Clinical trials: Prenatal Disorder
PPROM, Preterm
Preterm Rupture of Membranes Optimising Antibiotics Trial
The goal of this clinical trial is to learn which antibiotic regimen works best to prevent infection in pregnant women whose waters break early (preterm, pre-labour rupture of membranes, or PPROM) and assess the health outcomes…
- Trial name
- PROMOAT (NCT06906757)
- Testing
- Erythromycin 250mg and Amoxicillin 500mg
- Volunteers
- 3,900 people
- Sponsor
- University of Melbourne
Maternal Distress, Child Development
In Vitro Fertilization (IVF) and Prenatal Effects Independent of Genetics
This study examines how maternal stress during pregnancy affects infant brain and behavioral development, focusing on whether these effects are due to the prenatal environment or shared genes.
- Trial name
- NCT07296107
- Testing
- Prenatal maternal psychosocial and biological assessment protocol
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Columbia University
Early Pregnancy
Conversational AI Platform for Early Pregnancy Care City-wide Recruitment: A Feasibility Study
This study seeks to determine pregnant patients in the Philadelphia area can be recruited to a conversational AI texting platform.
- Trial name
- CIRCA (NCT07197892)
- Testing
- CIRCA Texting Platform
- Where
- United States
- Volunteers
- 2,637 people
- Sponsor
- University of Pennsylvania
Pregnancy Complications, Preterm Birth
Group Antenatal/Postnatal Care in Rwanda
The focus of this work is to improve antenatal care (ANC) and postnatal care (PNC) at the health center level in five districts in Rwanda (Bugesera, Burera, Nyamasheke, Nyarugenge, and Rubavu).
- Conditions
- Pregnancy Complications, Preterm Birth, Preterm Labor, Stillbirth
- Trial name
- PTBi Rwanda (NCT03154177)
- Testing
- Group ANC/PNC, Ultrasound+Pregnancy Testing
- Where
- 2 sites in Rwanda
- Volunteers
- 26,381 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Psychological, Mental Health Issue
STEP-COVID: A Program for Pregnant Women During the SARS-CoV-2 Pandemic
STEP-COVID (Supporting the Transition to and Engagement in Parenthood during the COVID-19 pandemic) is a manualized group intervention for pregnant women during the COVID-19 pandemic designed to foster emotion regulation and…
- Conditions
- Psychological, Mental Health Issue, Prenatal Stress, Maternal Distress
- Trial name
- NCT05419167
- Testing
- STEP-COVID
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Université du Québec à Trois-Rivières
Congenital Heart Disease
Parenting After Infant Congenital Heart Defect Diagnosis
The purpose of this research study is to learn about parents' experiences following diagnosis of a fetal/neonatal Congenital Heart Defect (CHD).
- Trial name
- NCT01503307
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Medical College of Wisconsin
Prenatal Depression, Ketamine
Low-dose S-ketamine in Women With Prenatal Depression
Prenatal depression is an important risk factor of postpartum depression. Low-dose ketamine has been used for depression treatment. As a stereoisomer of ketamine, s-ketamine has similar effects to ketamine in anti-depression.
- Conditions
- Prenatal Depression, Ketamine, Postpartum Depression
- Trial name
- NCT04414943
- Testing
- S-ketamine
- Where
- 7 sites in China
- Volunteers
- 364 people
- Sponsor
- Peking University First Hospital
Rheumatic; Heart Disease, Maternal, Affecting Fetus
Effect of Rheumatic Heart Disease on Maternal and Fetal Outcomes
It's prospective Cohort study to compare maternal and fetal outcomes in pregnant females between corrected and uncorrected rheumatic valve lesions
- Trial name
- NCT03029117
- Testing
- correction of rheumatic valve lesions
- Volunteers
- 125 people
- Sponsor
- Assiut University
Neonatal Abstinence Syndrome
RCT of High- vs. Standard-Calorie Formula for Methadone-Exposed Infants
Neonatal abstinence syndrome (NAS) symptoms contribute to poor infant weight gain. Early caloric enhancement for infants exposed to methadone is inexpensive, readily available, easy to implement and could improve early outcomes…
- Trial name
- NCT02178189
- Testing
- High Calorie Infant formula, Standard Calorie Infant Formula
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- University of Pittsburgh
Down Syndrome, Fetal Aneuploidy
Clinical Evaluation of the SEQureDx T21 Test In High Risk Pregnancies
Whole blood samples will be collected from high-risk pregnant women to validate the clinical performance of the SEQureDx Trisomy 21 Test.
- Trial name
- NCT01555346
- Where
- 29 sites in United States, Canada
- Volunteers
- 3,062 people
- Sponsor
- Sequenom, Inc.
Parkinson's Disease
TRANSEURO Open Label Transplant Study in Parkinson's Disease
The Transeuro Transplant study is a trial which will involve grafting foetal tissue into the brain of patients with Parkinson's disease, who are already been followed in the observational study.
- Trial name
- TRANSEURO (NCT01898390)
- Testing
- Transplant
- Volunteers
- 13 people
- Sponsor
- University of Cambridge
Birth Weight, Fetal Growth Retardation
Automated Fetal Weight Estimation: A Multicenter Validation Using Fractional Limb Volume
This trial is a collaborative study between 4 sites worldwide. A total of 600 research subjects will be enrolled. We will investigate the validity of using 5D Limb Volume software to improve on estimated fetal weight predictions…
- Conditions
- Birth Weight, Fetal Growth Retardation, Fetal Weight, Fetal Macrosomia
- Trial name
- NCT03002246
- Testing
- Ultrasound Examination
- Volunteers
- 330 people
- Sponsor
- Baylor College of Medicine
Pre-Eclampsia, Intrauterine Growth Restriction
Inter- and Multidisciplinary, Cross-sectoral Feto-neonatal Pathway
Due to the fetoneonatal pathway it is possible to identify pregnant women with an increased risk of fetal growth restriction or pre-eclampsia in early stages (from 10th week of pregnancy).
- Conditions
- Pre-Eclampsia, Intrauterine Growth Restriction, Maternal Care for Known or Suspected Poor Fetal Growth
- Trial name
- NCT04514276
- Testing
- consecutive fetoneonatal healthcare pathway
- Where
- 2 sites in Germany
- Volunteers
- 828 people
- Sponsor
- Technische Universität Dresden
Intrapartum Fever, Chorioamnionitis
Antipyretic Treatment for Intrapartum Fever: Dipyrone vs Acetaminophen (RCT)
Chorioamnionitis, or intraamniotic infection, is a common condition affecting 2-5% of all term births. This condition poses well-recognized maternal and neonatal risks, and entails a series of clinical management decisions…
- Trial name
- PARADIP (NCT06950840)
- Testing
- Acetaminophen, dipyrone
- Where
- Israel
- Volunteers
- 140 people
- Sponsor
- Wolfson Medical Center
Chlamydia Trachomatis Infection, Neonatal Infection
Antenatal Chlamydia Trachomatis and Neisseria Gonorrhoeae Testing to Prevent Adverse Neonatal Consequences
To assess the effectiveness of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) testing and treatment during pregnancy to reduce adverse pregnancy and birth outcomes compared to the standard of care (treatment based on…
- Conditions
- Chlamydia Trachomatis Infection, Neonatal Infection, Preterm Birth, Gonorrhea
- Trial name
- NCT04955717
- Testing
- Chlamydia trachomatis and Neisseria gonorrhoeae screening using the GeneXpert
- Where
- 2 sites in United States, Botswana
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Maternal Care Patterns, Nutrition, Healthy
The 1000 First Day of Life : Effect of Multi Micronutrients Supplementation on Pregnancy Outcomes
To monitor the effects of multi micronutrients supplementations during pregnancy towards pregnancy outcomes
- Conditions
- Maternal Care Patterns, Nutrition, Healthy, Nutritional Deficiency, Maternal-Fetal Relations
- Trial name
- NCT06035315
- Testing
- Multiple Micronutrients during pregnancy
- Where
- 2 sites in Indonesia
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Preterm Less Than 32wks With IVH, WMI/PVL, Late Preterm or Term (37-42wks) With Neonatal Encephalopathy Treated With Hypothermia for HIE
Cerebral/ Cortical Visual Impairment: Screening, Identification and Outcome Prediction in Neonates
Cerebral/Cortical Visual Impairment (CVI) is the leading cause of childhood visual impairment in the United States and other industrialized countries.
- Trial name
- CVI (NCT07275021)
- Testing
- Prospective Clinical and Neurodevelopmental Data Collection
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brigham and Women's Hospital
Pregnancy Related, Neurodevelopmental Disorders
Prenatal Iodine Supplementation and Early Childhood Neurodevelopment
A randomized controlled trial to determine the effect of reducing iodine from vitamin and mineral supplements for pregnant women who have adequate iodine intakes (>165 μg/d from food alone) on cognitive development of children at…
- Conditions
- Pregnancy Related, Neurodevelopmental Disorders, Nutrition Disorder, Fetal
- Trial name
- PoppiE (NCT04586348)
- Testing
- Low Iodine Supplement, Standard Iodine Supplement
- Where
- Australia
- Volunteers
- 794 people, healthy volunteers welcome
- Sponsor
- South Australian Health and Medical Research Institute
Preterm Delivery, Obstetrical Complications
Aspirin Dose Escalation for the Prevention of Recurrent Preterm Delivery Trial
This is a phase-III multi-center double-blind randomized clinical trial of 1,800 individuals with a history of prior preterm birth at less than 35 weeks gestation who are randomized to either 162 mg aspirin or 81 mg aspirin…
- Trial name
- ADEPT (NCT06980025)
- Testing
- 162mg Aspirin, 81mg Aspirin
- Where
- 14 sites in United States
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Congenital Toxoplasmosis
Prevention of Congenital Toxoplasmosis With Pyrimethamine + Sulfadiazine Versus Spiramycine During Pregnancy
Background : When a mother contracts toxoplasmosis during pregnancy, the parasite may be transmitted from to her unborn child. This results in congenital toxoplasmosis, which may cause damage to the eyes and nervous system of the…
- Trial name
- TOXOGEST (NCT01189448)
- Testing
- Pyrimethamine/Sulfadiazine, Spiramycine
- Where
- France
- Volunteers
- 149 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris