Clinical trials: Prenatal Screening
Antenatal Health, Antenatal Care
Healthy Expectancy Through Routine Antenatal STI Screening
This study will evaluate whether routine screening and treatment for two common sexually transmitted infections, chlamydia and gonorrhoea, during pregnancy can reduce preterm birth and other poor birth outcomes in Botswana, and…
- Conditions
- Antenatal Health, Antenatal Care, STI, Chlamydia Trachomatis Infection in Pregnancy
- Trial name
- HERA (NCT07458802)
- Testing
- Chlamydia trachomatis and Neisseria gonorrhoeae screening
- Where
- Botswana
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Adriane Wynn
Gestational Diabetes
Fetal Cardiac Function Parameters and HbA1c As Screening for Gestational Diabetes Mellitus
This is a prospective cohort study to assess the predictive value of fetal cardiac parameters, the change in fetal cardiac parameters (CFP), HbA1c, and/or the change in HbA1c (ΔHbA1c) for gestational diabetes.
- Trial name
- NCT05019508
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Pregnancy
Assessment of Women's Insight and Understanding of Down's Syndrome Screening by Non-invasive Prenatal Testing (NIPT) During Their First Ultrasound
Down's syndrome is the leading cause for mental retardation in France. Screening for this chromosomal abnormality is systematically proposed during pregnancy.
- Trial name
- DEPIST21 (NCT03549286)
- Testing
- Questionnaire passation
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Prenatal Disorder
Game-Based Decision Aid to Educate Pregnant Women About Prenatal Screening
Significant barriers exist for effectively informing women about prenatal screening in the clinical setting. This project developed and evaluated the efficacy of a game decision aid among pregnant women about prenatal screening…
- Trial name
- NCT03441672
- Testing
- Meaning of Screening
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of Utah
Pregnancy
Reducing False Positives in Prenatal Screening
Combined first-trimester screening represents the gold standard of risk assessment for the presence of trisomy 21, 18, and 13. The concept is based on the age risk, the measurement of fetal nuchal translucency (NT), and the…
- Trial name
- ReFaPo02 (NCT03375359)
- Testing
- cfDNA screening
- Where
- Germany
- Volunteers
- 1,127 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Umbilical Cord Issue, Intrauterine Growth Restriction
Three-dimensional Umbilical Cord Coiling Index
Previous studies have shown that abnormal coiling of the umbilical cord is associated with adverse perinatal outcome. For example, an umbilical cord that is non-coiled increases the chance of fetal morbidity and mortality…
- Conditions
- Umbilical Cord Issue, Intrauterine Growth Restriction, Fetal Distress
- Trial name
- NCT05727241
- Testing
- Ultrasound
- Where
- Israel
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Antenatal Depression, Antenatal Anxiety
Effectiveness and Cost-effectiveness of Simultaneous Screening and Intervention for Antenatal Depression and Anxiety Symptoms From a Transdiagnostic Perspective: A Scale-up Feasibility Study
This scale-up study aimed to explore the effectiveness of simultaneous screening and intervention of antenatal depression and anxiety in preventing postpartum depression and anxiety and how scale-up might be successfully…
- Trial name
- NCT07349368
- Testing
- implementation group
- Where
- China
- Volunteers
- 3,314 people, healthy volunteers welcome
- Sponsor
- Anhui Medical University
Genetic Counseling, Shared Decision Making
Comparing Game Facilitated Interactivity to Genetic Counseling for Prenatal Screening Education
Advancements in prenatal genetic screening have significantly improved the identification of chromosomal abnormalities and heritable conditions during pregnancy, yet current standards for patient education in this domain are…
- Conditions
- Genetic Counseling, Shared Decision Making, Pregnancy, Genetic Testing
- Trial name
- NCT05360095
- Testing
- Meaning of Screening, Genetic Counseling, Usual Care
- Where
- 3 sites in United States
- Volunteers
- 2,045 people, healthy volunteers welcome
- Sponsor
- Erin Rothwell
Pre-Eclampsia, Placenta Diseases
Trial of Early Screening Test for Pre-eclampsia and Growth Restriction
A study of aspirin use in pregnancy to prevent high blood pressure and growth restriction of the fetus
- Conditions
- Pre-Eclampsia, Placenta Diseases, Eclampsia Preeclampsia, Fetal Growth Retardation
- Trial name
- TEST (NCT03674606)
- Testing
- Low dose aspirin
- Where
- 2 sites in Ireland
- Volunteers
- 546 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Trisomy 21, Trisomy 18
Development of Non-invasive Prenatal Screening Test for Microdeletions Based on Fetal DNA Isolated From Maternal Blood
The purpose of this study is to collect maternal blood samples from pregnant women carrying a fetus with a confirmed diagnosis of chromosomal abnormality or genetic disorder including microdeletions in order to further develop a…
- Conditions
- Trisomy 21, Trisomy 18, Trisomy 13, Sex Chromosome Abnormalities
- Trial name
- MAPS (NCT01852708)
- Where
- 9 sites in United States, Spain and 1 more
- Volunteers
- 1,059 people, healthy volunteers welcome
- Sponsor
- Natera, Inc.
Females Undergoing PGD Technology for Medical Conditions
Isolation of Cell Free Fetal DNA From Spent Culture Medium and Its Potential Role for Preimplantation Genetic Diagnosis (PGD).
Preimplantation genetic testing for chromosomal screening is, at present, the most reliable method to assess the genetic status of preimplantation embryos.
- Trial name
- NCT06084377
- Testing
- Preimplantation Genetic Screening
- Where
- Syria
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Damascus University
Proteinuria, Preeclampsia
Validation of a PrCr Dipstick Diagnostic Test in Ghana
This evaluation will aim to generate a body of evidence that will determine performance characteristics of the current PrCr dipstick test and the feasibility of its use in target ANC settings.
- Trial name
- NCT03510286
- Testing
- Test-it™ PrCr Urinalysis Strips
- Where
- Ghana
- Volunteers
- 1,483 people, healthy volunteers welcome
- Sponsor
- PATH
Aneuploidy, Down Syndrome
Does an Educational Video for Aneuploidy Screening Improve Informed Choice Among Pregnant Women?
Informed decision-making regarding aneuploidy screening has been reported to be low. Poor knowledge and the lack of deliberation have been cited as reasons for uninformed choices, highlighting the need for adequate pre-test…
- Conditions
- Aneuploidy, Down Syndrome, Pregnancy Early
- Trial name
- EVA (NCT05492981)
- Testing
- Enhanced (intervention) education
- Where
- Singapore
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Aneuploidy
A Pilot Study for Implementation of First Trimester Screening of Aneuploidies in Campania Region
The study aims to compare two different protocols for first trimester screening of aneuploidies, one based on nuchal translucency and NIPT and another one based on the integration between combined test and NIPT, in order to…
- Trial name
- PISTA (NCT05798858)
- Testing
- NIPT
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Federico II University
Insulin Resistance, Diabetes
Validation of a Novel Screening Test for Maternal Insulin Resistance
This will be a validation study of Quantose IR and Quantose IGT to predict insulin resistance and identify patients with prediabetes. This is a pilot study of 100 subjects.
- Trial name
- NCT03388697
- Testing
- Quantose IR and Quantose IGT analysis, HOMA IR the standard testing for insulin resistance
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Fetal Growth Retardation, Fetal; Slow Growth
Third Trimester Screening of Fetal Growth Restriction
The aim of this trial is to assess the efficacy of two screening protocols for the detection of fetal growth disorders. In Italy at the moment the screening protocol should not be universal but only on clinical indications.
- Trial name
- RELAIS (NCT05787054)
- Testing
- Third trimester ultrasound
- Where
- Italy
- Volunteers
- 813 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Preterm Labour
Detection of Preterm Labour by Cervical Length
Detection of short cervix by transvaginal ultrasound and its evidence based management to prevent preterm birth .
- Trial name
- NCT04104984
- Testing
- transvaginal ultrasound, Progesterone Vaginal Suppository, cervical cercalage
- Volunteers
- 966 people, healthy volunteers welcome
- Sponsor
- Assiut University
Prenatal Disorder
Point of Care Ultrasound Screening for Abnormal Fetal Growth During Routine Antenatal Visits
Abdominal circumference (AC) in the fetus is the single most useful indicator of fetal growth abnormalities. Measurement of AC as well as DVP do not require extensive training.
- Trial name
- NCT03715036
- Testing
- Point-of-care US
- Where
- United States
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Pregnancy - Prenatal Testing
GRAPE-GDM Prospective Comperative Trial - Grape Juice as a Replacement Drink for Gestational Diabetes Screening
Study Type: Observational, prospective, multicenter comparative study Primary Purpose: The goal of this study is to evaluate whether grape juice can serve as an effective alternative to the standard 50g glucola drink for…
- Trial name
- GRAPE-GDM (NCT07323901)
- Testing
- Participants will consume 500 ml of commercially available grape juice which contains 50g of sugar, serving as an alternative glucose load.
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Bnai Zion Medical Center
2D Ultrasound, Cavum Septum Pellucidum
Screening of Septo-optic Dysplasia During a Fetal Examination at 16-20 Weeks of Gestation
Evaluation of prenatal optic chiasm (OC) is important for the differential diagnosis of septo-optic dysplasia (SOD), which is a congenital optic disc anomaly, and the absence of the cavum septum pellucidum (CSP).
- Conditions
- 2D Ultrasound, Cavum Septum Pellucidum, Septooptic Dysplasia, Optic Chiasma
- Trial name
- NCT05717855
- Testing
- Displaying optic chiasm for screening septooptic dysplasia
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital