Clinical trials: Preoperative Risk Assessment
Anesthesia, Preoperative Risk Prediction
Large Language Models Versus Anesthesiologists for ASA Physical Status Classification
The American Society of Anesthesiologists Physical Status (ASA-PS) classification is a cornerstone of preoperative risk assessment, yet interrater variability among clinicians is well documented.
- Conditions
- Anesthesia, Preoperative Risk Prediction, Preoperative Risk Assessment
- Trial name
- ASA-LLM (NCT07696221)
- Volunteers
- 350 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Ovarian Neoplasms
A Diagnostic Test to Evaluate Cancer Risk Before Surgery in Women With an Ovarian Mass
Ovarian cancer is a serious health risk with the highest death rate among gynecological cancers. Unfortunately, it's only possible to definitively diagnose ovarian cancer after surgery, as there are no reliable tests to determine…
- Trial name
- NCT06566716
- Testing
- CleoDX ovarian cancer test
- Where
- 19 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Cleo Diagnostics Ltd
Pediatric Surgical Patients
Evaluation of Preoperative Risk Factors in Children
This study aimed to evaluate preoperative risk factors in pediatric patients and to determine their effectiveness in predicting intensive care unit admission within 72 hours.
- Trial name
- NCT05852899
- Where
- Turkey (Türkiye)
- Volunteers
- 326 people
- Sponsor
- Istanbul University - Cerrahpasa
Surgical Procedures, Telemedicine
The Risk of Surgical Cancellation in Adult Patients Assessed by Telephone Versus In-person for Scheduled Non-cardiac Elective Surgery.
Telemedicine has been regulated in Colombia since 2006, with applications in anesthesia being explored since 2004 to improve accessibility and reduce costs.
- Conditions
- Surgical Procedures, Telemedicine, Preanesthetic Medication, Preoperative Care
- Trial name
- NCT06693869
- Where
- Colombia
- Volunteers
- 1,176 people
- Sponsor
- Universidad de Antioquia
Gastric Emptying, Preoperative Risk Assessment
Stomach Processing and Emptying Evaluation With Diet and Ultrasound
Gastric content is a key risk factor for aspiration during anesthesia. Although standard fasting times are recommended, various factors-including GLP-1 receptor agonists,-can delay gastric emptying.
- Conditions
- Gastric Emptying, Preoperative Risk Assessment, Healthy Volunteer Study
- Trial name
- SPEED-US (NCT06988397)
- Testing
- Physical activity after different type of meals
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Breast Cancer
A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy
This is a Phase III, two-arm, randomized, double-blind placebo-controlled study in participants with HER2-positive primary breast cancer who have received preoperative chemotherapy and HER2-directed therapy, including trastuzumab…
- Trial name
- Astefania (NCT04873362)
- Testing
- Atezolizumab, Trastuzumab Emtansine, Trastuzumab
- Where
- 238 sites in United States, Australia and 30 more
- Volunteers
- 1,188 people
- Sponsor
- Hoffmann-La Roche
Gastrointestinal Stromal Tumors
Gleevec Administered Preoperatively to Reduce Gastrointestinal Stromal Tumor (GIST)
The aim of this study is to demonstrate that the use of Gleevec in initially non-resectable gastrointestinal stromal tumors can lead to allow complete resection in 20% of cases.
- Trial name
- NCT00290485
- Testing
- Imatinib mesylate
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Gastric Content Aspiration Risk, Gastrointestinal Endoscopy
BBCMADE Nomogram Validation for High-Risk Gastric Content in Sedative Endoscopy
This prospective observational study aims to validate the BBCMADE nomogram (Body Mass Index, Brain infarction, Cirrhosis, Male sex, Age, Diabetes, Esophageal reflux) for predicting high-risk gastric content in patients undergoing…
- Conditions
- Gastric Content Aspiration Risk, Gastrointestinal Endoscopy, Anesthesia Complications
- Trial name
- BBCMADE (NCT07638917)
- Testing
- BBCMADE Nomogram, Endoscopic Gastric Volume and pH Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 533 people
- Sponsor
- Fusun Gozen
Prostatic Neoplasms
Pre-operative PET-MR of High Risk Prostate Cancer Patients for Assessment of Cancer Aggressiveness and Lymph Node Status
Prostate cancer is the most frequent cancer in Norwegian men. For optimal treatment, accurate staging of the disease at the time point of diagnosis is important.
- Trial name
- NCT02076503
- Testing
- PET-MR 18f-FACBC, histology (gold standard)
- Where
- Norway
- Volunteers
- 28 people
- Sponsor
- St. Olavs Hospital
Coagulation Disorder, Blood, Prolonged APTT
External Multicenter Validation of the APTTO Model for Prolonged APTT Using Clot Waveform Analysis
Prolonged activated partial thromboplastin time (APTT) is a frequent laboratory finding that may reflect a broad spectrum of underlying conditions, ranging from benign laboratory abnormalities to clinically relevant hemostatic…
- Trial name
- APTTO-EXT (NCT07418099)
- Testing
- Clot waveform analysis-based risk stratification (APTTO models)
- Where
- 16 sites in Spain
- Volunteers
- 1,500 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Breast Neoplasms, Surgery Scheduled
Proof of Concept of the Aiinane Preoperative Risk Assessment Tool.
BACKGROUND: Each year, over 13,000 patients in Catalonia and more than 4 million worldwide experience last-minute surgery cancellations (LMC) due to preoperative inefficiencies.
- Conditions
- Breast Neoplasms, Surgery Scheduled, Surgery Related Complications Rate, Preanesthetic Medication
- Trial name
- aiinane-24-1 (NCT07021235)
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Ancor Serrano
Preoperative Risk Assessment, ASA Physical Status Classification
AI-Based ASA Classification in Preoperative Patients
This prospective observational study aims to evaluate the performance of multiple artificial intelligence-based large language models in assigning American Society of Anesthesiologists Physical Status (ASA-PS) classifications in…
- Trial name
- AI-Based ASA C (NCT07407998)
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Bursa City Hospital
Preoperative Care
Prospective Validation of an Artificial Intelligence Tool for Pre-Anesthetic Assessment
This prospective observational cohort study aims to validate an artificial intelligence (AI) tool designed for pre-anesthetic assessment in Portuguese, tailored to the Brazilian healthcare context.
- Trial name
- NCT07290647
- Testing
- AI-based pre-anesthetic assessment, Anesthesiologist-led pre-anesthetic evaluation
- Where
- Brazil
- Volunteers
- 270 people
- Sponsor
- Hospital Nossa Senhora da Conceicao
Risk
Remembering Risk Using Visual Risk Display of MINS to Obtain Informed Consent to Undergo Elective Surgery
Disclosure of anticipated risks to individuals considering undergoing an elective operative procedure is an important aspect of informed consent process.
- Trial name
- NCT05098535
- Testing
- Visual Aid, Scripted Risk Discussion
- Where
- Canada
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Queen's University
Heart Transplant Failure and Rejection
Bioelectrical Impedance Spectroscopy in Heart Transplantation: Tracking Post-Transplant Changes in Body Composition and Correlation With Conventional Preoperative Risk Assessment Modalities
Patients with marginal physiologic reserve, severe frailty, and/or malnutrition may be regarded as unsuitable candidates for advanced cardiac replacement therapies.
- Trial name
- BIS (NCT03373279)
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Baylor Research Institute
Postoperative Care
Evaluation of ChatGPT-5 and Anesthesiologist Predictions of Postoperative Intensive Care Unit Admission Using Preoperative Clinical Data
Accurate prediction of postoperative intensive care unit (ICU) requirement is essential for patient safety and efficient use of limited ICU resources.
- Trial name
- NCT07395791
- Testing
- No intervention (observational study)
- Where
- Turkey (Türkiye)
- Volunteers
- 938 people
- Sponsor
- Beste Mutlu Dağlıoğlu
COPD, Preoperative Risk Assessment
COPD Assessment Test Score and Perioperative Risk in COPD
The goal of this observational cohort study is to evaluate whether the COPD Assessment Test (CAT) score can predict the risk of perioperative respiratory complications in patients aged 40 to 70 years with diagnosed Chronic…
- Trial name
- COPD (NCT07087626)
- Testing
- Arterial Blood Gas Analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Erzurum City Hospital
High-risk Prostate Cancer, Prostate Cancer
Ga-68-PSMA-11 in High-risk Prostate Cancer
This will be an open-label, single-arm, rater-blinded, multicenter, diagnostic phase 1/2 study to assess safety and diagnostic performance of Ga-68-PSMA-11 positron emission tomography / computer tomography (PET/CT) imaging to…
- Conditions
- High-risk Prostate Cancer, Prostate Cancer, Prostate Cancer Metastatic, Lymphnode Metastasis
- Trial name
- NCT03362359
- Testing
- Ga-68-PSMA-11
- Where
- 8 sites in Austria, Germany
- Volunteers
- 173 people
- Sponsor
- German Cancer Research Center
Endotracheal Intubation Risk Assessment
Anticipation of the Difficult Airway: the Preoperative Airway Assessment Form
The purpose of this study is to see if our experimental preoperative airway assessment form is a better indicator of difficult airway as compared to the anesthesia record that is presently used.
- Trial name
- NCT01037374
- Testing
- Preoperative assessment form
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- The University of Texas Health Science Center, Houston
Postoperative Complications (Cardiopulmonary)
Preoperative Exercise Testing and Perioperative Outcomes
The goal of this observational study is to learn whether results from a brief exercise test done before surgery can help identify adults who may be more likely to have problems after moderate- to high-risk noncardiac surgery.
- Trial name
- SAMPO (NCT07519733)
- Testing
- Recruited participants receive preoperative rapid submaximal cardiopulmonary exercise testing within the current risk assessment framework of the pre-surgical evaluation clinic
- Where
- United States
- Volunteers
- 992 people, healthy volunteers welcome
- Sponsor
- Yale University