Clinical trials: Preoperative
Breast Cancer
Sunitinib in Treating Patients With Newly Diagnosed Stage II or Stage III Breast Cancer That Can Be Removed by Surgery
RATIONALE: Sunitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- NCT00482755
- Testing
- sunitinib malate, immunohistochemistry staining method, laboratory biomarker analysis
- Where
- 2 sites in Canada
- Volunteers
- 4 people
- Sponsor
- NCIC Clinical Trials Group
Colon Carcinoma, Colorectal Carcinoma
Zanidatamab Before Surgery for the Treatment of HER2 Positive Colon and Rectal Cancer in Patients Planned for Curative Intent Treatment
This phase II trial studies how well giving zanidatamab before surgery (neoadjuvant) works in treating patients with colon and rectal cancer that is human epidermal growth factor receptor 2 positive (HER2+ve) who are planned for…
- Conditions
- Colon Carcinoma, Colorectal Carcinoma, Rectal Carcinoma, Stage I Colon Cancer AJCC v8
- Trial name
- NCT07405476
- Testing
- Zanidatamab, Resection, Patient Observation
- Where
- 4 sites in United States
- Volunteers
- 38 people
- Sponsor
- Emory University
Adenotonsillectomy
Intranasal Dexmedetomidine, Ketamine or Midazolam for Anxiety and Respiratory Complications in Children
This study is being done to find out which of three medications-dexmedetomidine, ketamine, or midazolam-is best at reducing anxiety and breathing problems in children having surgery to remove their tonsils and adenoids.
- Trial name
- INPERM (NCT07072117)
- Testing
- Intranasal Dexmedetomidine as a Premedication for Prevention of Anxiety & Respiratory Complications, Intranasal Ketamine as a Premedication for Prevention of Anxiety and Respiratory Complications, Intranasal Midazolam as a Premedication for Prevention of Anxiety and Respiratory Complications
- Where
- Egypt
- Volunteers
- 148 people
- Sponsor
- Zagazig University
Thyroid Diseases
Vit D Role in Post Thyroidectomy Hypocalcemia
Hypocalcemia after total thyroidectomy is usually transient but it is of main concern as it requires either prolonged stay in the hospital or readmission.
- Trial name
- NCT04094493
- Testing
- vit D
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Breast Cancer
Weekly Paclitaxel Plus Carboplatin in Preoperative Treatment of Breast Cancer
The purpose of this study is to evaluate the pathological complete response (pCR) rate in breast cancer patients treated with weekly paclitaxel plus carboplatin preoperative regimen.
- Trial name
- NCT01203267
- Testing
- Paclitaxel, Carboplatin
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Comparative Effectiveness
Equivalence of Oral Melatonin and Oral Midazolam in Preoperative Anxiolysis for Pediatric Fast-Track Cardiac Surgery
Equivalence of Oral Melatonin and Oral Midazolam in Preoperative Anxiolysis for Pediatric Fast-Track Cardiac Surgery
- Trial name
- NCT07900321
- Testing
- Melatonin, Midazolam
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Aortic Stenosis (Treated With TAVI)
Effect of Preoperative Iron Isomaltoside 1000 Administration on Hemoglobin Concentration in Patients Undergoing Transcatheter Aortic Valve Implantation
Transcatheter aortic valve implantation (TAVI) is a standard procedure for severe aortic stenosis patients with moderate or higher risk of surgery.
- Trial name
- NCT04346004
- Testing
- Normal saline, Iron isomaltoside
- Where
- South Korea
- Volunteers
- 214 people
- Sponsor
- Yonsei University
Behavior Problems, Pediatrics
Postoperative Behavioral Changes in Children.
In children scheduled for dental treatment, negative thoughts can lead to anxiety and make them resistant to treatment techniques.
- Conditions
- Behavior Problems, Pediatrics, Pediatric Pain and Anxiety
- Trial name
- NCT06761833
- Where
- Turkey (Türkiye)
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Baskent University
Sarcopenia, Pancreatic Cancer
Preoperative Prehabilitation for Sarcopenic Patients Prior to Pancreatic Surgery for Cancer
Major digestive surgery is associated with a significant rate of postoperative complications. To improve postoperative outcome, efforts are focused on postoperative course leading to the concept of rehabilitation.
- Trial name
- PSOAS (NCT04469504)
- Testing
- Prehabilitation program, Oral Impact
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Lille
Preoperative Anxiety, PAİN
The Effect of a Drama-Based Coloring Storybook on Children's Fear, Anxiety, and Pain Management in the Perioperative Process: "Alican's Brave Journey"
This randomized controlled study aims to evaluate the effect of a drama-based coloring storybook on children's fear, anxiety, and pain management during the perioperative process.
- Conditions
- Preoperative Anxiety, PAİN, Fear
- Trial name
- NCT07414628
- Testing
- Drama-Based Coloring Storybook Intervention
- Volunteers
- 72 people
- Sponsor
- Bingol University
Appendicitis Acute, Disbiosis
Differences In Microbiota Profiles Of Pediatric Appendicitis Cases
The microbial profile varies between simple appendicitis (SA) and complicated appendicitis (CA) cases. An appendectomy has been noted to temporarily diminish gut bacterial diversity.
