Clinical trials: Preoperative
Parotid Tumor
FArial NErf MRI in the Preoperative Assessment of PArotide Tumors
1. st visit: Inclusion, 3Tesla injected parotid MRI performed as part of routine care for characterization, to which two specific high resolution sequences will be added.
- Trial name
- NEFAPA (NCT04613349)
- Testing
- MRI
- Where
- France
- Volunteers
- 88 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Colorectal Liver Metastases
Preoperative Hepatic Arterial Infusion Chemotherapy
To assess the feasibility and results of liver resection after preoperative hepatic artery infusion (HAI) chemotherapy with FUDR.
- Trial name
- NCT00522509
- Testing
- Floxuridine FUDR
- Where
- Italy
- Sponsor
- IRCCS San Raffaele
Type2 Diabetes Mellitus
Basal Insulin Strategies Before Surgery
Many patients with Type 2 Diabetes Mellitus (T2DM) are currently being managed with Basal Insulin (BI). However, there is little evidence to support guidelines on dosing adjustments in the preoperative period.
- Trial name
- NCT03104738
- Testing
- 25% reduction of basal insulin dose
- Volunteers
- 40 people
- Sponsor
- Ohio State University
Sarcoma, Ewing, Chondrosarcoma
A Study to Evaluate the Utilization of 3D Printed Models in Pre-Operative Planning
This prospective, multi-center, randomized controlled study aims to assess the efficacy of utilizing 3D printed models in preoperative planning for the excision of tumors involving bony structures within the body.
- Conditions
- Sarcoma, Ewing, Chondrosarcoma, Osteosarcoma, Fibrous Histiocytoma
- Trial name
- NCT06387485
- Testing
- 3D Printed Anatomic Model, CT/MRI
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- Ricoh USA, Inc.
Brain Tumor Adult
Safety and Feasibility of Preoperative and Intraoperative Image-Guided Resection of Gliomas
This study evaluates the use of specialized magnetic resonance imaging (MRI) techniques including magnetic resonance (MR) perfusion and 2-hydroxyglutarate (2HG) spectroscopy in the surgical treatment of gliomas.
- Trial name
- NCT03542409
- Testing
- MR Perfusion Scan, 2HG Spectroscopy Scan, Standard of Care Intraoperative MRI
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Utah
Surgery, Aging
De-adopting Routine Preoperative Benzodiazepines for Older Surgical Patients
Over 21 million surgical procedures take place among adults aged 65 and older in the US each year, and most older surgical patients in the US now receive benzodiazepines (e.g., midazolam, lorazepam) during anesthesia care.
- Trial name
- DROP-Benzo (NCT05436392)
- Testing
- Peer Comparison Feedback, Patient Informational Letter
- Where
- United States
- Volunteers
- 517,611 people
- Sponsor
- University of Pennsylvania
Endometrial Cancer
A Pre-Op Window Study Evaluating Anti-Proliferative Effects of Atorvastatin on the Endometrium
This is a preoperative window, phase 0 study of short-term atorvastatin treatment in obese women who are to undergo surgical staging for endometrial cancer.
- Trial name
- NCT02767362
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Colorectal Cancer
Development and Validation of a Risk Prediction Model for Preoperative Frailty in Elderly Patients With Colorectal Cancer
Fried Scale and its related scales were used to analyze the status and risk factors of preoperative frailty in elderly patients with colorectal cancer.
- Trial name
- NCT05879861
- Where
- China
- Volunteers
- 364 people
- Sponsor
- Zunyi Medical College
Breast Cancer
Surgery to Remove the Sentinel Lymph Node and Axillary Lymph Nodes After Chemotherapy in Treating Women With Stage II, Stage IIIA, or Stage IIIB Breast Cancer
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00881361
- Testing
- systemic chemotherapy, axillary lymph node dissection, neoadjuvant therapy
- Where
- 324 sites in United States
- Volunteers
- 756 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Patient Education
Patient Information Videos on Operations Trial
This study evaluates whether rapid sequence animation videos (RSAV) are of use as an additional learning resource for the elective pre-operative patient.
- Trial name
- PIVOT (NCT03689751)
- Testing
- LSCS Video, TVT/TOT Video
- Volunteers
- 72 people
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Macular Holes
Preoperative Progression of Macular Holes
Knowledge of the natural history and progression of macular holes is mainly limited to the studies from the pre-optical coherence tomography era.
- Trial name
- NCT02203929
- Where
- Denmark
- Volunteers
- 37 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Cardiac Surgery, Nursing Care
Frailty and Dependency in Older Adults Undergoing Cardiac Surgery
Frailty and dependency are common conditions among older adults undergoing cardiac surgery and may adversely affect postoperative recovery and readiness for hospital discharge.
- Conditions
- Cardiac Surgery, Nursing Care, Perioperative Care
- Trial name
- NCT07755254
- Where
- Turkey (Türkiye)
- Volunteers
- 187 people
- Sponsor
- Aydin Adnan Menderes University
Colorectal Cancer
Radiation Therapy Plus Chemotherapy Followed by Surgery in Treating Patients With Locally Advanced Cancer of the Rectum
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00006366
- Testing
- fluorouracil, irinotecan hydrochloride, conventional surgery
- Where
- 235 sites in United States, Canada
- Sponsor
- Radiation Therapy Oncology Group
Primary Liver Cancer, Liver Metastasis
Evaluation of Preoperative Investigations in Patients With Liver Cancer
The aim of the study is to evaluate the diagnostic procedures emission tomography in combination with a CT scan (PET/CT) and endoscopic ultrasonography (EUS) in the preoperative evaluation of resectability of patients with…
- Trial name
- NCT00408122
- Testing
- PET/CT scan and EUS
- Where
- Denmark
- Volunteers
- 77 people
- Sponsor
- Odense University Hospital
Pain, Postoperative, Anxiety
Preoperative Virtual Reality to Reduce Pain on Gynaecologic Patients Undergoing Surgery
In the perioperative setting, distraction therapies have been used as a technique to reduce anxiety and pain in the perioperative period.
- Trial name
- NCT03685422
- Testing
- Virtual Reality
- Where
- Singapore
- Volunteers
- 220 people
- Sponsor
- KK Women's and Children's Hospital
End Stage Renal Disease, Chronic Kidney Diseases
Berinert (C1INH) vs Placebo for DGF/IRI
This is a Phase I/II double-blind, randomized, placebo-controlled study assessing safety and limited efficacy of intraoperative C1INH (500U/kidney) vs.
- Trial name
- NCT04696146
- Testing
- Berinert
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Cedars-Sinai Medical Center
Cognitive Impairment
Preoperative Survey
This study will examine preoperative concerns in older adults through the use of a self-administered questionnaire. The development of this questionnaire will involve adapting survey questions from previously validated studies…
- Trial name
- NCT05653154
- Where
- 2 sites in Canada
- Volunteers
- 264 people
- Sponsor
- University Health Network, Toronto
Premedication, Anaesthesia
Melatonin Premedication in Children Undergoing Surgery
Melatonin has been proposed as alternative to midazolam as a premedication in procedures preceding anaesthesia induction. The objective of this prospective, randomized, double-blind study is to investigate the possible effect of…
- Trial name
- NCT02265822
- Testing
- melatonin in children premedication, midazolam in children premedication
- Volunteers
- 92 people
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico "G. Martino"
Pain, Disability
Additional Effects of Pain Neuroscience Education With Standard Pre-operative Physiotherapy on Post-laminectomy Pain and Disability.
This randomized controlled trial investigates whether adding Pain Neuroscience Education (PNE) to standard pre-operative physiotherapy improves outcomes after lumbar laminectomy.
- Conditions
- Pain, Disability, Laminectomy, Physical Therapy
- Trial name
- NCT07801586
- Testing
- Experimental Group - Pain Neuroscience Education + Standard Pre-operative Protocol, Control Group - Standard Pre-Operative Care
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Foundation University Islamabad
Urinary Incontinence
Trial Study of the Efficacy of Intensive Preoperative Pelvic Floor Muscle Training to Decrease Post-prostatectomy Urinary Incontinence
Urinary incontinence after radical prostatectomy is a significant clinical problem despite advances in surgical techniques. In the literature, the incidence of post prostatectomy urinary incontinence varies widely from 0.5 to 87%…
- Trial name
- NCT01338584
- Testing
- Pelvic floor muscle training 3 weeks before radical prostatectomy, Intensive preoperative pelvic floor muscle training
- Where
- Hong Kong
- Volunteers
- 84 people
- Sponsor
- Queen Mary Hospital, Hong Kong
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