Clinical trials: Preoperative
Obesity, Morbid, Insulin Sensitivity
Predictors of Weight Loss and Metabolic Health After Bariatric Surgery
In this prospective study the investigators aim to identify preoperative predictors of improvement of metabolic health and weight loss after bariatric surgery focusing on inflammation, insulin sensitivity (in a subgroup of…
- Conditions
- Obesity, Morbid, Insulin Sensitivity, Bariatric Surgery Candidate, Feeding Behavior
- Trial name
- NCT05987631
- Where
- 3 sites in Netherlands
- Volunteers
- 1,200 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Adenocarcinoma of Rectum
A Randomised Trial of Preoperative Radiotherapy for Stage T3 Adenocarcinoma of Rectum
This is a multi-centre randomised trial comparing long course (LC) preoperative chemoradiation with short course (SC) preoperative radiotherapy for patients with localised T3 rectal cancer.
- Trial name
- NCT00145769
- Testing
- Short Course Adjuvent Chemotherapy, Long Course Adjuvant Chemotherapy, Short Course Radiotherapy
- Where
- 34 sites in Australia, New Zealand
- Volunteers
- 326 people
- Sponsor
- Trans Tasman Radiation Oncology Group
Basal Cell Carcinoma of Skin, Cutaneous Squamous Cell Carcinoma (CSCC)
Impact of Preoperative High-Frequency Ultrasound Cutaneous Lesion Extent Assessment on Excision Margin Positivity in Head and Neck Skin Cancer, and the Relationship Between Preoperative Assessment Methods, Inadequate Excision Margins, and Tumor Recurrence
Non-melanoma skin cancers (NMSC), particularly basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), are the most common malignancies in Caucasians, with the majority of tumors located in the head and neck due…
- Conditions
- Basal Cell Carcinoma of Skin, Cutaneous Squamous Cell Carcinoma (CSCC), Cutaneous Squamous Cell Carcinoma in Situ (CSCCis), Cutaneous Squamous Cell Carcinoma of the Head and Neck
- Trial name
- HFUS-CLEAR (NCT07361666)
- Testing
- High-Frequency Ultrasound, Dermoscopy
- Where
- Poland
- Volunteers
- 400 people
- Sponsor
- Państwowy Instytut Medyczny Ministerstwa Spraw Wewnętrznych i Administracji
Guideline Adherence, Anemia
Guideline Adherence for Preoperative Anemia Management in a PAC
Anemia in surgical patients is a common seriously problem; around 40 % of patients presenting for major surgery are anemic problem. Patients with major surgery have significantly higher rates of acute blood loss.
- Trial name
- NCT05447442
- Where
- Thailand
- Volunteers
- 93 people
- Sponsor
- Siriraj Hospital
Preoperative Anxiety
Comparing Two Doses of Oral Melatonin as Premedication in Children Undergoing Surgery
Preoperative anxiety is a common issue in pediatric anesthesia. Children often experience anxiety and uneasiness due to uncertain outcomes.
- Trial name
- NCT06489327
- Testing
- melatonin (Circadin ®) 0.2 mg/kg, melatonin (Circadin ®) 0.4 mg/kg
- Where
- 2 sites in Egypt, Iraq
- Volunteers
- 120 people
- Sponsor
- Al-Azhar University
Rectal Neoplasms
Preoperative Radiotherapy/ Oxaliplatin/ Capecitabine Treatment For Unresectable Locally-advanced Rectal Cancer
The purpose of this phase II trial is to determine the efficacy and safety of the combination of oxaliplatin, capecitabine and radiotherapy as preoperative therapy in locally advanced cancers of the rectum.
- Trial name
- PROCTFUL (NCT00263029)
- Testing
- Oxaliplatin, Capecitabine, Radiotherapy
- Volunteers
- 18 people
- Sponsor
- Sanofi
Preoperative Anxiety, Preoperative Sedation
Determination of ED50 and ED95 With Clinical Efficacy of Intranasal Dexmedetomidine Combined With Esketamine for Preoperative Sedation in Pediatric General Anesthesia
For pediatric patients undergoing general anesthesia, poor anesthesia induction compliance often has adverse effects on individual behavior in the early postoperative period.
- Conditions
- Preoperative Anxiety, Preoperative Sedation, Children, Dexmedetomidine
- Trial name
- NCT06853431
- Testing
- dexmedetomidine, Esketamine
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Intertrochanteric Femur Fracture, Hip Fracture Surgeries
Inflammatory Indices, Early Mortality, and ICU Stay in Geriatric PFN Patients
This retrospective observational cohort study aims to evaluate the association between preoperative and postoperative inflammatory indices and early postoperative outcomes in geriatric patients undergoing proximal femoral nailing…
- Conditions
- Intertrochanteric Femur Fracture, Hip Fracture Surgeries, Geriatric Anesthesia
- Trial name
- PFN-RAR (NCT07607886)
- Where
- Turkey (Türkiye)
- Volunteers
- 233 people
- Sponsor
- Saglik Bilimleri Universitesi
Catheter Site Discomfort
Preoperative Education With Image Illustrations Enhances Effect of Tetracaine Mucilage in Alleviating Postoperative CRBD
Catheter-related bladder discomfort (CRBD) is not uncommon in male patients under general anesthesia, and it may cause patient agitation and exacerbated postoperative pain.
- Trial name
- NCT03199105
- Testing
- Preoperative education with image illustrations and/or local tetracaine mucilage
- Where
- China
- Volunteers
- 64 people
- Sponsor
- West China Hospital
Dystonia
Predicting DBS Outcomes in Dystonia Using Wearable Gait Sensors
This study aims to investigate whether preoperative gait characteristics, measured by wearable sensors, can predict the clinical outcomes of Deep Brain Stimulation (DBS) in patients with dystonia.
- Trial name
- NCT07323602
- Testing
- Wearable Gait Sensor Analysis
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Ruijin Hospital
Breast Neoplasms
Treatment of Larotaxel/Docetaxel, +/- Trastuzumab, After Anthracycline-cyclophosphamide in Breast Cancer Patients
The primary objective of this study is to assess the pathological Complete Response (pCR) rate by treatment arm (according to Chevallier criteria).
- Trial name
- SATIN (NCT00485979)
- Testing
- larotaxel (XRP9881), docetaxel, trastuzumab
- Where
- 8 sites in Belgium, Brazil and 6 more
- Volunteers
- 330 people
- Sponsor
- Sanofi
Cataract Surgery
Evaluation of a Protocol of Pupil Dilation Before Laser-assisted Cataract Surgery
Laser-assisted cataract surgery is an innovative and growing procedure to improve the safety and results of modern cataract surgery.
- Trial name
- MYFLACS (NCT03375996)
- Testing
- cyclopentolate 0.5% eye drops
- Where
- France
- Volunteers
- 60 people
- Sponsor
- CHU de Reims
Breast Cancer, Postoperative Pain
Comparison of Pre-op and Post-op Pectoralis Nerve Block
The investigators will compare whether patients will have better pain control if they were to receive (PEC I/II block) before surgery or after mastectomy.
- Conditions
- Breast Cancer, Postoperative Pain, Anesthesia, Nerve Block
- Trial name
- NCT03653988
- Testing
- PEC I/II blocks by anesthesiologist - pre-operative, PEC I/II blocks by surgeon - intra-operative
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Melinda Seering
Bladder Cancer, Interstitial Cystitis
The Role of Preoperative Immunonutrition on Morbidity and Immune Response After Cystectomy (INCyst Trial)
The goal of this clinical trial research study is to evaluate the impact of preoperative oral immunonutrition (IN) on post-operative complications in patients undergoing a cystectomy.
- Conditions
- Bladder Cancer, Interstitial Cystitis, Painful Bladder Syndrome, Neurogenic Bladder
- Trial name
- INCyst (NCT05726786)
- Testing
- Immunonutrition
- Where
- 4 sites in Switzerland
- Volunteers
- 232 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Colorectal Cancer, Perioperative/Postoperative Complications
J-Pouch Coloanal Anastomosis Compared With Side-to-End Coloanal Anastomosis After Radiation Therapy and Surgery to Remove the Rectum in Treating Patients With Rectal Adenocarcinoma
RATIONALE: A coloanal anastomosis may be effective in restoring bowel function after radiation therapy and surgery to remove the rectum.
- Trial name
- NCT00070005
- Testing
- conventional surgery, management of therapy complications
- Where
- 9 sites in Netherlands
- Volunteers
- 100 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Abdominal Surgery
Preoperative and Postoperative Incentive Spirometry in Patients Undergoing Major Abdominal Surgery
The goal of this study is to determine the efficacy of incentive spirometry (IS) to improve pulmonary function in the preoperative and postoperative surgical setting.
- Trial name
- NCT04887922
- Testing
- MIR Spirobank G, ZEPHYRx®, Conventional spirometer
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Washington University School of Medicine
Diabetes, Diabetes Mellitus
Gastric Ultrasound of Diabetic and Non-Diabetic Patients Following Preoperative Fasting Instructions
This study evaluates the amount of fluid remaining in the stomach of diabetic patients after a standard fasting period, and compare it with non-diabetic patients coming for elective surgical procedures.
- Conditions
- Diabetes, Diabetes Mellitus, Diabetes Mellitus Type 1, Diabetes Mellitus Type 2
- Trial name
- NCT02888951
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- University Health Network, Toronto
Thoracic, Colorectal Disorders
Evaluating Intuitive 3D Models in Preoperative Surgical Planning for Thoracic and Colorectal Procedures.
The Study Objective: To evaluate the clinical utility of a 3D model with 2D CT/MRI scans during simulated preoperative surgical planning of open, laparoscopic, or robotic-assisted anatomic lung resection (segmentectomy…
- Trial name
- ISI-I3DM-01 (NCT06434727)
- Testing
- observational study
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- Intuitive Surgical
Inflammatory Breast Cancer, Stage IIA Breast Cancer
Carboplatin and Paclitaxel Albumin-Stabilized Nanoparticle Formulation Before Surgery in Treating Patients With Locally Advanced or Inflammatory Triple Negative Breast Cancer
This phase II trial studies how well carboplatin and nab-paclitaxel before surgery work in treating patients with triple negative breast cancer that is inflammatory or has spread from where it started to nearby tissue or lymph…
- Conditions
- Inflammatory Breast Cancer, Stage IIA Breast Cancer, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer
- Trial name
- NCT01525966
- Testing
- carboplatin, paclitaxel albumin-stabilized nanoparticle formulation, laboratory biomarker analysis
- Where
- 2 sites in United States
- Volunteers
- 67 people
- Sponsor
- City of Hope Medical Center
Shoulder Arthritis, Patient Education
Preoperative Rehabilitation and Education Program
Shoulder problems affect many Canadians yearly. While surgery is one of the best treatments for shoulder problems, patients are unaware about shoulder replacement surgeries, the exercises needed after surgery and how to safely…
- Conditions
- Shoulder Arthritis, Patient Education, Prehabilitation, Shoulder Arthroplasty
- Trial name
- PREPS (NCT05965986)
- Testing
- Experimental: PREPS only, Experimental: PREPS and therapy
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
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