- Conditions
- Appendicitis Acute, Disbiosis, Complicated Appendicitis, Simple Appandiscitis
- Trial name
- NCT07860307
- Testing
- Appendectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Adenocarcinoma of the Rectum, Stage II Rectal Cancer
Postoperative Chemotherapy With or Without Bevacizumab for Patients With Stage II or III Rectal Cancer
Drugs used in chemotherapy, such as oxaliplatin, leucovorin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Adenocarcinoma of the Rectum, Stage II Rectal Cancer, Stage III Rectal Cancer
- Trial name
- NCT00303628
- Testing
- oxaliplatin, fluorouracil, leucovorin calcium
- Where
- 617 sites in United States, Canada and 2 more
- Volunteers
- 355 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Preoperative Care, Nursing Education
The Effect of Simulation-Based Preoperative Nursing Care Education on Student
Today, different technologies are used in the stages of the education and training process. Simulation education approaches constitute an important group in health education and training.
- Conditions
- Preoperative Care, Nursing Education, Simulation, Clinical Practice
- Trial name
- NCT06632392
- Testing
- Simulation training, Theory training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Okan University
Postoperative Pain
Arthroplasty Inflammation Prophylaxis With Celecoxib
This double blinded, placebo controlled, study seeks to determine the efficacy of preoperative anti-inflammatory therapy on the reduction of postoperative pain in knee arthroplasty surgery.
- Trial name
- NCT00533247
- Testing
- Celecoxib
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zanbilowicz, Adam, DPM MS
Pediatric Anesthesia, Postoperative Nausea and Vomiting (PONV)
Inflammatory Biomarkers as Predictors of PONV Following Pediatric Orchiopexy
Orchiopexy is a common surgical procedure for the treatment of cryptorchidism in the pediatric population, with a high incidence of postoperative nausea and vomiting (PONV).
- Conditions
- Pediatric Anesthesia, Postoperative Nausea and Vomiting (PONV), Inflammatory Biomarkers
- Trial name
- NCT07148063
- Testing
- Measurement of Preoperative Inflammatory Biomarkers
- Where
- Turkey (Türkiye)
- Volunteers
- 170 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Magnesium Deficiency
Preoperative Ionized Magnesium Assessment
The reported incidence of hypomagnesemia is approximately 2% in the general population. Hypomagnesemia is a common problem, occurring in nearly 10%of general hospitalized patients and 17% of hospitalized cancer patients.
- Trial name
- NCT04972344
- Testing
- Ionized magnesium
- Where
- South Korea
- Volunteers
- 536 people
- Sponsor
- Seoul National University Bundang Hospital
Surgery, Malnutrition
Malnutrition is a Severe Health Issue for Cancer Patients. This Study Examines How Preoperative Nutritional Status Affects Postoperative Delirium in Patients Undergoing Major Abdominal Surgery for Gynecological and Gastrointestinal Tumors.
The World Health Organization (WHO) identifies malnutrition as a significant public health threat. It is a common issue among cancer patients due to various factors.
- Conditions
- Surgery, Malnutrition, Delirium, Postoperative, Abdominal Neoplasm
- Trial name
- NCT06657599
- Testing
- Major Abdominal Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Proliferative Diabetic Retinopathy, Diabetic Traction Retinal Detachment
Prospective Randomized Controlled Study of Intravitreal Injection of Bevacizumab for Proliferative Diabetic Retinopathy
We hypothesized that to reduce the adverse effects of intravitreal bevacizumab on ocular tissue and whole body, intravitreal injection of a low concentration of bevacizumab and conducting vitrectomy shortly after the injection is…
- Conditions
- Proliferative Diabetic Retinopathy, Diabetic Traction Retinal Detachment, Vitreous Hemorrhage
- Trial name
- NCT01854593
- Testing
- Bevacizumab, Vitrectomy
- Where
- Japan
- Volunteers
- 69 people
- Sponsor
- Nihon University
Lymphedema, Musculoskeletal Complications
Image-Guided Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Shoulder, Arm, Hip, or Leg
RATIONALE: Image-guided radiation therapy uses high-energy x-rays to kill tumor cells. Specialized radiation therapy that delivers a lower dose of radiation directly to the tumor may kill more tumor cells and cause less damage to…
- Conditions
- Lymphedema, Musculoskeletal Complications, Radiation Fibrosis, Radiation Toxicity
- Trial name
- NCT00589121
- Testing
- Chemotherapy, Radiation therapy, Surgery
- Where
- 17 sites in United States, Canada
- Volunteers
- 98 people
- Sponsor
- Radiation Therapy Oncology Group
Thoracic Surgery, E-health App
E-Health-Supported Preoperative Education
In the context of patient education, the integration of mobile applications-an e-health modality-among healthcare professionals and patients has garnered significant attention alongside technological advancements.
- Conditions
- Thoracic Surgery, E-health App, Preoperative Care, E-health
- Trial name
- NCT07588321
- Testing
- E-health education
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Dokuz Eylul University
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