring in Late Pregnancy
Anxiety, depression and poor sleep are common in the last months of pregnancy and often occur together. Medication options during pregnancy are limited, so simple, safe non-drug methods are needed.
- Conditions
- Pregnancy, Anxiety, Depression, Psychological Stress
- Trial name
- NCT07906743
- Testing
- Mandala Coloring Group
- Where
- Turkey (Türkiye)
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Fidan Balkaya
Sickle Cell Disease
Expanded Access Protocol for Gene Therapy Utilizing shmiR Lentivirus Vector to Induce Fetal Hemoglobin in Sickle Cell Disease
A promising approach for the treatment of genetic diseases is called gene therapy. Gene therapy is a relatively new field of medicine in which genetic material (mostly DNA) in the patient is changed to treat his or her own…
- Trial name
- GRASP-EA (NCT07640815)
- Testing
- Autologous CD34+ HSC cells transduced with the lentiviral vector containing a shRNA targeting BCL11a
- Where
- United States
- Sponsor
- David Williams
Endometrial Cancer
From Fetal-maternal Interface Immune Tolerance to Endometrial Cancer Immune Escape: Potential Targets for Immunotherapy
Non-interventional retro-prospective study on Endometrial tissue samples taken from surgically treated patients.
- Trial name
- NCT06273878
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- Regina Elena Cancer Institute
Pregnancy, Eclampsia
A Cluster-Randomized Trial of Ultrasound Use to Improve Pregnancy Outcomes in Low Income Country Settings
In many low-income countries, the use of ultrasound by medical officers and non-physician health care staff (e.g., midwives) for antenatal identification of high risk pregnancies is a new intervention requiring authoritative…
- Conditions
- Pregnancy, Eclampsia, Placenta Previa, Stillbirth
- Trial name
- NCT01990625
- Testing
- Antenatal Ultrasound Scan
- Where
- 5 sites in Guatemala, Kenya and 3 more
- Volunteers
- 45,038 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Meconium Aspiration Syndrome, Infant, Newborn, Disease
Time of Positive Pressure Ventilation in Non-vigorous Infants Born Through Meconium-stained Amniotic Fluid
Background: Meconium stained amniotic fluid (MSAF) complicates 3 to 14% of pregnancies, causing meconium aspiration syndrome (MAS) in 5-10% of neonates born.
- Conditions
- Meconium Aspiration Syndrome, Infant, Newborn, Disease, Neonatal Resuscitation
- Trial name
- MASTIME (NCT04076189)
- Testing
- Endotracheal suctioning, No endotracheal suctioning
- Where
- 2 sites in Italy
- Volunteers
- 40 people
- Sponsor
- University Hospital Padova
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